Accelerating Students Forward to Excellence with UCF Online

The Center for Distributed Learning, in the Division of Digital Learning at the University of Central Florida (UCF), has been instrumental in driving the use of educational technology to expand online teaching and learning opportunities. The advances have occurred while retaining the level of excellence for which its online learning has been nationally recognized and awarded over the last 20 years. As online educational trends have evolved due to a demand for more expansive offerings, the fully-online UCF Online initiative was born. UCF is accelerating students forward to excellence by expanding the reach of an affordable higher education with UCF Online. Reaching educational goals is attainable regardless of geographical limitations or life circumstances. The initial phase of UCF Online is designed to primarily serve transfer students in the state of Florida, as well as masters and doctoral students. To foster Florida state college transfer student transitions to UCF Online, partnerships are formed between UCF and some Florida colleges. UCF Online students may take advantage of many student benefits in addition to having exclusive access to UCF Online Success Coaches. Since UCF Online programs are fully-online, there is a waiver of some campus-based fees that also reduces access to some on-campus student resources and services

Chemistry to biology knowledge transfer does it work? Mapping of TLO’s by multi-evaluation techniques

Engaging and collaborative activities along with peer assessment allows students to deepen their discipline knowledge, practice team work and gain experience in judging the work of their peers. Thus these activities provide a rich context in which their learning is multi-faceted and is promoted in both discipline and generic domains, supporting the science threshold learning outcomes1. This learning was commenced in first year and then built on in a second year subject. Workshops that were based on active learning principles had previously been developed and used in large first year chemistry subjects2 . That innovation was implemented in another science discipline, with chemistry and biology teaching staff working collaboratively to introduce workshop sessions into BIOL213, a second year biochemistry subject. BIOL213 is largely a ‘service subject’ and has a failure rate of concern. The main aims of the teaching innovation were - to support knowledge transfer from one set of science discipline staff to another, to demonstrate proof of concept, to foster sharing of learning design across the faculty of science especially to research focused staff, to promote deeper student learning through active learning and consequently improve student performance. The evaluation of this innovation aimed to determine whether these teaching activities and assessment tasks had been effective in students achieving these learning outcomes, at threshold level or above, and to help map chemistry and biology disciplinary areas against the science TLOs. The project team were supported by advice, peer review, and leadership training from SaMnet action-learning team. 1.Jones, S and Yates B. 2011 SCIENCE Learning and Teaching Academic Standards Statement, September 2011. ISBN: 978-1-921856-29-7, http://www.olt.gov.au/system/files/resources/altc_standards_SCIENCE_240811_v3.pdf 2 O’BrienG and Bedford, S. (2012) Small group work in large chemistry classes: Workshops in First Year Chemistry. HEAcademy STEM Annual Conference 2012. http://www.heacademy.ac.uk/assets/documents/stem-conference/Physical_20Sciences/Glennys_OBrien.pd

Control of the Apple Clearwing Moth, Synanthedon myopaeformis, with Tree-Trunk Applications of Reduced-risk Insecticides, Nematodes and Barriers

