245 research outputs found
Fucosylation with fucosyltransferase VI or fucosyltransferase VII improves cord blood engraftment
- Author
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Background aims: Advantages associated with the use of cord blood (CB) transplantation include the availability of cryopreserved units, ethnic diversity and lower incidence of graft-versus-host disease compared with bone marrow or mobilized peripheral blood. However, poor engraftment remains a major obstacle. We and others have found that ex vivo fucosylation can enhance engraftment in murine models, and now ex vivo treatment of CB with fucosyltransferase (FT) VI before transplantation is under clinical evaluation (NCT01471067). However, FTVII appears to be more relevant to hematopoietic cells and may alter acceptor substrate diversity. The present study compared the ability of FTVI and FTVII to improve the rapidity, magnitude, multi-lineage and multi-tissue engraftment of human CB hematopoietic stem and progenitor cells (HSPCs) in vivo. Methods: CD34-selected CB HSPCs were treated with recombinant FTVI, FTVII or mock control and then injected into immunodeficient mice and monitored for multi-lineage and multi-tissue engraftment. Results: Both FTVI and FTVII fucosylated CB CD34+ cells in vitro, and both led to enhanced rates and magnitudes of engraftment compared with untreated CB CD34+ cells in vivo. Engraftment after treatment with either FT was robust at multiple time points and in multiple tissues with similar multi-lineage potential. In contrast, only FTVII was able to fucosylate T and B lymphocytes. Conclusions: Although FTVI and FTVII were found to be similarly able to fucosylate and enhance the engraftment of CB CD34+ cells, differences in their ability to fucosylate lymphocytes may modulate graft-versus-tumor or graft-versus-host effects and may allow further optimization of CB transplantation
All-sky search for long-duration gravitational wave transients with initial LIGO
- Author
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- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2016
- Field of study
We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society
All-sky search for long-duration gravitational wave transients with initial LIGO
- Author
- Abbott B.P.
- Abbott R.
- Abbott T.D.
- Abernathy M.R.
- Acernese F.
- Ackley K.
- Adams C.
- Adams T.
- Addesso P.
- Adhikari R.X.
- Adya V.B.
- Affeldt C.
- Agathos M.
- Agatsuma K.
- Aggarwal N.
- Aguiar O.D.
- Ain A.
- Ajith P.
- Allen B.
- Allocca A.
- Amariutei D.V.
- Anderson S.B.
- Anderson W.G.
- Arai K.
- Araya M.C.
- Arceneaux C.C.
- Areeda J.S.
- Arnaud N.
- Arun K.G.
- Ashton G.
- Ast M.
- Aston S.M.
- Astone P.
- Aufmuth P.
- Aulbert C.
- Babak S.
- Baiardi L.Cerboni
- Baker P.T.
- Baldaccini F.
- Ballardin G.
- Ballmer S.W.
- Barayoga J.C.
- Barclay S.E.
- Barish B.C.
- Barker D.
- Barone F.
- Barr B.
- Barsotti L.
- Barsuglia M.
- Barta D.
- Bartlett J.
- Bartos I.
- Bassiri R.
- Basti A.
- Batch J.C.
- Baune C.
- Bavigadda V.
- Bazzan M.
- Behnke B.
- Bejger M.
- Belczynski C.
- Bell A.S.
- Bell C.J.
- Berger B.K.
- Bergman J.
- Bergmann G.
- Berry C.P.L.
- Bersanetti D.
- Bertolini A.
- Betzwieser J.
- Bhagwat S.
- Bhandare R.
- Bilenko I.A.
- Billingsley G.
- Birch J.
- Birney R.
- Biscans S.
- Bisht A.
- Bitossi M.
- Biwer C.
- Bizouard M.A.
- Blackburn J.K.
- Blair C.D.
- Blair D.
- Blair R.M.
- Bloemen S.
- Bock O.
- Bodiya T.P.
- Boer M.
- Bogaert G.
- Bogan C.
- Bohe A.
- Bojtos P.
- Bond C.
- Bondu F.
- Bonnand R.
- Bork R.
- Boschi V.
- Bose S.
- Bozzi A.
- Bradaschia C.
- Brady P.R.
- Braginsky V.B.
- Branchesi M.
- Brau J.E.
- Briant T.
- Brillet A.
- Brinkmann M.
- Brisson V.
- Brockill P.
- Brooks A.F.
- Brown D.
- Brown D.A.
- Brown D.D.
- Brown N.M.
- Buchanan C.C.
- Buikema A.
- Bulik T.
- Bulten H.J.
- Buonanno A.
- Buskulic D.
- Buy C.
- Byer R.L.
- Cadonati L.
- Cagnoli G.
- Cahillane C.
- Calderón Bustillo J.
- Callister T.
- Calloni E.
- Camp J.B.
- Cannon K.C.
- Cao J.
- Capano C.D.
- Capocasa E.
- Carbognani F.
- Caride S.
- Casanueva Diaz J.
- Casentini C.
- Castro Gonzalez J.M.
- Caudill S.
- Cavaglià M.
- Cavalier F.
- Cavalieri R.
- Cella G.
- Cepeda C.
- Cerretani G.
- Cesarini E.
- Chakraborty R.
- Chalermsongsak T.
- Chamberlin S.J.
- Chan M.
- Chao S.
- Charlton P.
- Chassande-Mottin E.
- Chen H.Y.
- Chen Y.
- Cheng C.
- Chincarini A.
- Chiummo A.
- Cho H.S.
- Cho M.
- Chow J.H.
- Christensen N.
- Chu Q.
- Chua S.
- Chung S.
- Ciani G.
- Clara F.
- Clark J.A.
- Cleva F.
- Coccia E.
- Cohadon P.-F.
- Colla A.
- Collette C.G.
- Constancio M.
- Conte A.
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- Corbitt T.R.
- Cornish N.
- Corsi A.
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- Countryman S.T.
- Couvares P.
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- Creighton J.D.E.
