Tuning edge state localization in graphene nanoribbons by in-plane bending

The electronic properties of graphene are influenced by both geometric confinement and strain. We study the electronic structure of in-plane bent graphene nanoribbons, systems where confinement and strain are combined. To understand its electronic properties, we develop a tight-binding model that has a small computational cost and is based on exponentially decaying hopping and overlap parameters. Using this model, we show that the edge states in zigzag graphene nanoribbons are sensitive to bending and develop an effective dispersion that can be described by a one-dimensional atomic chain model. Because the velocity of the electrons at the edge is proportional to the slope of the dispersion, the edge states become gradually delocalized upon increasing the strength of bending.Comment: 11 pages, 8 figure

Branched-chain amino acids have equivalent effects to other essential amino acids on lifespan and ageing-related traits in Drosophila

Branched-chain amino acids (BCAAs) have been suggested to be particularly potent activators of TOR signalling. Moreover, increased circulating BCAAs are associated with higher risk of insulin resistance and diabetes in both mice and humans, and with increased mortality in mice. However, it remains unknown if BCAAs play a more prominent role in longevity than do other essential amino acids (EAAs). To test for a more prominent role of BCAAs in lifespan and related traits in Drosophila, we restricted either BCAAs or a control group of three other EAAs, threonine, histidine and lysine (THK). BCAA restriction induced compensatory feeding, lipid accumulation, stress resistance and amelioration of age-related gut pathology. It also extended lifespan in a dietary-nitrogen-dependent manner. Importantly, the control restriction of THK had similar effects on these phenotypes. Our control diet was designed to have every EAA equally limiting for growth and reproduction, and our findings therefore suggest that the level of the most limiting EAAs in the diet, rather than the specific EAAs that are limiting, determines the response of these phenotypes to EAA restriction

Dissipative dynamics of topological defects in frustrated Heisenberg spin systems

We study the dynamics of topological defects of a frustrated spin system displaying spiral order. As a starting point we consider the SO(3) nonlinear sigma model to describe long-wavelength fluctuations around the noncollinear spiral state. Besides the usual spin-wave magnetic excitations, the model allows for topologically non-trivial static solutions of the equations of motion, associated with the change of chirality (clockwise or counterclockwise) of the spiral. We consider two types of these topological defects, single vortices and vortex-antivortex pairs, and quantize the corresponding solutions by generalizing the semiclassical approach to a non-Abelian field theory. The use of the collective coordinates allows us to represent the defect as a particle coupled to a bath of harmonic oscillators, which can be integrated out employing the Feynman-Vernon path-integral formalism. The resulting effective action for the defect indicates that its motion is damped due to the scattering by the magnons. We derive a general expression for the damping coefficient of the defect, and evaluate its temperature dependence in both cases, for a single vortex and for a vortex-antivortex pair. Finally, we consider an application of the model for cuprates, where a spiral state has been argued to be realized in the spin-glass regime. By assuming that the defect motion contributes to the dissipative dynamics of the charges, we can compare our results with the measured inverse mobility in a wide range of temperature. The relatively good agreement between our calculations and the experiments confirms the possible relevance of an incommensurate spiral order for lightly doped cuprates.Comment: 22 pages, 7 figures, final published versio

Individual variation in avian avoidance behaviours in response to repeated, simulated vehicle approach

Birds exhibit variation in alert and flight behaviours in response to vehicles within and between species, but it is unclear how properties inherent to individuals influence variation in avoidance responses over time. We examined individual variation in avoidance behaviours of Brown-headed Cowbirds (Molothrus ater (Boddaert, 1783)) in response to repeated presentation of a simulated vehicle approach in a video playback scenario. Wemodeled temporal alert and flight behaviours to determine whether overall behavioural variation resulted primarily from variation within individuals (i.e., intraindividual variation) or between individuals (i.e., interindividual variation). We examined reaction norms (individual × treatment day) and whether birds showed plasticity in responses via habituation or sensitization. Repeatability in the response metrics for individuals was low (~0.22 for alert and flight), indicating that model variation was due primarily to within-individual variation rather than between-individual variation. We observed sensitization in alert responses over time, but no sensitization or habituation in flight responses. Our results indicate that individuals learned to anticipate the vehicle approach but did not vary their escape behaviour, suggesting that alert and flight behaviours might be affected differently by cues associated with oncoming objects or experience with them. We consider our findings in light of the ongoing development of strategies to reduce animal–vehicle collisions. Si les oiseaux présentent des variations intraspécifiques et interspécifiques des comportements d’alerte et de fuite en réaction aux véhicules, l’influence des propriétés individuelles sur les variations des réactions d’évitement avec le temps n’est pas bien établie. Nous avons examiné les variations individuelles des comportements d’évitement de vachers à tête brune (Molothrus ater (Boddaert, 1783)) en réponse à la présentation répétée d’une approche de véhicule simulée dans un scénario de reprise vidéo. Nous avons modélisé les comportements d’alerte et de fuite dans le temps afin de déterminer si les variations comportementales globales résultaient principalement de variations intraindividuelles ou interindividuelles. Nous avons examiné les normes de réaction (individu × jour du traitement) et si les réactions des oiseaux présentaient une plasticité sous forme d’accoutumance ou de sensibilisation. La répétabilité des mesures de réaction pour les individus était faible (~0,22 pour l’alerte et la fuite), ce qui indique que les variations modélisées étaient principalement dues à des variations intraindividuelles plutôt qu’interindividuelles. Nous avons noté une sensibilisation dans les réactions d’alerte avec le temps, mais aucune sensibilisation ou accoutumance dans les réactions de fuite. Nos résultats indiquent que les individus ont appris à anticiper l’approche d’un véhicule, mais n’ont pas modifié leur comportement d’échappement, ce qui porte à croire que les comportements d’alerte et de fuite des oiseaux pourraient être influencés différemment par des signaux associés à des objets se dirigeant vers eux ou par leur expérience individuelle de tels signaux. Nous discutons de nos constatations dans le contexte de l’élaboration de stratégies pour réduire les collisions entre animaux et véhicules. [Traduit par la Rédaction