Apple clearwing moth (ACM), Synanthedonmyopaeformis Borkhausen (Lepidoptera: Sesiidae), wasdiscovered in an apple orchard in Cawston, British Columbia in 2005.  This xylophagous, invasive Europeanspecies has become a serious problem in high-density apple orchards wheresize-controlling rootstocks are attacked by the wood-boring larvae.  Seven screening trials with reduced-riskinsecticides for conventional (seven treatments) and organic apple production (threetreatments) were established in two commercial high-density mixed-variety appleplantings in Cawston.  Our objectiveswere (1) to screen several new synthetic insecticides having novel chemistriesthat purportedly have reduced risks, (2) to evaluate use of several organically-approvedspray materials, including nematodes, and (3) to compare the efficacy ofvarious products when applied at different times during the growing season.  Single, hand-gun sprays delivering treatmentsin 2000 L of water ha-1 at 200 psi were applied as curative sprays targeting mature larvae inrootstock-scion graft unions in May and October 2008, and June 2009.  Among seven treatments tested, only theinsect growth regulator, Rimon® 10 EC (10% novaluron), at 2.4 L a.i.ha-1, caused significant reductions in adult emergence compared withuntreated controls in all experiments.  Whenapplied twice as preventativetreatments during flight of male ACM in 2008, Altacor®, Belt®,Delegate™ and Rimon all caused significant reductions in adult emergence thefollowing year; Rimon caused the greatest reduction (-96.4%).  In a similar 2009 trial only Rimon reducedpopulations the following year.  One curative or two preventative applications of the organic materials, Entrust®,Crocker’s Fish Oil®, or Purespray Green Oil™, at anyspray timing, did not control ACM.  The nematode,Steinernema feltiae (Filipjev) (1×105infective juvenile nematodes / 100 ml of water / tree) provided significant controlof ACM in one spring 2008 trial.  In two 2009nematode-only experiments, a sawdust paste tree-trunk barrier applied over nematodeapplications made either in May or August, caused significant reductions in emergenceof ACM adults.  Curative tree-trunk spraysof Rimon 10 EC at the tested rate are recommended for control of ACM inconventional apple orchards.  There is noeffective organic control for ACM at this time, but tree-trunk barriers andnematodes may warrant further study

A marker of biological age explains individual variation in the strength of the adult stress response

This research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) under grants BB/J016446/1, BB/J015091/1 and BB/J016292/1. The project has also received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement no. AdG 666669 (D.N.) and 268926 (P.M.)) K.A.S. was also funded by a BBSRC David Phillips Research Fellowship. The raw data and R script from this experiment are publicly available at: https://doi.org/10.5281/zenodo.846830 [38].The acute stress response functions to prioritize behavioural and physiological processes that maximize survival in the face of immediate threat. There is variation between individuals in the strength of the adult stress response that is of interest in both evolutionary biology and medicine. Age is an established source of this variation-stress responsiveness diminishes with increasing age in a range of species-but unexplained variation remains. Since individuals of the same chronological age may differ markedly in their pace of biological ageing, we asked whether biological age-measured here via erythrocyte telomere length-predicts variation in stress responsiveness in adult animals of the same chronological age. We studied two cohorts of European starlings in which we had previously manipulated the rate of biological ageing by experimentally altering the competition experienced by chicks in the fortnight following hatching. We predicted that individuals with greater developmental telomere attrition, and hence greater biological age, would show an attenuated corticosterone (CORT) response to an acute stressor when tested as adults. In both cohorts, we found that birds with greater developmental telomere attrition had lower peak CORT levels and a more negative change in CORT levels between 15 and 30 min following stress exposure. Our results, therefore, provide strong evidence that a measure of biological age explains individual variation in stress responsiveness: birds that were biologically older were less stress responsive. Our results provide a novel explanation for the phenomenon of developmental programming of the stress response: observed changes in stress physiology as a result of exposure to early-life adversity may reflect changes in ageing.Publisher PDFPeer reviewe

Library Publishing Research Agenda

This publication is an exploration of areas in which research is needed to support practice in the field of library publishing. The Research Agenda offers exploratory overviews of six topics (assessment, labor, accessibility, non-traditional research outputs, peer review, and partnerships), each of which includes a summary, potential research questions, and a list of relevant resources. This publication will be of interest to anyone conducting or interested in conducting research in the field. The Research Agenda was authored by LPC’s Research Committee with input from the LPC community. HTML versio

Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones

Neurodegenerative diseases are characterized by progressive degeneration of selective neurones in the nervous system, but the underlying mechanisms involved in neuroprotection and neurodegeneration remain unclear. Dysfunction of the ubiquitin proteasome system is one of the proposed hypotheses for the cause and progression of neuronal loss. We have performed quantitative two-dimensional fluorescence difference in-gel electrophoresis combined with peptide mass fingerprinting to reveal proteome changes associated with neurodegeneration following 26S proteasomal depletion in mouse forebrain neurones. Differentially expressed proteins were validated by Western blotting, biochemical assays and immunohistochemistry. Of significance was increased expression of the antioxidant enzyme peroxiredoxin 6 (PRDX6) in astrocytes, associated with oxidative stress. Interestingly, PRDX6 is a bifunctional enzyme with antioxidant peroxidase and phospholipase A2 (PLA2) activities. The PLA2 activity of PRDX6 was also increased following 26S proteasomal depletion and may be involved in neuroprotective or neurodegenerative mechanisms. This is the first in vivo report of oxidative stress caused directly by neuronal proteasome dysfunction in the mammalian brain. The results contribute to understanding neuronal–glial interactions in disease pathogenesis, provide an in vivo link between prominent disease hypotheses and importantly, are of relevance to a heterogeneous spectrum of neurodegenerative diseases

Childhood asthma prevalence: cross-sectional record linkage study comparing parent-reported wheeze with general practitioner-recorded asthma diagnoses from primary care electronic health records in Wales

Introduction Electronic health records (EHRs) are increasingly used to estimate the prevalence of childhood asthma. The relation of these estimates to those obtained from parent-reported wheezing suggestive of asthma is unclear. We hypothesised that parent-reported wheezing would be more prevalent than general practitioner (GP)-recorded asthma diagnoses in preschool-aged children. Methods 1529 of 1840 (83%) Millennium Cohort Study children registered with GPs in the Welsh Secure Anonymised Information Linkage databank were linked. Prevalences of parent-reported wheezing and GP-recorded asthma diagnoses in the previous 12 months were estimated, respectively, from parent report at ages 3, 5, 7 and 11 years, and from Read codes for asthma diagnoses and prescriptions based on GP EHRs over the same time period. Prevalences were weighted to account for clustered survey design and non-response. Cohen’s kappa statistics were used to assess agreement. Results Parent-reported wheezing was more prevalent than GP-recorded asthma diagnoses at 3 and 5 years. Both diminished with age: by age 11, prevalences of parent-reported wheezing and GP-recorded asthma diagnosis were 12.9% (95% CI 10.6 to 15.4) and 10.9% (8.8 to 13.3), respectively (difference: 2% (−0.5 to 4.5)). Other GP-recorded respiratory diagnoses accounted for 45.7% (95% CI 37.7 to 53.9) and 44.8% (33.9 to 56.2) of the excess in parent-reported wheezing at ages 3 and 5 years, respectively. Conclusion Parent-reported wheezing is more prevalent than GP-recorded asthma diagnoses in the preschool years, and this difference diminishes in primary school aged children. Further research is needed to evaluate the implications of these differences for the characterisation of longitudinal childhood asthma phenotypes from EHRs

Identifying interventions with Gypsies, Roma and Travellers to promote immunisation uptake: methodological approach and findings

Background: In the UK, Gypsy, Roma and Traveller (GRT) communities are generally considered to be at risk of low or variable immunisation uptake. Many strategies to increase uptake for the general population are relevant for GRT communities, however additional approaches may also be required, and importantly one cannot assume that “one size fits all”. Robust methods are needed to identify content and methods of delivery that are likely to be acceptable, feasible, effective and cost effective. In this paper, we describe the approach taken to identify potential interventions to increase uptake of immunisations in six GRT communities in four UK cities; and present the list of prioritised interventions that emerged.Methods: This work was conducted in three stages: (1) a modified intervention mapping process to identify ideas for potential interventions; (2) a two-step prioritisation activity at workshops with 51 GRTs and 25 Service Providers to agree a prioritised list of potentially feasible and acceptable interventions for each community; (3) crosscommunity synthesis to produce a final list of interventions. The theoretical framework underpinning the study was the Social Ecological Model.Results: Five priority interventions were agreed across communities and Service Providers to improve the uptake of immunisation amongst GRTs who are housed or settled on an authorised site. These interventions are all at the Institutional (e.g. cultural competence training) and Policy (e.g. protected funding) levels of the Social Ecological Model.Conclusions: The “upstream” nature of the five interventions reinforces the key role of GP practices, frontline workers and wider NHS systems on improving immunisation uptake. All five interventions have potentially broader applicability than GRTs. We believe that their impact would be enhanced if delivered as a combined package. The robust intervention development and co production methods described could usefully be applied to other communities where poor uptake of immunisation is a concern

