9 research outputs found
Regional citrate anticoagulation vs no‐anticoagulation for CRRT in hyperlactatemia patients with increased bleeding risk: A retrospective cohort study
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Continuous renal replacement therapy without anticoagulation in critically ill patients at high risk of bleeding: A systematic review and meta‐analysis
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Quantification of Systemic Delivery of Substrates for Intermediate Metabolism during Citrate Anticoagulation of Continuous Renal Replacement Therapy
- Author
- Ali Y
- Antonin Jabor
- Balik M
- Bollmann MD
- Chadha V
- Fencl V
- Ferdinand Polak
- Hetzel GR
- Hetzel GR
- Jan Hruby
- Jaroslava Vavrova
- Katerina Rusinova
- Kleger GR
- Kozik-Jaromin J
- Kramer L
- Leverve X
- Levy B
- Mariano F
- Martin Balik
- Meier-Kriesche HU
- Michal Otahal
- Monchi M
- Morgera S
- Mykhaylo Zakharchenko
- Oudemans HM
- Oudemans HM
- Oudemans HM
- Oudemans van Straaten HM
- Swartz R
- Tolwani AJ
- Uchino S
- Uchino S
- Whitfield LR
- Zdenek Stach
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2012
- Field of study
Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registry.
- Author
- Aguirre-Bermeo H
- Alfaro-Farias M
- Apolo J
- Arias-Sanchez P
- Aslanidis T
- Bouaoud S
- Buehler PK
- Buerkle C
- Carsetti A
- Castro P
- Cereghetti S
- Ceruti S
- Colombo R
- David S
- Dullenkopf A
- Elhadi M
- Escos-Orta JO
- Filipovic M
- Fodor P
- Fogagnolo A
- Franch-Llasat D
- Franchitti Laurent M
- Fumeaux T
- Gamberini E
- Gangitano G
- Gehring N
- Guerci P
- Hillgaertner F
- Hilty MP
- Jakob SM
- Jeitziner MM
- Keiser S
- Kleger GR
- Ksouri H
- Laube M
- Locher P
- Lozano-Gómez H
- Marrel J
- Martín-Delgado MC
- Montomoli J
- Moser A
- Ouyahia A
- Perez MH
- Pietsch U
- Que YA
- Rezoagli E
- RISC-19-ICU Investigators.
- Roche-Campo F
- Rodríguez-García R
- Schott P
- Schrag C
- Schuepbach RA
- Siegemund M
- Stahl K
- Studhalter M
- Turrini F
- Vizmanos-Lamotte G
- Weber AB
- Wendel-Garcia PD
- Wengenmayer T
- Wu MA
- Yuen B
- Zellweger N
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Background: It remains elusive how the characteristics, the course of disease, the clinical management and the outcomes of critically ill COVID-19 patients admitted to intensive care units (ICU) worldwide have changed over the course of the pandemic.
Methods: Prospective, observational registry constituted by 90 ICUs across 22 countries worldwide including patients with a laboratory-confirmed, critical presentation of COVID-19 requiring advanced organ support. Hierarchical, generalized linear mixed-effect models accounting for hospital and country variability were employed to analyse the continuous evolution of the studied variables over the pandemic.
Results: Four thousand forty-one patients were included from March 2020 to September 2021. Over this period, the age of the admitted patients (62 [95% CI 60-63] years vs 64 [62-66] years, p < 0.001) and the severity of organ dysfunction at ICU admission decreased (Sequential Organ Failure Assessment 8.2 [7.6-9.0] vs 5.8 [5.3-6.4], p < 0.001) and increased, while more female patients (26 [23-29]% vs 41 [35-48]%, p < 0.001) were admitted. The time span between symptom onset and hospitalization as well as ICU admission became longer later in the pandemic (6.7 [6.2-7.2| days vs 9.7 [8.9-10.5] days, p < 0.001). The PaO2/FiO2 at admission was lower (132 [123-141] mmHg vs 101 [91-113] mmHg, p < 0.001) but showed faster improvements over the initial 5 days of ICU stay in late 2021 compared to early 2020 (34 [20-48] mmHg vs 70 [41-100] mmHg, p = 0.05). The number of patients treated with steroids and tocilizumab increased, while the use of therapeutic anticoagulation presented an inverse U-shaped behaviour over the course of the pandemic. The proportion of patients treated with high-flow oxygen (5 [4-7]% vs 20 [14-29], p < 0.001) and non-invasive mechanical ventilation (14 [11-18]% vs 24 [17-33]%, p < 0.001) throughout the pandemic increased concomitant to a decrease in invasive mechanical ventilation (82 [76-86]% vs 74 [64-82]%, p < 0.001). The ICU mortality (23 [19-26]% vs 17 [12-25]%, p < 0.001) and length of stay (14 [13-16] days vs 11 [10-13] days, p < 0.001) decreased over 19 months of the pandemic.
