The Effects of Vocational Support Programs on Individuals with Autism Spectrum Disorders

Purpose: The purpose of this review is to examine the effects of vocational support programs versus the absence of vocational support programs on employment rates, social skills, and quality of life of transition-aged youth diagnosed with autism spectrum disorders and related diagnoses. Methods: The CINAHL, Cochrane Collection Plus, Medline, PubMed, and UpToDate databases were searched for articles pertaining to our purpose statement. Four reviewers analyzed the articles for results and extracted data regarding sample characteristics, treatment characteristics, assessment tools, and outcomes. Results: Nine studies were included, all of which related to the effects of vocational support programs on individuals with ASD and related diagnoses. Conclusion: Across the board, data strongly suggested that vocational support interventions increased employment rates, improved social skills, and enhanced quality of life for individuals with ASD and related diagnoses

Contribution of nitrification and denitrification to N2O emissions from urine patches

Urine deposition by grazing livestock causes an immediate increase in nitrous oxide (N2O) emissions, but the responsible mechanisms are not well understood. A nitrogen-15 (15N) labelling study was conducted in an organic grass-clover sward to examine the initial effect of urine on the rates and N2O loss ratio of nitrification (i.e. moles of N2O-N produced per moles of nitrate produced) and denitrification (i.e. moles of N2O produced per moles of N2O + N2 produced). The effect of artificial urine (52.9 g N m-2) and ammonium solution (52.9 g N m-2) was examined in separate experiments at 45 and 35% water-filled pore space (WFPS), respectively, and in each experiment a water control was included. The N2O loss derived from nitrification or denitrification was determined in the field immediately after application of 15N-labelled solutions. During the next 24 h, gross nitrification rates were measured in the field, whereas the denitrification rates were measured in soil cores in the laboratory. Compared with the water control, urine application increased the N2O emission from 3.9 to 42.3 μg N2O-N m-2 h-1, whereas application of ammonium increased the emission from 0.9 to 6.1 μg N2O-N m-2 h-1. In the urine-affected soil, nitrification and denitrification contributed equally to the N2O emission, and the increased N2O loss resulted from a combination of higher rates and higher N2O loss ratios of the processes. In the present study, an enhanced nitrification rate seemed to be the most important factor explaining the high initial N2O emission from urine patches deposited on well-aerated soils

Are electric vehicles masculinized? Gender, identity, and environmental values in Nordic transport practices and vehicle-to-grid (V2G) preferences

In this paper, we provide a comparative and mixed methods assessment of the gendered dimensions of electric mobility and stated preferences for electric vehicles in the Nordic region. This includes the potential for such vehicles to be configured in a vehicle-to-grid (V2G) manner, where they can store energy and offer services to the grid, generating revenue and accelerating decarbonisation. Based primarily on a survey distributed to a mix of more than 5,000 respondents across five countries, research interviews, and focus groups, and supplemented with a comprehensive literature review, we examine how perceptions, attitudes, values and identities towards electric mobility differ by gender. We use this data to test, and largely confirm, with some exceptions, three hypotheses: H1: Men use cars (conventional and electric) more than women, more often own a car or EV, drive further than women, and use less public transport. H2: Women have stronger preferences for the environmentally friendly or safety attributes of vehicles (such as EVs and V2G), reflecting higher levels of environmental awareness. H3: Women attach less importance to acceleration, power, or sound, whereas men will emphasize range, sex appeal, and acceleration. In examining these hypotheses about gender, we reveal the more complex social dynamics behind how potential adopters in Denmark, Finland, Iceland, Norway, and Sweden consider and calculate various aspects of conventional mobility, electric mobility, and V2G

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.