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- Crowder S.G.
- Cumming A.
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- Dal Canton T.
- Danilishin S.L.
- Danzmann K.
- Darman N.S.
- Dattilo V.
- Dave I.
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- Davies G.S.
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- Day R.
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- Del Pozzo W.
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- Dolique V.
- Donovan F.
- Dooley K.L.
- Doravari S.
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- Etzel T.
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- Fournier J.-D.
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- Gaonkar S.G.
- Garufi F.
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- Gemme G.
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- Germain V.
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- Gorodetsky M.L.
- Gossan S.E.
- Gosselin M.
- Gouaty R.
- Graef C.
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- Guidi G.M.
- Guo X.
- Gupta A.
- Gupta M.K.
- Gushwa K.E.
- Gustafson E.K.
- Gustafson R.
- Hacker J.J.
- Hall B.R.
- Hall E.D.
- Hammond G.
- Haney M.
- Hanke M.M.
- Hanks J.
- Hanna C.
- Hannam M.D.
- Hanson J.
- Hardwick T.
- Haris K.
- Harms J.
- Harry G.M.
- Harry I.W.
- Hart M.J.
- Hartman M.T.
- Haster C.-J.
- Haughian K.
- Heidmann A.
- Heintze M.C.
- Heitmann H.
- Hello P.
- Hemming G.
- Hendry M.
- Heng I.S.
- Hennig J.
- Heptonstall A.W.
- Heurs Michèle
- Hild S.
- Hoak D.
- Hodge K.A.
- Hofman D.
- Hollitt S.E.
- Holt K.
- Holz D.E.
- Hopkins P.
- Hosken D.J.
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- Houston E.A.
- Howell E.J.
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- Hughey B.
- Husa S.
- Huttner S.H.
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- Jani K.
- Jaranowski P.
- Jawahar S.
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- Jonker R.J.G.
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- Weinert M.
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- Westphal T.
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- Williams R.D.
- Williamson A.R.
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- Willke B.
- Wimmer M.H.
- Winkler W.
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- Wittel H.
- Woan G.
- Worden J.
- Wright J.L.
- Wu G.
- Yablon J.
- Yam W.
- Yamamoto H.
- Yancey C.C.
- Yu H.
- Yvert M.
- Zadrożny A.
- Zangrando L.
- Zanolin M.
- Zendri J.-P.
- Zevin M.
- Zhang F.
- Zhang L.
- Zhang M.
- Zhang Y.
- Zhao C.
- Zhou M.
- Zhou Z.
- Zhu X.J.
- Zucker M.E.
- Zuraw S.E.
- Zweizig J.
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2016
- Field of study
We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society
Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3b
- Author
- Abbott R.
- Abbott T.D.
- Acernese F.
- Ackley K.
- Adams C.
- Adhikari N.
- Adhikari R.X.
- Adya V.B.
- Affeldt C.
- Agarwal D.
- Agathos M.
- Agatsuma K.
- Aggarwal N.
- Aguiar O.D.
- Aiello L.
- Ain A.
- Ajith P.
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- Publication venue
- London : Institute of Physics Publ.
- Publication date
- 01/01/2022
- Field of study
We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTC-2020 March 27 17:00 UTC). We conduct two independent searches: A generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate. © 2022. The Author(s). Published by the American Astronomical Society
Narrowband Searches for Continuous and Long-duration Transient Gravitational Waves from Known Pulsars in the LIGO-Virgo Third Observing Run
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- Xu W.-R.
- Yamada T.
- Yamamoto H.
- Yamamoto K.
- Yamamoto K.
- Yamamoto T.
- Yamashita K.
- Yamazaki R.
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- Yang Y.
- Yang Z.
- Yap M.J.
- Yeeles D.W.
- Yelikar A.B.
- Ying M.
- Yokogawa K.
- Yokoyama J.
- Yokozawa T.
- Yoo J.
- Yoshioka T.
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- Yuzurihara H.
- Zadrozny A.
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- Zhou R.
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- Zhu X.J.
- Zhu Z.-H.
- Zucker M.E.
- Zweizig J.
- Publication venue
- London : Institute of Physics Publ.
- Publication date
- 01/01/2022
- Field of study
Isolated neutron stars that are asymmetric with respect to their spin axis are possible sources of detectable continuous gravitational waves. This paper presents a fully coherent search for such signals from eighteen pulsars in data from LIGO and Virgo's third observing run (O3). For known pulsars, efficient and sensitive matched-filter searches can be carried out if one assumes the gravitational radiation is phase-locked to the electromagnetic emission. In the search presented here, we relax this assumption and allow both the frequency and the time derivative of the frequency of the gravitational waves to vary in a small range around those inferred from electromagnetic observations. We find no evidence for continuous gravitational waves, and set upper limits on the strain amplitude for each target. These limits are more constraining for seven of the targets than the spin-down limit defined by ascribing all rotational energy loss to gravitational radiation. In an additional search, we look in O3 data for long-duration (hours-months) transient gravitational waves in the aftermath of pulsar glitches for six targets with a total of nine glitches. We report two marginal outliers from this search, but find no clear evidence for such emission either. The resulting duration-dependent strain upper limits do not surpass indirect energy constraints for any of these targets. © 2022. The Author(s). Published by the American Astronomical Society
Search for jet extinction in the inclusive jet-pT spectrum from proton-proton collisions at s=8 TeV
- Author
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- Abbrescia M.Bb
- Abdullin S.Dz
- Abdulsalam A.Ax
- Acosta D.Ea
- Acosta J.G.En
- Adair A.Ey
- Adam W.B
