Isotope shifts and hyperfine structure of the Fe I 372 nm resonance line

We report measurements of the isotope shifts of the $3d^64s^2 a ^5D_4 - 3d^64s4p z ^5F_5^o$ Fe I resonance line at 372 nm between all four stable isotopes $^{54}$Fe, $^{56}$Fe, $^{57}$Fe, and $^{58}$Fe, as well as the complete hyperfine structure of that line for $^{57}$Fe, the only stable isotope having a non-zero nuclear spin. The field and specific mass shift coefficients of the transition have been derived from the data, as well as the experimental value for the hyperfine structure magnetic dipole coupling constant $A$ of the excited state of the transition in $^{57}$Fe: $A(3d^64s4p z ^5F_5^o) = 81.69(86)$ MHz. The measurements were done by means of Doppler-free laser saturated-absorption spectroscopy in a Fe-Ar hollow cathode using both natural and enriched iron samples. The measured isotope shifts and hyperfine constants are reported with uncertainties at the percent level.Comment: 5 pages, 5 figure

Development of a Pneumatic High Speed Nakajima Testing Device

Forming limit diagrams are an essential tool for describing the formability of sheet materials in the deep-drawing process. Here, the well known and frequently employed procedures are the Nakajima and the Marciniak-Tests. Whereas these procedures' standardisation is quite advanced in the quasi-static range, numerous different test procedures exist in the range of elevated forming speeds. In the first part of this work, an overview of the various procedures is given for generating forming limit diagrams in the high speed range. In the second part, a pneumatically operated testing device is introduced which was developed at the Institute for Material Science for performing Nakajima-Tests in the high speed range. Using this device, standard specimens can be dynamically formed according to the Nakajima-Test. The testing device is to be employed for scientifically exploring the deformation mechanisms operating at very high forming speeds. The testing device’s mode of functioning is demonstrated by means of forming discs of an EN AW-6082 aluminium alloy sheet. In doing this, the testing apparatus is mainly characterised by holding the testing conditions constant during the tests: This particularly concerns the velocity of the tool for forming the sheet discs

GROND coverage of the main peak of Gamma-Ray Burst 130925A

Prompt or early optical emission in gamma-ray bursts is notoriously difficult to measure, and observations of the dozen cases show a large variety of properties. Yet, such early emission promises to help us achieve a better understanding of the GRB emission process(es). We performed dedicated observations of the ultra-long duration (T90 about 7000 s) GRB 130925A in the optical/near-infrared with the 7-channel "Gamma-Ray Burst Optical and Near-infrared Detector" (GROND) at the 2.2m MPG/ESO telescope. We detect an optical/NIR flare with an amplitude of nearly 2 mag which is delayed with respect to the keV--MeV prompt emission by about 300--400 s. The decay time of this flare is shorter than the duration of the flare (500 s) or its delay. While we cannot offer a straightforward explanation, we discuss the implications of the flare properties and suggest ways toward understanding it.Comment: 9 pages, 9 figures, accepted for publ. in A&

Measuring the Quantum State of a Large Angular Momentum

We demonstrate a general method to measure the quantum state of an angular momentum of arbitrary magnitude. The (2F+1) x (2F+1) density matrix is completely determined from a set of Stern-Gerlach measurements with (4F+1) different orientations of the quantization axis. We implement the protocol for laser cooled Cesium atoms in the 6S_{1/2}(F=4) hyperfine ground state and apply it to a variety of test states prepared by optical pumping and Larmor precession. A comparison of input and measured states shows typical reconstruction fidelities of about 0.95.Comment: 4 pages, 6 figures, submitted to PR

Accidental hepatic artery ligation in humans

Despite the vast amount of information from experimental animals, it has been difficult to obtain a clear-cut picture of the effects of ligation of the hepatic artery in humans with relatively normal livers. The last complete review of this subject in 1933 indicated that a mortality in excess of 50 per cent could be expected in non-cirrhotic patients with injury of the hepatic artery or its principal branches. Five cases of dearterialization of the normal human liver have been observed. These were due to accidental interruption of the right hepatic artery in four and the proper hepatic artery in one. The injured vessel was repaired in one case and ligated in the others. In four of the five patients the vascular disruption was the sole injury. In the other the common bile duct was also lacerated. There was no evidence of hepatic necrosis in any case although one patient died from complications of common duct repair. Transient changes in SGOT and temporary low grade bilirubinemia were commonly noted. In addition, all cases of ligation of the hepatic artery reported since 1933 have been compiled. On the basis of reviewed, as well as the presently reported cases, it is concluded that ligation of the hepatic artery or one of its branches in the patient with relatively normal hepatic function is not ordinarily fatal in the otherwise uncomplicated case. Adequate perfusion of the liver can usually be provided by the remaining portal venous flow and whatever arterial collaterals are present, unless additional factors further reduce the portal venous flow or increase hepatic oxygen need. These factors include fever, shock and anoxia. The key to therapy in unreconstructed injuries to the hepatic artery is avoidance of these secondary influences. © 1964

