The (New) roles of prototypes during the co-development of digital product service systems

This paper investigates different roles that prototypes play during the development of digital Product Service Systems (PSSs). A literature review reveals that prototyping supports designers during the design process, as well as during knowledge sharing processes with stakeholders. To create a better understanding of these two co-existing roles of prototyping, we executed a research-through-design project in the healthcare domain. This design project was centred around the development of four different prototypes that the designer sequentially developed. A major input into the design process was co-reflection sessions between the designer and different stakeholders. We analysed the prototyping process and the co-reflection sessions. Moreover, we executed a conversational analysis to understand the actual knowledge sharing processes between the designer and the different stakeholders. The results present a detailed overview of the different (co-existing) roles of the prototypes. We distinguished two new types of prototypes which were both related to the development of the intangible aspects of the digital PSS: (1) service interface prototrial aimed at exploring several options for detailing the different intangible aspects of the digital PSS, and (2) service provotype to stimulate collaborative creation of the intangible aspects of the digital PSS in an early stage

Untersuchungen zur Selbstassemblierung zyklischer Dipeptide

Die Fähigkeit Phe-beinhaltender Diketopiperazine (DKPs) zur Selbstassemblierung in Wasser wurde ausführlich untersucht. Trotz der einfachen Struktur und des geringen Molekulargewichts der DKPs konnten eine beachtliche Stabilität sowie selbstheilende Eigenschaften der resultierenden Hydrogele nachgewiesen werden. Es lässt sich hervorheben, dass es sich bei dem vorgestellten DKP Cyclo[Gly-L-Phe] (204,23 g/mol) um den niedermolekularsten Hydrogelator auf Peptid-Basis handelt, der bisher beschrieben wurde. Weiterhin konnte die Coassemblierung von zwei verschiedenen Phe-beinhaltenden DKPs zu Hydrogelen mit veränderten Materialeigenschaften nachgewiesen werden. Neben der erhöhten Stabilität eines gemischten Hydrogels gegenüber sauren und basischen Bedingungen konnte eine signifikant verbesserte Regenerationsfähigkeit beobachtet werden. Zudem wurde die verzögerte Freisetzung von physikalisch eingeschlossenen Wirkstoffen für eine potentielle biomedizinische Anwendung erfolgreich untersucht. Mit coassemblierten Hydrogelen aus einem Cys-beinhaltenden und einem His-beinhaltenden konnte ein kooperativer Effekt der funktionellen Gruppen nachgewiesen werden. Die veränderte Reaktivität durch einen kooperativen Effekt der HisH+ Cys- Paare wurde durch die Untersuchung der Reaktionskinetik einer Modellreaktion bestätigt. Weiterhin konnten durch das Mischen von Phe- mit Leu-basierten DKPs CH-π-Wechselwirkungen ermöglicht werden, welche für eine hoch geordnete Coassemblierung in den Hydrogelen genutzt werden konnte. Die alternierende Anordnung der DKPs in den coassemblierten Hydrogelen wurde durch eine gesteigerte katalytische Effizienz nachgewiesen. Durch das Mischen von zwei einfachen DKPs konnten schließlich Hydrogele mit einer enzymmimetischen Aktivität erhalten werden, deren Aufbau auf dem gezielten Einsatz von CH-π-Wechselwirkungen basiert

The (New) roles of prototypes during the co-development of digital product service systems

This paper investigates different roles that prototypes play during the development of digital Product Service Systems (PSSs). A literature review reveals that prototyping supports designers during the design process, as well as during knowledge sharing processes with stakeholders. To create a better understanding of these two co-existing roles of prototyping, we executed a research-through-design project in the healthcare domain. This design project was centred around the development of four different prototypes that the designer sequentially developed. A major input into the design process was co-reflection sessions between the designer and different stakeholders. We analysed the prototyping process and the co-reflection sessions. Moreover, we executed a conversational analysis to understand the actual knowledge sharing processes between the designer and the different stakeholders. The results present a detailed overview of the different (co-existing) roles of the prototypes. We distinguished two new types of prototypes which were both related to the development of the intangible aspects of the digital PSS: (1) service interface prototrial aimed at exploring several options for detailing the different intangible aspects of the digital PSS, and (2) service provotype to stimulate collaborative creation of the intangible aspects of the digital PSS in an early stage