Generating an unlimited source of human insulin-producing cells is a prerequisite to advance β cell replacement therapy for diabetes. Here, we describe a 3D culture system that supports the expansion of adult human pancreatic tissue and the generation of a cell subpopulation with progenitor characteristics. These cells display high aldehyde dehydrogenase activity (ALDHhi), express pancreatic progenitors markers (PDX1, PTF1A, CPA1, and MYC), and can form new organoids in contrast to ALDHlo cells. Interestingly, gene expression profiling revealed that ALDHhi cells are closer to human fetal pancreatic tissue compared with adult pancreatic tissue. Endocrine lineage markers were detected upon in vitro differentiation. Engrafted organoids differentiated toward insulin-positive (INS+) cells, and circulating human C-peptide was detected upon glucose challenge 1 month after transplantation. Engrafted ALDHhi cells formed INS+ cells. We conclude that adult human pancreatic tissue has potential for expansion into 3D structures harboring progenitor cells with endocrine differentiation potential

From flying rockets to Tesla: examining the sustainable mobility preferences of primary school children in Denmark and the Netherlands

The relationship between children and cars is not directly obvious, but they are a core group of passengers moving daily from and to school and they are future potential buyers. Moreover, many of the values, worldviews, and patterns of energy (and mobility) consumption enshrined in adults become formed and perhaps cemented in childhood. Lastly, children are not directly concerned with many of the choices and information that adults handle, so measuring what they know could proxy for popular knowledge in society. This paper offers a first international comparison between 587 surveyed schoolchildren between 9-13 years of age in Denmark and the Netherlands on EV knowledge and current and future car transport. Results indicate that national and regional context matter, as do gender, age, and to a certain extent the level experience with low-carbon innovations such as electric vehicles. In general, however, children rank the environmental impact of cars just below personal safety and we can conclude that they are aware of EVs and their main benefits. Simultaneously, they also know that EVs are costlier to purchase. Most important, the children overwhelmingly agree on the future direction of car-based transport with cars that are safer, more energy efficient and alternatively fueled

Imported Malaria in Children in Industrialized Countries, 1992–2002

Children account for a considerable proportion of cases imported to the United States and Europe

Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen-1 (AMA-1) Administered in Adjuvant System AS01B or AS02A

Contains fulltext : 79496.pdf (publisher's version ) (Open Access)BACKGROUND: This Phase 1/2a study evaluated the safety, immunogenicity, and efficacy of an experimental malaria vaccine comprised of the recombinant Plasmodium falciparum protein apical membrane antigen-1 (AMA-1) representing the 3D7 allele formulated with either the AS01B or AS02A Adjuvant Systems. METHODOLOGY/PRINCIPAL FINDINGS: After a preliminary safety evaluation of low dose AMA-1/AS01B (10 microg/0.5 mL) in 5 adults, 30 malaria-naive adults were randomly allocated to receive full dose (50 microg/0.5 mL) of AMA-1/AS01B (n = 15) or AMA-1/AS02A (n = 15), followed by a malaria challenge. All vaccinations were administered intramuscularly on a 0-, 1-, 2-month schedule. All volunteers experienced transient injection site erythema, swelling and pain. Two weeks post-third vaccination, anti-AMA-1 Geometric Mean Antibody Concentrations (GMCs) with 95% Confidence Intervals (CIs) were high: low dose AMA-1/AS01B 196 microg/mL (103-371 microg/mL), full dose AMA-1/AS01B 279 microg/mL (210-369 microg/mL) and full dose AMA-1/AS02A 216 microg/mL (169-276 microg/mL) with no significant difference among the 3 groups. The three vaccine formulations elicited equivalent functional antibody responses, as measured by growth inhibition assay (GIA), against homologous but not against heterologous (FVO) parasites as well as demonstrable interferon-gamma (IFN-gamma) responses. To assess efficacy, volunteers were challenged with P. falciparum-infected mosquitoes, and all became parasitemic, with no significant difference in the prepatent period by either light microscopy or quantitative polymerase chain reaction (qPCR). However, a small but significant reduction of parasitemia in the AMA-1/AS02A group was seen with a statistical model employing qPCR measurements. SIGNIFICANCE: All three vaccine formulations were found to be safe and highly immunogenic. These immune responses did not translate into significant vaccine efficacy in malaria-naive adults employing a primary sporozoite challenge model, but encouragingly, estimation of parasite growth rates from qPCR data may suggest a partial biological effect of the vaccine. Further evaluation of the immunogenicity and efficacy of the AMA-1/AS02A formulation is ongoing in a malaria-experienced pediatric population in Mali. TRIAL REGISTRATION: www.clinicaltrials.gov NCT00385047

