Re-Establishing Food Retail in St. John, Kansas

Presenters lead a session that highlights a case study on developing a new grocery facility in a town of 1200 people. They describe what it took and the lessons learned, such as defining the size of the market; feasibility; and compensating when the market isn’t big enough to justify the investment they want from a public policy/town survival viewpoint. Some perspectives gained during the experience include conducting a market study; the value of a Citizen Committee; the real issue of population decline and job creation; how other businesses can be incorporated into the store (such as fuel, laundromat, liquor store, cell phone provider, etc.); the need for an experienced established operator; and what it takes to build a business and keep grocery stores going

The Teran de los Rios-Massanet Expedition of 1691: a scholarly edition and comparative study

This thesis edits and compares two diaries written during one of the earliest Spanish expeditions into Texas during 1691-1692. The first governor of the Province of the Tejas Indians, Domingo Ter??n de los R??os, steered the military and exploratory aspects of this significant expedition during 1691 and 1692, while Father Dami??n Massanet investigated the anticipated establishment of missions in the frontier borderland of New Spain. Both men kept individual accounts of the expedition at the behest of the Crown. Textual evidence for these diaries consists of the original manuscript of Ter??n??s diary with three extant copies, and Massanet??s original manuscript with two copies. Until now, unedited transcriptions and an English-language translation have served as the source for historical studies of this expedition, but to date none of these manuscripts has been edited critically. Having compared systematically the most reliable manuscript of Ter??n??s diary, as well as the original Massanet diary, this thesis presents findings that pertain to the shared and divergent content and language found in the diaries. The findings include new historical information and clarification of discrepancies in daily events, distances traveled, assignment of names to specific places, and interactions with the indigenous population. The differences manifested in each diary highlight the disparity in purpose and perspective between a military expedition and a spiritual mission. Likewise, the findings underscore the challenges and differences of opinion faced by two leaders of a consolidated expedition. This thesis includes an introductory chapter with the following segments: background of the two expeditions of 1689 and 1690 that preceded and laid the foundation for the third, more ambitious expedition of Ter??n and Massanet; an overview of the third expedition; and a review of the literature concerning the expedition. The second chapter concerns the transcriptions of the diaries of Ter??n and Massanet, and contains the following divisions: methodology; descriptions of both manuscripts; the norms of transcription; the transcription of Massanet??s manuscript; and the transcription of Ter??n??s manuscript that corresponds to the dates of the Massanet diary. After the transcriptions is an analysis of the first month of the expedition, from May 16 to June 16. This analysis deals with the content and language of the diaries. The final chapter presents conclusions and areas for future research. This work is relevant for historians, linguists, philologists, anthropologists, archeologists and other scholars interested in the history of the Spanish Southwest

Great Expectations: The Mismatched Selves of a Beginning Teacher

As university supervisors we were alerted to heightened emotional responses (i.e., crying, not eating, not sleeping), expressed by paid-interns in an accelerated Master of Arts in Teaching (M.A.T.) cohort of STEM practitioners. While research has shown teachers prepared in alternative programs tend to have greater difficulties (Darling-Hammond, 1990), few studies have examined alternatively prepared teachers’ beliefs and expectations about teaching and learning (Tigchlaar, Brouwer, & Vermut, 2010; Good et al., 2006). This inquiry describes one paid-intern’s teaching expectations during her first year of teaching. In this phenomenological case study, part of a larger cross-case study, we collected data from interviews, observation notes and university supervisor evaluations in an effort to answer: (1) What are the expectations about teaching of a student in an accelerated M.A.T. program who is also a first-year teacher completing a paid internship and (2) In what ways did she address those expectations? We utilized self-discrepancy theory (Higgins, 1987) that provides an understanding of how expectations can produce negative effects, such as anxiety or depression. Discoveries suggest the intern held idealistic expectations about teaching, influenced by her personality, prior experiences, and the accelerated M.A.T. program, which she could not reconcile with her experiences as a teacher

Eisman and Warrack Standard & Poor\u27s Structured Finance Teleconference Transcript

Transcript of Standard & Poor\u27s Structured Finance meeting/conference call discussing its press release issued that same morning announcing that it placed 612 subprime RMBS classes on Credit Watch Negative

The Mouse Cer1 (Cerberus related or homologue) Gene Is Not Required for Anterior Pattern Formation

AbstractCer1 is the mouse homologue of the Xenopus Cerberus gene whose product is able to induce development of head structures during embryonic development. The Cer1 protein is a member of the cysteine knot superfamily and is expressed in anterior regions of the mouse gastrula. A segmental pattern of expression with nascent and newly formed somites is also seen. This suggests an additional role in development of the axial skeleton, musculature, or peripheral nervous system. Xenopus animal cap assays and mouse germ-layer explant recombination experiments indicate that the mouse protein can act as a patterning molecule for anterior development in Xenopus, including induction of Otx2 expression, and suggest it may have a similar role in mouse development. However, we present here genetic data that demonstrate that Cer1 is not necessary for anterior patterning, Otx2 expression, somite formation, or even normal mouse morphogenesis

Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b

The serrated pathway to colorectal tumor formation involves oncogenic mutations in the BRAF gene which are sufficient for initiation of hyperplastic growth but not for tumor progression. The analysis of colorectal tumors revealed that overexpression of splice variant Rac1b occurs in around 80% of tumors with mutant B-Raf and both events were shown to cooperate in tumor cell survival. Here we provide evidence for increased expression of Rac1b in samples from inflammatory bowel disease patients as well as following experimentally induced colitis in mice. The increase of Rac1b in the mouse model was specifically prevented by the non-steroidal anti-inflammatory drug ibuprofen, which also inhibited Rac1b expression in cultured HT29 colorectal tumour cells through a cyclooxygenase inhibition-independent mechanism. Accordingly, the presence of ibuprofen led to a reduction of HT29 cell survival in vitro and inhibited Rac1b-dependent tumor growth of HT29 xenografts. Together, our results suggest that stromal cues, namely inflammation can trigger changes in Rac1b expression in the colon and identify ibuprofen as a highly specific and efficient inhibitor of Rac1b overexpression in colorectal tumors. Our data suggest that the use of ibuprofen may be beneficial in the treatment of patients with serrated colorectal tumors and in cancer prophylaxis following colon inflammation disorders