- Adams M.R.Ee
- Adams T.Ec
- Adiguzel A.Dc
- Adler V.G
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- Afanasiev S.Ci
- Agapitos A.Ao
- Agram J.-L.ad
- Ahmad A.Cf
- Ahmad M.Cf
- Ahuja S.Av
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- Akgun B.Ey
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- Alcaraz Maestre J.Cr
- Aldaya Martin M.Al
- Alderweireldt S.D
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- Alimena J.Do
- Alverson G.Eq
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- Amapane N.Bo
- Amsler C.Cy
- Anagnostou G.An
- Anastassov A.Er
- Anderson J.Dz
- Andrea J.Ad
- Andreev V.Cn
- Andreev Y.Cl
- Andrews W.Ds
- Androsov K.Bm
- Antonelli L.Et
- Antunovic Z.S
- Apanasevich L.Ee
- Apollinari G.Dz
- Appelt E.Ff
- Apresyan A.Du
- Apyan A.El
- Arcidiacono R.Bo
- Arenton M.W.Fg
- Argiro S.Bo
- Arneodo M.Bo
- Arora S.Fb
- Asavapibhop B.Db
- Asawatangtrakuldee C.P
- Asin I.Ak
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- Aslanoglou X.Ap
- Assran Y.W
- Ata M.Ai
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- Azhgirey I.Cp
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- Azzi P.Bj
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- B\ue4ni L.Cx
- B\uf6ser C.Am
- Baarmand M.M.Ed
- Babb J.Dr
- Baber M.Dj
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- Bachmair F.Cx
- Bachtis M.Cv
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- Baillon P.Cv
- Bainbridge R.Dj
- Bakhshiansohi H.Az
- Bakirci M.N.Dc
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- Baus C.Am
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- Beaudette F.Ac
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- Beernaert K.G
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- Behrenhoff W.Ak
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- Beir\ue3o Da Cruz E Silva C.Ci
- Belforte S.Bp
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- Butler J.N.Dz
- Butler P.H.Ce
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- Bylsma B.Et
- Cabrillo I.J.Cu
- Caebergs T.I
- Caillol C.F
- Caiulo D.Bm
- Cakir A.Ak
- Calabria C.Bb
- Calamba A.Dv
- Calderon De La Barca Sanchez M.Dp
- Calderon A.Cu
- Cali I.A.El
- Calligaris L.Ak
- Calvert B.Ek
- Calvo E.Cr
- Campagnari C.Dt
- Campanini R.Bc
- Campbell A.Ak
- Camporesi T.Cv
- Candelise V.Bp
- Canelli M.F.Cy
- Cankocak K.Df
- Capiluppi P.Bc
- Cappello G.Bd
- Cardaci M.Cz
- Carlsmith D.Fi
- Carlson B.Dv
- Carrillo Montoya C.A.Af
- Carrillo Moreno S.Ca
- Cartiglia N.Bo
- Carvalho W.K
- Carver M.Ea
- Casal B.Cx
- Casarsa M.Bp
- Casasso S.Bo
- Casimiro Linares E.Cc
- Castaldi R.Bm
- Castello R.H
- Castilla-Valdez H.Bz
- Castro A.Bc
- Caudron A.H
- Cavallari F.Bn
- Cavallo F.R.Bc
- Cavallo N.Bi
- Cavanaugh R.Ee
- Ceard L.H
- Centis Vignali M.Al
- Cepeda M.Fi
- Cerati G.B.Ds
- Cerci S.Dc
- Cerminara G.Cv
- Cerrada M.Cr
- Chabert E.C.Ad
- Chakaberia I.Ei
- Chamizo Llatas M.Cr
- Chan K.M.Es
- Chan M.El
- Chang P.Da
- Chang S.Bq
- Chang Y.H.Da
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- Chanon N.Cx
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- Chasco M.Eq
- Chasserat J.Af
- Chatterjee A.Dx
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- Chertok M.Dp
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- Cimmino A.G
- Ciocci M.A.Bm
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- Clare R.Dr
- Clarida W.Ef
- Clarke C.Fg
- Clement E.Dh
- Clerbaux B.F
- Cockerill D.J.A.Di
- Codispoti G.Bc
- Colafranceschi S.Cv
- Colaleo A.Bb
- Cole J.E.Dk
- Colino N.Cr
- Collard C.Ad
- Colling D.Dj
- Contardo D.Af
- Conte E.Ad
- Contreras-Campana C.Fb
- Contreras-Campana E.Fb
- Conway J.Dp
- Conway R.Dp
- Cooper S.I.Dm
- Cornelis T.D
- Correa Martins Junior M.J
- Cossutti F.Bp
- Costa M.Bo
- Costa S.Bd
- Costantini S.G
- Costanza F.Ak
- Couderc F.Ab
- Coughlan J.A.Di
- Cousins R.Dq
- Covarelli R.Ez
- Cowden C.Fe
- Cox B.Fg
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- Creanza D.Bb
- Cremaldi L.M.En
- Cripps N.Dj
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- Cuevas J.Ct
- Cuffiani M.Bc
- Cumalat J.P.Dw
- Curry D.Ea
- Cussans D.Dh
- Cust\uf3dio A.K
- Cutajar M.Dj
- Cutts D.Do
- Cwiok M.Ch
- Czellar S.Ar
- D\u2019Agnolo R.T.Ds
- D\u2019Alessandro R.Be
- D\u2019Alfonso M.Cv
- D\u2019Enterria D.Cv
- D\u2019Hondt J.E
- D\u2019Imperio G.Bn
- D\ufcnser M.Cx
- Da Costa E.M.K
- Da Silveira G.G.H
- Dabrowski A.Cv
- Daci N.E
- Dahmes B.Em
- Dahms T.Ac
- Dalchenko M.Ac
- Dall\u2019Osso M.Bj
- Dallavalle G.M.Bc
- Damgov J.Fe
- Danielson T.Dt
- Das S.Ea
- Daskalakis G.An
- Dasu S.Fi
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- David A.Cv
- Davies G.Dj
- de Barbaro P.Ez
- De Benedetti A.Em
- De Boer W.Am
- De Cosa A.Cy
- De Filippis N.Bb
- De Gruttola M.Ea
- De Guio F.Cv
- De Jesus Damiao D.K
- De La Cruz B.Cr
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- De Lentdecker G.F
- De Mattia M.Ew
- De Oliveira Martins C.K
- De Palma M.Bb
- De Roeck A.Cv
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- De Visscher S.Cv
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- Degano A.Bo
- Deisher A.Cx
- Deiters K.Cw
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- Dildick S.G
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- Dittmann J.Dl
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- Dominik W.Ch
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- Dremin I.Cn
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- Du R.O
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- Ekmedzic M.Cq
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- Erdmann M.Ai
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- Escalante Del Valle A.Cr
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- Ferencek D.Fb
- Ferguson T.Dv
- Ferguson W.Dj
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- Fernandez Bedoya C.Cr
- Fernandez Menendez J.Ct
- Fernandez Perez Tomei T.R.L
- Fernandez M.Cu
- Ferreira Parracho P.G.Ci
- Ferri F.Ab
- Ferro C.Cz
- Ferro F.Bg
- Field R.D.Ea
- Filipovic N.Ac
- Finco L.Bo
- Finger M.