The updated spectral catalogue of INTEGRAL Gamma-Ray Bursts

We present a catalogue with the properties of all the bursts detected and localized by the IBIS instrument onboard the INTEGRAL satellite from November 2002 to September 2008. The sample is composed of 56 bursts, corresponding to a rate of ~ 0.8 GRB per month. Thanks to the performances of the INTEGRAL Burst Alert System, 50% of the IBIS GRBs have detected afterglows, while 5% have redshift measurements. A spectral analysis of the 43 bursts in the INTEGRAL public archive has been carried out using the most recent software and calibration, deriving an updated, homogeneous and accurate catalogue with the spectral features of the sample. When possible also a time-resolved spectral analysis has been carried out. The GRBs in the sample have 20-200 keV fluences in the range 5 x 1E-8 --2.5 x 1E-4 erg cm-2, and peak fluxes in the range 0.11 - 56 ph cm-2 s-1. While most of the spectra are well fitted by a power law with photon index ~ 1.6, we found that 9 bursts are better described by a cut-off power law, resulting in Ep values in the range 35--190 keV. Altough these results are comparable with those obtained with BAT onboard Swift, there is a marginal evidence that ISGRI detects dimmer bursts than Swift/BAT. Using the revised spectral parameters and an updated sky exposure map that takes into account also the effects of the GRB trigger efficiency, we strengthen the evidence for a spatial correlation with the super galactic plane of the faint bursts with long spectral lag (Foley et al.,2008).Comment: Corrected some typos, added some references; Accepted by Astronomy & Astrophysics, in pres

Structural Brain Changes Related to Disease Duration in Patients with Asthma

Dyspnea is the impairing, cardinal symptom patients with asthma repeatedly experience over the course of the disease. However, its accurate perception is also crucial for timely initiation of treatment. Reduced perception of dyspnea is associated with negative treatment outcome, but the underlying brain mechanisms of perceived dyspnea in patients with asthma remain poorly understood. We examined whether increasing disease duration in fourteen patients with mild-to-moderate asthma is related to structural brain changes in the insular cortex and brainstem periaqueductal grey (PAG). In addition, the association between structural brain changes and perceived dyspnea were studied. By using magnetic resonance imaging in combination with voxel-based morphometry, gray matter volumes of the insular cortex and the PAG were analysed and correlated with asthma duration and perceived affective unpleasantness of resistive load induced dyspnea. Whereas no associations were observed for the insular cortex, longer duration of asthma was associated with increased gray matter volume in the PAG. Moreover, increased PAG gray matter volume was related to reduced ratings of dyspnea unpleasantness. Our results demonstrate that increasing disease duration is associated with increased gray matter volume in the brainstem PAG in patients with mild-to-moderate asthma. This structural brain change might contribute to the reduced perception of dyspnea in some patients with asthma and negatively impact the treatment outcome

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

2-Oxoglutarate (2OG)-dependent oxygenases have important roles in the regulation of gene expression via demethylation of N-methylated chromatin components1,2 and in the hydroxylation of transcription factors3 and splicing factor proteins4. Recently, 2OG-dependent oxygenases that catalyse hydroxylation of transfer RNA5,6,7 and ribosomal proteins8 have been shown to be important in translation relating to cellular growth, TH17-cell differentiation and translational accuracy9,10,11,12. The finding that ribosomal oxygenases (ROXs) occur in organisms ranging from prokaryotes to humans8 raises questions as to their structural and evolutionary relationships. In Escherichia coli, YcfD catalyses arginine hydroxylation in the ribosomal protein L16; in humans, MYC-induced nuclear antigen (MINA53; also known as MINA) and nucleolar protein 66 (NO66) catalyse histidine hydroxylation in the ribosomal proteins RPL27A and RPL8, respectively. The functional assignments of ROXs open therapeutic possibilities via either ROX inhibition or targeting of differentially modified ribosomes. Despite differences in the residue and protein selectivities of prokaryotic and eukaryotic ROXs, comparison of the crystal structures of E. coli YcfD and Rhodothermus marinus YcfD with those of human MINA53 and NO66 reveals highly conserved folds and novel dimerization modes defining a new structural subfamily of 2OG-dependent oxygenases. ROX structures with and without their substrates support their functional assignments as hydroxylases but not demethylases, and reveal how the subfamily has evolved to catalyse the hydroxylation of different residue side chains of ribosomal proteins. Comparison of ROX crystal structures with those of other JmjC-domain-containing hydroxylases, including the hypoxia-inducible factor asparaginyl hydroxylase FIH and histone Nε-methyl lysine demethylases, identifies branch points in 2OG-dependent oxygenase evolution and distinguishes between JmjC-containing hydroxylases and demethylases catalysing modifications of translational and transcriptional machinery. The structures reveal that new protein hydroxylation activities can evolve by changing the coordination position from which the iron-bound substrate-oxidizing species reacts. This coordination flexibility has probably contributed to the evolution of the wide range of reactions catalysed by oxygenases

Measurement of the B+ --> p pbar K+ Branching Fraction and Study of the Decay Dynamics

With a sample of 232x10^6 Upsilon(4S) --> BBbar events collected with the BaBar detector, we study the decay B+ --> p pbar K+ excluding charmonium decays to ppbar. We measure a branching fraction Br(B+ --> p pbar K+)=(6.7+/-0.5+/-0.4)x10^{-6}. An enhancement at low ppbar mass is observed and the Dalitz plot asymmetry suggests dominance of the penguin amplitude in this B decay. We search for a pentaquark candidate Theta*++ decaying into pK+ in the mass range 1.43 to 2.00 GeV/c2 and set limits on Br(B+ --> Theta*++pbar)xBr(Theta*++ --> pK+) at the 10^{-7} level.Comment: 8 pages, 7 postscript figures, submitted to Phys. Rev. D (Rapid Communications