Gaze sensitivity: function and mechanisms from sensory and cognitive perspectives

Sensitivity to the gaze of other individuals has long been a primary focus in sociocognitive research on humans and other animals. Information about where others are looking may often be of adaptive value in social interactions and predator avoidance, but studies across a range of taxa indicate there are substantial differences in the extent to which animals obtain and use information about other individuals' gaze direction. As the literature expands, it is becoming increasingly difficult to make comparisons across taxa as experiments adopt and adjust different methodologies to account for differences between species in their socioecology, sensory systems and possibly also their underlying cognitive mechanisms. Furthermore, as more species are found to exhibit gaze sensitivity, more terminology arises to describe the behaviours. To clarify the field, we propose a restricted nomenclature that defines gaze sensitivity in terms of observable behaviour, independent of the underlying mechanisms. This is particularly useful in nonhuman animal studies where cognitive interpretations are ambiguous. We then describe how socioecological factors may influence whether species will attend to gaze cues, and suggest links between ultimate factors and proximate mechanisms such as cognition and perception. In particular, we argue that variation in sensory systems, such as retinal specializations and the position of the eyes, will determine whether gaze cues (e.g. head movement) are perceivable during visual fixation. We end by making methodological recommendations on how to apply these variations in socioecology and visual systems to advance the field of gaze research

Can experience reduce collisions between birds and vehicles?

Bird collisions with vehicles cause serious safety, financial and conservation concerns worldwide, but the causes of such collisions are poorly described. We investigated how experience with vehicles influenced avian avoidance responses. We trained three groups of vehicle-naiıve rock pigeons Columba livia with 32 near-miss vehicle approaches over 4 weeks at 60 and 120 km h-1, and also included individuals that heard but did not see the approaches (control group). We subsequently measured flight initiation distance (FID) and whether individuals ‘collided’ with a virtual vehicle directly approaching at 120 or 240 km h-1 using video playback. We found that inexperienced individuals (i.e. the control group) had longer FIDs than experienced birds, although only one of 90 individuals across groups successfully avoided virtual collision. Vehicle approach speed during video playback and the interaction of approach speed and training group did not influence FID. Our results suggest that a habituation-like effect based on repeated observations of passing vehicles could contribute to ineffective vehicle avoidance responses by birds when collisions are imminent. Novel strategies should be developed to enhance avoidance responses to high-speed vehicles to minimize bird mortality

Antiferromagnetic Ising spin glass competing with BCS pairing interaction in a transverse field

The competition among spin glass (SG), antiferromagnetism (AF) and local pairing superconductivity (PAIR) is studied in a two-sublattice fermionic Ising spin glass model with a local BCS pairing interaction in the presence of an applied magnetic transverse field $\Gamma$. In the present approach, spins in different sublattices interact with a Gaussian random coupling with an antiferromagnetic mean $J_0$ and standard deviation $J$. The problem is formulated in the path integral formalism in which spin operators are represented by bilinear combinations of Grassmann variables. The saddle-point Grand Canonical potential is obtained within the static approximation and the replica symmetric ansatz. The results are analysed in phase diagrams in which the AF and the SG phases can occur for small $g$ ($g$ is the strength of the local superconductor coupling written in units of $J$), while the PAIR phase appears as unique solution for large $g$. However, there is a complex line transition separating the PAIR phase from the others. It is second order at high temperature that ends in a tricritical point. The quantum fluctuations affect deeply the transition lines and the tricritical point due to the presence of $\Gamma$.Comment: 16 pages, 6 figures, accepted Eur. Phys. J.

Multi-boson effects and the normalization of the two-pion correlation function

The two-pion correlation function can be defined as a ratio of either the measured momentum distributions or the normalized momentum space probabilities. We show that the first alternative avoids certain ambiguities since then the normalization of the two-pion correlator contains important information on the multiplicity distribution of the event ensemble which is lost in the second alternative. We illustrate this explicitly for specific classes of event ensembles.Comment: 6 pages, three figures,submit to PR

Antiproliferative activity and mode of action analysis of novel amino and amido substituted phenantrene and naphtho[2,1-b]thiophene derivatives

Herein we present and describe the design and synthesis of novel phenantrene derivatives substituted with either amino or amido side chains and their biological activity. Antiproliferative activities were assessed in vitro on a panel of human cancer cell lines. Tested compounds showed moderate activity against cancer cells in comparison with 5-fluorouracile. Among all tested compounds, some compounds substituted with cyano groups showed a pronounced and selective activity in the nanomolar range of inhibitory concentrations against HeLa and HepG2. The strongest selective activity against HeLa cells was observed for acrylonitriles 8 and 11 and their cyclic analogues 15 and 17 substituted with two cyano groups with a corresponding IC50 = 0.33, 0.21, 0.65 and 0.45 μM, respectively. Compounds 11 showed the most pronounced selectivity being almost non cytotoxic to normal fibroblasts. Additionally, mode of biological action analysis was performed in silico and in vitro by Western blot analysis of HIF-1-α relative expression for compounds 8 and 11