Premier John Jay: The Most Important Man in America

When John Jay returned from France in 1784, the Confederation Congress asked him to become Secretary for Foreign Affairs. After negotiating favorable terms for the department of foreign affairs and getting Congress to move the seat of government to New York City, Jay accepted the position. For the next five years Jay served as the de facto prime minister of the United States. His 500 reports to Congress on all diplomatic matters and many domestic concerns provided much needed guidance for Congress. He, in fact, was the glue that held the loose alliance of states together during the difficult postwar depression years. Many of his policies were adopted by his successor, Thomas Jefferson, who served as America's first secretary of state in the Washington administration

Massachusetts Historical Society, “The Adams Family Papers: An Electronic Archive”- Review of \u3ci\u3eMy Dearest Friend: Letters of Abigail and John Adams. Edited by Margaret A. Hogan and C. James Taylor\u3c/i\u3e

My Dearest Friend contains 289 letters “selected from the entire corpus” of the Adams letters from 1762 to 1801 and “is meant to show both the consistency of their relationship and the evolution of the family through the entire founding era.” A three-page epilogue on the death of Abigail consists of a short headnote and two letters exchanged between John and John Quincy Adams. All but three of the letters in My Dearest Friend are in the Adams Family manuscript collection given by the Adams family to the Massachusetts Historical Society (MHS) in 1956. The letters were all microfilmed on 608 reels by the MHS in the 1950s and sold to research libraries throughout the world. The Abigail and John letters appear on the MHS Web site (www.masshist.org) at “The Adams Family Papers: An Electronic Archive.” (See below.) Abigail and John’s letters also appear among the volumes of The Adams Family Correspondence published by The Bel - knap Press of Harvard University Press. Nine volumes have been published to date, covering the years through 1793. All of the published Adams volumes appear on the MHS Web site and are also digitally available on Rotunda, University of Virginia Press

V838 Monocerotis: the central star and its environment a decade after outburst

Aims. V838 Monocerotis erupted in 2002, brightened in a series of outbursts, and eventually developed a spectacular light echo. A very red star emerged a few months after the outburst. The whole event has been interpreted as the result of a merger. Methods. We obtained near-IR and mid-IR interferometric observations of V838 Mon with the AMBER and MIDI recombiners located at the Very Large Telescope Interferometer (VLTI) array. The MIDI two-beam observations were obtained with the 8m Unit Telescopes between October 2011 and February 2012. The AMBER three-beam observations were obtained with the compact array (B$\leq$m) in April 2013 and the long array (B$\leq$140m) in May 2014, using the 1.8m Auxiliary Telescopes. Results. A significant new result is the detection of a compact structure around V838 Mon, as seen from MIDI data. The extension of the structure increases from a FWHM of 25 mas at 8 {\mu}m to 70 mas at 13 {\mu}m. At the adopted distance of D = 6.1 $\pm$ 0.6 kpc, the dust is distributed from about 150 to 400 AU around V838 Mon. The MIDI visibilities reveal a flattened structure whose aspect ratio increases with wavelength. The major axis is roughly oriented around a position angle of -10 degrees, which aligns with previous polarimetric studies reported in the literature. This flattening can be interpreted as a relic of the 2002 eruption or by the influence of the currently embedded B3V companion. The AMBER data provide a new diameter for the pseudo-photosphere, which shows that its diameter has decreased by about 40% in 10yrs, reaching a radius R$_*$ = 750 $\pm$ 200 R$_{\odot}$ (3.5 $\pm$ 1.0 AU). Conclusions. After the 2002 eruption, interpreted as the merging of two stars, it seems that the resulting source is relaxing to a normal state. The nearby environment exhibits an equatorial over-density of dust up to several hundreds of AU.Comment: Astronomy and Astrophysics (2014) Will be set by the publishe

Performance and durability of broadband antireflection coatings for thin film CdTe solar cells