Protective immunity to pre-erythrocytic stage malaria

The development of a vaccine against malaria is a major research priority given the burden of disease, death and economic loss inflicted upon the tropical world by this parasite. Despite decades of effort, however, a vaccine remains elusive. The best candidate is a subunit vaccine termed RTS,S but this provides only partial protection against clinical disease. This review examines what is known about protective immunity against pre-erythrocytic stage malaria by considering the humoral and T cell-mediated immune responses that are induced by attenuated sporozoites and by the RTS,S vaccine. On the basis of these observations a set of research priorities are defined that are crucial for the development of a vaccine capable of inducing long-lasting and high-grade protection against malaria

The Library as Safe Space

Purpose: This chapter will explain how libraries define safe space through policies, procedures, and professional codes of ethics. The chapter will generate a history of the concept of libraries as safe space, will explain how libraries attempt to create safe spaces in physical and online environments, and will show how library practices both help and harm patrons in need of safe space. Design/methodology/approach: This chapter provides a review of the literature that illustrates how libraries provide safe space—or not—for their patrons. The author will deconstruct the ALA Code of Ethics and Bill of Rights to demonstrate how libraries remain heteronormative institutions that do not recognize the existence of diverse patrons or employees, and how this phenomenon manifests in libraries. Findings: Libraries, either through their physical construction or through policies and procedures, have become spaces for illegal activities and discrimination. Populations who would be most likely to use libraries often report barriers to access. Practical Implications: Libraries should revisit their policies and procedures, as well as assess their physical and online spaces, to determine whether or not they truly provide safe space for their patrons. While libraries can become safer spaces, they should clearly communicate what types of safety they actually provide. Originality/value: This chapter offers a critique of libraries as safe spaces, which will challenge popular opinions of libraries, and compel the profession to improve

T Cell Responses to the RTS,S/AS01E and RTS,S/AS02D Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children

BACKGROUND: The Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS,S is being developed for protection of young children against malaria in sub-Saharan Africa. RTS,S formulated with the liposome based adjuvant AS01(E) or the oil-in-water based adjuvant AS02(D) induces P. falciparum circumsporozoite (CSP) antigen-specific antibody and T cell responses which have been associated with protection in the experimental malaria challenge model in adults. METHODS: This study was designed to evaluate the safety and immunogenicity induced over a 19 month period by three vaccination schedules (0,1-, 0,1,2- and 0,1,7-month) of RTS,S/AS01(E) and RTS,S/AS02(D) in children aged 5-17 months in two research centers in Ghana. Control Rabies vaccine using the 0,1,2-month schedule was used in one of two study sites. RESULTS: Whole blood antigen stimulation followed by intra-cellular cytokine staining showed RTS,S/AS01(E) induced CSP specific CD4 T cells producing IL-2, TNF-α, and IFN-γ. Higher T cell responses were induced by a 0,1,7-month immunization schedule as compared with a 0,1- or 0,1,2-month schedule. RTS,S/AS01(E) induced higher CD4 T cell responses as compared to RTS,S/AS02(D) when given on a 0,1,7-month schedule. CONCLUSIONS: These findings support further Phase III evaluation of RTS,S/AS01(E). The role of immune effectors and immunization schedules on vaccine protection are currently under evaluation. TRIAL REGISTRATION: ClinicalTrials.gov NCT00360230