Redefining Knee Balance in a Medially Stabilized Prosthesis: An In-Vitro Study

Background To date, there is still no consensus on what soft tissues must be preserved and what structures can be safely released during total knee arthroplasty (TKA) with a medially stabilized implant. Objective The aim of this study was to analyze the effect of a progressive selective release of the medial and lateral soft tissues in a knee implanted with a medially stabilized prosthesis. Method Six cadaveric fresh-frozen full leg specimens were tested. In each case, kinematic pattern and mediolateral laxity were measured in three stages: firstly, prior to implantation; secondly, after the implantation of the trial components, but before any soft tissue release; and thirdly, progressively as soft tissue was released with the trial implant in place. The incremental impact of each selective release on knee balance was then analyzed. Results In all cases sagittal stability was not affected by the progressive release of the lateral soft tissue envelope. It was possible to perform progressive lateral release provided the anterior one-third of the iliotibial band (ITB) remained intact. Progressive medial release could be performed on the medial side provided the anterior fibers of the superficial medial collateral ligament (sMCL) remained intact. Conclusion The medially conforming implant remains stable provided the anterior fibers of sMCL and the anterior fibers of the ITB remain intact. The implant's sagittal stability is mainly dependent on its medial ball-in-socket design

Avant-propos

Sociétés chaudes et sociétés froides, sociétés de tradition écrite, apanage de l’enquête historique, et sociétés de tradition orale, pâture pour les anthropologues, ne s’opposent pas tout uniment, comme on le pensait encore du temps où les études en diachronie étaient si commodes à séparer de la reconstruction des systèmes synchroniques. D’autre part, les religions du Livre et les religions du faire rituel ne se laissent pas non plus distinguer absolument : il ne sert de rien, pour restaurer ..

