Proof of concept of energy harvesting from aeroacoustic noise

This paper reports the testing of a new mechanism converting energy radiated from an acoustic source, i.e. a small cavity created on an aircraft outside skin and inducing high frequency oscillations of airflow passing over it. This acoustic noise is then converted into electrical energy. We have submitted in a wind tunnel a set of cavities to an airflow varying the Mach number, creating high sound levels. In a second set of experiments, we have submitted passive microphones to high acoustic levels and stored in capacitors the electrical energy collected at the microphone output. Finally, directions for future work are identified

Impact of early complications on outcomes in patients with implantable cardioverter-defibrillator for primary prevention

International audienceBackground - The lifesaving benefit of implantable cardioverter-defibrillators (ICDs) has been demonstrated. Their use has increased considerably in the past decade, but related complications have become a major concern. Objective - The purpose of this study was to assess the incidence and effect on outcomes of early (≤30 days) complications after ICD implantation for primary prevention in a large French population. Methods - We analyzed data from 5539 patients from the multicenter French DAI-PP (Défibrillateur Automatique Implantable-Prévention Primaire) registry (2002-2012) who had coronary artery disease or dilated cardiomyopathy and were implanted with an ICD for primary prevention. Results - Overall, early complications occurred in 707 patients (13.5%), mainly related to lead dislodgment or hematoma (57%). Independent factors associated with occurrence of early complications were severe renal impairment (odds ratio [OR] 1.66, 95% confidence interval [CI] 1.17-2.37, P = .02), age ≥75 years (OR 1.01, 95% CI 1.00-1.02, P = .03), cardiac resynchronization therapy (OR 1.58, 95% CI 1.16-2.17, P = .01), and anticoagulant therapy (OR 1.28, 95% CI 1.02-1.61, P = .03). During a mean ± SD follow-up of 3.1 ± 2.3 years, 824 (15.8%) patients experienced ≥1 late complication (>30 days), and 782 (14.9%) patients died. After adjustment, early complications remained associated with occurrence of late complications (OR 2.15, 95% CI 1.73-2.66, P < .0001) and mortality (OR 1.70, 95% CI 1.34-2.17, P = .003). Conclusion - Early complications are common after ICD implantation for primary prevention, occurring in 1 in 7 patients, and are associated with an increased risk of late complications and overall mortality. Further studies are needed to investigate the underlying mechanisms of such associations

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases

Recent Ebola outbreaks underscore the importance of continuous prevention and disease control efforts. Authorized vaccines include Merck’s Ervebo (rVSV-ZEBOV) and Johnson & Johnson’s two-dose combination (Ad26.ZEBOV/MVA-BN-Filo). Here, in a five-year follow-up of the PREVAC randomized trial (NCT02876328), we report the results of the immunology ancillary study of the trial. The primary endpoint is to evaluate long-term memory T-cell responses induced by three vaccine regimens: Ad26–MVA, rVSV, and rVSV–booster. Polyfunctional EBOV-specific CD4+ T-cell responses increase after Ad26 priming and are further boosted by MVA, whereas minimal responses are observed in the rVSV groups, declining after one year. In-vitro expansion for eight days show sustained EBOV-specific T-cell responses for up to 60 months post-prime vaccination with both Ad26-MVA and rVSV, with no decline. Cytokine production analysis identify shared biomarkers between the Ad26-MVA and rVSV groups. In secondary endpoint, we observed an elevation of pro-inflammatory cytokines at Day 7 in the rVSV group. Finally, we establish a correlation between EBOV-specific T-cell responses and anti-EBOV IgG responses. Our findings can guide booster vaccination recommendations and help identify populations likely to benefit from revaccination

Les Hémorphines (contribution à l'étude de leurs interactions potentielles dans le système Rénine - Angiotensine et de leur catabolisme rénal et suggestion de leur utilité en tant que marqueur potentiel du cancer du sein)

LA ROCHELLE-BU (173002101) / SudocSudocFranceF

Hydrolyse de l'alpha-lactalbumine caprine en réacteur à l'ultrafiltration (génération et caractérisation de peptides issus de l'hydrolyse pepsique)

LE LACTOSERUM CAPRIN, UTILISE ICI, EST UN SOUS-PRODUIT MECONNU DE L'INDUSTRIE FROMAGERE LOCALE. SON HYDROLYSE PAR LA PEPSINE EST SELECTIVE : SEULE L'ALPHA-LACTALBUMINE ET LA SERUM ALBUMINE SONT HYDROLYSEES A PH2 ET 40\C TANDIS QUE LA BETA-LACTOGLOBULINE RESTE INTACTE. DANS LE BUT DE PURIFIER LA BETA-LACTOGLOBULINE ET DE PRODUIRE DES PEPTIDES DERIVES DE L'ALPHA-LACTALBUMINE, NOUS AVONS MIS EN UVRE UN REACTEUR ENZYMATIQUE COUPLE A UNE MEMBRANE D'ULTRAFILTRATION MINERALE DE SEUIL DE COUPURE 30 KDA. CE REACTEUR A PERMIS D'HYDROLYSER 800 ML DE LACTOSERUM EN 4H. LA PERTE D'ACTIVITE ENZYMATIQUE EST COMPENSEE PAR AJOUT DE PEPSINE APRES UNE HEURE. L'EFFICACITE DU SYSTEME DEPEND DE LA NATURE DE LA COUCHE DE POLARISATION FORMEE, ELLE-MEME LIEE AUX CONDITIONS EXPERIMENTALES. LE COLMATAGE DE LA MEMBRANE A PU ETRE LIMITE EN AJOUTANT 3MM DE CYSTEINE AU LACTOSERUM. LA PRESENCE DE 0,3M DE NACL AUGMENTAIT LE TAUX DE PASSAGE DES PEPTIDES MAIS EGALEMENT LE COLMATAGE ET REDUISAIT LA DUREE DE FONCTIONNEMENT DU REACTEUR. LES PEPTIDES CONTENUS DANS LE PERMEAT ISSU DE L'HYDROLYSE CONTINUE DE LACTOSERUM CAPRIN, POSSEDENT DES MASSES MOLECULAIRES COMPRISES ENTRE 150 A 6500 DA, DONT 36% INFERIEURES A 600 DA, 24% COMPRISES ENTRE 600 ET 2000 DA ET 40% SUPERIEURES A 2000 DA ET UN PONT DISULFURE. UN DES PEPTIDES IDENTIFIE RESULTAIT DE LA REASSOCIATION DE DEUX PEPTIDES VIA UN ECHANGE DE PONTS DISULFURES. PARMI CES PEPTIDES, NOUS AVONS PU IDENTIFIER ET CARACTERISER L'ALPHA-LACTORPHINE, PEPTIDE BIOACTIF MULTIFONCTIONNEL DEJA DECRIT DANS UN HYDROLYSAT PEPSIQUE D'ALPHA-LACTALBUMINE BOVINE. L'ENSEMBLE DES PEPTIDES DU PERMEAT NE PRESENTAIT PAS D'ACTIVITE OPIOIDE ET UNE ASSEZ FAIBLE ACTIVITE ANTI-HYPERTENSIVE (ANTI-ENZYME DE CONVERSION DE L'ANGIOTENSINE (ECA)). TOUTEFOIS, UN FRACTIONNEMENT DE CET HYDROLYSAT A PERMIS DE METTRE EN EVIDENCE DES ACTIVITES ANTI-ECA ATTEIGNANT 83%.LA ROCHELLE-BU (173002101) / SudocSudocFranceF

Les Hémorphines : peptides bioactifs issus de l’hémoglobine

International audienc