Conclusion: Characteristics and disease course of critically ill COVID-19 patients have continuously evolved, concomitant to the clinical management, throughout the pandemic leading to a younger, less severely ill ICU population with distinctly different clinical, pulmonary and inflammatory presentations than at the onset of the pandemic
Fecal microbiota transfer for refractory intestinal graft‐versus‐host disease — Experience from two German tertiary centers
- Author
- Abu‐Sbeih H
- Aguilar‐Guisado M
- Allegretti JR
- Andermann TM
- Biagi E
- Callahan BJ
- Cammarota G
- Caporaso JG
- Castilla‐Llorente C
- Chen Z
- Chong PP
- Dailey FE
- Darmstadt GL
- DeFilipp Z
- DeFilipp Z
- DeFilipp Z
- Devanga Ragupathi NK
- Dicks LMT
- D’Haens GR
- Eriguchi Y
- Ferrara JLM
- Ferrara JLM
- Fredricks DN
- Gea‐Banacloche J
- Golob JL
- Grkovic L
- Han L
- Harris AC
- Holler E
- Honda K
- Hooper LV
- Ingham AC
- Jenq RR
- Kaito S
- Kakihana K
- Kao D
- Kleger A
- Klindworth A
- Kotloff KL
- Kumari R
- Lee M‐W
- Lee S‐E
- Lier YF
- Liu C
- MacMillan ML
- Malard F
- Martin PJ
- Mathewson ND
- McDonald LC
- McMurdie PJ
- Naymagon S
- Nishi K
- Nood E
- Ooijevaar RE
- Ott SJ
- Pedregosa F
- Peled JU
- Peri R
- Peyrin‐Biroulet L
- Qi X
- Quast C
- Quraishi MN
- R Core Team
- Rey K
- Round JL
- Shlomchik WD
- Shono Y
- Shono Y
- Shouval R
- Shouval R
- Spindelboeck W
- Staffas A
- Tacke D
- Vermeire S
- Wardill HR
- Weber D
- Weber D
- Willing BP
- Wortelboer K
- Youngster I
- Youngster I
- Zeiser R
- Zhang F
- Zhao X‐S
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Rationale Steroid refractory graft-vs-host disease (sr-GvHD) represents a challenging complication after allogeneic hematopoietic cell transplantation (allo-HCT). Intestinal microbiota (IM) diversity and dysbiosis were identified as influencing factors for the development of acute GvHD. Fecal microbiota transfer (FMT) is hypothesized to restore IM dysbiosis, but there is limited knowledge about the significance of FMT in the treatment of sr-GvHD. Objectives We studied the effects of FMT on sr-GvHD in allo-HCT patients from two German tertiary clinical centers (n = 11 patients; period: March 2017 until July 2019). To assess safety and clinical efficacy, we analyzed clinical data pre- and post-FMT (day -14 to +30 relative to FMT). Moreover, IM were analyzed in donor samples and in a subset of patients pre- and post-FMT by 16S rRNA sequencing. Results Post-FMT, we observed no intervention-associated, systemic inflammatory responses and only minor side effects (5/11 patients: abdominal pain and transformation of peristalsis-each 3/11 and vomiting-1/11). Stool frequencies and volumes were significantly reduced [pre- vs post-FMT (d14): P < .05, respectively] as well as clear attenuation regarding both grading