The magnetic precursor of L1448-mm: Excitation differences between ion and neutral fluids

Shock modelling predicts an electron density enhancement within the magnetic precursor of C-shocks. Previous observations of SiO, H13CO+, HN13C and H13CN toward the young L1448-mm outflow showed an over-excitation of the ion fluid that was attributed to an electron density enhancement in the precursor. We re-visit this interpretation and test if it still holds when we consider different source morphologies and kinetic temperatures for the observed molecules, and also give some insight on the spatial extent of the electron density enhancement around L1448-mm. We estimate the opacities of H13CO+ and HN13C by observing the J=3\to2 lines of rarer isotopologues to confirm that the emission is optically thin. To model the excitation of the molecules, we use the large velocity gradient (LVG) approximation with updated collisional coefficients to i) re- analyse the observations toward the positions where the over-excitation of H13CO+ has previously been observed [i.e. toward L1448- mm at offsets (0,0) and (0,-10)], and ii) to investigate if the electron density enhancement is still required for the cases of extended and compact emission, and for kinetic temperatures of up to 400 K. We also report several lines of SiO, HN13C and H13CO+ toward new positions around this outflow, to investigate the spatial extent of the over-excitation of the ions in L1448-mm. From the isotopologue observations, we find that the emission of H13CO+ and HN13C from the precursor is optically thin if this emission is extended. Using the new collisional coefficients, an electron density enhancement is still needed to explain the excitation of H13CO+ for extended emission and for gas temperatures of\le 400 K toward L1448-mm (0,-10), and possibly also toward L1448-mm (0,0). For compact emission the data cannot be fitted. We do not find any evidence for the over-excitation of the ion fluid toward the newly observed positions around L1448-mm. The observed line emission of SiO, H13CO+ and HN13C toward L1448-mm (0,0) and (0,-10) is consistent with an electron density enhancement in the precursor component, if this emission is spatially extended. This is also true for the case of high gas temperatures (\le400 K) toward the (0,-10) offset. The electron density enhancement seems to be restricted to the southern, redshifted lobe of the L1448-mm outflow. Interferometric images of the line emission of these molecules are needed to confirm the spatial extent of the over-excitation of the ions and thus, of the electron density enhancement in the magnetic precursor of L1448-mm.Comment: Accepted for publication in A&A; 9 pages, 3 figure

Informe sobre la situación del Área de Antropología Social en las universidades y centros de investigación en relación con el reconocimiento de la actividad investigadora por parte de la CNEAI en forma de sexenios

El objetivo de este informe es hacer una primera aproximación al grado de implantación de este procedimiento de evaluación (sexenios, en adelante) en el área de la Antropología Social y, a partir de ahí, identificar los obstáculos principales en relación con el procedimiento empleado que impiden lograr una mayor tasa de éxito. Como veremos, existe una disonancia entre los "criterios CNEAI" y los "criterios de la Antropología" de lo que significa "calidad científica" en nuestra área, situación que sugiere la urgente necesidad de repensar y recalibrar ese procedimiento de evaluación. A la vista de los resultados, el fin último de este informe es elevar al organismo oficial evaluador una serie de recomendaciones y propuestas concretas de mejora

Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer

Engrailed variant-2 (EN2) has been suggested as a potential diagnostic biomarker; however, its presence and functional role in prostate cancer (PCa) cells is still controversial or unknown. Here, we analyzed 1) the expression/secretion profile of EN2 in five independent samples cohorts from PCa patients and controls (prostate tissues and/or urine) to determine its utility as a PCa biomarker; and 2) the functional role of EN2 in normal (RWPE1) and tumor (LNCaP/22Rv1/PC3) prostate cells to explore its potential value as therapeutic target. EN2 was overexpressed in our two cohorts of PCa tissues compared to control and in tumor cell lines compared with normal-like prostate cells. This profile was corroborated in silico in three independent data sets [The Cancer Genome Atlas(TCGA)/Memorial Sloan Kettering Cancer Center (MSKCC)/Grasso]. Consistently, urine EN2 levels were elevated and enabled discrimination between PCa and control patients. EN2 treatment increased cell proliferation in LNCaP/22Rv1/PC3 cells, migration in RWPE1/PC3 cells, and PSA secretion in LNCaP cells. These effects were associated, at least in the androgen-sensitive LNCaP cells, with increased AKT and androgen-receptor phosphorylation levels and with modulation of key cancer-associated genes. Consistently, EN2 treatment also regulated androgen-receptor activity (full-length and splicing variants) in androgen-sensitive 22Rv1 cells. Altogether, this study demonstrates the potential utility of EN2 as a non-invasive diagnostic biomarker for PCa and provides novel and valuable information to further investigate its putative utility to develop new therapeutic tools in PCa

