331 research outputs found
New variable stars in the Galactic Bulge: I. The bright regime
We report the detection of 1143 variable stars towards the Galactic bulge,
including 320 previously uncatalogued variables, using time-series photometry
extracted from data obtained with the VIMOS imager at the Very Large Telescope.
Observations of the Sagittarius Window Eclipsing Extrasolar Planet Search
(SWEEPS) field in the Galactic Bulge were taken over 2 years between March and
October at a cadence of 4 days, enabling the detection of variables with
periods up to 100 days. Many of these were already known, but we detected
a significant number of new variables, including 26 Cepheids, a further 18
Cepheid candidates, and many contact binaries. Here we publish the catalog of
the new variables, containing coordinates, mean magnitudes as well as periods
and classification; full light curves for these variables are also made
available electronically.Comment: 14 pages, 9 figures; submitted to MNRA
Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers
Introduction: We examined if a combination of proliferation markers and estrogen receptor (ER) activity could predict early versus late relapses in ER-positive breast cancer and inform the choice and length of adjuvant endocrine therapy.
Methods: Baseline affymetrix gene-expression profiles from ER-positive patients who received no systemic therapy (n = 559), adjuvant tamoxifen for 5 years (cohort-1: n = 683, cohort-2: n = 282) and from 58 patients treated with neoadjuvant letrozole for 3 months (gene-expression available at baseline, 14 and 90 days) were analyzed. A proliferation score based on the expression of mitotic kinases (MKS) and an ER-related score (ERS) adopted from Oncotype DX® were calculated. The same analysis was performed using the Genomic Grade Index as proliferation marker and the luminal gene score from the PAM50 classifier as measure of estrogen-related genes. Median values were used to define low and high marker groups and four combinations were created. Relapses were grouped into time cohorts of 0-2.5, 0-5, 5-10 years.
Results: In the overall 10 years period, the proportional hazards assumption was violated for several biomarker groups indicating time-dependent effects. In tamoxifen-treated patients Low-MKS/Low-ERS cancers had continuously increasing risk of relapse that was higher after 5 years than Low-MKS/High-ERS cancers [0 to 10 year, HR 3.36; p = 0.013]. High-MKS/High-ERS cancers had low risk of early relapse [0-2.5 years HR 0.13; p = 0.0006], but high risk of late relapse which was higher than in the High-MKS/Low-ERS group [after 5 years HR 3.86; p = 0.007]. The High-MKS/Low-ERS subset had most of the early relapses [0 to 2.5 years, HR 6.53; p < 0.0001] especially in node negative tumors and showed minimal response to neoadjuvant letrozole. These findings were qualitatively confirmed in a smaller independent cohort of tamoxifen-treated patients. Using different biomarkers provided similar results.
Conclusions: Early relapses are highest in highly proliferative/low-ERS cancers, in particular in node negative tumors. Relapses occurring after 5 years of adjuvant tamoxifen are highest among the highly-proliferative/high-ERS tumors although their risk of recurrence is modest in the first 5 years on tamoxifen. These tumors could be the best candidates for extended endocrine therapy
The Transiting System GJ1214: High-Precision Defocused Transit Observations and a Search for Evidence of Transit Timing Variation
Aims: We present 11 high-precision photometric transit observations of the
transiting super-Earth planet GJ1214b. Combining these data with observations
from other authors, we investigate the ephemeris for possible signs of transit
timing variations (TTVs) using a Bayesian approach.
Methods: The observations were obtained using telescope-defocusing
techniques, and achieve a high precision with random errors in the photometry
as low as 1mmag per point. To investigate the possibility of TTVs in the light
curve, we calculate the overall probability of a TTV signal using Bayesian
methods.
Results: The observations are used to determine the photometric parameters
and the physical properties of the GJ1214 system. Our results are in good
agreement with published values. Individual times of mid-transit are measured
with uncertainties as low as 10s, allowing us to reduce the uncertainty in the
orbital period by a factor of two.