and staging of sr-GvHD was present upon FMT. Moreover, IM analyses revealed an increase of alpha diversity as well as a compositional shifts toward the donor post-FMT. Conclusions In our study, we observed positive effects on sr-GVHD after FMT without the occurrence of major adverse events. Although these findings are in line with published data on beneficial effects of FMT in sr-GvHD, further randomized clinical studies are urgently needed to better define the clinical validity including mode of action
Protein kinase D2: a versatile player in cancer biology
- Author
- A Alpsoy
- A Auer
- A Barrallo-Gimeno
- A Brunet
- A Eisenberg-Lerner
- A Goginashvili
- A Hausser
- A Hausser
- A Hayashi
- A Kleger
- A Rykx
- A Trauzold
- Aikawa
- Alexander Becher
- AM Diaz Anel
- AM Valverde
- B Huck
- B Nolen
- B Sipos
- C Aicart-Ramos
- C Bossard
- C Culver
- C Du
- C D’Souza-Schorey
- C Pfeifhofer
- C Pfeifhofer
- C Wille
- C Wille
- C Wong
- C Yan
- C Yeaman
- CL Baron
- CR LaValle
- D Hanahan
- D Hanahan
- D Miwa
- E Bernhart
- E Bernhart
- E Minet
- E Oancea
- E Vivier
- EL Meredith
- EL Meredith
- ER Sharlow
- F Dequiedt
- F Gabhann Mac
- FJ Johannes
- G Bergers
- G Bergers
- G Kroemer
- G Manning
- G Soria
- G Sumara
- G Wichert von
- G Wichert von
- GG Gamber
- GL Semenza
- GR Dou
- GV Pusapati
- H Ichijo
- H Zeng
- H Zheng
- I Marchiq
- IM Evans
- J Blume von
- J Chen
- J Chen
- J Chen
- J Fielitz
- J Geng
- J Li
- J Lint Van
- J Pouysségur
- J Yoo
- J Zhang
- JG Donaldson
- JL Zugaza
- JM Adams
- Johan Van Lint
- JS Bonifacino
- JS Isaacs
- JW Choi
- K Janssens
- K Kessenbrock
- K Moulick
- K Nishikawa
- K Polyak
- KL Eales
- KL Scott
- KM George
- Koch
- L Jakobsson
- L Monovich
- L Neckers
- L Qin
- LN Jackson
- M Armacki
- M Avkiran
- M Barbara
- M Cobbaut
- M Egeblad
- M Egeblad
- M Hellström
- M Hollenbach
- M Huse
- M Jaggi
- M Liljedahl
- M Müller
- M Scheiter
- M Spitaler
- M Tandon
- M Tandon
- M Yilmaz
- MA Pearson
- Mathias Cobbaut
- MF Fanelli
- MH Biswas
- Mitchell
- MW Klymkowsky
- MY Shabelnik
- N Azoitei
- N Azoitei
- N Azoitei
- N Durand
- N Ochi
- N Wei
- N Wei
- Ninel Azoitei
- O Rey
- O Rey
- P Cohen
- P Storz
- P Storz
- P Storz
- P Storz
- PC McDonald
- Q Hao
- Q Hao
- Q Hao
- QJ Wang
- R Benedito
- S Borges
- S Chouaib
- S Guha
- S Ijichi
- S Nhek
- S Patel
- S Sturany
- S Sturany
- SA Matthews
- SA Matthews
- SP Sidorenko
- SW Lowe
- T Chiu
- T Chiu
- T Eiseler
- T Eiseler
- T Eiseler
- T Eiseler
- T Finkel
- T Fugmann
- T Fugmann
- T Gruber
- T Iglesias
- T Mihailovic
- TA Young
- Thomas Seufferlein
- TR Brummelkamp
- TS Steiner
- TS Steiner
- U Marklund
- V Baeriswyl
- V Malhotra
- W Zhang
- X Zhou
- Y Kim
- Y Wang
- Y Wang
- Y Zhu
- YG Yoo
- YT Bryceson
- YW Qiang
- Z Zou