- Finger M.V
- Fiore L.Bb
- Fiorendi S.Bh
- Fiori F.Bm
- Fischer R.Ai
- Fisher M.Ea
- Fisk I.Dz
- Fl\ufcgge G.Aj
- Flacher H.Dh
- Flanagan W.Fd
- Flix J.Cr
- Florent A.Ac
- Florez C.Q
- Flouris G.Ap
- Flowers K.Dt
- Flowers S.Et
- Flucke G.Ak
- Fo\ue0 L.Bm
- Focardi E.Be
- Folgueras S.Ct
- Fonseca De Souza S.K
- Fontaine J.-C.ad
- Ford W.T.Dw
- Forthomme L.H
- Foudas C.Ap
- Fouz M.C.Cr
- Fr\ufchwirth R.B
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- Franco Sevilla M.Dt
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- Frazier R.Dh
- Freeman J.Dz
- Frensch F.Am
- Friedl M.B
- Friis E.Fi
- Frueboes T.Cg
- Fulcher J.Dj
- Funk W.Cv
- Furic I.K.Ea
- Futyan D.Dj
- G\uf3rski M.Cg
- G\uf6rner M.Al
- G\ufclmez E.De
- G\ufcth A.Ai
- Gabusi M.Bk
- Gadrat S.Ae
- Galanti M.Bj
- Gallinaro M.Ci
- Gallo E.Be
- Gamsizkan H.Dd
- Ganguly S.Ay
- Ganjour S.Ab
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- Garabedian A.Do
- Garcia G.G
- Garcia J.G.Ak
- Garcia-Abia P.Cr
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- Gardner M.Dp
- Garutti E.Al
- Gary J.W.Dr
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- Gauthier L.Ee
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- Gaz A.Dw
- Geenen H.Aj
- Geffert P.Dt
- Geiser A.Ak
- Geisler M.Aj
- Gel\ue9 D.Ad
- Genchev V.M
- Gennai S.Bh
- George C.Dt
- Geralis T.An
- Gerber C.E.Ee
- Gerosa R.Bh
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- Geurts F.J.M.Ey
- Ghete V.M.B
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- Ghosh S.Ay
- Giacomelli P.Bc
- Giakoumopoulou V.A.An
- Giammanco A.H
- Giassi A.Bm
- Giffels M.Am
- Gigi D.Cv
- Gilbert A.Dj
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- Giubilato P.Bj
- Givernaud A.Ab
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- Glushkov I.N
- Gninenko S.Cl
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- Godinovic N.R
- Godshalk A.Ep
- Goebel K.Al
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- Gokbulut G.Dc
- Goldenzweig P.Ez
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- Golf F.Dt
- Golovtsov V.Ck
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- Gomez Ceballos G.El
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- Gomez J.P.Q
- Goncharov M.El
- Gonzalez Caballero I.Ct
- Gonzalez Lopez O.Cr
- Gonzalez Suarez R.Eo
- Gonzi S.Be
- Goodell J.Fg
- Gorbunov I.Cj
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- Gottschalk E.Dz
- Goulianos K.Fa
- Gouskos L.Dt
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- Govoni P.Bh
- Goy Lopez S.Cr
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- Grab C.Cx
- Grandi C.Bc
- Granier de Cassagnac R.Ac
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- Gurpinar E.Dc
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- H\uf6ing R.S.Al
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- Haas J.Ec
- Hadjiiska R.N
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- Hebda P.Eu
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- Heredia-de La Cruz I.Bz
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- Hindrichs O.Ah
- Hinzmann A.Cy
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- Hu Z.Ew
- Hughes R.Et
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- Innocente V.Cv
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- Ivanov A.Ei
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- Ivova Rikova M.Dr
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- Jacob J.Dh
- Jafari A.Az
- Jain S.Aw
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- Janot P.Cv
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- Kalogeropoulos A.Ak
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- Karapinar G.Dd
- Karapostoli G.Dj
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- Karjavin V.Cj
- Karmgard D.J.Es
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- Khukhunaishvili A.Ez
- Khurana R.Aw
- Khurshid T.Cf
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- Kilminster B.Cy
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- Kirsanov M.Cl
- Kirschenmann H.Al
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- Klanner R.Al
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- Klein K.Ah
- Kleinwort C.Ak
- Klima B.Dz
- Klingebiel D.Ai
- Klute M.El
- Klyukhin V.Co
- Kn\ufcnz V.B
- Knowlton D.Eo
- Knutsson A.D
- Knutzen S.Ai
- Ko W.Dp
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- Kodolova O.Co
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- Kottachchi Kankanamge Don C.Fh
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- Kovitanggoon K.Fe
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- Kukartsev G.Do
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- Kumar S.Ay
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- Kunori S.Fe
- Kuo C.M.Cz
- Kurca T.Af
- Kurt P.Ee
- Kuznetsova E.Am
- Kwan S.Dz
- Kwon E.Bw
- Kyberd P.Dk
- Kypreos T.Ea
- Kyriakis A.An
- L\ue9onard A.F
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- Lai Y.S.El
- Laird E.Do
- Lamichhane P.Fh
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- Lanaro A.Fi
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- Landsberg G.Do
- Lane R.Dj
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- Lange C.Cy
- Lange D.Ej
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- Langenegger U.Cw
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- Lariccia P.Bl
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- Lee S.Br
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- Lei Y.J.Da
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- Libeiro T.Fe
- Ligabue F.