Switzerland committed to innovation : the Swiss Network of Technology Assessment

Switzerland showed its commitment to innovation in health care since the early 80th, implementing agencies and government units with the mission to promote and to appropriately govern innovation. The Swiss Network of Technology Assessment (SNHTA) was founded in 1998. The aim is the promotion and implementation of Health Technology Assessment projects in Switzerland by providing a neutral forum for the identification and the pursuit of common interests. This includes the coordination, exchange and dissemination of experiences of HTA projects and the implementation of the results. The collaboration in international projects is a priority. Ultimately SNHTA has the goal to improve efficacy, cost effectiveness and social accountability. An inventory survey amongst the members confirmed a high level of diverse specialised competencies, mainly employed within the institution. Only 20% of the HTA specific competencies are used for external activities. The need for integration of all partners in the field of innovation in a network has been recognised by the Swiss government. This lead to the creation of a webplatform in which all players involved in the business of medical technologies are involved. This platform (swiss medtech), includes patients, insurers, industry, universities and professional organisations. The joined activities include agreements on intellectual property and the integrated patient care chain. New ways to connect players in innovation are needed to face the challenge of increasing costs and diminishing resources. [Authors]]]> Technology Assessment, Biomedical eng oai:serval.unil.ch:BIB_A9B14948D993 2022-10-01T01:26:48Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_A9B14948D993 Structural domains implicated in ER degradation of alpha subunits of Na,K-ATPase info:doi:10.1111/j.1749-6632.1997.tb52312.x info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.1997.tb52312.x info:eu-repo/semantics/altIdentifier/pmid/9405856 Beguin, P. Geering, K. info:eu-repo/semantics/article article 1997-11 Annals of the New York Academy of Sciences, vol. 834, pp. 540-2 info:eu-repo/semantics/altIdentifier/pissn/0077-8923 Animals Bufonidae Endoplasmic Reticulum/*enzymology Female Intracellular Membranes/enzymology/ultrastructure Macromolecular Substances Microsomes/enzymology/ultrastructure Na(+)-K(+)-Exchanging ATPase/*chemistry/*metabolism Oocytes/physiology Protein Conformation Recombinant Proteins/chemistry/metabolism Sequence Deletion Xenopus oai:serval.unil.ch:BIB_A9B1A7211DAD 2022-10-01T01:26:48Z openaire documents <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_A9B1A7211DAD Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. info:doi:10.1038/s41467-019-12958-0 info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-019-12958-0 info:eu-repo/semantics/altIdentifier/pmid/31719535 Noordam, R. Bos, M.M. Wang, H. Winkler, T.W. Bentley, A.R. Kilpeläinen, T.O. de Vries, P.S. Sung, Y.J. Schwander, K. Cade, B.E. Manning, A. Aschard, H. Brown, M.R. Chen, H. Franceschini, N. Musani, S.K. Richard, M. Vojinovic, D. Aslibekyan, S. Bartz, T.M. de Las Fuentes, L. Feitosa, M. Horimoto, A.R. Ilkov, M. Kho, M. Kraja, A. Li, C. Lim, E. Liu, Y. Mook-Kanamori, D.O. Rankinen, T. Tajuddin, S.M. van der Spek, A. Wang, Z. Marten, J. Laville, V. Alver, M. Evangelou, E. Graff, M.E. He, M. Kühnel, B. Lyytikäinen, L.P. Marques-Vidal, P. Nolte, I.M. Palmer, N.D. Rauramaa, R. Shu, X.O. Snieder, H. Weiss, S. Wen, W. Yanek, L.R. Adolfo, C. Ballantyne, C. Bielak, L. Biermasz, N.R. Boerwinkle, E. Dimou, N. Eiriksdottir, G. Gao, C. Gharib, S.A. Gottlieb, D.J. Haba-Rubio, J. Harris, T.B. Heikkinen, S. Heinzer, R. Hixson, J.E. Homuth, G. Ikram, M.A. Komulainen, P. Krieger, J.E. Lee, J. Liu, J. Lohman, K.K. Luik, A.I. Mägi, R. Martin, L.W. Meitinger, T. Metspalu, A. Milaneschi, Y. Nalls, M.A. O'Connell, J. Peters, A. Peyser, P. Raitakari, O.T. Reiner, A.P. Rensen, PCN Rice, T.K. Rich, S.S. Roenneberg, T. Rotter, J.I. Schreiner, P.J. Shikany, J. Sidney, S.S. Sims, M. Sitlani, C.M. Sofer, T. Strauch, K. Swertz, M.A. Taylor, K.D. Uitterlinden, A.G. van Duijn, C.M. Völzke, H. Waldenberger, M. Wallance, R.B. van Dijk, K.W. Yu, C. Zonderman, A.B. Becker, D.M. Elliott, P. Esko, T. Gieger, C. Grabe, H.J. Lakka, T.A. Lehtimäki, T. North, K.E. Penninx, BWJH Vollenweider, P. Wagenknecht, L.E. Wu, T. Xiang, Y.B. Zheng, W. Arnett, D.K. Bouchard, C. Evans, M.K. Gudnason, V. Kardia, S. Kelly, T.N. Kritchevsky, S.B. Loos, RJF Pereira, A.C. Province, M. Psaty, B.M. Rotimi, C. Zhu, X. Amin, N. Cupples, L.A. Fornage, M. Fox, E.F. Guo, X. Gauderman, W.J. Rice, K. Kooperberg, C. Munroe, P.B. Liu, C.T. Morrison, A.C. Rao, D.C. van Heemst, D. Redline, S. info:eu-repo/semantics/article article 2019-11-12 Nature communications, vol. 10, no. 1, pp. 5121 info:eu-repo/semantics/altIdentifier/eissn/2041-1723 urn:issn:2041-1723 <![CDATA[Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles

CoCAS: a ChIP-on-chip analysis suite

Motivation: High-density tiling microarrays are increasingly used in combination with ChIP assays to study transcriptional regulation. To ease the analysis of the large amounts of data generated by this approach, we have developed ChIP-on-chip Analysis Suite (CoCAS), a standalone software suite which implements optimized ChIP-on-chip data normalization, improved peak detection, as well as quality control reports. Our software allows dye swap, replicate correlation and connects easily with genome browsers and other peak detection algorithms. CoCAS can readily be used on the latest generation of Agilent high-density arrays. Also, the implemented peak detection methods are suitable for other datasets, including ChIP-Seq output

Novel Prediction Methods of Multicarrier Multipactor for Space Industry Standards