- ZC Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A first update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdollahi H
- Abdullah T
- Abecasis GR
- Abedalthagafi M
- Abul-Husn NS
- Acquilini D
- Adams EL
- Adamsara A
- Adeleye O
- Adra D
- Afilalo J
- Afilalo M
- Afrasiabi Z
- Agüero D
- Ahmadi S
- Akhtar S
- Aksentijevich A
- Al-Afghani H
- Al-Awdah L
- Alaamery M
- Alahmadey ZZ
- Alaverdian D
- Alavere H
- Albader A
- Albaiceta GM
- Albakri JK
- AlBardis H
- Albeladi M
- Albesher N
- Albrich W
- Albrich WC
- AlDhawi N
- Aleagha AE
- Alghamdi B
- Alghamdi J
- Ali A
- Aliannejad R
- Aljawini N
- AlJohani S
- Alkwai S
- Allos R
- AlMalik A
- Almalki F
- Almohammed I
- Almutairi M
- Alotaibi S
- Alowayn AM
- Alqahtani S
- Alqubaishi F
- Alrashed M
- Alshareef A
- Alsolm E
- Alswailm M
- AlZahrani D
- Amirsavadkouhi A
- Amitrano S
- Andolfo I
- Andretta F
- Andreucci E
- Andrews SJ
- Anedda F
- Anemoli V
- Angelantonio ED
- Annis A
- Antinori A
- Antoni MD
- Anwar M
- Arabi YM
- Arciero E
- Armstrong J
- Arning N
- Arranz MJ
- Arribas E
- Artuso R
- Arumugam P
- Ascolillo S
- Ashraf S
- Atkinson EG
- Aucella F
- Auld D
- Azarzar S
- Bachetti T
- Baillie JK
- Balaconis MK
- Baldassarri M
- Ball CA
- Baltzell AH
- Band G
- Bandini M
- Baraka D
- Baras A
- Baratti S
- Barbieri C
- Barda B
- Bargagli E
- Barhoush E
- Barnes KC
- Baroni S
- Bartels M
- Bassetti M
- Batini C
- Baya N
- Beck A
- Beckmann ND
- Bedini JL
- Bee CE
- Beguin Y
- Belbin GM
- Belhaj Y
- Beligni G
- Belisle A
- Belli MA
- Below J
- Benetti E
- Bennett D
- Bergantini L
- Bergomi P
- Berkowitz N
- Bernardo D
- Biagio AD
- Bianchi F
- Bibert S
- Bibert S
- Biesecker L
- Biscarini F
- Blay N
- Bochud M
- Bochud P-Y
- Bochud P-Y
- Bochud PY
- Bochud PY
- Boezen M
- Boillat N
- Boillat-Blanco N
- Bottà G
- Bouab M
- Boughton AP
- Bouras K
- Bradford Y
- Brahier T
- Brassard N
- Breen G
- Brenner B
- Britvan B
- Brumpton BM
- Bruno R
- Bruttini M
- Bryant S
- Bryant S
- Buring JE
- Busani S
- Bussotti M
- Butler-Laporte G
- Butterworth AS
- Buxbaum JD
- Caldarelli GP
- Callier S
- Cameli P
- Campbell A
- Campbell A
- Canaccini A
- Cantarini L
- Cantor MN
- Capasso M
- Capitani K
- Cappelli S
- Carella M
- Carey DJ
- Carreras A
- Carriero ML
- Castaño-Vinyals G
- Castelli F
- Castori M
- Catena E
- Caulfield MJ
- Ceri S
- Cerny A
- Chamnanphon M
- Chan G
- Chang X
- Chang X
- Chariyavilaskul P
- Charney AW
- Chasman DI
- Chassot J
- Chassé M
- Chaudhary K
- Chavan S
- Chen H-H
- Cheng N
- Chetruengchai W
- Chittoor G
- Cho JH
- Cho K
- Choi S
- Chowdhury M
- Chung R
- Churchhouse C
- Chwialkowska K
- Claassen S
- Claringbould A
- Clerc O
- Coignet M
- Coiro G
- Colligan G
- Collins BL
- Colobrán R
- Colombo R
- Conen A
- Conticini E
- Cordioli M
- Cordioli M
- Corridi M
- Cortés B
- Cossarizza A
- Coto E
- COVID-19 Host Genetics Initiative
