Атеросклероз: патогенетические механизмы и принципы лечения

Проведен анализ факторов риска развития атеросклероза, дана оценка ряда теорий, объясняющих появление атеросклеротических изменений коронарных артерий. Подчеркивается роль эндотелиальной дисфункции в прогрессировании и обострении сердечно−сосудистых заболеваний. Проанализированы современные подходы к лечению атеросклероза.Risk factors of atherosclerosis development are described, a number of theories explaining atherosclerotic changes appearance in the coronary arteries are analyzed critically. The role of endothelial dysfunction in progress and exacerbation of cardiovascular diseases is emphasized. Contemporary approaches to atherosclerosis treatment are discussed

Experimental and Computational Evidence for the Mechanism of Intradiol Catechol Dioxygenation by Non- Heme Iron(III) Complexes

Catechol intradiol dioxygenation is a unique reaction catalyzed by iron-dependent enzymes and nonheme iron(III) complexes. The mechanism by which these systems activate dioxygen in this important metabolic process remains controversial. Using a combination of kinetic measurements and computational modelling of multiple iron(III) catecholato complexes, we have elucidated the catechol cleavage mechanism and show that oxygen binds the iron center by partial dissociation of the substrate from the iron complex. The iron(III) superoxide complex that is formed subsequently attacks the carbon atom of the substrate by a rate-determining C-O bond formation step