- Liko D.B
- Lin C.Fg
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- Lo Vetere M.Bg
- Lobanov A.Ak
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- Lopes Pegna D.Ew
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- Loveless R.Fi
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- Lowette S.E
- Lu R.-S.da
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- Lucas C.Dh
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- Luetic J.T
- Luiggi Lopez E.Dw
- Lujan P.Eu
- Luk M.Do
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- Luukka P.Z
- Luyckx S.D
- Lychkovskaya N.Cm
- Lykken J.Dz
- Lynch S.Es
- Lyons L.Dj
- M\ue4enp\ue4\ue4 T.Z
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- Ma T.El
- Macneill I.Ds
- Maes M.E
- Maeshima K.Dz
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- Mao Y.Ff
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- Marco J.Cu
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- Martinez Rivero C.Cu
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- Martinez G.Eb
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- Martins T.D.R.J
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- Milenovic P.Ea
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- Mossolov V.C
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- Murray M.Eh
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- Murzin V.Ck
- Musella P.Cv
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- Musienko Y.Dz
- Mussgiller A.Ak
- My S.Bb
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- Nam S.K.Bq
- Narain M.Do
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- Novgorodova O.Ak
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- Nowak F.Ak
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- Obraztsov S.Co
- Ocalan K.Dd
- Ocampo Rios A.A.G
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- Oliveros S.En
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- Osipenkov I.Fd
- Ostapchuk A.Ah
- Ott J.Al
- Ozdemir K.Dc
- Ozok F.Ef
- Ozturk S.Dc
- P\ue9rez-Calero Yzquierdo A.Cr
- Pacher L.Bo
- Padeken K.Ai
- Padhi S.Ds
- Padley B.P.Ey
- Padula S.S.L
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- Paktinat Mehdiabadi S.Az
- Palichik V.Cj
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- Palla F.Bm
- Palmer C.Ds
- Panagiotou A.Ao
- Pandolfi F.Cx
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- Panwalkar S.Fb
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- Zabel J.Ey
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- Zaganidis N.G
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- Zanetti A.Bp
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- Zeuner W.D.Cv
- Zeyrek M.Dd
- Zhang J.Eq
- Zhang L.P
- Zheng Y.Ew
- Zhokin A.Cm
- Zhu R.Y.Du
- Zhukov V.Ah
- Zhukova V.El
- Zito G.Bb
- Zotto P.Bj
- Zou W.P
- Zsigmond A.J.Aq
- Zucchetta A.Bj
- Zuranski A.Eu
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2014
- Field of study
Published by the American Physical Society under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published articles title, journal citation, and DOI.The first search at the LHC for the extinction of QCD jet production is presented, using data collected with the CMS detector corresponding to an integrated luminosity of 10.7 fb−1 of proton-proton collisions at a center-of-mass energy of 8 TeV. The extinction model studied in this analysis is motivated by the search for signatures of strong gravity at the TeV scale (terascale gravity) and assumes the existence of string couplings in the strong-coupling limit. In this limit, the string model predicts the suppression of all high-transverse-momentum standard model processes, including jet production, beyond a certain energy scale. To test this prediction, the measured transverse-momentum spectrum is compared to the theoretical prediction of the standard model. No significant deficit of events is found at high transverse momentum. A 95% confidence level lower limit of 3.3 TeV is set on the extinction mass scale
International nosocomial infection control consortium (INICC) report, data summary of 36 countries, for 2004-2009
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2012
- Field of study
The results of a surveillance study conducted by the International Nosocomial Infection Control Consortium (INICC) from January 2004 through December 2009 in 422 intensive care units (ICUs) of 36 countries in Latin America, Asia, Africa, and Europe are reported. During the 6-year study period, using Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated health care-associated infections, we gathered prospective data from 313,008 patients hospitalized in the consortium's ICUs for an aggregate of 2,194,897 ICU bed-days. Despite the fact that the use of devices in the developing countries' ICUs was remarkably similar to that reported in US ICUs in the CDC's NHSN, rates of device-associated nosocomial infection were significantly higher in the ICUs of the INICC hospitals; the pooled rate of central line-associated bloodstream infection in the INICC ICUs of 6.8 per 1,000 central line-days was more than 3-fold higher than the 2.0 per 1,000 central line-days reported in comparable US ICUs. The overall rate of ventilator-associated pneumonia also was far higher (15.8 vs 3.3 per 1,000 ventilator-days), as was the rate of catheter-associated urinary tract infection (6.3 vs. 3.3 per 1,000 catheter-days). Notably, the frequencies of resistance of Pseudomonas aeruginosa isolates to imipenem (47.2% vs 23.0%), Klebsiella pneumoniae isolates to ceftazidime (76.3% vs 27.1%), Escherichia coli isolates to ceftazidime (66.7% vs 8.1%), Staphylococcus aureus isolates to methicillin (84.4% vs 56.8%), were also higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 7.3% (for catheter-associated urinary tract infection) to 15.2% (for ventilator-associated pneumonia). Copyright © 2012 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved
A century of trends in adult human height
- Author
- Abdeen Ziad A.
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adams Robert
- Aekplakorn Wichai
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmadvand Alireza
- Ahrens Wolfgang
- Al-Hazzaa Hazzaa M.
- Al-Othman Amani Rashed
- Ali Mohamed M.