- Coviello DA
- Croci L
- Croci S
- Crook DW
- Crooks K
- Crotti L
- Cullell N
- Curtis CJ
- Cusick C
- Cárcel-Márquez J
- Daga S
- Dalmau D
- Daly M
- Daly MJ
- Danesh J
- Darcis G
- Davis L
- Daya M
- de Cid R
- de Felipe Mimbrera A
- de geus EEJC
- de la Cal-Sabater P
- DeDiego ML
- Deelen P
- Dei S
- Deloukas P
- Desanctis E
- Desgranges F
- di Bartolomeo C
- Dietl B
- Do R
- Dobaño C
- Doddato G
- Domenico PD
- Domingo C
- Domínguez-Mayoral A
- Donati A
- Donner K
- Durand M
- Durham C
- D’Acremont V
- D’Alessandro M
- D’Arminio Monforte A
- D’Mellow K
- Earle SG
- Egger T
- Eid MA
- El-Jawhari JJ
- El-Lawaty WM
- El-shanshory MR
- El-Sherbiny YM
- Elhadidy TA
- Elnagdy MH
- Eltoukhy MM
- Emiliozzi A
- Emma D
- Erard V
- Erard V
- Esko T
- Estoppey Younes S
- Fabbiani M
- Falcone M
- Fallerini C
- Farré X
- Fava F
- Fawns-Ritchie C
- Fawns-Ritchie C
- fawzy MS
- Felemban WA
- Feng Y-CA
- Feri M
- Fernandez-Cadenas I
- Ferreira MAR
- Ferri C
- Filipovic M
- Filippidis P
- Finer S
- Finer S
- Finucane H
- Fiorentino G
- Fiz-López A
- Forgetta V
- Foucras S
- Fowler T
- Franchi F
- Francisci D
- Franco G
- Franke L
- Frediani B
- Free RC
- Frenckell CV
- Friolet R
- Frippiat F
- Frischknecht M
- Frithiof R
- Frullanti E
- Furini S
- Gabbi C
- Gabrieli A
- Gaddis M
- Galván-Femenía I
- Ganna A
- Garcia-Aymerich J
- García-Clemente M
- García-Madrona S
- Gass MC
- Gatti F
- Gaziano JM
- Georges M
- Gettler K
- Ghosh B
- Giannattasio F
- Gignoux CR
- Giliberti A
- Giorli A
- Giot J-B
- Girardis M
- Girshick A
- Glessner JR
- Glessner JT
- Gofflot S
- Goldstein JI
- Gomez J
- Gonseth Nussle S
- González-Villa E
- Gori M
- Grassi D
- Green RC
- Griffiths C
- Griffiths CJ
- Grip J
- Guarnaccia A
- Guerrini S
- Guidelli L
- Guillet A
- Guindo-Martinez M
- Guiot J
- Guntz J
- Gupta R
- Guturu H
- Guyat-Jacques C
- Guyatt AL
- Guzman C
- Guéry B
- Haefliger D
- Hakonarson H
- Hakonarson H
- Halawani RT
- Harerimana N
- Harris JR
- Harthi FA
- Hasanato R
- Hayward C
- Hayward C
- Hegazy MAF
- Helgeland Ø
- Henry D
- Hensen K
- Hiester LL
- Hirankarn N
- Ho Y-L
- Hoggart C
- Hollox EJ
- Hong EL
- Horowitz JE
- Hosseini A
- Hottenga JJ
- Huang QQ
- Huang QQ
- Huckins LM
- Huffman JE
- Hultström M
- Hunt KA
- Hunt KA
- Hurles M
- Hussain S
- Huynen P
- Hveem K
- Hügli O
- Iglesias LL
- Ikram MA
- Iolascon A
- Islam K
- Itan Y
- Jacques J
- Jantarabenjakul W
- Jaquet M
- Jiménez-Xarrié E
- John C
- Jordan DM
- Josyula NS
- Jung J
- Justice AE
- Kahlert CR
- Kallaste A
- Kamdar D
- Kamdar D
- Kampouri EE
- Kanai M
- Kanai M
- Karczewski KJ
- Karjalainen J
- Karlson EW
- Karp A
- Kaufmann DE
- Kaunisto M
- Keller K
- Kenny EE
- Kerchberger VE
- Kerr SM
- Khafaga WT
- Khan A
- Khan A
- Khattab AK
- Kimchi N
- King D
- Kisand K
- Kivinen K
- Kleger G-R.
