The Relationship of Perceptions of Service and Support Adequacy to Family Quality of Life for Families of Children with Deafblindness

This study investigated the relationship between families' perceptions of supports and services and family quality of life (FQOL) for families of children with deafblindness, and the potential of satisfaction with family-professional partnerships and child age as moderators of this relationship. The study was guided by the Unified Theory of Family Quality of Life. Two-hundred and twenty-seven families of children with deafblindness between the ages of birth and 22 completed the Service Adequacy and Family Quality of Life for Families of Children who are Deafblind Survey. Results indicated that families' perceptions of supports and services were significantly related to FQOL and that this relationship was dependent on the level of satisfaction families had with family-professional partnerships and the age of the person with deafblindness in the family. Important predictors included friend and family support, related services, and information services. In addition, four interaction effects significantly predicted FQOL: (a) education services adequacy x family-professional partnerships, (b) related services adequacy x family-professional partnerships, (c) friend and family support adequacy x age, and (d) child care adequacy x age. A discussion of the findings is provided and implications for practice, policy, and future research are discussed

Knowledge-to-Action Guides: Preparing Families to Be Partners in Making Educational Decisions

Posted in application of the KU Faculty's Open Access policy

Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety

Artículo científico indizadoGlyphosate is the active ingredient of some of the most highly produced and used herbicides worldwide. The intensive applications of glyphosate-based herbicides and its half-life in water lead to its presence in many aquatic ecosystems. Whereas recent studies have reported neurotoxic effects of glyphosate including autism- related effects, most of them used extremely high (mg/L to g/L) concentrations, so it is still unclear if chronic, low environmentally relevant concentrations of this compound (ng/L to μg/L) can induce neurotoxicity. In this study we analyzed the neurotoxicity of glyphosate in adult zebrafish after waterborne exposure to environmentally relevant concentrations (0.3 and 3 μg/L) for two weeks. Our data showed that exposed fish presented a significant impairment of exploratory and social behaviors consistent with increased anxiety. The anterior brain of the exposed fish presented a significant increase in dopamine and serotonin levels, as well as in the DOPAC/dopamine and homovanillic acid/dopamine turnover ratios. Moreover, the expression of genes involved in the dopaminergic system, as th1, th2, comtb, and scl6a3 was downregulated. Finally, the brain of exposed fish presented a significant increase in the catalase and superoxide dismutase activities, with a concomitant decrease of glutathione stores. These changes in the antioxidant defense system are consistent with the observed increase in oxidative stress, reflected by the increase in the levels of lipid peroxidation in the brain. The presented results show that current glyphosate concentrations commonly found in many aquatic ecosystems may have detrimental consequences on fish survival by decreasing exploration of the environment or altering social interactions. Furthermore, as zebrafish is also a vertebrate model widely used in human neurobehavioral studies, these results are relevant not only for environmental risk assessment, but also for understanding the risk of chronic low-dose exposures on human health.This work was supported by the Spanish Government with FEDER Funds (CTM2017-83242-R; D.R.) and the network of recognized research groups by the Catalan Government (2017 SGR_902). J.B. was supported by a Spanish fellowship PRE2018-083513. Mention of spe- cific products or trade names does not indicate endorsement by the US federal government

Neurobiology of rodent self-grooming and its value for translational neuroscience

Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders-including models of autism spectrum disorder and obsessive compulsive disorder-that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.National Institutes of Health (U.S.) (Grant NS025529)National Institutes of Health (U.S.) (Grant HD028341)National Institutes of Health (U.S.) (Grant MH060379

Three-Dimensional Neurophenotyping of Adult Zebrafish Behavior

The use of adult zebrafish (Danio rerio) in neurobehavioral research is rapidly expanding. The present large-scale study applied the newest video-tracking and data-mining technologies to further examine zebrafish anxiety-like phenotypes. Here, we generated temporal and spatial three-dimensional (3D) reconstructions of zebrafish locomotion, globally assessed behavioral profiles evoked by several anxiogenic and anxiolytic manipulations, mapped individual endpoints to 3D reconstructions, and performed cluster analysis to reconfirm behavioral correlates of high- and low-anxiety states. The application of 3D swim path reconstructions consolidates behavioral data (while increasing data density) and provides a novel way to examine and represent zebrafish behavior. It also enables rapid optimization of video tracking settings to improve quantification of automated parameters, and suggests that spatiotemporal organization of zebrafish swimming activity can be affected by various experimental manipulations in a manner predicted by their anxiolytic or anxiogenic nature. Our approach markedly enhances the power of zebrafish behavioral analyses, providing innovative framework for high-throughput 3D phenotyping of adult zebrafish behavior

MicroRNA: A signature for cancer progression

MicroRNAs (miRNAs) are a group of small non-coding RNAs that post-transcriptionally control expression of genes by targeting mRNAs. miRNA alterations partake in the establishment and progression of different types of human cancer. Consequently, expression profiling of miRNA in human cancers has correlations with cancer detection, staging, progression, and response to therapies. Particularly, amplification, deletion, abnormal pattern of epigenetic factors and the transcriptional factors that mediate regulation of primary miRNA frequently change the landscape of miRNA expression in cancer. Indeed, changes in the quantity and quality of miRNAs are associated with the initiation of cancer, its progression and metastasis. Additionally, miRNA profiling has been used to categorize genes that can affect oncogenic pathways in cancer. Here, we discuss several circulating miRNA signatures, their expression profiles in different types of cancer and their impacts on cellular processes

Evaluation of a babesiosis card agglutination test

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El futuro es perifrástico: un análisis sociolingüístico de la expresión de futuridad en dos comunidades mexicanas

In this comparative study of the expression of futurity in the Spanish of Mexicans in the United States and the sociolinguistically understudied city of Xalapa, Mexico, I explore the distribution of the variants of futurity: the morphological future (MF), the periphrastic future (PF) and the simple present (SP) and the constraints conditioning their occurrence. The data were extracted from sociolinguistic interviews with two socially stratified groups of consultants from each community under study. I conducted statistical regression analyses to test the effects of five social and nine linguistic constraints. The results indicate that the PF registers the highest rate of occurrence with a frequency of 67.6% and the MF is disappearing at the expense of the other variants. In comparison to other studies, Orozco (2007a), Lastra & Martín Butragueño (2010), Claes & Ortíz-López (2011), Gutiérrez (1995) and Blas Arroyo (2007, 2008) found that the PF is the most favored variant at the expense of the others. When comparing the tendencies of these communities with those under study, it becomes apparent that the Mexicans in Baton Rouge and Xalapa are at a more advanced level toward the preferential use of the PF. The type of verb, as reported in previous studies (cf. Orozco 2005, 2007), is the linguistic constraint that most strongly influences the expression of futurity. Regarding the social constraints, in Louisiana and Xalapa, for example, both age and level of education condition the use of the future. Gender, however, shows no significant effect, which differs from what occurs in Barranquilla and New York (Orozco 2007b, Forthcoming), Mexico City (Lastra & Martín Butragueño 2010) and Puerto Rico (Claes & Ortíz López 2011). In general, the significant linguistic factors are consistent with the findings of other speech communities with regard to the type of verb and reflect the universality of the process of grammaticalization. The lack of statistical significance for gender suggests that women and men have similar sociolinguistic behavior. This opens the possibility of exploring other linguistic variables in these and other Mexican communities to determine whether the social trends that are found are limited to the expression of futurity or to the communities under study

Cataractogenic effects of proton radiation

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