- Alkerwi Ala’a
- Alvarez-Pedrerol Mar
- Aly Eman
- Amouyel Philippe
- Amuzu Antoinette
- Andersen Lars Bo
- Anderssen Sigmund A.
- Anjana Ranjit Mohan
- Aounallah-Skhiri Hajer
- Arfan Ikram M.
- Ariansen Inger
- Aris Tahir
- Arlappa Nimmathota
- Arveiler Dominique
- Assah Felix K.
- Avdicová Mária
- Azizi Fereidoun
- Babu Bontha V.
- Bahijri Suhad
- Balakrishna Nagalla
- Bandosz Piotr
- Banegas José R.
- Bao Khanh Le Nguyen
- Bao Tran Quoc
- Barbagallo Carlo M.
- Barceló Alberto
- Barkat Amina
- Barros Mauro V.
- Bata Iqbal
- Batieha Anwar M.
- Batista Rosangela L.
- Baur Louise A.
- Beaglehole Robert
- Benet Mikhail
- Bennett James E.
- Bentham James
- Bernabe-Ortiz Antonio
- Bernotiene Gailute
- Bettiol Heloisa
- Bhagyalaxmi Aroor
- Bharadwaj Sumit
- Bhargava Santosh K.
- Bhatti Zaid
- Bhutta Zulfiqar A.
- Bi Hongsheng
- Bi Yufang
- Bixby Honor
- Bjerregaard Peter
- Bjertness Espen
- Bjertness Marius B.
- Björkelund Cecilia
- Blokstra Anneke
- Bo Simona
- Bobak Martin
- Boddy Lynne M.
- Boehm Bernhard O.
- Boeing Heiner
- Boissonnet Carlos P.
- Boker Lital Keinan
- Bongard Vanina
- Bovet Pascal
- Braeckman Lutgart
- Bragt Marjolijn C.E.
- Brajkovich Imperia
- Branca Francesco
- Breckenkamp Juergen
- Brenner Hermann
- Brewster Lizzy M.
- Brian Garry R.
- Bruno Graziella
- Bueno-de-Mesquita H. Bas
- Bugge Anna
- Burns Con
- Cacciottolo Joseph
- Cadena Leticia Hernandez
- Cama Tilema
- Cameron Christine
- Camolas José
- Can Günay
- Capuano Vincenzo
- Cardoso Viviane C.
- Carlsson Axel C.
- Carvalho Maria J.
- Casanueva Felipe F.
- Casas Juan Pablo
- Caserta Carmelo A.
- Chamukuttan Snehalatha
- Chan Angelique W.
- Chan Queenie
- Chaturvedi Himanshu K.
- Chaturvedi Nishi
- Chen Chien Jen
- Chen Fangfang
- Chen Huashuai
- Chen Shuohua
- Chen Zhengming
- Cheng Ching Yu
- Chetrit Angela
- Chiolero Arnaud
- Chiou Shu Ti
- Chirita-Emandi Adela
- Cho Belong
- Cho Yumi
- Christensen Kaare
- Chudek Jerzy
- Cifkova Renata
- Claessens Frank
- Clays Els
- Concin Hans
- Cooper Cyrus
- Cooper Rachel
- Coppinger Tara C.
- Costanzo Simona
- Cottel Dominique
- Cowan Melanie
- Cowell Chris
- Craig Cora L.
- Crujeiras Ana B.
- Cândido Ana Paula C.
- Dallongeville Jean
- Damasceno Albertino
- Damsgaard Camilla T.
- Danaei Goodarz
- Dankner Rachel
- Dauchet Luc
- De Backer Guy
- De Bacquer Dirk
- de Gaetano Giovanni
- De Henauw Stefaan
- De León Antonio Cabrera
- De Smedt Delphine
- Deepa Mohan
- Deev Alexander D.
- Dehghan Abbas
- Del Cristo Rodriguez-Perez María
- Delisle Hélène
- Delpeuch Francis
- Deschamps Valérie
- Dhana Klodian
- Di Castelnuovo Augusto F.
- Di Cesare Mariachiara
- Dias-da-Costa Juvenal Soares
- Diaz Alejandro
- Djalalinia Shirin
- Do Carmo Franco Maria
- Do Ha T.P.
- Dobson Annette J.
- Donfrancesco Chiara
- Donoso Silvana P.
- Doua Kouamelan
- Drygas Wojciech
- Dzerve Vilnis
- Döring Angela
- D’Arrigo Graziella
- d’Orsi Eleonora
- Egbagbe Eruke E.
- Eggertsen Robert
- Ekelund Ulf
- El Ati Jalila
- Elliott Paul
- Engle-Stone Reina
- Erasmus Rajiv T.
- Erem Cihangir
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- Fernanda Lima-Costa M.
- Fernández-Bergés Daniel
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- Ferrari Marika
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- Finn Joseph D.
- Fischer Krista
- Flores Eric Monterubio
- Foo Leng Huat
- Forslund Ann Sofie
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- Fortmann Stephen P.
- Fortunato Léa
- Fouad Heba M.
- Francis Damian K.
- Franco Oscar H.
- Frontera Guillermo
- Fuchs Flavio D.
- Fuchs Sandra C.
- Fujita Yuki
- Furusawa Takuro
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- Gaciong Zbigniew
- Gafencu Mihai
- Gareta Dickman
- Garnett Sarah P.
- Gaspoz Jean Michel
- Gasull Magda
- Gates Louise
- Geleijnse Johanna M.
- Ghasemian Anoosheh
- Giampaoli Simona
- Gianfagna Francesco
- Giovannelli Jonathan
- Giwercman Aleksander
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- González Rivas Juan P.
- Gonçalves Helen
- Gorbea Mariano Bonet
- Gottrand Frederic
- Graff-Iversen Sidsel
- Grafnetter Dušan
- Grajda Aneta
- Grammatikopoulou Maria G.
- Gregor Ronald D.
