The Insecure City

Urban anthropologist Kristin Monroe takes urban anthropology in a new and meaningful direction—the story of traffic in the Middle East, focusing on Beirut. As bombs reappeared recently following an impasse between competing political groups and their international backers, residents of the city were forced to contend with many forms of insecurity, forging their lives amid a contentious, often violent, political and economic landscape. Images and headlines in the news media tracked the dramatic events that characterized this unstable situation, but they did not provide a picture of what ordinary life was like for urban dwellers in a city terrorized by political sectarianism and the treat of bombs. The Insecure City is an ethnographic exploration of the experiences of moving through Beirut. Driving is characterized by precariousness, the anticipation of violence, and the constant presence of class, political, and state power

Masculinity, Migration, and Forced Conscription in the Syrian War

In this essay, I provide a different perspective on the Syrian conflict by examining how the war’s reach can also be located amid the losses, interruptions, and experiences of those Syrians who have until now largely escaped its incredible violence. By looking closely at how the war has altered the life trajectories of and produced distinct modes of vulnerability for military-age men, I develop an argument about how, although they avoid fighting by going to work in Qatar, the lives of a group of Syrian men remain defined by conscription. Through my investigation of how these men are located in a landscape of conscription that extends beyond the borders of Syria, I build on anthropological knowledge of how masculinity is shaped by and through contexts of political destabilization. I demonstrate how, in fulfilling their end of the patriarchal bargain through political obedience and economic production, these men lose a particular stage of manhood and the aspirations, projects, and affective promises it holds

The Insecure City: Space, Power, and Mobility in Beirut

Fifteen years after the end of a protracted civil and regional war, Beirut broke out in violence once again, forcing residents to contend with many forms of insecurity, amid an often violent political and economic landscape. Providing a picture of what ordinary life is like for urban dwellers surviving sectarian violence, The Insecure City captures the day-to-day experiences of citizens of Beirut moving through a war-torn landscape. While living in Beirut, Kristin Monroe conducted interviews with a diverse group of residents of the city. She found that when people spoke about getting around in Beirut, they were also expressing larger concerns about social, political, and economic life. It was not only violence that threatened Beirut’s ordinary residents, but also class dynamics that made life even more precarious. For instance, the installation of checkpoints and the rerouting of traffic—set up for the security of the elite—forced the less fortunate to alter their lives in ways that made them more at risk. Similarly, the ability to pass through security blockades often had to do with an individual’s visible markers of class, such as clothing, hairstyle, and type of car. Monroe examines how understandings and practices of spatial mobility in the city reflect social differences, and how such experiences led residents to be bitterly critical of their government. In The Insecure City, Monroe takes urban anthropology in a new and meaningful direction, discussing traffic in the Middle East to show that when people move through Beirut they are experiencing the intersection of citizen and state, of the more and less privileged, and, in general, the city’s politically polarized geography.https://uknowledge.uky.edu/anthro_book/1001/thumbnail.jp

A molecular‐level perspective on the frequency, distribution, and consequences of messenger RNA modifications

Cells use chemical modifications to alter the sterics, charge, and conformations of large biomolecules, modulating their biogenesis, function, and stability. Until recently post‐transcriptional RNA modifications were thought to be largely limited to nonprotein coding RNA species. However, this dogma has rapidly transformed with the discovery of a host of modifications in protein coding messenger RNAs (mRNAs). Recent advancements in genome‐wide sequencing technologies have enabled the identification of mRNA modifications as a potential new frontier in gene regulation—leading to the development of the epitranscriptome field. As a result, there has been a flurry of multiple groundbreaking discoveries, including new modifications, nucleoside modifying enzymes (“writers” and “erasers”), and RNA binding proteins that recognize chemical modifications (“readers”). These discoveries opened the door to understanding how post‐transcriptional mRNA modifications can modulate the mRNA lifecycle, and established a link between the epitranscriptome and human health and disease. Despite a rapidly growing recognition of their importance, fundamental questions regarding the identity, prevalence, and functional consequences of mRNA modifications remain to be answered. Here, we highlight quantitative studies that characterize mRNA modification abundance, frequency, and interactions with cellular machinery. As the field progresses, we see a need for the further integration of quantitative and reductionist approaches to complement transcriptome wide studies in order to establish a molecular‐level framework for understanding the consequences of mRNA chemical modifications on biological processes.This article is categorized under:RNA Structure and Dynamics > RNA Structure, Dynamics and ChemistryRNA Processing > RNA Editing and ModificationThe integration of biochemical, structural, and transcriptome wide approaches is shaping a quantitative framework for understanding the biological consequences of mRNA modifications.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155973/1/wrna1586.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155973/2/wrna1586_am.pd

A qualitative study examining the benefits and challenges of incorporating patient-reported outcome substance use and mental health questionnaires into clinical practice to improve outcomes on the HIV care continuum.

