Dixmier traces on noncompact isospectral deformations

We extend the isospectral deformations of Connes, Landi and Dubois-Violette to the case of Riemannian spin manifolds carrying a proper action of the noncompact abelian group $R^l$. Under deformation by a torus action, a standard formula relates Dixmier traces of measurable operators to integrals of functions on the manifold. We show that this relation persists for actions of $R^l$, under mild restrictions on the geometry of the manifold which guarantee the Dixmier traceability of those operators.Comment: 30 pages, no figures; several minor improvements, to appear in J. Funct. Ana

Extended Candidature And Non-Completion Of A Ph.D. At Makerere University, Uganda

Although student persistence in graduate programs is widely regarded as an important topic in the literature of higher education, many such works focus on the completion of studies. This paper examines the dynamics of attrition resulting in either delayed or non-completion of doctoral studies. Administrative data of 294 Ph.D. students at Makerere University in the 2000 to 2005 enrollment cohorts were analyzed. The total elapsed time from first enrollment to submission of a final dissertation or thesis copy was taken as a measure of completion time. A multinomial logistic was applied for assessing the likelihood of completion and extended candidature, rather than withdrawal, five years after initial enrollment in doctoral studies. In the results, the estimates rates of extended candidature (48.6%) and withdrawal (36.4%) indicate a low timely completion rate of doctoral students at Makerere. The observed associations, modeled by a range of candidate, candidature, and institutional variables, including discipline area, suggest the need for establishing measures to promote progress in doctoral studies at early stages of commencement as well as throughout the course of candidature

Louse- and flea-borne rickettsioses: biological and genomic analyses

In contrast to 15 or more validated and/or proposed tick-borne spotted fever group species, only three named medically important rickettsial species are associated with insects. These insect-borne rickettsiae are comprised of two highly pathogenic species, Rickettsia prowazekii (the agent of epidemic typhus) and R. typhi (the agent of murine typhus), as well as R. felis, a species with unconfirmed pathogenicity. Rickettsial association with obligate hematophagous insects such as the human body louse (R. prowazekii transmitted by Pediculus h. humanus) and several flea species (R. typhi and R. felis, as well as R. prowazekii in sylvatic form) provides rickettsiae the potential for further multiplications, longer transmission cycles and rapid spread among susceptible human populations. Both human body lice and fleas are intermittent feeders capable of multiple blood meals per generation, facilitating the efficient transmission of rickettsiae to several disparate hosts within urban/rural ecosystems. While taking into consideration the existing knowledge of rickettsial biology and genomic attributes, we have analyzed and summarized the interacting features that are unique to both the rickettsiae and their vector fleas and lice. Furthermore, factors that underlie rickettsial changing ecology, where native mammalian populations are involved in the maintenance of rickettsial cycle and transmission, are discussed

Etude De L’efficacité De L’huile De Thevetia Neriifolia Pour Le Contrôle De Anopheles Gambiae S.L Résistant Aux Pyréthrinoïdes

Effective control of pyrethroid-resistant malaria vectors requires new alternative measures. The purpose of this study is to test the effectiveness of Thevetia oil extracted from seed kernels to control malaria transmission by An. gambiae s.l. Sensitivity tests were carried out on larvae of Stages 3 and 4 of An. gambiae s.s of wild-type and pyrethroid-resistant Kis-kdr. The susceptible reference strain "Kisumu" served as a control. Mortality was read 24 hours and 48 hours after exposure. LD50 and 90 for 24 hours and 48 hours were determined using the log-probit method of determining the dose corresponding to a proportion. The high LD50s determined in 24 hours and 48 hours correspond to doses that kill 50% of Stage 3 larvae in wild populations in 24 hours and 48 hours. Low LD50s refer to stage 4 "Kisumu" larvae. The strong DL90 in 24 hours and 48 hours correspond respectively to stage 3 larvae of the Kis-kdr and wild-type strains. The comparison of the LD between the different strains shows the influence of the resistance on the sensitivity of the larvae of the strains resistant to the oil tested. However, the larvicidal effect of Thevetia oil on the larvae of resistant strains may elicit formulations for alternative measures in vector resistance management to pyrethroids

The MUSE Hubble Ultra Deep Field Survey X. Lyα\alpha Equivalent Widths at 2.9<z<6.62.9 < z < 6.6