- Grodzicki Tomasz
- Gross Marcela Gonzalez
- Gruden Grabriella
- Grujic Vera
- Grøntved Anders
- Gu Dongfeng
- Gualdi-Russo Emanuela
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- Gunter Marc
- Guo Xiuhua
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- Gurzkowska Beata
- Gutierrez Laura
- Gutzwiller Felix
- Hajifathalian Kaveh
- Halkjær Jytte
- Hambleton Ian R.
- Hamid Zargar Abdul
- Hardy Rebecca
- Hata Jun
- Hayes Alison J.
- He Jiang
- Hendriks Marleen Elisabeth
- Herrala Sauli
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- Hihtaniemi Ilpo Tapani
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- Htet Aung Soe
- Htike Maung Maung Than
- Hu Yonghua
- Husseini Abdullatif
- Huu Chinh Nguyen
- Huybrechts Inge
- Hwalla Nahla
- Iacoviello Licia
- Iannone Anna G.
- Ibrahim Mohsen M.
- Ikeda Nayu
- Irazola Vilma E.
- Islam Muhammad
- Ivkovic Vanja
- Iwasaki Masanori
- Jackson Rod T.
- Jacobs Jeremy M.
- Jafar Tazeen
- Jaime Miranda J.
- Jamil Kazi M.
- Jamrozik Konrad
- Janszky Imre
- Jasienska Grazyna
- Jelakovic Bojan
- Jiang Chao Qiang
- Joffres Michel
- Johansson Mattias
- Jonas Jost B.
- Joshi Pradeep
- Juolevi Anne
- Jurak Gregor
- Jureša Vesna
- Jørgensen Torben
- Kaaks Rudolf
- Kafatos Anthony
- Kalter-Leibovici Ofra
- Kapantais Efthymios
- Kasaeian Amir
- Katz Joanne
- Kaur Prabhdeep
- Kavousi Maryam
- Keil Ulrich
- Keinänen-Kiukaanniemi Sirkka
- Kelishadi Roya
- Kemper Han C.G.
- Kengne Andre P.
- Kersting Mathilde
- Key Timothy
- Khader Yousef Saleh
- Khalili Davood
- Khang Young Ho
- Khaw Kay Tee H.
- Khouw Ilse M.S.L.
- Kiechl Stefan
- Killewo Japhet
- Kim Jeongseon
- Klimont Jeannette
- Klumbiene Jurate
- Koirala Bhawesh
- Kolle Elin
- Kolsteren Patrick
- Kontis Vasilis
- Korrovits Paul
- Koskinen Seppo
- Kouda Katsuyasu
- Koziel Slawomir
- Kratzer Wolfgang
- Krishna Kumar R.
- Krokstad Steinar
- Kromhout Daan
- Kruger Herculina S.
- Kubinova Ruzena
- Kujala Urho M.
- Kula Krzysztof
- Kulaga Zbigniew
- Kumar Rachakulla Hari
- Kurjata Pawel
- Kusuma Yadlapalli S.
- Kuulasmaa Kari
- Kyobutungi Catherine
- Laamiri Fatima Zahra
- Laatikainen Tiina
- Lachat Carl
- Laid Youcef
- Lam Tai Hing
- Landrove Orlando
- Lanska Vera
- Lappas Georg
- Larijani Bagher
- Laugsand Lars E.
- Laxmaiah Avula
- Le Tuyen D.
- Leclercq Catherine
- Lee Jeannette
- Lee Jeonghee
- Lehtimäki Terho
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- León-Muñoz Luz M.
- Li Yanping
- Lilly Christa L.
- Lim Wei Yen
- Lin Hsien Ho
- Lin Xu
- Linneberg Allan
- Lissner Lauren
- Litwin Mieczyslaw
- Liu Jing
- Lorbeer Roberto
- Lotufo Paulo A.
- Lozano José Eugenio
- Lu Yuan
- Luksiene Dalia
- Lundqvist Annamari
- Lunet Nuno
- Lytsy Per
- Ma Guansheng
- Ma Jun
- Machado-Coelho George L.L.
- Machi Suka
- Maggi Stefania
- Magliano Dianna J.
- Maire Bernard
- Makdisse Marcia
- Malekzadeh Reza
- Malhotra Rahul
- Malyutina Sofia
- Manios Yannis
- Mann Jim I.
- Manzato Enzo
- Margozzini Paula
- Markey Oonagh
- Marques-Vidal Pedro
- Marrugat Jaume
- Martin-Prevel Yves
- Martinez Eduardo Salazar
- Martorell Reynaldo
- Masoodi Shariq R.
- Mathiesen Ellisiv B.
- Matsha Tandi E.
- Mazur Artur
- Mbanya Jean Claude N.
- McFarlane Shelly R.
- McGarvey Stephen T.
- McKee Martin
- McLachlan Stela
- McLean Rachael M.
- McNulty Breige A.
- Mediene-Benchekor Sounnia
- Meirhaeghe Aline
- Meisinger Christa
- Menezes Ana Maria B.
- Mensink Gert B.M.
- Meshram Indrapal I.
- Metspalu Andres
- Mi Jie
- Michaelsen Kim F.
- Mikkel Kairit
- Miller Jody C.
- Miquel Juan Francisco
- Mišigoj-Durakovic Marjeta
- Mohamed Mostafa K.
- Mohammad Kazem
- Mohammadifard Noushin
- Mohan Viswanathan
- Molbo Drude
- Molnár Dénes
- Mondo Charles K.
- Monterrubio Eric A.
- Monyeki Kotsedi Daniel K.
- Moreira Leila B.
- Morejon Alain
- Moreno Luis A.
- Morgan Karen
- Mortensen Erik Lykke
- Moschonis George
- Mossakowska Malgorzata
- Mostafa Aya
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- Motta Jorge
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- Navarrete-Muñoz Eva Maria
- Neal William A.
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- Nervi Flavio
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- Nguyen Nguyen D.
- Nguyen Quang Ngoc
- Nieto-Martínez Ramfis E.