- Knapp C
- Knight S
- Koelling N
- Kogevinas M
- Koskelainen S
- Kosmicki JA
- Kousathanas A
- Kristiansson K
- Laane E
- Labkowsky A
- Laisk T
- Lambermont B
- Lannepoudenx Y
- Lanting P
- Lathrop GM
- Lauren PE
- Laurent L
- Lavery C
- Leader JB
- Lee PH
- Lee S
- Lee SH
- Lee Y
- LeFaive J
- Lena F
- Leonard P
- Lepage P
- Lepamets M
- Lerner R
- Levy T
- Li B
- Li KW
- Li R
- Liao RG
- Lin S-K
- Lipcsey M
- Lista M
- Llucià-Carol L
- Loos RJF
- Lopera E
- Lorubbio M
- Lozano F
- Lu W
- Lucas A
- Luchi S
- Ludovisi S
- Läll K
- MacArthur D
- MacLaughlin B
- Maggiolo F
- Magnus P
- Mahmoud ES
- Malaise O
- Mamlouk N
- Mancarella S
- Mandalà M
- Mangino M
- Mangul S
- Manson JE
- Mantovani S
- Manuel O
- Marcantonio S
- Marchetti O
- Marciano C
- Mari F
- Maricic T
- Martin AR
- Martin H
- Martin HC
- Martinelli E
- Martí-Fàbregas J
- Martín-Nalda A
- Martínez AP
- Masjuan J
- Mason D
- Mason D
- Massadeh S
- Masucci L
- Mazzei MA
- McCormick JB
- McCurdy S
- Medina-Gomez C
- Meigs JB
- Meloni I
- Menatti E
- Mencarelli MA
- Menéndez-Valladares P
- Mercader J
- Mercader JM
- Merla G
- Metsalu K
- Metspalu A
- Meuris C
- Meuwly JY
- Miah S
- Milani L
- Miraglia FG
- Mirshahi T
- Misset B
- Moahmed HS
- Moghaddam SBM
- Mohamed AAS
- Mondelli MU
- Monica MD
- Montagnani F
- Montillier P
- Mooser V
- Moreno V
- Morris M
- Morrison DR
- Moutschen M
- Moutsianas L
- Muiño E
- Munting A
- Murphy SN
- Mussini C
- Mutairi AA
- Márquez L
- Mägi R
- Naaber P
- Naderpour Z
- Nadkarni GN
- Nakanishi T
- Neale BM
- Neale BM
- Negro TR
- Nencioni C
- Neofytos D
- Neofytos D
- Newman B
- Nguyen H
- Niavarani A
- Niblo K
- Niemi MEK
- Nilaratanakul V
- Nivard MMG
- Nkambul L
- Nkambul L
- Nkambule L
- Nkambule L
- North K
- Noto K
- Nussle SG
- Oddo M
- Odhams CA
- Ognibene A
- Okasha K
- Oliveira M
- Ori APS
- O’Connell AM
- O’Donnell CJ
- O’Mahony L
- O’Reilly P
- Paciosi F
- Packer RJ
- Pagani JL
- Pagani JL
- Palmer DS
- Palmieri M
- Palotie A
- Palotie A
- Pancrazzi A
- Panese S
- Pantet O
- Papadimitriou-Olivgeris M
- Parati G
- Parisi SG
- Park D
- Parravicini P
- Partha R
- Pasko D
- Pathak GA
- Pavlovic M
- Peloso G
- Perez EF
- Perez-Tur J
- Perna R
- Perola M
- Perrella A
- Perret A
- Peruggia M
- Pessina G
- Pesukova J
- Peterson P
- Petitjean L
- Petrocelli P
- Phokaew C
- Piacentini P
- Picchiotti N
- Pietro MD
- Pigazzini S
- Pinoli P
- Pinto AM
- Pirinen M
- Piscopo C
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- Ripamonti D
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- Scotton PG
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- Sebra RP
- Seed C
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- Segura T
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- Serrano-Heras G
- Sesso HD
- Shahin D
- Sharififard B
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- Shotelersuk V
- Shrine N
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- Sloofman LG
- Smieszek SP
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- Smoller JW
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- Tamm A
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- Tenesa A
- Thompson RC
- Thys M
- Timmers PRHJ
- Tiseo G
- Tita R
- Tobin MD
- Tommasi A
- Torky MS
- Torrents D
- Torvorapanit P
- Trankiem A
- Trembath RC
- Trembath RC
- Trivedi B
- Trivedi B
- Trogstad L-IS
- Trotta T
- Tsao P
- Tschopp J
- Tselios C
- Tsuo K
- Tumbarello M
- Turley P
- Uitterlinden AG
- Underwood SJ
- Vaghi M
- Valente S
- Valentino F
- van Blokland I
- van Heel D
- van Heel DA
- van Heel DA
- Van Singer M
- Vecchia M
- Veerapen K
- Venn LD
- Venturelli S
- Vergori A
- Verma A
- Verma SS
- Verzuri A
- Viala B
- Villalonga JM
- Vincenti A
- Viollet RM
- Vivo OD
- Voide C
- Voide C
- Vollenweider P
- Vollenweider P
- von Hohenstaufen KA
- von Mering C
- Vonk JM
- Vulesevic B
- Wain LV
- Walker S
- Walters RK
- Wang J
- Wang X
- Wanying Z
- Warmerdam R
- Weiss ST
- Wicks SJ
- Willer C
- Williams AT
- Wilson DJ
- Wilson JF
- Wolford B
- Wolford B
- Wolford B
- Woolley AE
- Wozniak H
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- Wright J
- Wyllie DH
- Xue X
- Yadav A
- Yassen AM
- Zanella I
- Zeberg H
- Zguro K
- Zhang M
- Zhao JH
- Zhou W
- Zhou W
- Zlatopolsky M
- zu Bentrup FM
- Zucchi P
- Zyndorf M
- Zöllner S