Light reflection from the glass surface of a photovoltaic (PV) module is a significant source of energy loss for all types of PV devices. The reflection at the glass and air interface accounts for 4% of the total energy. Single layer antireflection coatings with sufficiently low refractive index have been used, such as those using magnesium fluoride or porous silica, but these are only effective over a narrow range of wavelengths. In this paper, the authors report on the design, deposition, and testing of multilayer broadband antireflection coatings. These coatings reduce the weighted average reflection over the wavelength range used by thin film CdTe devices to just 1.22%, resulting in a 3.6% relative increase in device efficiency. The authors have used multilayer stacks consisting of silica and zirconia layers deposited using reactive magnetron sputtering. Details of the stack design, sputter deposition process parameters, and the optical and microstructural properties of the layers are provided. Antireflection coatings on glass exposed to the outdoors must not degrade over the lifetime of the module. A comprehensive set of accelerated environmental durability tests has been carried out in accordance with IEC 61646 PV qualification tests. The durability tests confirmed no damage to the coatings or performance drop as a result of thermal cycling or damp heat. All attempts to perform pull tests resulted in either adhesive or substrate failure, with no damage to the coating itself. The coatings also passed acid attack tests. Scratch resistance, abrasion resistance, and adhesion tests have also been conducted. The optical performance of the coatings was monitored during these tests, and the coatings were visually inspected for any sign of mechanical failure. These tests provide confidence that broadband antireflection coatings are highly durable and will maintain their performance over the lifetime of the solar module. All dielectric metal-oxide multilayer coatings have better optical performance and superior durability compared with alternative single layer porous sol–gel coatings. Thin film CdTe devices are particularly problematic because the antireflection coating is applied to one side of the glass, while device layers are deposited directly on to the opposite glass surface in the superstrate configuration. In thin film CdTe production, the glass is exposed to high temperature processes during the absorber deposition and the cadmium chloride activation treatment. If glass precoated with a broadband antireflection coating is to be used, then the coating must withstand temperatures of up to 550 C. Surprisingly, our studies have shown that multilayer silica/zirconia antireflection coatings on soda lime glass remain unaffected by temperatures reaching 600 C, at which point mild crazing is observed. This is an important observation, demonstrating that low cost glass, which is preprocessed with a broadband antireflection coating, is directly useable in thin film CdTe module production

Single-Band Model for Diluted Magnetic Semiconductors: Dynamical and Transport Properties and Relevance of Clustered States

Dynamical and transport properties of a simple single-band spin-fermion lattice model for (III,Mn)V diluted magnetic semiconductors (DMS) is here discussed using Monte Carlo simulations. This effort is a continuation of previous work (G. Alvarez, Phys. Rev. Lett. 89, 277202 (2002)) where the static properties of the model were studied. The present results support the view that the relevant regime of J/t (standard notation) is that of intermediate coupling, where carriers are only partially trapped near Mn spins, and locally ordered regions (clusters) are present above the Curie temperature T_C. This conclusion is based on the calculation of the resistivity vs. temperature, that shows a soft metal to insulator transition near T_C, as well on the analysis of the density-of-states and optical conductivity. In addition, in the clustered regime a large magnetoresistance is observed in simulations. Formal analogies between DMS and manganites are also discussed.Comment: Revtex4, 20 figures. References updated, minor changes to figures and tex

ACR guidance document on MR safe practices: 2013

Because there are many potential risks in the MR environment and reports of adverse incidents involving patients, equipment and personnel, the need for a guidance document on MR safe practices emerged. Initially published in 2002, the ACR MR Safe Practices Guidelines established de facto industry standards for safe and responsible practices in clinical and research MR environments. As the MR industry changes the document is reviewed, modified and updated. The most recent version will reflect these changes. J. Magn. Reson. Imaging 2013;37:501–530. © 2013 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/96674/1/24011_ftp.pd

Opportunities for improving animal welfare in rodent models of epilepsy and seizures

