Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of SARS-CoV-2 genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three available genomic nomenclature systems for SARS-CoV-2 to all sequence data from the WHO European Region available during the COVID-19 pandemic until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation. We provide a comparison of the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.Peer reviewe

Effect of Whole Cottonseed, Gossypol, and Ruminally Protected Lysine Supplementation on Milk Yield and Composition

To determine whether the gossypol content of the diet affected availability of dietary Lys, 4 cows with ruminal and duodenal cannulas and 16 intact cows in early lactation were assigned to diets containing either glanded cottonseed, glanded cottonseed plus 15 g/d of ruminally protected Lys, glandless cottonseed, or glandless cottonseed plus 15 g/d of ruminally protected Lys. The experimental design was a 4 × 4 Latin square design with 3-wk experimental periods. Gossypol concentrations in plasma were lower when cows were fed glandless cottonseed. Lysine supplementation increased the flow and percentage of Lys in duodenal digesta and increased the concentration of Lys in plasma. Neither type of cottonseed nor Lys supplementation affected dry matter intake. Yields of milk and fat-corrected milk from cannulated cows were not affected by diet, but yields from intact cows were increased by Lys supplementation. For both cannulated and intact cows, Lys supplementation increased the percentage of milk protein, and milk protein yield was increased by Lys in intact cows. Dietary gossypol did not affect the response to Lys, indicating that dietary gossypol had little or no effect on the availability of Lys for dairy cows

Wakefield Generation in Hydrogen and Lithium Plasmas at FACET-II: Diagnostics and First Beam-Plasma Interaction Results

International audiencePlasma Wakefield Acceleration (PWFA) provides ultrahigh acceleration gradients of 10s of GeV/m, providing a novel path towards efficient, compact, TeV-scale linear colliders and high brightness free electron lasers. Critical to the success of these applications is demonstrating simultaneously high gradient acceleration, high energy transfer efficiency, and preservation of emittance, charge, and energy spread. Experiments at the FACET-II National User Facility at SLAC National Accelerator Laboratory aim to achieve all of these milestones in a single stage plasma wakefield accelerator, providing a 10 GeV energy gain in a <1 m plasma with high energy transfer efficiency. Such a demonstration depends critically on diagnostics able to measure emittance with mm-mrad accuracy, energy spectra to determine both %-level energy spread and broadband energy gain and loss, incoming longitudinal phase space, and matching dynamics. This paper discusses the experimental setup at FACET-II, including the incoming beam parameters from the FACET-II linac, plasma sources, and diagnostics developed to meet this challenge. Initial progress on the generation of beam ionized wakes in meter-scale hydrogen gas is discussed, as well as commissioning of the plasma sources and diagnostics

Psychopathic traits in young children

Callous and unemotional (CU) traits provide researchers and clinicians with an additional dimension when assessing children displaying early-onset conduct problems. Evidence from genetic, brain and cognitive studies to date suggests that antisocial children with psychopathic personality traits are genetically more vulnerable to antisocial behaviour than their antisocial peers. Neuroimaging studies in adults with psychopathy have demonstrated amygdala hyporeactivity to emotional stimuli, while there is some suggestion that adults with antisocial behaviour but no psychopathy may show the opposite pattern. Child neuroimaging data in this area are still thin on the ground; however, behavioural data support the hypothesis that antisocial children with callous-unemotional traits may have some amygdala abnormality. When compared with each other, antisocial children with callous-unemotional traits demonstrate hyposensitivity to others’ distress, while other antisocial children appear hypersensitive to anger directed towards them. New research combining different levels of analyses will no doubt provide further insight about the distinct developmental patterns associated with psychopathy, and help to inform methods of intervention, allowing treatment of antisocial behaviour to be targeted according to whether elevated levels of CU traits are presen