The Circumstellar Disk of the Butterfly Star in Taurus

We present a model of the circumstellar environment of the so-called ``Butterfly Star'' in Taurus (IRAS 04302+2247). The appearance of this young stellar object is dominated by a large circumstellar disk seen edge-on and the light scattering lobes above the disk. The model is based on multi-wavelength continuum observations: Millimeter maps and high-resolution near-infrared images obtained with HST/NICMOS. It was found that the disk and envelope parameters are comparable with those of the circumstellar environment of other young stellar objects. A main result is that the dust properties must be different in the circumstellar disk and in the envelope: While a grain size distribution with grain radii up to 100 micron is required to reproduce the millimeter observations of the disk, the envelope is dominated by smaller grains similar to those of the interstellar medium. Preprint with high figure quality available at: http://spider.ipac.caltech.edu/staff/swolf/homepage/public/preprints/i04302.psComment: 32 pages, 9 figure

Activating NPPT distillation with an infinitesimal amount of bound entanglement

We show that bipartite quantum states of any dimension, which do not have a positive partial transpose, become 1-distillable when one adds an infinitesimal amount of bound entanglement. To this end we investigate the activation properties of a new class of symmetric bound entangled states of full rank. It is shown that in this set there exist universal activator states capable of activating the distillation of any NPPT state.Comment: 4 pages, revtex4, 1 figure, references correcte

Spatial processes in linear ordering

Memory performance in linear order reasoning tasks (A > B, B > C, C > D, etc.) shows quicker, and more accurate responses to queries on wider (AD) than narrower (AB) pairs on a hypothetical linear mental model (A – B – C – D). While indicative of an analogue representation, research so far did not provide positive evidence for spatial processes in the construction of such models. In a series of 7 experiments we report such evidence. Participants respond quicker when the dominant element in a pair is presented on the left (or top) rather than on the right (or bottom). The left-anchoring tendency reverses in a sample with Farsi background (reading/writing from right to left). Alternative explanations and confounds are tested. A theoretical model is proposed that integrates basic assumptions about acquired reading/writing habits as a scaffold for spatial simulation, and primacy/dominance representation within such spatial simulations

A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland

<p>Abstract</p> <p>Background</p> <p>A genome-wide search for genes that predispose to type 1 diabetes using linkage analysis was performed using 900 microsatellite markers in 70 nuclear families with affected siblings from Finland, a population expected to be more genetically homogeneous than others, and having the highest incidence of type 1 diabetes in the world and, yet, the highest proportion in Europe of cases (10%) carrying neither of the highest risk <it>HLA </it>haplotypes that include DR3 or DR4 alleles.</p> <p>Results</p> <p>In addition to the evidence of linkage to the <it>HLA </it>region on 6p21 (nominal p = 4.0 × 10^-6), significant evidence of linkage in other chromosome regions was not detected with a single-locus analysis. The two-locus analysis conditional on the <it>HLA </it>gave a maximum lod score (MLS) of 3.1 (nominal p = 2 × 10^-4) on chromosome 9p13 under an additive model; MLS of 2.1 (nominal p = 6.1 × 10^-3) on chromosome 17p12 and MLS of 2.5 (nominal p = 2.9 × 10^-3) on chromosome 18p11 under a general model.</p> <p>Conclusion</p> <p>Our genome scan data confirmed the primary contribution of the <it>HLA </it>genes also in the high-risk Finnish population, and suggest that non-<it>HLA </it>genes also contribute to the familial clustering of type 1 diabetes in Finland.</p

Ethacrynic Acid Exhibits Selective Toxicity to Chronic Lymphocytic Leukemia Cells by Inhibition of the Wnt/β-Catenin Pathway