LSST Science Book, Version 2.0

A survey that can cover the sky in optical bands over wide fields to faint magnitudes with a fast cadence will enable many of the exciting science opportunities of the next decade. The Large Synoptic Survey Telescope (LSST) will have an effective aperture of 6.7 meters and an imaging camera with field of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over 20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a total point-source depth of r~27.5. The LSST Science Book describes the basic parameters of the LSST hardware, software, and observing plans. The book discusses educational and outreach opportunities, then goes on to describe a broad range of science that LSST will revolutionize: mapping the inner and outer Solar System, stellar populations in the Milky Way and nearby galaxies, the structure of the Milky Way disk and halo and other objects in the Local Volume, transient and variable objects both at low and high redshift, and the properties of normal and active galaxies at low and high redshift. It then turns to far-field cosmological topics, exploring properties of supernovae to z~1, strong and weak lensing, the large-scale distribution of galaxies and baryon oscillations, and how these different probes may be combined to constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at http://www.lsst.org/lsst/sciboo

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

The JWST Discovery of the Triply-imaged Type Ia "Supernova H0pe" and Observations of the Galaxy Cluster PLCK G165.7+67.0

A Type Ia supernova (SN) at $z=1.78$ was discovered in James Webb Space Telescope Near Infrared Camera imaging of the galaxy cluster PLCK G165.7+67.0 (G165; $z = 0.35$). The SN is situated 1.5-2kpc from its host galaxy Arc 2 and appears in three different locations as a result of gravitational lensing by G165. These data can yield a value for Hubble's constant using time delays from this multiply-imaged SN Ia that we call "SN H0pe." Over the entire field we identified 21 image multiplicities, confirmed five of them using Near-Infrared Spectrograph (NIRspec), and constructed a new lens model that gives a total mass within 600kpc of ($2.6 \pm 0.3) \times 10^{14}$ M$_{\odot}$. The photometry uncovered a galaxy overdensity at Arc 2's redshift. NIRSpec confirmed six member galaxies, four of which surround Arc 2 with relative velocity $\lesssim$900 km s$^{-1}$ and projected physical extent $\lesssim$33 kpc. Arc 2 dominates the stellar mass ($(5.0 \pm 0.1) \times 10^{11}$ M$_{\odot}$), which is a factor of ten higher than other members of this compact galaxy group. These other group members have specific star formation rates (sSFR) of 2-260Gyr$^{-1}$ derived from the H$\alpha$-line flux corrected for stellar absorption, dust extinction, and slit losses. Another group centered on the dusty star forming galaxy Arc 1 is at $z=2.24$. The total SFR for the Arc 1 group ($gtrsim$ M$_{\odot}$ yr$^{-1}$) translates to a supernova rate of $\sim$1 SNe yr$^{-1}$, suggesting that regular monitoring of this cluster may yield additional SNe.Comment: 27 pages, submitted to Ap

The assessment of pain in older people: UK National Guidelines

We are facing a huge increase in the older population over the next 30 years. This brings an anticipated increase in the prevalence of chronic pain and with this comes the challenge of assessment of pain in many varied settings. Our first iteration of this document was published in 2007. But there has been a proliferation of literature and research since then, so we have developed a new set of guidelines. Different patterns and sites of pain were seen in men and women. Age differences suggest that pain prevalence increased with age up to 85 years and then decreased. The available studies on barriers and attitudes to pain management point towards an adherence to bio-medically orientated beliefs about pain, concern amongst clinicians in relation to activity recommendations, and a negative orientation in general towards patients with chronic painful conditions. A multidisciplinary approach to the assessment and treatment of pain is essential, but the assessment is a complex process which is hampered by many communication issues, including cognitive ability and socio-cultural factors. Such issues are part of the UK ageing population. Structured pain education should be implemented that provides all health professionals (whether professionally or non-professionally trained) with standardised education and training in the assessment and management of pain according to level of experience. Although subjective, patient self-report is the most valid and reliable indicator of pain and it may be necessary to ask questions about pain in different ways in order to elicit a response. A number of valid and reliable self-report measures are available and can be used even when moderate dementia exists. The Numerical Rating Scale or verbal descriptors can be used with people who have mild to moderate cognitive impairment. For people with severe cognitive impairment Pain in Advanced Dementia (PAINAD) and Doloplus-2 are recommended. PAINAD and Doloplus-2 scales continue to show positive results in terms of reliability and validity. There has been no recent evaluation of the Abbey pain scale although it is widely used throughout the UK. There is a need for more research into pain assessment using the collaborative role of the multidisciplinary team in all care settings. Self-report questionnaires of function are limited in their ability to capture the fluctuations in capacity and ability. The concentration on items of relevance to the population of interest means that issues of personal relevance can be obscured. Strong associations were seen between pain and depressed mood with each being a risk factor for the other. Additionally, loneliness and social isolation were associated with an increased risk of pain. Clinicians should be cognisant that social isolation and or depressive signs and symptoms may be indicators of pre-existing pain or a predictor of future pain onset. There are a number of evidence based guidelines on pain assessment in older people with or without cognitive impairment from around the world, including Australia and Europe