Conclusions: A Bayesian analysis reveals that it is highly improbable that
the observed transit times is explained by TTV, when compared with the simpler
alternative of a linear ephemeris.Comment: Submitted to A&
Limb-darkening measurements for a cool red giant in microlensing event OGLE 2004-BLG-482
Aims: We present a detailed analysis of OGLE 2004-BLG-482, a relatively
high-magnification single-lens microlensing event which exhibits clear
extended-source effects. These events are relatively rare, but they potentially
contain unique information on the stellar atmosphere properties of their source
star, as shown in this study. Methods: Our dense photometric coverage of the
overall light curve and a proper microlensing modelling allow us to derive
measurements of the OGLE 2004-BLG-482 source star's linear limb-darkening
coefficients in three bands, including standard Johnson-Cousins I and R, as
well as in a broad clear filter. In particular, we discuss in detail the
problems of multi-band and multi-site modelling on the expected precision of
our results. We also obtained high-resolution UVES spectra as part of a ToO
programme at ESO VLT from which we derive the source star's precise fundamental
parameters. Results: From the high-resolution UVES spectra, we find that OGLE
2004-BLG-482's source star is a red giant of MK type a bit later than M3, with
Teff = 3667 +/- 150 K, log g = 2.1 +/- 1.0 and an assumed solar metallicity.
This is confirmed by an OGLE calibrated colour-magnitude diagram. We then
obtain from a detailed microlensing modelling of the light curve linear
limb-darkening coefficients that we compare to model-atmosphere predictions
available in the literature, and find a very good agreement for the I and R
bands. In addition, we perform a similar analysis using an alternative
description of limb darkening based on a principal component analysis of ATLAS
limb-darkening profiles, and also find a very good agreement between
measurements and model predictions.Comment: Accepted in A&
High-precision photometry by telescope defocussing - VI. WASP-24, WASP-25 and WASP-26
The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013/) under grant agreement nos. 229517 and 268421. This publication was supported by grants NPRP 09-476-1-078 and NPRP X-019-1-006 from Qatar National Research Fund (a member of Qatar Foundation). TCH acknowledges financial support from the Korea Research Council for Fundamental Science and Technology (KRCF) through the Young Research Scientist Fellowship Programme and is supported by the KASI (Korea Astronomy and Space Science Institute) grant 2012-1-410-02/2013-9-400-00. SG, XW and XF acknowledge the support from NSFC under the grant no. 10873031. The research is supported by the ASTERISK project (ASTERoseismic Investigations with SONG and Kepler) funded by the European Research Council (grant agreement no. 267864). DR, YD, AE, FF (ARC), OW (FNRS research fellow) and J Surdej acknowledge support from the Communauté française de Belgique – Actions de recherche concertées – Académie Wallonie-Europe.We present time series photometric observations of 13 transits in the planetary systems WASP-24, WASP-25 and WASP-26. All three systems have orbital obliquity measurements, WASP-24 and WASP-26 have been observed with Spitzer, and WASP-25 was previously comparatively neglected. Our light curves were obtained using the telescope-defocussing method and have scatters of 0.5–1.2 mmag relative to their best-fitting geometric models. We use these data to measure the physical properties and orbital ephemerides of the systems to high precision, finding that our improved measurements are in good agreement with previous studies. High-resolution Lucky Imaging observations of all three targets show no evidence for faint stars close enough to contaminate our photometry. We confirm the eclipsing nature of the star closest to WASP-24 and present the detection of a detached eclipsing binary within 4.25 arcmin of WASP-26.Publisher PDFPeer reviewe
A systematic fitting scheme for caustic-crossing microlensing events
We outline a method for fitting binary-lens caustic-crossing microlensing
events based on the alternative model parameterisation proposed and detailed in
Cassan (2008). As an illustration of our methodology, we present an analysis of
OGLE-2007-BLG-472, a double-peaked Galactic microlensing event with a source
crossing the whole caustic structure in less than three days. In order to
identify all possible models we conduct an extensive search of the parameter
space, followed by a refinement of the parameters with a Markov Chain-Monte
Carlo algorithm. We find a number of low-chi2 regions in the parameter space,
which lead to several distinct competitive best models. We examine the
parameters for each of them, and estimate their physical properties. We find
that our fitting strategy locates several minima that are difficult to find
