Elevated Gestational IL-13 During Fetal Development Is Associated With Hyperactivity and Inattention in Eight-Year-Old Children

Maternal immune activation (MIA) during fetal development leads to behavioral and psychological disorders in the offspring. Concomitantly, insufficient supply of polyunsaturated fatty acids (PUFAs) is suspected to contribute to early neuronal maldevelopment due to the immune modulatory capabilities of PUFAs. However, human data are missing considering both of these aspects and their impact on children's behavioral outcomes. In line, this study aimed to elucidate the influence of gestational cytokines and PUFA-containing lipids during late pregnancy on behavioral sequelae in childhood, particularly focusing on an immune activation shaped by a history of maternal atopic diseases instead of a pathogen-mediated immune response. Based on the prospective mother-child cohort LINA we assessed the unstimulated blood cytokine profiles and concentrations of PUFA-containing lipids of 293 mothers at the 34th week of pregnancy. Maternal history of atopic diseases was obtained from questionnaires and behavior in eight-year-old children was assessed by the standardized Strength and Difficulties Questionnaires (SDQ) generating scores for hyperactivity/inattention, emotional symptoms, conduct problems, and peer relationship problems. Elevated IL-13 increased the risk for the child to show behavioral difficulties, in particular, hyperactive/inattentive behavior [adj. OR (95% CI): 2.47 (1.51-4.02), n = 255 vs. 38] at the age of eight years. Although the presence of maternal atopic dermatitis (AD) was associated with increased gestational IL-13 concentrations [adj. MR (95% CI): 1.17 (1.04-1.32)], no effect on children's behavioral difficulties was observed. However, a decrease in the PUFA containing lipid species PC aa C38:6 was not only associated with an increased gestational IL-13 concentration but also mediated the indirect effect of low PC aa C38:6 concentrations on children's abnormal behavior independent of maternal AD. We additionally assessed whether maternal IL-13 and PC aa C38:6 concentrations translate their effect by altering children's cord blood PC aa C38:6 and IL-13. While also the children's cord blood IL-13 was related to children's behavior, no effect of children's PC aa C38:6 was observed. This is the first study demonstrating that elevated gestational IL-13 increases the risk for children to develop behavioral difficulties. Analyses suggest that a reduced supply of gestational PC aa C38:6 contributes to elevated gestational IL-13 leading to behavioral sequelae in the offspring

The Opacity of Galactic Disks at z~0.7

We compare the surface brightness-inclination relation for a sample of COSMOS pure disk galaxies at z~0.7 with an artificially redshifted sample of SDSS disks well matched to the COSMOS sample in terms of rest-frame photometry and morphology, as well as their selection and analysis. The offset between the average surface brightness of face-on and edge-on disks in the redshifted SDSS sample matches that predicted by measurements of the optical depth of galactic disks in the nearby universe. In contrast, large disks at z~0.7 have a virtually flat surface brightness-inclination relation, suggesting that they are more opaque than their local counterparts. This could be explained by either an increased amount of optically thick material in disks at higher redshift, or a different spatial distribution of the dust.Comment: 7 pages, 3 figures. Accepted for publication in ApJL

Mergers in Double-Peaked [O III] Active Galactic Nuclei

As a natural consequence of galaxy mergers, binary active galactic nuclei (AGNs) should be commonplace. Nevertheless, observational confirmations are rare, especially for binaries with separations less than ten kpc. Such a system may show two sets of narrow emission lines in a single spectrum owing to the orbital motion of the binary. We have obtained high-resolution near-infrared images of 50 double-peaked [O III] 5007 AGNs with the Keck II laser guide star adaptive optics system. The Sloan Digital Sky Survey sample is compiled from the literature and consists of 17 type-1 AGNs between 0.18 < z < 0.56 and 33 type-2 AGNs between 0.03 < z < 0.24. The new images reveal eight type-1 and eight type-2 sources that are apparently undergoing mergers. These are strong candidates of kpc-scale binary AGNs, because they show multiple components separated between 0.6 and 12 kpc and often disturbed morphologies. Because most of the type-1s are at higher redshifts than the type-2s, the higher merger fraction of type-1s (47+/-20%) compared to that of type-2s (24+/-10%) can be attributed to the general evolution of galaxy merger fraction with redshift. Furthermore, we show that AGN mergers are outliers of the M_BH-sigma relation because of over-estimated stellar velocity dispersions, illustrating the importance of removing mergers from the samples defining the M_BH-sigma relations. Finally, we find that the emission-line properties are indistinguishable for spatially resolved and unresolved sources, emphasizing that scenarios involving a single AGN can produce the same double-peaked line profiles and they account for at least 70% of the double-peaked [O III] AGNs.Comment: ApJ accepted with major revisions, main results unchanged. 7 pages, 5 figures, 1 table, emulateapj styl