Animal models of epilepsy and seizures, mostly involving mice and rats, are used to understand the pathophysiology of the different forms of epilepsy and their comorbidities, to identify biomarkers, and to discover new antiepileptic drugs and treatments for comorbidities. Such models represent an important area for application of the 3Rs (replacement, reduction and refinement of animal use). This report provides background information and recommendations aimed at minimising pain, suffering and distress in rodent models of epilepsy and seizures in order to improve animal welfare and optimise the quality of studies in this area. The report includes practical guidance on principles of choosing a model, induction procedures, in vivo recordings, perioperative care, welfare assessment, humane endpoints, social housing, environmental enrichment, reporting of studies and data sharing. In addition, some model-specific welfare considerations are discussed, and data gaps and areas for further research are identified. The guidance is based upon a systematic review of the scientific literature, survey of the international epilepsy research community, consultation with veterinarians and animal care and welfare officers, and the expert opinion and practical experience of the members of a Working Group convened by the United Kingdom's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs)

Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation

Although type-2-induced (T2-induced) epithelial dysfunction is likely to profoundly alter epithelial differentiation and repair in asthma, the mechanisms for these effects are poorly understood. A role for specific mucins, heavily N-glycosylated epithelial glycoproteins, in orchestrating epithelial cell fate in response to T2 stimuli has not previously been investigated. Levels of a sialylated MUC4 beta isoform were found to be increased in airway specimens from asthmatic patients in association with T2 inflammation. We hypothesized that IL-13 would increase sialylation of MUC4 beta, thereby altering its function and that the beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) would regulate the sialylation. Using human biologic specimens and cultured primary human airway epithelial cells (HAECs), we demonstrated that IL-13 increases ST6GAL1-mediated sialylation of MUC4 beta and that both were increased in asthma, particularly in sputum supernatant and/or fresh isolated HAECs with elevated T2 biomarkers. ST6GAL1-induced sialylation of MUC4 beta altered its lectin binding and secretion. Both ST6GAL1 and MUC4 beta inhibited epithelial cell proliferation while promoting goblet cell differentiation. These in vivo and in vitro data provide strong evidence for a critical role for ST6GAL1-induced sialylation of MUC4 beta in epithelial dysfunction associated with T2-high asthma, thereby identifying specific sialylation pathways as potential targets in asthma.NIH [R01 HL069174]; National Heart, Lung, and Blood Institute [R01 HL064937, R01 HL069116, P01 HL103453, R01 HL69167, U01 HL109086, U10 HL109152, R21 AI122071]; National Institute of Allergy and Infectious Diseases [P01 AI106684]; Nikon A1 [NIH 1S10OD019973-01]This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterised by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide association studies have reported signals of association implicating multiple pathways including host defence, telomere maintenance, signalling and cell-cell adhesion. Objectives: To improve our understanding of factors that increase IPF susceptibility by identifying previously unreported genetic associations. Methods and measurements: We conducted genome-wide analyses across three independent studies and meta-analysed these results to generate the largest genome-wide association study of IPF to date (2,668 IPF cases and 8,591 controls). We performed replication in two independent studies (1,456 IPF cases and 11,874 controls) and functional analyses (including statistical fine-mapping, investigations into gene expression and testing for enrichment of IPF susceptibility signals in regulatory regions) to determine putatively causal genes. Polygenic risk scores were used to assess the collective effect of variants not reported as associated with IPF. Main results: We identified and replicated three new genome-wide significant (P<5×10−8) signals of association with IPF susceptibility (associated with altered gene expression of KIF15, MAD1L1 and DEPTOR) and confirmed associations at 11 previously reported loci. Polygenic risk score analyses showed that the combined effect of many thousands of as-yet unreported IPF susceptibility variants contribute to IPF susceptibility. Conclusions: The observation that decreased DEPTOR expression associates with increased susceptibility to IPF, supports recent studies demonstrating the importance of mTOR signalling in lung fibrosis. New signals of association implicating KIF15 and MAD1L1 suggest a possible role of mitotic spindle-assembly genes in IPF susceptibility