with other modelling strategies and is therefore a more appropriate method to
fit this type of events.Comment: 12 pages, 11 figure
Relativistic deflection of background starlight measures the mass of a nearby white dwarf star
Based in part on observations made with the NASA/ESA Hubble Space Telescope, obtained at STScI, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. HST data used in this paper are available from the Mikulski Archive for Space Telescopes at STScI (https://archive.stsci.edu/hst/search.php), under proposal ID 13457 and 14448. Support for this program was provided by NASA through a grant from STScI. The Pan-STARRS1 Surveys (PS1) have been made possible through contributions of the Institute for Astronomy, the University of Hawaii, the Pan-STARRS Project Office, the Max-Planck Society and its participating institutes, The Johns Hopkins University, Durham University, the University of Edinburgh, Queen's University Belfast, the Harvard-Smithsonian Center for Astrophysics, the Las Cumbres Observatory Global Telescope Network Incorporated, the National Central University of Taiwan, the Space Telescope Science Institute, NASA Administration under Grant No. NNX08AR22G, the National Science Foundation under Grant No. AST-1238877, the University of Maryland, and Eotvos Lorand University. MD thanks Qatar National Research Fund (QNRF) for support by grant NPRP 09-476-1-078.Gravitational deflection of starlight around the Sun during the 1919 total solar eclipse provided measurements that confirmed Einstein's general theory of relativity. We have used the Hubble Space Telescope to measure the analogous process of astrometric microlensing caused by a nearby star, the white dwarf Stein 2051 B. As Stein 2051 B passed closely in front of a background star, the background star's position was deflected. Measurement of this deflection at multiple epochs allowed us to determine the mass of Stein 2051 B - the sixth-nearest white dwarf to the Sun - as 0.675 ± 0.051 solar masses. This mass determination provides confirmation of the physics of degenerate matter and lends support to white dwarf evolutionary theory.PostprintPeer reviewe
RoboTAP: Target priorities for robotic microlensing observations
Context. The ability to automatically select scientifically-important transient events from an alert stream of many such events, and to conduct follow-up observations in response, will become increasingly important in astronomy. With wide-angle time domain surveys pushing to fainter limiting magnitudes, the capability to follow-up on transient alerts far exceeds our follow-up telescope resources, and effective target prioritization becomes essential. The RoboNet-II microlensing program is a pathfinder project, which has developed an automated target selection process (RoboTAP) for gravitational microlensing events, which are observed in real time using the Las Cumbres Observatory telescope network.
Aims. Follow-up telescopes typically have a much smaller field of view compared to surveys, therefore the most promising microlensing events must be automatically selected at any given time from an annual sample exceeding 2000 events. The main challenge is to select between events with a high planet detection sensitivity, with the aim of detecting many planets and characterizing planetary anomalies.
Methods. Our target selection algorithm is a hybrid system based on estimates of the planet detection zones around a microlens. It follows automatic anomaly alerts and respects the expected survey coverage of specific events.
Results. We introduce the RoboTAP algorithm, whose purpose is to select and prioritize microlensing events with high sensitivity to planetary companions. In this work, we determine the planet sensitivity of the RoboNet follow-up program and provide a working example of how a broker can be designed for a real-life transient science program conducting follow-up observations in response to alerts; we explore the issues that will confront similar programs being developed for the Large Synoptic Survey Telescope (LSST) and other time domain surveys
Multiple-input multiple-output causal strategies for gene selection
Traditional strategies for selecting variables in high dimensional classification problems aim to find sets of maximally relevant variables able to explain the target variations. If these techniques may be effective in generalization accuracy they often do not reveal direct causes. The latter is essentially related to the fact that high correlation (or relevance) does not imply causation. In this study, we show how to efficiently incorporate causal information into gene selection by moving from a single-input single-output to a multiple-input multiple-output setting.Journal ArticleResearch Support, N.I.H. ExtramuralResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe
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