Net contribution and predictive ability of the CUN-BAE body fatness index in relation to cardiometabolic conditions

BACKGROUND: The CUN-BAE (Clínica Universidad de Navarra-Body adiposity estimator) index is an anthropometric index based on age, sex and body mass index (BMI) for a refined prediction of body fatness in adults. CUN-BAE may help detect metabolically unhealthy individuals with otherwise normal weight according to BMI or waist circumference (WC). The aim of this study was to evaluate whether CUN-BAE, independent of its components (BMI, age and sex), was associated with cardiometabolic conditions including arterial hypertension, diabetes mellitus and metabolic syndrome (MetS). METHODS: The ENRICA study was based on a cross-sectional sample of non-institutionalized men and women representative of the adult Spanish population. Body weight, height, and WC were measured in all participants. The residual of CUN-BAE (rCUN-BAE), i.e. the part of the index not explained by its components, was calculated. The associations of CUN-BAE, rCUN-BAE, BMI and WC with hypertension, diabetes and MetS were analysed by multivariate logistic regression, and the Akaike information criterion (AIC) was calculated. RESULTS: The sample included 12,122 individuals. rCUN-BAE was associated with hypertension (OR 1.14, 95% CI 1.07-1.21) and MetS (OR 1.48, 1.37-1.60), but not with diabetes (OR 1.05, 0.94-1.16). In subjects with a BMI?<?25 kg/m2, CUN-BAE was significantly associated with all three outcome variables. CUN-BAE was more strongly associated with the cardiometabolic conditions than BMI and WC and fit similar AICs. CONCLUSIONS: The CUN-BAE index for body fatness was positively associated with hypertension, diabetes and MetS in adults independent of BMI or WC. CUN-BAE may help to identify individuals with cardiometabolic conditions beyond BMI, but this needs to be confirmed in prospective settings.Funding: The ENRICA study was funded and financed by Sanofi-Aventis. Specific funding for this analysis came from the governmental Spain FIS PI12/1166 and PI11/01379 projects and from the “UAM Chair in Epidemiology and Control of Cardiovascular Risk”

Natural transmission of Leishmania infantum through experimentally infected Phlebotomus perniciosus highlights the virulence of Leishmania parasites circulating in the human visceral leishmaniasis outbreak in Madrid, Spain

International audienceAbstractA human leishmaniasis outbreak is occurring in the Madrid region, Spain, with the parasite and vector involved being Leishmania infantum and Phlebotomus perniciosus respectively. The aim of this study was to investigate the virulence of L. infantum isolates from the focus using a natural transmission model. Hamsters were infected by intraperitoneal inoculation (IP) or by bites of sand flies experimentally infected with L. infantum isolates obtained from P. perniciosus collected in the outbreak area (IPER/ES/2012/BOS1FL1 and IPER/ES/2012/POL2FL6) and a well characterized L. infantum strain JPCM5 (MCAN/ES/98/LLM-877). Hamster infections were monitored by clinical examination, serology, culture, parasite burden, Giemsa-stained imprints, PCR, histopathology and xenodiagnostic studies. Establishment of infection of L. infantum was achieved with the JPCM5 strain and outbreak isolates by both P. perniciosus infective bites or IP route. However, high virulence of BOS1FL1 and POL2FL6 isolates was highlighted by the clinical outcome of disease, high parasite detection in spleen and liver, high parasitic loads and positivity of Leishmania serology. Transmission by bite of POL2FL6 infected flies generated a slower progression of clinical disease than IP infection, but both groups were infective to P. perniciosus by xenodiagnosis at 2 months post-infection. Conversely, hamsters inoculated with JPCM5 were not infective to sand flies. Histopathology studies confirmed the wide spread of POL2FL6 parasites to several organs. A visceral leishmaniasis model that mimics the natural transmission in nature allowed us to highlight the high virulence of isolates that are circulating in the focus. These findings contribute to a better understanding of the outbreak epidemiology

