Impacto productivo de la gestión de almacenes en empresas dedicadas a la fabricación de módulos publicitarios en la ciudad de lima. Una revisión sistemática de la literatura científica de los últimos 10 años

En la actualidad las empresas que se dedican al rubro de la fabricación de módulos publicitarios tienen la necesidad de cumplir con los requerimientos que el cliente demanda respetando la calidad tanto de la materia prima, la fabricación y el producto terminado. Asimismo, la buena atención al cliente debe formar parte de su estrategia para que de esta manera puedan sostenerse en el tiempo y competir en el mercado, sin embargo, podemos notar que gran parte de las empresas no cuentan con un plan definido a mediano y largo plazo respecto a la gestión de sus almacenes ya que constantemente presentan problemas en dicha área debido a la mala administración, distribución, planificación y organización, causando un impacto negativo en la productividad. El objetivo de la presente investigación consiste en realizar una revisión sistemática de la literatura basada en artículos, revistas científicas y tesis publicadas en idioma español, a través de un riguroso análisis para ver el diseño de la investigación, el sector al que pertenece, los instrumentos utilizados y las variables de acuerdo al tipo de estudio; sobre las principales características de la gestión de almacén en las empresas. La búsqueda de información se realizó en la base de datos Redalyc, Repositorio PUCP, Repositorio UCV, Repositorio UPN, Repositorio USSP, Repositorio UPC, Repositorio USIL, Repositorio UNMSM y Google académico. Los artículos seleccionados como unidad de estudio estuvieron conformado por 40 entre artículos y tesis, los cuales estuvieron sujeto a evaluaciones del contenido sobre gestión de almacén, impacto en la productividad, se puede concluir que los artículos y tesis no presentan uniformidad. Además, el estudio indica que la gestión de almacén impacta en la productividad y calidad, así como la importancia de conocer la gestión de almacén

Perception of trust and commitment in the financial sector in Bogota (Colombia)

This study aims to determine the variables through which financial sector entities can establish retention processes and create long-term and quality relationships with Bogota's financial consumers. This was done by applying a survey to a sample of 384 people. The perception of trust and commitment of financialconsumers is between regular and non-conforming however, it was possible to establish significant variations between such perception associated with age groups, number of years linked to the financial institution, marital status, type of economic activity and the number of financial products

Plan de mercadeo de la empresa Artplastic situada en la ciudad de Bogotá fabricadora de cuadros artesanales

Art Plastic es una empresa dedicada a la producción y comercialización de cuadros artesanales, en el sector de Usaquén en la ciudad de Bogotá; Art plastic busca poner en el mercado pinturas innovadoras conservando el estilo artístico a precios competitivos ofreciendo calidad. El presente plan de mercadeo tiene como fin analizar las oportunidades de mercado, la competencia, las estrategias de promoción, distribución, precios, los materiales que se van a necesitar para la elaboración de nuestro producto y se realizara un estudio financiero como la proyección de ventas, costos directos e indirectos, administrativos y estados financieros

Plan de mercadeo de la empresa Artplastic situada en la ciudad de Bogotá fabricadora de cuadros artesanales

Art Plastic es una empresa dedicada a la producción y comercialización de cuadros artesanales, en el sector de Usaquén en la ciudad de Bogotá; Art plastic busca poner en el mercado pinturas innovadoras conservando el estilo artístico a precios competitivos ofreciendo calidad. El presente plan de mercadeo tiene como fin analizar las oportunidades de mercado, la competencia, las estrategias de promoción, distribución, precios, los materiales que se van a necesitar para la elaboración de nuestro producto y se realizara un estudio financiero como la proyección de ventas, costos directos e indirectos, administrativos y estados financieros

High Affinity Antigen Recognition of the Dual Specific Variants of Herceptin Is Entropy-Driven in Spite of Structural Plasticity