A group-galaxy cross-correlation function analysis in zCOSMOS

We present a group-galaxy cross-correlation analysis using a group catalog produced from the 16,500 spectra from the optical zCOSMOS galaxy survey. Our aim is to perform a consistency test in the redshift range 0.2 < z < 0.8 between the clustering strength of the groups and mass estimates that are based on the richness of the groups. We measure the linear bias of the groups by means of a group-galaxy cross-correlation analysis and convert it into mass using the bias-mass relation for a given cosmology, checking the systematic errors using realistic group and galaxy mock catalogs. The measured bias for the zCOSMOS groups increases with group richness as expected by the theory of cosmic structure formation and yields masses that are reasonably consistent with the masses estimated from the richness directly, considering the scatter that is obtained from the 24 mock catalogs. An exception are the richest groups at high redshift (estimated to be more massive than 10^13.5 M_sun), for which the measured bias is significantly larger than for any of the 24 mock catalogs (corresponding to a 3-sigma effect), which is attributed to the extremely large structure that is present in the COSMOS field at z ~ 0.7. Our results are in general agreement with previous studies that reported unusually strong clustering in the COSMOS field.Comment: 13 pages, 9 figures, published in Ap

The X-Ray Zurich Environmental Study (X-ZENS). I. Chandra and XMM-Newton observations of active galactic nuclei in galaxies in nearby groups

We describe X-ray observations with Chandra and XMM-Newton of 18 galaxy groups (M_group ~ 1-6x10^13 Msolar, z~0.05) from the Zurich Environmental Study (ZENS). We aim to establish the frequency and properties, unaffected by host galaxy dilution and obscuration, of AGNs in central and satellite galaxy members, also as a function of halo-centric distance. X-ray point-source detections are reported for 22 of 177 observed galaxies, down to a limit of f_(0.5-8 keV) ~ 5x10^-15 erg cm^-2 s^-1, corresponding to a limiting luminosity of L_(0.5-8 keV)~3x10^40 erg s^-1. With the majority of the X-ray sources attributed to AGNs of low-to-moderate levels (L/L_Edd>~10^-4), we discuss the detection rate in the context of the occupation of AGNs to halos of this mass scale and redshift, and compare the structural/morphological properties between AGN-active and non-active galaxies of different rank and location within the group halos. We see a slight tendency for AGN hosts to have either relatively brighter/denser disks (or relatively fainter/diffuse bulges) than non-active galaxies of similar mass. At galaxy mass scales <10^11 Msolar, central galaxies appear to be a factor ~4 more likely to host AGNs than satellite galaxies of similar mass. This effect, coupled with the tendency for AGNs to reside in massive galaxies, explains the (weak) trend for AGNs to be preferentially found in the inner regions of groups, with no detectable trend with halo-centric distance in the frequency of AGNs within the satellite population. Finally, our data support other analyses in finding that the rate of decline with redshift of AGN activity in groups matches that of the global AGN population, indicating that either AGNs occur preferentially in groups, or that the evolution rate is independent of halo mass. These trends are of potential importance, and require X-ray coverage of a larger sample to be solidly confirmed.Comment: 18 pages, 13 figures, submitted to The Astrophysical Journal, this is a revised version that addresses the referee's comment

Mergers of luminous early-type galaxies in the local universe and gravitational wave background

Supermassive black hole (SMBH) coalescence in galaxy mergers is believed to be one of the primary sources of very low frequency gravitational waves (GWs). Significant contribution of the GWs comes from mergers of massive galaxies with redshifts z<2. Very few previous studies gave the merger rate of massive galaxies. % We selected a large sample (1209) of close pairs of galaxies with projected separations 7<r_p<50 kpc from 87,889 luminous early-type galaxies (M_r<-21.5) from the Sloan Digital Sky Survey Data Release 6. These pairs constitute a complete volume-limited sample in the local universe (z<0.12). Using our newly developed technique, 249 mergers have been identified by searching for interaction features. From them, we found that the merger fraction of luminous early-type galaxies is 0.8%, and the merger rate in the local universe is % R_g=(1.0+/-0.4)*10^{-5} Mpc^{-3} Gyr^{-1}} % with an uncertainty mainly depending on the merging timescale. % We estimated the masses of SMBHs in the centers of merging galaxies based on their luminosities. We found that the chirp mass distribution of the SMBH binaries follows a power law with an index of -3.0+/-0.5 in the range 5*10^8--5*10^{9} M_{\odot}. % Using the SMBH population in the mergers and assuming that the SMBHs can be efficiently driven into the GW regime, we investigated the stochastic GW background in the frequency range 10^{-9}--10^{-7} Hz. We obtained the spectrum of the GW background of h_c(f)=10^{-15}(f/yr^{-1})^{-2/3}, which is one magnitude higher than that obtained by Jaffe & Backer in 2003, but consistent with those calculated from galaxy-formation models.Comment: 27 pages, 9 figures, Corrected typos and reference

Extreme emission-line galaxies out to z∼\sim1 in zCOSMOS. I. Sample and characterization of global properties