Impact of COVID-19 infection on the outcome of patients with ischemic stroke

BACKGROUND AND PURPOSE: We evaluated whether stroke severity, functional outcome, and mortality are different in patients with ischemic stroke with or without coronavirus disease 2019 (COVID-19) infection. METHODS: A prospective, observational, multicentre cohort study in Catalonia, Spain. Recruitment was consecutive from mid-March to mid-May 2020. Patients had an acute ischemic stroke within 48 hours and a previous modified Rankin Scale (mRS) score of 0 to 3. We collected demographic data, vascular risk factors, prior mRS score, National Institutes of Health Stroke Scale score, rate of reperfusion therapies, logistics, and metrics. Primary end point was functional outcome at 3 months. Favourable outcome was defined depending on the previous mRS score. Secondary outcome was mortality at 3 months. We performed mRS shift and multivariable analyses. RESULTS: We evaluated 701 patients (mean age 72.3±13.3 years, 60.5% men) and 91 (13%) had COVID-19 infection. Median baseline National Institutes of Health Stroke Scale score was higher in patients with COVID-19 compared with patients without COVID-19 (8 [3–18] versus 6 [2–14], P=0.049). Proportion of patients with a favourable functional outcome was 33.7% in the COVID-19 and 47% in the non-COVID-19 group. However, after a multivariable logistic regression analysis, COVID-19 infection did not increase the probability of unfavourable functional outcome. Mortality rate was 39.3% among patients with COVID-19 and 16.1% in the non-COVID-19 group. In the multivariable logistic regression analysis, COVID-19 infection was a risk factor for mortality (hazard ratio, 3.14 [95% CI, 2.10–4.71]; P<0.001). CONCLUSIONS: Patients with ischemic stroke and COVID-19 infection have more severe strokes and a higher mortality than patients with stroke without COVID-19 infection. However, functional outcome is comparable in both groups

Nueva ecuación para estimar el asiento de zapatas sobre arenas basado en el método de elementos finitos

In the design of shallow foundations normally used in rural buildings on sand, the settlement criterion is more critical than the bearing capacity of the soil. Likewise, it has also been found that widely used methods to estimate the footings settlement on sand, generates differences with the observed in full scale field tests. The aim of this study was to find a new equation based on finite element method (FEM) easy to apply to estimate the footings settlement on sand. This new equation considers the effect of the depth of the founding level, the footing breadth, the equivalent soil stiffness, the Poisson’s ratio and the net increase in the effective stress on settlement values. To obtain this equation, a three-dimensional finite element model was generated and subsequently validated using actual footings settlement measured during field tests. The results of settlement predictions extracted from this method are slightly better than those obtained by other methods, but this equation has the advantage of being easier and faster to apply, which implies a savings in computation time.En el diseño de las cimentaciones superficiales normalmente utilizadas en las construcciones rurales sobre arena, el criterio de asientos es más crítico que el de capacidad de carga del suelo. Igualmente se ha encontrado que los métodos más utilizados para estimar el asiento de zapatas sobre arenas generan diferencias con los observados en ensayos de campo a escala real. El objetivo de este estudio fue encontrar una nueva ecuación, basada en el método de elementos finitos (MEF) fácil de aplicar, para estimar el asiento de zapatas sobre arena. Esta nueva ecuación considera el efecto de la profundidad de cimentación, la anchura de la zapata, la rigidez equivalente del suelo, el coeficiente de Poisson y el incremento neto de la presión efectiva sobre los valores del asiento. Para obtener esta ecuación, se generó un modelo tridimensional de elementos finitos y se validó posteriormente utilizando los asientos reales de zapatas medidos durante ensayos de campo. Los resultados de las predicciones del asiento extraídos de esta formulación son ligeramente mejores que los obtenidos por otros métodos, pero esta formulación tiene la ventaja de ser más fácil y rápida de aplicar, lo que implica un ahorro en el tiempo de cálculo con el ordenador