Molecular Targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the Zebrafish Ovary: Insights into TCDD-induced Endocrine Disruption and Reproductive Toxicity

TCDD is a reproductive toxicant and endocrine disruptor, yet the mechanisms by which it causes these reproductive alterations are not fully understood. In order to provide additional insight into the molecular mechanisms that underlie TCDD\u27s reproductive toxicity, we assessed TCDD-induced transcriptional changes in the ovary as they relate to previously described impacts on serum estradiol concentrations and altered follicular development in zebrafish. In silico computational approaches were used to correlate candidate regulatory motifs with observed changes in gene expression. Our data suggest that TCDD inhibits follicle maturation via attenuated gonadotropin responsiveness and/or depressed estradiol biosynthesis, and that interference of estrogen-regulated signal transduction may also contribute to TCDD\u27s impacts on follicular development. TCDD may also alter ovarian function by disrupting various signaling pathways such as glucose and lipid metabolism, and regulation of transcription. Furthermore, events downstream from initial TCDD molecular-targets likely contribute to ovarian toxicity following chronic exposure to TCDD. Data presented here provide further insight into the mechanisms by which TCDD disrupts follicular development and reproduction in fish, and can be used to formulate new hypotheses regarding previously documented ovarian toxicity

A giant radio halo in the low luminosity X-ray cluster Abell 523

Radio halos are extended and diffuse non-thermal radio sources present at the cluster center, not obviously associated with any individual galaxy. A strong correlation has been found between the cluster X-ray luminosity and the halo radio power. We observe and analyze the diffuse radio emission present in the complex merging structure Abell 523, classified as a low luminosity X-ray cluster, to discuss its properties in the context of the halo total radio power versus X-ray luminosity correlation. We reduced VLA archive observations at 1.4 GHz to derive a deep radio image of the diffuse emission, and compared radio, optical, and X-ray data. Low-resolution VLA images detect a giant radio halo associated with a complex merging region. The properties of this new halo agree with those of radio halos in general discussed in the literature, but its radio power is about a factor of ten higher than expected on the basis of the cluster X-ray luminosity. Our study of this giant radio source demonstrates that radio halos can also be present in clusters with a low X-ray luminosity. Only a few similar cases have so far been found . This result suggests that this source represent a new class of objects, that cannot be explained by classical radio halo models. We suggest that the particle reacceleration related to merging processes is very efficient and/or the X-ray luminosity is not a good indicator of the past merging activity of a cluster.Comment: 5 pages, 6 figures, Astronomy and Astrophysics Letter in pres

Deep images of cluster radio halos

New radio data are presented for the clusters A401, A545, A754, A1914, A2219 and A2390, where the presence of diffuse radio emission was suggested from the images of the NRAO VLA Sky Survey. Sensitive images of these clusters, obtained with the Very Large Array (VLA)at 20 cm confirm the existence of the diffuse sources and allow us to derive their fluxes and intrinsic parameters.The correlation between the halo radio power and cluster X-ray luminosity is derived for a large sample of halo clusters, and is briefly discussed.Comment: 9 pages, 13 figures, Astron. Astrophys. in pres

The short GRB070707 afterglow and its very faint host galaxy

We present the results from an ESO/VLT campaign aimed at studying the afterglow properties of the short/hard gamma ray burst GRB 070707. Observations were carried out at ten different epochs from ~0.5 to ~80 days after the event. The optical flux decayed steeply with a power-law decay index greater than 3, later levelling off at R~27.3 mag; this is likely the emission level of the host galaxy, the faintest yet detected for a short GRB. Spectroscopic observations did not reveal any line features/edges that could unambiguously pinpoint the GRB redshift, but set a limit z < 3.6. In the range of allowed redshifts, the host has a low luminosity, comparable to that of long-duration GRBs. The existence of such faint host galaxies suggests caution when associating short GRBs with bright, offset galaxies, where the true host might just be too dim for detection. The steepness of the decay of the optical afterglow of GRB 070707 challenges external shock models for the optical afterglow of short/hard GRBs. We argue that this behaviour might results from prolonged activity of the central engine or require alternative scenarios.Comment: 6 pages, 5 figures, accepted by A&

Dark matter distribution in the Coma cluster from galaxy kinematics: breaking the mass-anisotropy degeneracy