Developing a self-healing supramolecular nucleoside hydrogel

Low molecular weight gelator hydrogels provide a viable alternative to traditional polymer based drug delivery platforms, owing to their tunable stability and in most cases inherent biocompatibility. Here we report the first self-healing nucleoside hydrogel using N4-octanoyl-2′-deoxycytidine (0.5% w/v) for drug delivery. The hydrogel's cross-linked nanofibrillar structure, was characterised using oscillatory rheology and confirmed using SEM and TEM imaging. The potential of this gel for drug delivery was explored in vitro using fluorescently labelled tracers. Cell viability assays were conducted using pancreatic cell lines which tolerated the gels well; whilst no adverse effects on the viability or proliferation of cells were observed for fibroblast cell lines

Lessons from Expert Focus Groups on how to Better Support Adults with Mild Intellectual Disabilities to Engage in Co-Design

Co-design techniques generally rely upon higher-order cognitive skills, such as abstraction and creativity, meaning they may be inaccessible to people with intellectual disabilities (ID). Consequently, investigators must adjust the methods employed throughout their studies to ensure the complex needs of people with ID are appropriately catered to. Yet, there are a lack of guidelines to support researchers in this process, with previous literature often neglecting to discuss the decisions made during the development of their study protocols. We propose a new procedure to overcome this lack of support, by utilizing the knowledge of “experts” in ID to design a more accessible workshop for the target population. 12 experts across two focus groups were successful in identifying accessibility barriers throughout a set of typical early co-design activities. Recommendations to overcome these barriers are discussed along with lessons on how to better support people with ID to engage in co-design

Hydrogel and Organogel Formation by Hierarchical Self-Assembly of Cyclic Peptides Nanotubes

Breaking away from the linear structure of previously reported peptide-based gelators, this study reports the first example of gel formation based on the use of cyclic peptides made of alternating d- and l-amino acids, known to self-assemble in solution to form long nanotubes. Herein, a library of cyclic peptides was systemically studied for their gelation properties in various solvents, uncovering key parameters driving both organogel and hydrogel formation. The hierarchical nature of the self-assembly process in water was characterised by a combination of electron microscopy imaging and small-angle X-ray scattering, revealing a porous network of entangled nanofibres composed by the aggregation of several cyclic peptide nanotubes. Rheology measurements then confirmed the formation of soft hydrogel

Design thinking and design doing: Describing a process of people-centred innovation

The research forms part of the author’s long-term enquiry into the challenges of implementing Design Thinking (DT) and its relationship to Inclusive Design (ID), something that has been understudied and under-researched. Both fields advocate research with users and have a history spanning decades, but they have remained largely separate in terms of academic research and practical application. The author was approached by the series editor for his expertise at the intersection of ID and DT. “State of the art” DT ideas and approaches were evaluated through study of circa 50 recent academic publications, papers and journal articles. Field research was based on personal leadership of over 70 ID projects with government, business, and the voluntary sector leading to frontline discoveries and insights. Peer-reviewed academic publication, conference presentation, and keynote delivery helped test ideas before making the link between ID and DT and delivering the publication. This 13,000 word, sole-authored chapter outlines gaps in the long-term effectiveness of DT, outlining five principles that aim to engender a more sustainable approach by aligning it to ID. These five ideas give an overview of newly-articulated frameworks, tools and methods for academic and industry application. The chapter sets a context for 16 other chapters within the publication and establishes the need for more empirical research to link between DT and ID. The ideas in the chapter have been used to direct practice-based research projects and education programmes at the RCA as well as organisations in its network. 700 Hong Kong civil servants have been trained using these ideas, alongside numerous industry organisations including Tata Consulting Services and Panasonic