BACKGROUND: Inadequate identification and treatment of substance use (SU) and mental health (MH) disorders hinders retention in HIV care. The objective of this study was to elicit stakeholder input on integration of SU/MH screening using computer-assisted patient-reported outcomes (PROs) into clinical practice. METHODS: We conducted semi-structured interviews with HIV-positive patients who self-reported SU/MH symptoms on a computer-assisted PROs (n = 19) and HIV primary care providers (n = 11) recruited from an urban academic HIV clinic. Interviews were audio-recorded and transcribed. We iteratively developed codes and organized key themes using editing style analysis. RESULTS: Two themes emerged: (1) Honest Disclosure: Some providers felt PROs might improve SU/MH disclosure; more were concerned that patients would not respond honestly if their provider saw the results. Patients were also divided, stating PROs could help overcome stigma but that it could be harder to disclose SU/MH to a computer versus a live person. (2) Added Value in the Clinical Encounter: Most providers felt PROs would fill a practice gap. Patients had concerns regarding confidentiality but indicated PROs would help providers take better care of them. CONCLUSIONS: Both patients and providers indicated that PROs are potentially useful clinical tools to improve detection of SU/MH. However, patients and providers expressed conflicting viewpoints about disclosure of SU/MH using computerized PROs. Future studies implementing PROs screening interventions must assess concerns over confidentiality and honest disclosure of SU/MH to understand the effectiveness of PROs as a clinical tool. More research is also needed on patient-centered integration of the results of PROs in HIV care

Evaluation of standardized psychological screening for pediatric inpatients.

Objective: This study aimed to examine the efficacy of a psychological screening tool for hospitalized pediatric patients to identify those at high risk for adjustment difficulties and optimize referrals to pediatric behavioral health (BH) providers. Specifically, this study evaluated the PROMIS® Parent Proxy 25 to capture the psychosocial needs of the inpatient pediatric population admitted to the general medicine floor in a free standing children’s hospital. Methods: The PROMIS® Parent Proxy 25 was administered to parents of children ages 5 to 17 (N = 128). Chart review was used to group children into those who did or did not receive BH consultation during their admission. Results: Results indicate that the PROMIS® Parent Proxy Anxiety and Depression scales consistently differentiated between children’s consultation status while also indicating a notable level of unmet need in children who did not receive BH consultation. Examination of patterns of scale elevations also provides further information to guide consultations to BH services. Conclusions: Results suggest that the PROMIS® Parent Proxy 25 may be a useful screening tool to determine pediatric patients who need BH referrals. Parental responses to the screener may also be used by CL services to identify patients with BH needs, which would enhance medical provider assessment of patient needs and factors impacting patient functioning

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Characterization of Recurrence Patterns and Outcomes of Medulloblastoma in Adults: The University of Texas MD Anderson Cancer Center Experience

BACKGROUND: Medulloblastoma in adults is rare and treatment decisions are largely driven from pediatric literature. We sought to characterize recurrent medulloblastoma in adults. METHODS: From a single-institution dataset of 200 adult patients diagnosed with medulloblastoma during 1978-2017, those with recurrence were analyzed for clinical features, treatment, and outcome. RESULTS: Of the 200 patients, 82 (41%) with median age of 29 years (18-59) had recurrence after a median follow-up time of 8.4 years (95% CI = 7.1, 10.3). Of these, 30 (37%) were standard-risk, 31 (38%) were high-risk, and 21 (26%) had unknown-risk diseases at the time of initial diagnosis. Forty-eight (58%) presented with recurrence outside the posterior fossa, of whom 35 (43%) had distant recurrence only. Median Progression-free survival (PFS) and OS from initial surgery were 33.5 and 62.4 months, respectively. Neither PFS nor OS from initial diagnosis differed between the standard-risk and high-risk groups in those who experience recurrence ( CONCLUSIONS: Recurrent medulloblastoma in adults has a poor prognosis irrespective of initial risk stratification. Recurrence commonly arises outside the posterior fossa years after initial diagnosis

Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus

Embryonic diapause is a reproductive strategy widespread in the animal kingdom. This phenomenon is defined by a temporary arrest in blastocyst growth and metabolic activity within a quiescent uterus without implantation until the environmental and maternal milieu become favorable for pregnancy to progress. We found that uterine Msx expression persists during diapause across species; their inactivation in the mouse uterus results in termination of diapause with the development of implantation-like responses (“pseudoimplantation”) that ultimately succumbed to resorption. To understand the cause of this failure, we compared proteome profiles between floxed and Msx-deleted uteri. In deleted uteri, several functional networks, including transcription/translation, ubiquitin-proteasome, inflammation, and endoplasmic reticulum stress, were dysregulated. Computational modeling predicted intersection of these pathways on an enhanced inflammatory signature. Further studies showed that this signature was reflected in increased phosphorylated IκB levels and nuclear NFκB in deleted uteri. This was associated with enhanced proteasome activity and endoplasmic reticulum stress. Interestingly, treatment with anti-inflammatory glucocorticoid (dexamethasone) reduced the inflammatory signature with improvement of the diapause phenotype. These findings highlight an unexpected role of uterine Msx in limiting aberrant inflammatory responses to maintain embryonic diapause