We study velocity moments of elliptical galaxies in the Coma cluster using Jeans equations. The dark matter distribution in the cluster is modelled by a generalised formula based upon the results of cosmological N-body simulations. Its inner slope (cuspy or flat), concentration, and mass within the virial radius are kept as free parameters, as well as the velocity anisotropy, assumed independent of position. We show that the study of line-of-sight velocity dispersion alone does not allow to constrain the parameters. By a joint analysis of the observed profiles of velocity dispersion and kurtosis we are able to break the degeneracy between the mass distribution and velocity anisotropy. We determine the dark matter distribution at radial distances larger than 3% of the virial radius and we find that the galaxy orbits are close to isotropic. Due to limited resolution, different inner slopes are found to be consistent with the data and we observe a strong degeneracy between the inner slope $\alpha$ and concentration $c$: the best-fitting profiles have the two parameters related with $c=19 - 9.6 \alpha$. Our best-fitting NFW profile has concentration $c=9$, which is 50% higher than standard values found in cosmological simulations for objects of similar mass. The total mass within the virial radius of $2.9 h_{70}^{-1}$ Mpc is 1.4 \times 10^{15} h_{70}^{-1} M_{\sun} (with 30% accuracy), 85% of which is dark. At this distance from the cluster centre, the mass-to-light ratio in the blue band is $351 h_{70}$ solar units. The total mass within the virial radius leads to estimates of the density parameter of the Universe, assuming that clusters trace the mass-to-light ratio and baryonic fraction of the Universe, with $\Omega_0=0.29 \pm 0.1$.Comment: 13 pages, 10 figures, revised version accepted by MNRAS with discussion on substructure and equilibrium of elliptical galaxies adde

The intracluster magnetic field power spectrum in Abell 2382

The goal of this work is to put constraints on the strength and structure of the magnetic field in the cluster of galaxies A2382. We investigate the relationship between magnetic field and Faraday rotation effects in the cluster, using numerical simulations as a reference for the observed polarization properties. For this purpose we present Very Large Array observations at 20 cm and 6 cm of two polarized radio sources embedded in A2382, and we obtained detailed rotation measure images for both of them. We simulated random three-dimensional magnetic field models with different power spectra and thus produced synthetic rotation measure images. By comparing our simulations with the observed polarization properties of the radio sources, we can determine the strength and the power spectrum of intra-cluster magnetic field fluctuations that best reproduce the observations. The data are consistent with a power law magnetic field power spectrum with the Kolmogorov index $n=11/3$, while the outer scale of the magnetic field fluctuations is of the order of 35 kpc. The average magnetic field strength at the cluster center is about 3 $\mu$G and decreases in the external region as the square root of the electron gas density. The average magnetic field strength in the central 1 Mpc$^{3}$ is about 1 $\mu$G.Comment: Comments: 18 pages, 13 figures, accepted by A&A. For a version with high quality figures, see http://erg.ca.astro.it/preprints/guidetti2007

The Northern ROSAT All-Sky (NORAS) Galaxy Cluster Survey I: X-ray Properties of Clusters Detected as Extended X-ray Sources

In the construction of an X-ray selected sample of galaxy clusters for cosmological studies, we have assembled a sample of 495 X-ray sources found to show extended X-ray emission in the first processing of the ROSAT All-Sky Survey. The sample covers the celestial region with declination $\delta \ge 0\deg$ and galactic latitude $|b_{II}| \ge 20\deg$ and comprises sources with a count rate $\ge 0.06$ counts s$^{-1}$ and a source extent likelihood of 7. In an optical follow-up identification program we find 378 (76%) of these sources to be clusters of galaxies. ...Comment: 61 pages; ApJS in press; fixed bug in table file; also available at (better image quality) http://www.xray.mpe.mpg.de/theorie/NORAS

The Apparent and Intrinsic Shape of the APM Galaxy Clusters

We estimate the distribution of intrinsic shapes of APM galaxy clusters from the distribution of their apparent shapes. We measure the projected cluster ellipticities using two alternative methods. The first method is based on moments of the discrete galaxy distribution while the second is based on moments of the smoothed galaxy distribution. We study the performance of both methods using Monte Carlo cluster simulations covering the range of APM cluster distances and including a random distribution of background galaxies. We find that the first method suffers from severe systematic biases, whereas the second is more reliable. After excluding clusters dominated by substructure and quantifying the systematic biases in our estimated shape parameters, we recover a corrected distribution of projected ellipticities. We use the non-parametric kernel method to estimate the smooth apparent ellipticity distribution, and numerically invert a set of integral equations to recover the corresponding distribution of intrinsic ellipticities under the assumption that the clusters are either oblate or prolate spheroids. The prolate spheroidal model fits the APM cluster data best.Comment: 8 pages, including 7 figures, accepted for publication in MNRA