Integrating electronic health records from different sources across the UK: lessons from a record linkage study

Background Harmonisation of different data sources from various electronic health records (EHRs) across systems enhances the potential scope and granularity of data available to health data research. Objective To describe data harmonisation of routine electronic healthcare records in Wales and Scotland linked to a UK longitudinal birth cohort, the Millennium Cohort Study (MCS). Methods Comparable secondary care data was linked, with parental consent, to MCS information for 1838 and 1431 children participating in MCS and residing in Wales and Scotland, by assigning, respectively, unique Anonymised Linkage Fields to personbased records in the privacy protecting Secure Anonymised Information Linkage (SAIL) databank at Swansea University, and by the National Health Service (NHS) Information Standards Division. Survey and non-response weights were created to account for the clustered sample, sample attrition and consent to linkage. Heterogeneous variables from the Patient Episode Dataset for Wales, Emergency Department Data Set for Wales, Scottish Medical Record 01 and Accident and Emergency dataset for Scotland were harmonised enabling data to be pooled and standardised for research. Findings Overall linkage to harmonised health care data was achieved for 98.9% (99.9% for Wales and 97.6% for Scotland) of consented MCS participants. 66% of children experienced at least one hospital admission (total 5747 hospital admissions) up to their 14th birthday, while 60% attended A&E departments at least once (total 5221 attendances) between their 9th and 14th birthday. We managed date granularity by generating random dates of birth, standardising periods of data collection, identifying inconsistencies and then mapping and bridging differences in definitions of periods of care across countries and datasets. Conclusions Combining and harmonising data from multiple sources and linking them to information from a longitudinal cohort create useful resources for population health research. These methods are reproducible and can be utilised by other researchers and projects

Measuring the timeliness of childhood vaccinations: Using cohort data and routine health records to evaluate quality of immunisation services

Background: To achieve full benefits of vaccination programmes, high uptake and timely receipt of vaccinations are required. Objectives: To examine uptake and timeliness of infant and pre-school booster vaccines using cohort study data linked to health records. Methods: We included 1782 children, born between 2000 and 2001, participating in the Millennium Cohort Study and resident in Wales, whose parents gave consent for linkage to National Community Child Health Database records at the age seven year contact. We examined age at receipt, timeliness of vaccination (early, on-time, delayed, or never), and intervals between vaccine doses, based on the recommended schedule for children at that time, of the following vaccines: primary (diphtheria, tetanus, pertussis (DTP), polio, Meningococcal C (Men C), Haemophilus influenzae type b (Hib)); first dose of measles, mumps and rubella (MMR); and pre-school childhood vaccinations (DTP, polio, MMR). We compared parental report with child health recorded MMR vaccination status at age three years. Results: While 94% of children received the first dose of primary vaccines early or on time, this was lower for subsequent doses (82%, 65% and 88% for second and third doses and pre-school booster respectively). Median intervals between doses exceeded the recommended schedule for all but the first dose with marked variation between children. There was high concordance (97%) between parental reported and child health recorded MMR status. Conclusions: Routine immunisation records provide useful information on timely receipt of vaccines and can be used to assess the quality of childhood vaccination programmes. Parental report of MMR vaccine status is reliable