Aberrant activation of Wnt/β-catenin signaling promotes the development of several cancers. It has been demonstrated that the Wnt signaling pathway is activated in chronic lymphocytic leukemia (CLL) cells, and that uncontrolled Wnt/β-catenin signaling may contribute to the defect in apoptosis that characterizes this malignancy. Thus, the Wnt signaling pathway is an attractive candidate for developing targeted therapies for CLL. assays further confirmed the inhibitory effect of EA on Wnt/β-catenin signaling. Cell viability assays showed that EA selectively induced cell death in primary CLL cells. Exposure of CLL cells to EA decreased the expression of Wnt/β-catenin target genes, including LEF-1, cyclin D1 and fibronectin. Immune co-precipitation experiments demonstrated that EA could directly bind to LEF-1 protein and destabilize the LEF-1/β-catenin complex. N-acetyl-L-cysteine (NAC), which can react with the α, β-unsaturated ketone in EA, but not other anti-oxidants, prevented the drug's inhibition of Wnt/β-catenin activation and its ability to induce apoptosis in CLL cells.Our studies indicate that EA selectively suppresses CLL survival due to inhibition of Wnt/β-catenin signaling. Antagonizing Wnt signaling in CLL with EA or related drugs may represent an effective treatment of this disease

The WiggleZ Dark Energy Survey: Direct constraints on blue galaxy intrinsic alignments at intermediate redshifts

Correlations between the intrinsic shapes of galaxy pairs, and between the intrinsic shapes of galaxies and the large-scale density field, may be induced by tidal fields. These correlations, which have been detected at low redshifts (z<0.35) for bright red galaxies in the Sloan Digital Sky Survey (SDSS), and for which upper limits exist for blue galaxies at z~0.1, provide a window into galaxy formation and evolution, and are also an important contaminant for current and future weak lensing surveys. Measurements of these alignments at intermediate redshifts (z~0.6) that are more relevant for cosmic shear observations are very important for understanding the origin and redshift evolution of these alignments, and for minimising their impact on weak lensing measurements. We present the first such intermediate-redshift measurement for blue galaxies, using galaxy shape measurements from SDSS and spectroscopic redshifts from the WiggleZ Dark Energy Survey. Our null detection allows us to place upper limits on the contamination of weak lensing measurements by blue galaxy intrinsic alignments that, for the first time, do not require significant model-dependent extrapolation from the z~0.1 SDSS observations. Also, combining the SDSS and WiggleZ constraints gives us a long redshift baseline with which to constrain intrinsic alignment models and contamination of the cosmic shear power spectrum. Assuming that the alignments can be explained by linear alignment with the smoothed local density field, we find that a measurement of \sigma_8 in a blue-galaxy dominated, CFHTLS-like survey would be contaminated by at most +/-0.02 (95% confidence level, SDSS and WiggleZ) or +/-0.03 (WiggleZ alone) due to intrinsic alignments. [Abridged]Comment: 18 pages, 12 figures, accepted to MNRAS; v2 has correction to one author's name, NO other changes; v3 has minor changes in explanation and calculations, no significant difference in results or conclusions; v4 has an additional footnote about model interpretation, no changes to data/calculations/result

No evidence for an association of plasma homocysteine levels and refractive error - Results from the population-based Gutenberg Health Study (GHS)

Purpose There is a strong association between severe hyperhomocysteinemia and myopia. Thus we studied the hypothesis that even moderately increased levels of homocysteine (Hcy) might be a potentially treatable risk factor for myopia. Methods The Gutenberg Health Study (GHS) is a population-based, prospective, observational cohort study in Germany, including 15,010 participants aged between 35 and 74 at recruitment. The baseline examination was conducted from 2007-2012. Refraction was measured using autorefraction (HARK 599, Carl Zeiss AG, Jena, Germany). Hcy was measured by an immunoassay. We included only phakic participants without a history of corneal surgery or corneal laser treatment. We used linear regression models to evaluate the potential association between Hcy and refraction at baseline, and between Hcy and change in refraction between baseline and 5-year-follow-up examination. We used generalized estimating equation models to account for the correlation between fellow eyes. Results We included 13,749 participants, categorized as having no myopia (spherical equivalent > -0.75 D, 65.2%), low myopia (-0.75 D-2.75 D, 21.5%), moderate myopia (-3.00 D- 5.75 D, 9.8%) and high myopia (≤ -6

