Der Photonendetektor für die Schule als Einstieg in die Quantenphysik

Vielfältige fachdidaktische Forschungs- und Entwicklungsarbeiten der letzten Jahre zielen auf einen adäquaten, schülergerechten Zugang zur Quantenphysik. Beispielsweise fokussiert das in München entwickelte Konzept milq auf grundlegende Phänomene der Quantenphysik und damit verbundene Deutungsfragen, wobei für den Einstieg in die Quantenphysik hier vor allem Simulationen und Videos verwendet werden. In Ergänzung dieses Ansatzes haben wir einen Flächendetektor zum Nachweis geringer Lichtintensitäten entwickelt, um darauf aufbauend in schulpraxistauglichen Realexperimenten grundlegende Phänomene der Quantenphysik am Doppelspaltexperiment zu visualisieren. Unter Verwendung eines Lasers als Lichtquelle wird mit dem Detektor ein Demonstrationsexperiment aufgebaut, das auf jüngeren fachdidaktischen Entwicklungsarbeiten verschiedener Gruppen basiert und zielorientiert für einen praxistauglichen Schuleinsatz angepasst wurde

Der Photonendetektor für die Schule als Einstieg in die Quantenphysik

Vielfältige fachdidaktische Forschungs- und Entwicklungsarbeiten der letzten Jahre zielen auf einen adäquaten, schülergerechten Zugang zur Quantenphysik. Beispielsweise fokussiert das in München entwickelte Konzept milq auf grundlegende Phänomene der Quantenphysik und damit verbundene Deutungsfragen, wobei für den Einstieg in die Quantenphysik hier vor allem Simulationen und Videos verwendet werden. In Ergänzung dieses Ansatzes haben wir einen Flächendetektor zum Nachweis geringer Lichtintensitäten entwickelt, um darauf aufbauend in schulpraxistauglichen Realexperimenten grundlegende Phänomene der Quantenphysik am Doppelspaltexperiment zu visualisieren. Unter Verwendung eines Lasers als Lichtquelle wird mit dem Detektor ein Demonstrationsexperiment aufgebaut, das auf jüngeren fachdidaktischen Entwicklungsarbeiten verschiedener Gruppen basiert und zielorientiert für einen praxistauglichen Schuleinsatz angepasst wurde

Environmental hot spot analysis in agricultural lifecycle assessments – three case studies

Present-day agricultural technology is facing the challenge of limiting the environmental impacts of agricultural production – such as greenhouse gas emissions and demand for additional land – while meeting growing demands for agricultural products. Using the well-established method of life-cycle assessment (LCA), potential environmental impacts of agricultural production chains can be quantified and analyzed. This study presents three case studies of how the method can pinpoint environmental hot spots at different levels of agricultural production systems. The first case study centers on the tractor as the key source of transportation and traction in modern agriculture. A common Austrian tractor model was investigated over its life-cycle, using primary data from a manufacturer and measured load profiles for field work. In all but one of the impact categories studied, potential impacts were dominated by the operation phase of the tractor’s life-cycle (mainly due to diesel fuel consumption), with 84.4-99.6% of total impacts. The production phase (raw materials and final assembly) caused between 0.4% and 12.1% of impacts, while disposal of the tractor was below 1.9% in all impact categories. The second case study shifts the focus to an entire production chain for a common biogas feedstock, maize silage. System boundaries incorporate the effect of auxiliary materials such as fertilizer and pesticides manufacturing and application. The operation of machinery in the silage production chain was found to be critical to its environmental impact. For the climate change indicator GWP100 (global warming potential, 100-year reference period), emissions from tractor operation accounted for 15 g CO2-eq per kg silage (64% of total GWP100), followed by field emissions during fertilizer (biogas digestate) application with 6 g CO2-eq per kg silage (24% of total GWP100). At a larger system scale that includes a silage-fed biogas plant with electricity generated by a biogas engine, silage cultivation operations are no longer the largest contributor; the most important contributor (49.8%) is methane slip from the exhaust of the biogas engine. In the third case study, the biogas plant model is energy system in an Alpine municipality of Western Austria is expanded to include a hypothetical system that uses mainly hay from currently unused alpine grassland in a local biogas plant. Here, the relative environmental impacts depend strongly on the fossil fuels that are assumed to be displaced by the local biogas plant; methane slip emissions from the exhaust dominate the impact of the hypothetical local biogas scenario. Taken together, the case studies demonstrate the potential and limitations of LCA as a technique to support decisions of agricultural stakeholders at a variety of scales. Choosing the proper system scale is key to a successful application of this method

Proof of concept for wind turbine wake investigations with the RPAS SUMO

The Small Unmanned Meteorological Observer (SUMO) has been operated in the vicinity of five research turbines of the Energy Research Centre of the Netherlands (ECN) at the test site Wieringermeer. The intention of the campaign was to proof the capability of the system for wind turbine wake investigations also for situations above rated wind speed. In rather high wind conditions of 15-20 ms−1 on May 10, 2014, the system showed a satisfying in-flight behavior and performed five racetrack flights. The racetrack patterns flown parallel to the row of the five turbines (four flights downstream the turbine row, one upstream) enable the characterization and investigation of the strength, i.e. the reduction in the mean wind, and structure, i.e. the horizontal extension and turbulent kinetic energy (TKE) distribution of single turbine wakes.publishedVersio