We present rest-frame Ly$\alpha$ equivalent widths (EW) of 417 Ly$\alpha$ emitters (LAEs) detected with Multi Unit Spectroscopic Explorer (MUSE) on the Very Large Telescope (VLT) at $2.9 < z < 6.6$ in the Hubble Ultra Deep Field. Based on the deep MUSE spectroscopy and ancillary Hubble Space Telescope (HST) photometry data, we carefully measured EW values taking into account extended Ly$\alpha$ emission and UV continuum slopes ($\beta$). Our LAEs reach unprecedented depths, both in Ly$\alpha$ luminosities and UV absolute magnitudes, from log($L_{\rm Ly\alpha}$/erg s$^{-1}$) $\sim$41.0 to 43.0 and from Muv $\sim$ -16 to -21 (0.01-1.0 $L^{*}_{\rm z=3}$). The EW values span the range of $\sim$ 5 to 240 \AA\ or larger, and their distribution can be well fitted by an exponential law $N = N_{\rm 0}$ exp($-$EW/$w_{\rm 0}$). Owing to the high dynamic range in Muv, we find that the scale factor, $w_{\rm 0}$, depends on Muv in the sense that including fainter Muv objects increases $w_{\rm 0}$, i.e., the Ando effect. The results indicate that selection functions affect the EW scale factor. Taking these effects into account, we find that our $w_{\rm 0}$ values are consistent with those in the literature within $1\sigma$ uncertainties at $2.9 < z < 6.6$ at a given threshold of Muv and $L_{\rm Ly\alpha}$. Interestingly, we find 12 objects with EW $>200$ \AA\ above $1\sigma$ uncertainties. Two of these 12 LAEs show signatures of merger or AGN activity: the weak CIV $\lambda 1549$ emission line. For the remaining 10 very large EW LAEs, we find that the EW values can be reproduced by young stellar ages ($< 100$ Myr) and low metallicities ($\lesssim 0.02$ $Z_{\rm \odot}$). Otherwise, at least part of the Ly$\alpha$ emission in these LAEs needs to arise from anisotropic radiative transfer effects, fluorescence by hidden AGN or quasi-stellar object activity, or gravitational cooling.Comment: 22 pages, 12 figures, 9 tables, accepted for publication in A&A (MUSE UDF Series Paper X

Correctly validating results from single molecule data: the case of stretched exponential decay in the catalytic activity of single lipase B molecules

The question of how to validate and interpret correctly the waiting time probability density functions (WT-PDFs) from single molecule data is addressed. It is shown by simulation that when a stretched exponential WT-PDF, with a stretched exponent alfa and a time scale parameter tau, generates the off periods of a two-state trajectory, a reliable recovery of the input WT-PDF from the trajectory is obtained even when the bin size used to define the trajectory, dt, is much larger than the parameter tau. This holds true as long as the first moment of the WT-PDF is much larger than dt. Our results validate the results in an earlier study of the activity of single Lipase B molecules and disprove recent related critique

A coronary heart disease risk model for predicting the effect of potent antiretroviral therapy in HIV-1 infected men

Background Many HIV-infected patients on highly active antiretroviral therapy (HAART) experience metabolic complications including dyslipidaemia and insulin resistance, which may increase their coronary heart disease (CHD) risk. We developed a prognostic model for CHD tailored to the changes in risk factors observed in patients starting HAART. Methods Data from five cohort studies (British Regional Heart Study, Caerphilly and Speedwell Studies, Framingham Offspring Study, Whitehall II) on 13 100 men aged 40-70 and 114 443 years of follow up were used. CHD was defined as myocardial infarction or death from CHD. Model fit was assessed using the Akaike Information Criterion; generalizability across cohorts was examined using internal-external cross-validation. Results A parametric model based on the Gompertz distribution generalized best. Variables included in the model were systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, triglyceride, glucose, diabetes mellitus, body mass index and smoking status. Compared with patients not on HAART, the estimated CHD hazard ratio (HR) for patients on HAART was 1.46 (95% CI 1.15-1.86) for moderate and 2.48 (95% CI 1.76-3.51) for severe metabolic complications. Conclusions The change in the risk of CHD in HIV-infected men starting HAART can be estimated based on typical changes in risk factors, assuming that HRs estimated using data from non-infected men are applicable to HIV-infected men. Based on this model the risk of CHD is likely to increase, but increases may often be modest, and could be offset by lifestyle change

Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma

HOXA genes encode critical transcriptional regulators of embryonic development that have been implicated in cancer. In this study, we documented functional relevance and mechanism of activation of HOXA9 in glioblastoma (GBM), the most common malignant brain tumor. Expression of HOXA genes was investigated using reverse transcription-PCR in primary gliomas and glioblastoma cell lines and was validated in two sets of expression array data. In a subset of GBM, HOXA genes are aberrently activated within confined chromosomal domains. Transcriptional activation of the HOXA cluster was reversible by a phosphoinostide 3-kinase (PI3K) inhibitor through an epigenetic mechanism involving histone H3K27 trimethylation. Functional studies of HOXA9 showed its capacity to decrease apoptosis and increase cellular proliferation along with tumor necrosis factor-related apoptosis-including ligand resistance. Notably, aberrant expression of HOXA9 was independently predictive of shorter overall and progression-free survival in two GBM patient sets and improved survival prediction by MGMT promoter methylation. Thus, HOXA9 activation is a novel, independent, and negative prognostic marker in GBM that is reversible through a PI3K-associated epigenetic mechanism. Our findings suggest a transcriptional pathway through which PI3K activates oncogenic HOXA expression with implications for mTOR or PI3K targeted therapies.NIH grants NIH CA094971 (J.F. Costello) and NIH/NCI F32 CA113039-01 (J.S. Smith); Karen Osney Brownstein Endowed Chair (J.F. Costello); UC Discovery grant Bio05-10501 (J.F. Costello and H.S. Phillips); Portuguese Science and Technology Foundation SFRH/BD/15258/2004 (B.M. Costa); and Luso-American Development Foundation, Portugal 186/06 (B.M. Costa

Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies.

IntroductionQuantitative in vivo measurement of brain amyloid burden is important for both research and clinical purposes. However, the existence of multiple imaging tracers presents challenges to the interpretation of such measurements. This study presents a direct comparison of Pittsburgh compound B-based and florbetapir-based amyloid imaging in the same participants from two independent cohorts using a crossover design.MethodsPittsburgh compound B and florbetapir amyloid PET imaging data from three different cohorts were analyzed using previously established pipelines to obtain global amyloid burden measurements. These measurements were converted to the Centiloid scale to allow fair comparison between the two tracers. The mean and inter-individual variability of the two tracers were compared using multivariate linear models both cross-sectionally and longitudinally.ResultsGlobal amyloid burden measured using the two tracers were strongly correlated in both cohorts. However, higher variability was observed when florbetapir was used as the imaging tracer. The variability may be partially caused by white matter signal as partial volume correction reduces the variability and improves the correlations between the two tracers. Amyloid burden measured using both tracers was found to be in association with clinical and psychometric measurements. Longitudinal comparison of the two tracers was also performed in similar but separate cohorts whose baseline amyloid load was considered elevated (i.e., amyloid positive). No significant difference was detected in the average annualized rate of change measurements made with these two tracers.DiscussionAlthough the amyloid burden measurements were quite similar using these two tracers as expected, difference was observable even after conversion into the Centiloid scale. Further investigation is warranted to identify optimal strategies to harmonize amyloid imaging data acquired using different tracers

Addressing social issues in a universal HIV test and treat intervention trial (ANRS 12249 TasP) in South Africa: methods for appraisal

Background: The Universal HIV Test and Treat (UTT) strategy represents a challenge for science, but is also a challenge for individuals and societies. Are repeated offers of provider-initiated HIV testing and immediate antiretroviral therapy (ART) socially-acceptable and can these become normalized over time? Can UTT be implemented without potentially adding to individual and community stigma, or threatening individual rights? What are the social, cultural and economic implications of UTT for households and communities? And can UTT be implemented within capacity constraints and other threats to the overall provision of HIV services? The answers to these research questions will be critical for routine implementation of UTT strategies. Methods/design: A social science research programme is nested within the ANRS 12249 Treatment-as-Prevention (TasP) cluster-randomised trial in rural South Africa. The programme aims to inform understanding of the (i) social, economic and environmental factors affecting uptake of services at each step of the continuum of HIV prevention, treatment and care and (ii) the causal impacts of the TasP intervention package on social and economic factors at the individual, household, community and health system level. We describe a multidisciplinary, multi-level, mixed-method research protocol that includes individual, household, community and clinic surveys, and combines quantitative and qualitative methods. Discussion: The UTT strategy is changing the overall approach to HIV prevention, treatment and care, and substantial social consequences may be anticipated, such as changes in social representations of HIV transmission, prevention, HIV testing and ART use, as well as changes in individual perceptions and behaviours in terms of uptake and frequency of HIV testing and ART initiation at high CD4. Triangulation of social science studies within the ANRS 12249 TasP trial will provide comprehensive insights into the acceptability and feasibility of the TasP intervention package at individual, community, patient and health system level, to complement the trial's clinical and epidemiological outcomes. It will also increase understanding of the causal impacts of UTT on social and economic outcomes, which will be critical for the long-term sustainability and routine UTT implementation. Trial registration: Clinicaltrials.gov: NCT01509508; South African Trial Register: DOH-27-0512-3974