NGC6240: Merger-Induced Star Formation & Gas Dynamics

We present spatially resolved integral field spectroscopic K-band data at a resolution of 0.13" (60pc) and interferometric CO(2-1) line observations of the prototypical merging system NGC6240. Despite the clear rotational signature, the stellar kinematics in the two nuclei are dominated by dispersion. We use Jeans modelling to derive the masses and the mass-to-light ratios of the nuclei. Combining the luminosities with the spatially resolved Br-gamma equivalent width shows that only 1/3 of the K-band continuum from the nuclei is associated with the most recent star forming episode; and that less than 30% of the system's bolometric luminosity and only 9% of its stellar mass is due to this starburst. The star formation properties, calculated from typical merger star formation histories, demonstrate the impact of different assumptions about the star formation history. The properties of the nuclei, and the existence of a prominent old stellar population, indicate that the nuclei are remnants of the progenitor galaxies' bulges.Comment: 18 pages, 14 figures. Accepted for publication in A&

Reflection of Scandinavian Ice Sheet Fluctuations in Norwegian Sea Sediments during the Past 150,000 Years

The record of glacier fluctuations in western Scandinavia, as reconstructed from continental data, has been correlated with records of ice-rafted detritus (IRD) from well-dated sediment cores from the Norwegian Sea covering the past 150,000 yr B.P. The input of IRD into the ocean is used as a proxy for ice sheet advances onto the shelf and, thus, for the calibration of a glaciation curve. The marine results generally support land-based reconstructions of glacier fluctuations and improve the time-control on glacial advances. The Saalian ice sheet decayed very rapidly approximately 125,000 yr B.P. In the Early Weichselian, a minor but significant IRD maximum indicates the presence of icebergs in isotope substage 5b (especially between 95,000 and 83,000 yr B.P.). Reduced amounts of calcareous nannofossils indicate that surface waters were influenced by meltwater discharges during isotope substages 5d and 5b. An extensive build-up of inland ice began again during isotope stage 4, but maximum glaciation was reached only in early stage 3 (58,000-53,000 yr B.P.). Marine sediments have minimum carbonate content, indicating strong dilution by lithogenic ice-rafted material. Generally, the IRD accumulation rate was considerably higher in stages 4-2 than in stage 5. A marked peak in IRD accumulation rates from 47,000 to 43,000 yr B.P. correlates well with a second Middle Weichselian ice sheet advance dated by the Laschamp/Olby paleomagnetic event. Minimum ice extent during the Ålesund interstade (38,500-32,500 yr B.P.) and several glacial oscillations during the Late Weichselian are also seen in the IRD record. Of several late Weichselian glacial oscillations on the shelf, at least four correspond to the North Atlantic Heinrich events. Ice sheet behavior was either coupled or linked by external forcing during these events, whereas internal ice sheet mechanisms may account for the noncoherent fluctuations

The DIRTY Model II: Self-Consistent Treatment of Dust Heating and Emission in a 3-D Radiative Transfer Code

In this paper and a companion paper we present the DIRTY model, a Monte Carlo radiative transfer code, self-consistently including dust heating and emission, and accounting for the effects of the transient heating of small grains. The code is completely general; the density structure of the dust, the number and type of heating sources, and their geometric configurations can be specified arbitrarily within the model space. Source photons are tracked through the scattering and absorbing medium using Monte Carlo techniques and the effects of multiple scattering are included. The dust scattering, absorbing, and emitting properties are calculated from realistic dust models derived by fitting observed extinction curves in Local Group galaxies including the Magellanic Clouds and the Milky Way. The dust temperature and the emitted dust spectrum are calculated self consistently from the absorbed energy including the effects of temperature fluctuations in small grains. Dust self-absorption is also accounted for, allowing the treatment of high optical depths, by treating photons emitted by the dust as an additional heating source and adopting an iterative radiative transfer scheme. As an illustrative case, we apply the DIRTY radiative transfer code to starburst galaxies wherein the heating sources are derived from stellar evolutionary synthesis models. Within the context of the starburst model, we examine the dependence of the UV to FIR SED, dust temperatures, and dust masses predicted by DIRTY on variations of the input parameters.Comment: 23 pages (emulateapj, single column), 17 figures. To appear in the ApJ, in pres