- Åsvold BO
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Mapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
- Acosta-Herrera M
- Acquilini D
- Acquilini D
- Adachi T
- Adachi Y
- Adams C
- Adams K
- Adanini O
- Adeleye O
- Adeniji K
- Adra D
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agranoff D
- Agrawal S
- Aguirre LA
- Agwuh K
- Ahmad HF
- Ahmad N
- Ahmed A
- Ahmed C
- Ahmed KA
- Ai M
- Ail D
- Akeroyd L
- Akhtar MN
- Akhtar S
- Akinkugbe O
- Aksentijevich A
- Al Thani A
- Al-Muftah W
- Al-Sarraj Y
- Alarcon C
- Alarcon-Riquelme ME
- Alasdair F
- Alaverdian D
- Alavere H
- Albertos R
- Albillos A
- Albrecht W
- Albrich W
- Albrich WC
- Aldera EL
- Aldridge J
- Alegria A
- Alex B
- Alexander P
- Alfonso J
- Algera AG
- Ali A
- Ali IMA
- Ali S
- Aliberti S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen S
- Allibone S
- Allison KS
- Allos R
- Ally SM
- Almaden-Boyle C
- Altabaibeh A
- Altmueller J
- Alvaro A
- Amar D
- Amin V
- Amitrano S
- Amiya S
- Ampuero J
- Anan R
- Anania S
- Anastasescu E
- Anderson F
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andolfo I
- Andrade V
- Andretta F
- Andreucci E
- Andreucci E
- Andrew A
- Andrew B
- Andrew G
- Andrews E
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrikopoulos P
- Anedda F
- Aneli S
- Anemoli V
- Angelini C
- Angus B
- Annis A
- Antcliffe D
- Antinori A
- Antoni MD
- Anumakonda V
- Anwar M
- Anzai T
- Apetri E
- Arai D
- Arana E
- Arbane G
- Archer K
- Arciero E
- Arden T
- Arias SS
- Arif S
- Arimura K
- Armstrong J
- Armstrong JA
- Armstrong L
- Armstrong R
- Arning N
- Arnold S
- Arora J
- Artuso R
- Arumugam P
- Asakura T
- Asano K
- Aschard H
- Ascolillo S
- Ashish A
- Ashley E
- Ashraf S
- Ashraf S
- Ashton L
- Ashworth M
- Asiimwe IG
- Aslibekyan S
- Asselta R
- Atanasovska B
- Atkinson D
- Atkinson EG
- Attwood B
- Aucella F
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- Auld F
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- Awano N
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- Badia JR
- Badji RM
- Bahmer T
- Baikady RR
- Baillie JK
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- Bernardo D
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- Bevan E
- Bewley J
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- Bhatia N
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- Blakemore H
- Blanco-Grau A
- Blasi F
- Blay N
- Blay N
- Blow S
- Blunt M
- Boada M
- Board S
- Bocciardi R
- Bocciolone M
- Bochud M
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- Bochud PY
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- Boer C
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- Brusco A
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- Bunni L
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- Burn I
- Burnett C
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- Burtenshaw A
- Burtenshaw A
- Burton M
- Busani S
- Busson A
- Bussotti M
- Bustamante C
- Butcher D
- Buti M
- Butler A
- Butler S
- Butler-Laporte G
- Butler-Laporte G
- Butler-Laporte G
- Butler-Laporte G
- Butte MJ
- Butterworth AS
- Butterworth-Cowin N
- Button H
- Buxbaum JD
- Buxbaum JD
- Buxbaum JD
- Byun J
- Caba Llero-Garralda A
- Cabrelli L
- Caceres M
- Cadilla CL
- Cagova L
- Caldarelli GP
- Calderon EJ
- Callaghan M
- Callier S
- Camby S
- Cameli P
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- Campbell R
- Campos S
- Camsooksai J
- Canaccini A
- Canakoglu A
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- Cappadona C
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- Carbral-Ortega L
- Cardamone G
- Carella M
- Carey DJ
- Carli D
- Carlucci N
- Carmody M
- Carmody S
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- Carrabba M
- Carracedo AD
- Carreras Nolla A
- Carreras A
- Carriero ML
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- Carter S
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- Caruth V
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- Castelli F
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- Castori M
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- Caterson J
- Cathcart S
- Catlow L
- Catterall BWA
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- Caulfield MJ
- Cavazza A
- Cawley K
- Cawthron K