[EN] Multipactor prediction methods are of high relevance for the space industry in order to prevent its appearance during the design phase of RF high-power components. Up to the present time, prediction for multicarrier signals has been covered by an empirical rule, the 20-gap-crossing rule (20GCR), proposed in the 2003 version of the multipactor standard published by the European Cooperation for Space Standardization (ECSS). The 20GCR has been widely used by the space industry, although some studies have demonstrated that it might be inaccurate in some situations. The latest version of the ECSS multipactor standard, published in 2020, presents two novel methods for multipactor prediction with multicarrier signals: the pulsed method and the envelope sweep (ES) method, both simple, accurate enough, and suitable for industry standards. While the pulsed model is a simple and fast method based on a 1-D analytical theory, the ES method is more accurate and able to deal with real 3-D microwave structures. This article details both multipactor prediction methods, as well as their practical validation with a large dataset from previous analytical studies and experimental activities.The authors would like to thank the ESA-ESTEC and ASD-Eurospace for the creation and support of the ECSSE-ST-20-01 working group for the update of the ECSS multipactor standard, which has been the motivation of this work.Anza, S.; Puech, J.; Raboso, D.; Wochner, U.; Mader, P.; Koch, O.; Angevain, J.... (2022). Novel Prediction Methods of Multicarrier Multipactor for Space Industry Standards. IEEE Transactions on Microwave Theory and Techniques. 70(1):670-684. https://doi.org/10.1109/TMTT.2021.312009567068470

Gating a single-molecule transistor with individual atoms

Transistors, regardless of their size, rely on electrical gates to control the conductance between source and drain contacts. In atomic-scale transistors, this conductance is sensitive to single electrons hopping via individual orbitals1, 2. Single-electron transport in molecular transistors has been previously studied using top-down approaches to gating, such as lithography and break junctions1, 3, 4, 5, 6, 7, 8, 9, 10, 11. But atomically precise control of the gate—which is crucial to transistor action at the smallest size scales—is not possible with these approaches. Here, we used individual charged atoms, manipulated by a scanning tunnelling microscope12, to create the electrical gates for a single-molecule transistor. This degree of control allowed us to tune the molecule into the regime of sequential single-electron tunnelling, albeit with a conductance gap more than one order of magnitude larger than observed previously8, 11, 13, 14. This unexpected behaviour arises from the existence of two different orientational conformations of the molecule, depending on its charge state. Our results show that strong coupling between these charge and conformational degrees of freedom leads to new behaviour beyond the established picture of single-electron transport in atomic-scale transistors

The History of Biomechanics in Total Hip Arthroplasty.

Biomechanics of the hip joint describes how the complex combination of osseous, ligamentous, and muscular structures transfers the weight of the body from the axial skeleton into the appendicular skeleton of the lower limbs. Throughout history, several biomechanical studies based on theoretical mathematics, in vitro, in vivo as well as in silico models have been successfully performed. The insights gained from these studies have improved our understanding of the development of mechanical hip pathologies such as osteoarthritis, hip fractures, and developmental dysplasia of the hip. The main treatment of end-stage degeneration of the hip is total hip arthroplasty (THA). The increasing number of patients undergoing this surgical procedure, as well as their demand for more than just pain relief and leading an active lifestyle, has challenged surgeons and implant manufacturers to deliver higher function as well as longevity with the prosthesis. The science of biomechanics has played and will continue to play a crucial and integral role in achieving these goals. The aim of this article, therefore, is to present to the readers the key concepts in biomechanics of the hip and their application to THA

The skeleton of the staghorn coral Acropora millepora: molecular and structural characterization

15 pagesInternational audienceThe scleractinian coral Acropora millepora is one of the most studied species from the Great Barrier Reef. This species has been used to understand evolutionary, immune and developmental processes in cnidarians. It has also been subject of several ecological studies in order to elucidate reef responses to environmental changes such as temperature rise and ocean acidification (OA). In these contexts, several nucleic acid resources were made available. When combined to a recent proteomic analysis of the coral skeletal organic matrix (SOM), they enabled the identification of several skeletal matrix proteins, making A. millepora into an emerging model for biomineralization studies. Here we describe the skeletal microstructure of A. millepora skeleton, together with a functional and biochemical characterization of its occluded SOM that focuses on the protein and saccharidic moieties. The skeletal matrix proteins show a large range of isoelectric points, compositional patterns and signatures. Besides secreted proteins, there are a significant number of proteins with membrane attachment sites such as transmembrane domains and GPI anchors as well as proteins with integrin binding sites. These features show that the skeletal proteins must have strong adhesion properties in order to function in the calcifying space. Moreover this data suggest a molecular connection between the calcifying epithelium and the skeletal tissue during biocalcification. In terms of sugar moieties, the enrichment of the SOM in arabinose is striking, and the monosaccharide composition exhibits the same signature as that of mucus of acroporid corals. Finally, we observe that the interaction of the acetic acid soluble SOM on the morphology of in vitro grown CaCO3 crystals is very pronounced when compared with the calcifying matrices of some mollusks. In light of these results, we wish to commend Acropora millepora as a model for biocalcification studies in scleractinians, from molecular and structural viewpoints