- Ning Guang
- Ninomiya Toshiharu
- Nishtar Sania
- Noale Marianna
- Norat Teresa
- Noto Davide
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- Osler Merete
- Osmond Clive
- Ostojic Sergej M.
- Otero Johanna A.
- Overvad Kim
- Owusu-Dabo Ellis
- Paccaud Fred Michel
- Paciorek Christopher J.
- Padez Cristina
- Pahomova Elena
- Pajak Andrzej
- Palli Domenico
- Palloni Alberto
- Palmieri Luigi
- Panda-Jonas Songhomitra
- Panza Francesco
- Parnell Winsome R.
- Parsaeian Mahboubeh
- Pecin Ivan
- Pednekar Mangesh S.
- Peeters Petra H.
- Peixoto Sergio Viana
- Peltonen Markku
- Pereira Alexandre C.
- Peters Annette
- Petkeviciene Janina
- Peykari Niloofar
- Pham Son Thai
- Pigeot Iris
- Pikhart Hynek
- Pilav Aida
- Pilotto Lorenza
- Pistelli Francesco
- Pitakaka Freda
- Piwonska Aleksandra
- Plans-Rubió Pedro
- Poh Bee Koon
- Porta Miquel
- Portegies Marileen L.P.
- Poulimeneas Dimitrios
- Pradeepa Rajendra
- Prashant Mathur
- Price Jacqueline F.
- Puiu Maria
- Punab Margus
- Pérez Cynthia M.
- Qasrawi Radwan F.
- Qorbani Mostafa
- Raddadi Rajaa Al
- Radic Ivana
- Radisauskas Ricardas
- Rahman Mah mudur
- Raitakari Olli
- Raj Manu
- Ramachandran Ambady
- Ramke Jacqueline
- Ramos Rafel
- Rampal Sanjay
- Rao Kodavanti Mallikharjuna
- Rao Sudha Ramachandra
- Rasmussen Finn
- Redon Josep
- Reganit Paul Ferdinand M.
- Ribeiro Robespierre
- Riboli Elio
- Rigo Fernando
- Riley Leanne M.
- Rinke de Wit Tobias F.
- Ritti-Dias Raphael M.
- Rivera Juan A.
- Robinson Sian M.
- Robitaille Cynthia
- Rodríguez-Artalejo Fernando
- Rodríguez-Villamizar Laura A.
- Rojas-Martinez Rosalba
- Rojroong-Wasinkul Nipa
- Romaguera Dora
- Romdhane Habiba Ben
- Ronkainen Kimmo
- Rosengren Annika
- Rouse Ian
- Rubinstein Adolfo
- Rui Ornelas
- Ruiz-Betancourt Blanca Sandra
- Russo Horimoto Andrea R.V.
- Rutkowski Marcin
- Rühli Frank J.
- Sabanayagam Charumathi
- Sachdev Harshpal S.
- Saidi Olfa
- Salanave Benoit
- Salomaa Veikko
- Salonen Jukka T.
- Salvetti Massimo
- Stevens Gretchen A.
- Sánchez-Abanto Jose
- Yusof Safiah Md
- Yusoff Muhammad Fadhli Mohd
- Zhou Bin
- Publication venue
- 'eLife Sciences Publications, Ltd'
- Publication date
- 26/07/2016
- Field of study
Repositioning of the global epicentre of non-optimal cholesterol
- Author
- Aadahl M.
- Abarca-Gómez L.
- Abu-Rmeileh N.M.
- Acosta-Cazares B.
- Adams R.J.
- Aekplakorn W.
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- Aghazadeh-Attari J.
- Aguilar-Salinas C.A.
- Agyemang C.
- Ahluwalia T.S.
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- Ahmadi A.
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- Ajlouni K.
- al-Safi Ismail A.
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- Barkat A.
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- Batyrbek A.
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- Beaglehole R.
- Bebakar W.M.W.
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- Vrkic T.Z.
- Wade A.N.
- Wagner A.
- Walton J.
- Wang M.-D.
- Wang N.
- Wang Q.
- Wang Y.-W.
- Wang Y.X.
- Wannamethee S.G.
- Wedderkopp N.
- Wei W.
- Whincup P.H.
- Widhalm K.
- Widyahening I.S.
- Wiecek A.
- Wijga A.H.
- Wilks R.J.
- Willeit J.
- Willeit P.
- Wilsgaard T.
- Wojtyniak B.
- Wong A.
- Wong N.I.
- Wong T.Y.
- Wong-McClure R.A.
- Woo J.
- Woodward M.
- Wu F.C.
- Wu S.
- Xu H.
- Xu L.
- Yan W.
- Yang X.
- Yasuharu T.
- Ye X.
- Yeow T.P.
- Yiallouros P.K.
- Yoosefi M.
- Yoshihara A.
- You S.-L.
- Younger-Coleman N.O.
- Yusoff A.F.
- Yusoff M.F.M.
- Zainuddin A.A.
- Zakavi S.R.
- Zali M.R.
- Zamani F.
- Zambon S.
- Zampelas A.
- Zaw K.K.
- Zdrojewski T.
- Zhang Z.-Y.
- Zhao D.
- Zhao W.
- Zhen S.
- Zheng Y.
- Zholdin B.
- Zhou B.
- Zhussupov B.
- Zoghlami N.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 27/10/2022
- Field of study
High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.</p
The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Aali A.
- Abbas Q.
- Abbasi B.
- Abbasi-Kangevari M.
- Abbasi-Kangevari Z.
- Abbastabar H.
- Abd-Elsalam S.
- Abdelmasseh M.
- Abdelwahab A.A.
- Abdoli G.
- Abdulkadir H.A.
- Abedi A.
- Abegaz K.H.
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- Aboagye R.G.
- Abolhassani H.
- Absalan A.
- Abtew Yo.D.
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- Adnani Q.E.S.
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- Šekerija M.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). INTERPRETATION: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden
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