We present a thorough characterization of a large sample of 183 extreme emission-line galaxies (EELGs) at redshift 0.11 < z < 0.93 selected from the 20k zCOSMOS Bright Survey because of their unusually large emission line equivalent widths. We use multiwavelength COSMOS photometry, HST-ACS I-band imaging and optical zCOSMOS spectroscopy to derive the main global properties of EELGs, such as sizes, masses, SFRs, reliable metallicities from both "direct" and "strong-line" methods. The EELGs are compact (R_50 ~ 1.3 kpc), low-mass (log(M*/Msol)~7-10) galaxies forming stars at unusually high specific SFR (log(sSFR/yr) up to ~ -7) compared to main sequence SFGs of the same stellar mass and redshift. At UV wavelengths, the EELGs are luminous and show high surface brightness and include strong Ly$\alpha$ emitters, as revealed by GALEX spectroscopy. We show that zCOSMOS EELGs are high-ionization, low-metallicity systems, with median 12+log(O/H)=8.16, including a handful of extremely metal-deficient galaxies (<10% solar). While ~80% of the EELGs show non-axisymmetric morphologies, including clumpy and tadpole galaxies, we find that ~29% of them show additional low surface-brightness features, which strongly suggest recent or ongoing interactions. As star-forming dwarfs in the local Universe, EELGs are most often found in relative isolation. While only very few EELGs belong to compact groups, almost one third of them are found in spectroscopically confirmed loose pairs or triplets. We conclude that EELGs are galaxies caught in a transient and probably early period of their evolution, where they are efficiently building-up a significant fraction of their present-day stellar mass in an ongoing galaxy-wide starburst. Therefore, the EELGs constitute an ideal benchmark for comparison studies between low- and high-redshift low-mass star-forming galaxies.Comment: Accepted in A&A. Final replacement to match the version in press. It includes a minor change in the title and a new figur

The Evolution of the Number Density of Large Disk Galaxies in COSMOS

We study a sample of approximately 16,500 galaxies with I_(ACS,AB) ≤ 22.5 in the central 38% of the COSMOS field, which are extracted from a catalog constructed from the Cycle 12 ACS F814W COSMOS data set. Structural information on the galaxies is derived by fitting single Sérsic models to their two-dimensional surface brightness distributions. In this paper we focus on the disk galaxy population (as classified by the Zurich Estimator of Structural Types), and investigate the evolution of the number density of disk galaxies larger than approximately 5 kpc between redshift z ~ 1 and the present epoch. Specifically, we use the measurements of the half-light radii derived from the Sérsic fits to construct, as a function of redshift, the size function Φ(r_(1/2), z) of both the total disk galaxy population and of disk galaxies split in four bins of bulge-to-disk ratio. In each redshift bin, the size function specifies the number of galaxies per unit comoving volume and per unit half-light radius r_(1/2). Furthermore, we use a selected sample of roughly 1800 SDSS galaxies to calibrate our results with respect to the local universe. We find the following: (1) The number density of disk galaxies with intermediate sizes (r_(1/2) ~ 5-7 kpc) remains nearly constant from z ~ 1 to today. Unless the growth and destruction of such systems exactly balanced in the last eight billion years, they must have neither grown nor been destroyed over this period. (2) The number density of the largest disks (r_(1/2) > 7 kpc) decreases by a factor of about 2 out to z ~ 1. (3) There is a constancy—or even slight increase—in the number density of large bulgeless disks out to z ~ 1; the deficit of large disks at early epochs seems to arise from a smaller number of bulged disks. Our results indicate that the bulk of the large disk galaxy population has completed its growth by z ~ 1 and support the theory that secular evolution processes produce—or at least add stellar mass to—the bulge components of disk galaxies

The zCOSMOS 20k Group Catalog

We present an optical group catalog between 0.1 < z < 1 based on 16,500 high-quality spectroscopic redshifts in the completed zCOSMOS-bright survey. The catalog published herein contains 1498 groups in total and 192 groups with more than five observed members. The catalog includes both group properties and the identification of the member galaxies. Based on mock catalogs, the completeness and purity of groups with three and more members should be both about 83% with respect to all groups that should have been detectable within the survey, and more than 75% of the groups should exhibit a one-to-one correspondence to the "real" groups. Particularly at high redshift, there are apparently more galaxies in groups in the COSMOS field than expected from mock catalogs. We detect clear evidence for the growth of cosmic structure over the last seven billion years in the sense that the fraction of galaxies that are found in groups (in volume-limited samples) increases significantly with cosmic time. In the second part of the paper, we develop a method for associating galaxies that only have photo-z to our spectroscopically identified groups. We show that this leads to improved definition of group centers, improved identification of the most massive galaxies in the groups, and improved identification of central and satellite galaxies, where we define the former to be galaxies at the minimum of the gravitational potential wells. Subsamples of centrals and satellites in the groups can be defined with purities up to 80%, while a straight binary classification of all group and non-group galaxies into centrals and satellites achieves purities of 85% and 75%, respectively, for the spectroscopic sample.Comment: 26 pages, 21 figures, published in ApJ (along with machine-readable tables