Calixpyrroles, calixpyridinopyrroles and calixpyridines

The present invention provides calixpyrrole, calixpyridinopyrrole, and calixpyridine macrocycles, having 4, 5, 6, 7, or 8 heterocyclic rings, as well as syntheses, derivatives, conjugates, multimers, and solid supports thereof. Such macrocycles have proved to be effective and selective ion- and neutral molecule-binding agents forming supramolecular ensembles, and ion- and neutral molecule-separation agents. The macrocycles are fully meso-non-hydrogen-substituted porphyrinogens, a few molecules of which were previously known but not recognized as possessing anion- or molecule-binding properties. The binding mode is noncovalent, primarily that of hydrogen-bonding, thereby providing a new mode for liquid chromatography, that of Hydrogen Bonding Liquid Chromatography. Further useful applications of the macrocycles provided herein include environmental remediation by removal of undesired ions or neutral molecules, and removal of phosphate for kidney dialysis.Board of Regents, University of Texas Syste

Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis

CCL17 is produced by conventional dendritic cells, signals through CCR4 on regulatory T (Treg) cells and drives atherosclerosis by suppressing Treg functions through yet undefined mechanisms. Here we show that conventional dendritic cells from CCL17-deficient mice display a pro-tolerogenic phenotype and transcriptome that is not phenocopied in mice lacking its cognate receptor CCR4. In the plasma of CCL17-deficient mice, CCL3 was the only decreased cytokine/chemokine. We found that CCL17 signaled through CCR8 as an alternate high-affinity receptor, which induced CCL3 expression and suppressed Treg functions in the absence of CCR4. Genetic ablation of CCL3 and CCR8 in CD4+ T cells reduced CCL3 secretion, boosted FoxP3+ Treg numbers and limited atherosclerosis. Conversely, CCL3 administration exacerbated atherosclerosis and restrained Treg differentiation. In symptomatic versus asymptomatic human carotid atheroma, CCL3 expression was increased, whereas FoxP3 expression was reduced. Together, we identified a non-canonical chemokine pathway whereby CCL17 interacts with CCR8 to yield a CCL3-dependent suppression of atheroprotective Treg cells. Doring, van der Vorst, Yan, Neideck et al. present a non-canonical chemokine pathway involving CCL17 signaling through CCR8, which induces CCL3 expression independent of CCR4 and suppresses the functions of atheroprotective Treg cells

Planet Formation Imager (PFI): Science vision and key requirements

The Planet Formation Imager (PFI) project aims to provide a strong scientific vision for ground-based optical astronomy beyond the upcoming generation of Extremely Large Telescopes. We make the case that a breakthrough in angular resolution imaging capabilities is required in order to unravel the processes involved in planet formation. PFI will be optimised to provide a complete census of the protoplanet population at all stellocentric radii and over the age range from 0.1 to ∼100 Myr. Within this age period, planetary systems undergo dramatic changes and the final architecture of planetary systems is determined. Our goal is to study the planetary birth on the natural spatial scale where the material is assembled, which is the Hill Sphere of the forming planet, and to characterise the protoplanetary cores by measuring their masses and physical properties. Our science working group has investigated the observational characteristics of these young protoplanets as well as the migration mechanisms that might alter the system architecture. We simulated the imprints that the planets leave in the disk and study how PFI could revolutionise areas ranging from exoplanet to extragalactic science. In this contribution we outline the key science drivers of PFI and discuss the requirements that will guide the technology choices, the site selection, and potential science/technology tradeoffs

A new clinico-pathological classification system for mesial temporal sclerosis

We propose a histopathological classification system for hippocampal cell loss in patients suffering from mesial temporal lobe epilepsies (MTLE). One hundred and seventy-eight surgically resected specimens were microscopically examined with respect to neuronal cell loss in hippocampal subfields CA1–CA4 and dentate gyrus. Five distinct patterns were recognized within a consecutive cohort of anatomically well-preserved surgical specimens. The first group comprised hippocampi with neuronal cell densities not significantly different from age matched autopsy controls [no mesial temporal sclerosis (no MTS); n = 34, 19%]. A classical pattern with severe cell loss in CA1 and moderate neuronal loss in all other subfields excluding CA2 was observed in 33 cases (19%), whereas the vast majority of cases showed extensive neuronal cell loss in all hippocampal subfields (n = 94, 53%). Due to considerable similarities of neuronal cell loss patterns and clinical histories, we designated these two groups as MTS type 1a and 1b, respectively. We further distinguished two atypical variants characterized either by severe neuronal loss restricted to sector CA1 (MTS type 2; n = 10, 6%) or to the hilar region (MTS type 3, n = 7, 4%). Correlation with clinical data pointed to an early age of initial precipitating injury (IPI < 3 years) as important predictor of hippocampal pathology, i.e. MTS type 1a and 1b. In MTS type 2, IPIs were documented at a later age (mean 6 years), whereas in MTS type 3 and normal appearing hippocampus (no MTS) the first event appeared beyond the age of 13 and 16 years, respectively. In addition, postsurgical outcome was significantly worse in atypical MTS, especially MTS type 3 with only 28% of patients having seizure relief after 1-year follow-up period, compared to successful seizure control in MTS types 1a and 1b (72 and 73%). Our classification system appears suitable for stratifying the clinically heterogeneous group of MTLE patients also with respect to postsurgical outcome studies

Semiconductor Superlattices: A model system for nonlinear transport

Electric transport in semiconductor superlattices is dominated by pronounced negative differential conductivity. In this report the standard transport theories for superlattices, i.e. miniband conduction, Wannier-Stark-hopping, and sequential tunneling, are reviewed in detail. Their relation to each other is clarified by a comparison with a quantum transport model based on nonequilibrium Green functions. It is demonstrated how the occurrence of negative differential conductivity causes inhomogeneous electric field distributions, yielding either a characteristic sawtooth shape of the current-voltage characteristic or self-sustained current oscillations. An additional ac-voltage in the THz range is included in the theory as well. The results display absolute negative conductance, photon-assisted tunneling, the possibility of gain, and a negative tunneling capacitance.Comment: 121 pages, figures included, to appear in Physics Reports (2001