The antigen-binding site of Herceptin, an anti-human Epidermal Growth Factor Receptor 2 (HER2) antibody, was engineered to add a second specificity toward Vascular Endothelial Growth Factor (VEGF) to create a high affinity two-in-one antibody bH1. Crystal structures of bH1 in complex with either antigen showed that, in comparison to Herceptin, this antibody exhibited greater conformational variability, also called “structural plasticity”. Here, we analyzed the biophysical and thermodynamic properties of the dual specific variants of Herceptin to understand how a single antibody binds two unrelated protein antigens. We showed that while bH1 and the affinity-improved bH1-44, in particular, maintained many properties of Herceptin including binding affinity, kinetics and the use of residues for antigen recognition, they differed in the binding thermodynamics. The interactions of bH1 and its variants with both antigens were characterized by large favorable entropy changes whereas the Herceptin/HER2 interaction involved a large favorable enthalpy change. By dissecting the total entropy change and the energy barrier for dual interaction, we determined that the significant structural plasticity of the bH1 antibodies demanded by the dual specificity did not translate into the expected increase of entropic penalty relative to Herceptin. Clearly, dual antigen recognition of the Herceptin variants involves divergent antibody conformations of nearly equivalent energetic states. Hence, increasing the structural plasticity of an antigen-binding site without increasing the entropic cost may play a role for antibodies to evolve multi-specificity. Our report represents the first comprehensive biophysical analysis of a high affinity dual specific antibody binding two unrelated protein antigens, furthering our understanding of the thermodynamics that drive the vast antigen recognition capacity of the antibody repertoire

Pre-Clinical Evaluation of a Replication-Competent Recombinant Adenovirus Serotype 4 Vaccine Expressing Influenza H5 Hemagglutinin

Influenza virus remains a significant health and social concern in part because of newly emerging strains, such as avian H5N1 virus. We have developed a prototype H5N1 vaccine using a recombinant, replication-competent Adenovirus serotype 4 (Ad4) vector, derived from the U.S. military Ad4 vaccine strain, to express the hemagglutinin (HA) gene from A/Vietnam/1194/2004 influenza virus (Ad4-H5-Vtn). Our hypothesis is that a mucosally-delivered replicating Ad4-H5-Vtn recombinant vector will be safe and induce protective immunity against H5N1 influenza virus infection and disease pathogenesis.The Ad4-H5-Vtn vaccine was designed with a partial deletion of the E3 region of Ad4 to accommodate the influenza HA gene. Replication and growth kinetics of the vaccine virus in multiple human cell lines indicated that the vaccine virus is attenuated relative to the wild type virus. Expression of the HA transgene in infected cells was documented by flow cytometry, western blot analysis and induction of HA-specific antibody and cellular immune responses in mice. Of particular note, mice immunized intranasally with the Ad4-H5-Vtn vaccine were protected against lethal H5N1 reassortant viral challenge even in the presence of pre-existing immunity to the Ad4 wild type virus.Several non-clinical attributes of this vaccine including safety, induction of HA-specific humoral and cellular immunity, and efficacy were demonstrated using an animal model to support Phase 1 clinical trial evaluation of this new vaccine

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Linkages Between Biculturalism and Executive Functioning Among Immigrant Latinx-American Youth

Due to globalized movement, the U.S. has a growing population of Latinx adolescents who are exposed to two cultures, the mainstream and the heritage culture, and are in a critical period of identity and cognitive development. The process of continuously negotiating dual cultures, and attaining bilingualism, may have ramifications for youth’s development of executive functioning (EF) skills. Limited research has examined the dynamic of biculturalism, and EF skills while considering bilingualism, particularly among Latinx adolescent youth within the U.S. The present study investigated how biculturalism contributors such as cultural identification and bicultural identity integration related to three EF skills: inhibition, shift, and working memory based on youth-report and parent-report with 81 Latinx adolescents ages 13-15. Hierarchical regressions analyses results did not support cultural identification nor bicultural identity integration as predictors of EF inhibition, shift, or working memory skill. However, bilingualism was a consistent predictor across the three skills for youth-rated EF outcomes. This finding has implications for further understanding the linkages between bilingualism, a carrier of culture, and supporting Latinx adolescents in their academic achievement and psycho-social well-being. GPA was also a consistent predictor across the three parent-rated EF outcome skills, having implications for understanding parental conceptualizations of youth’s achievement bridging GPA with EF skill