- Cazzaniga M
- Cea C
- Cecconi M
- Ceri S
- Ceri S
- Ceriotti F
- Cerny A
- Cerrato L
- Chablani M
- Chadbourn I
- Chadwick D
- Chadwick D
- Chambler D
- Chan G
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- Chand M
- Chandler B
- Chang D
- Chang TS
- Chang X
- Chang Y
- Chapman S
- Charles B
- Charlesworth R
- Charney AW
- Charnock R
- Chasse M
- Chassot J
- Chaudhary K
- Chavan S
- Chechi K
- Chee N
- Cheema Y
- Chen H-H
- Cheng N
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- Chernitsov A
- Cherubini A
- Chetam L
- Cheyne C
- Chiba S
- Chihara Y
- Child J
- Childs D
- Chittoor G
- Chiu A
- Cho JH
- Cho K
- Choe K-W
- Choi S
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- Choudhury Y
- Chowdhury M
- Christle J
- Chubachi S
- Chueca N
- Chukkambotla S
- Chukkambotla S
- Chung R
- Chung W
- Churchhouse C
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- Cirulli ET
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- Claire W
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- Clapham M
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- Clark V
- Clarke D
- Clarke EA
- Clarke N
- Clarkson M
- Clayton S
- Clement I
- Clements S
- Clerc O
- Cloherty A
- Clohisey S
- Clohisey S
- Clohisey S
- Clohisey S
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- Cockrell M
- Coetzee S
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- Collins BL
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- Cordero AIH
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- Cordioli M
- Cordioli M
- Cordioli M
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- Cornely OA
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- Costantino G
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- Coton Z
- Coulding M
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- Cutler S
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- de Gordoa LO-R
- de Gordoa LO-R
- De Grandi A
- de Jong H
- de Jong MD
- De la Horra C
- De Neef M
- de Pablo R
- de Rojas I
- de Salazar A
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- De Vivo O
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- de Vries H
- Deacon B
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- Death Y
- Deboever C
- Debreceni G
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- Delaneau O
- Delgado CC
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- Dellot P
- Deloukas P
- Demetriou C
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- Dent K
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- Depante M
- Dervisevic S
- Desanctis E
- Desgranges F
- deSouza F
- Di Angelantonio E
- di Bartolomeo C
- Di Biagio A
- Di Domenico P
- Di Pietro M
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- Domingues F
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- Doonan R
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- Dutta AK
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- Zlatopolsky M
- Zoller H
- Zollner S
- Zongo O
- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
A first update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdollahi H
- Abdullah T
- Abecasis GR
- Abedalthagafi M
- Abul-Husn NS
- Acquilini D
- Adams EL
- Adamsara A
- Adeleye O
- Adra D
- Afilalo J
- Afilalo M
- Afrasiabi Z
- Agüero D
- Ahmadi S
- Akhtar S
- Aksentijevich A
- Al-Afghani H
- Al-Awdah L
- Alaamery M
- Alahmadey ZZ
- Alaverdian D
- Alavere H
- Albader A
- Albaiceta GM
- Albakri JK
- AlBardis H
- Albeladi M
- Albesher N
- Albrich W
- Albrich WC
- AlDhawi N
- Aleagha AE
- Alghamdi B
- Alghamdi J
- Ali A
- Aliannejad R
- Aljawini N
- AlJohani S
- Alkwai S
- Allos R
- AlMalik A
- Almalki F
- Almohammed I
- Almutairi M
- Alotaibi S
- Alowayn AM
- Alqahtani S
- Alqubaishi F
- Alrashed M
- Alshareef A
- Alsolm E
- Alswailm M
- AlZahrani D
- Amirsavadkouhi A
- Amitrano S
- Andolfo I
- Andretta F
- Andreucci E
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- Anemoli V
- Angelantonio ED
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- Antinori A
- Antoni MD
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- Arranz MJ
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- zu Bentrup FM
- Zucchi P
- Zyndorf M
- Zöllner S
- Åsvold BO
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study