110 research outputs found
Can Neutron Star Mergers Alone Explain the r-process Enrichment of the Milky Way?
© 2023. The Author(s). Published by the American Astronomical Society. This is an open access article under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/Comparing Galactic chemical evolution models to the observed elemental abundances in the Milky Way, we show that neutron star mergers can be a leading r-process site only if at low metallicities such mergers have very short delay times and significant ejecta masses that are facilitated by the masses of the compact objects. Namely, black holeâneutron star mergers, depending on the black hole spins, can play an important role in the early chemical enrichment of the Milky Way. We also show that none of the binary population synthesis models used in this Letter, i.e., COMPAS, StarTrack, Brussels, ComBinE, and BPASS, can currently reproduce the elemental abundance observations. The predictions are problematic not only for neutron star mergers, but also for Type Ia supernovae, which may point to shortcomings in binary evolution models.Peer reviewe
Head Position in Stroke Trial (HeadPoST)- sitting-up vs lying-flat positioning of patients with acute stroke: study protocol for a cluster randomised controlled trial
Background
Positioning a patient lying-flat in the acute phase of ischaemic stroke may improve recovery and reduce disability, but such a possibility has not been formally tested in a randomised trial. We therefore initiated the Head Position in Stroke Trial (HeadPoST) to determine the effects of lying-flat (0°) compared with sitting-up (â„30°) head positioning in the first 24 hours of hospital admission for patients with acute stroke.
Methods/Design
We plan to conduct an international, cluster randomised, crossover, open, blinded outcome-assessed clinical trial involving 140 study hospitals (clusters) with established acute stroke care programs. Each hospital will be randomly assigned to sequential policies of lying-flat (0°) or sitting-up (â„30°) head position as a âbusiness as usualâ stroke care policy during the first 24 hours of admittance. Each hospital is required to recruit 60 consecutive patients with acute ischaemic stroke (AIS), and all patients with acute intracerebral haemorrhage (ICH) (an estimated average of 10), in the first randomised head position policy before crossing over to the second head position policy with a similar recruitment target. After collection of in-hospital clinical and management data and 7-day outcomes, central trained blinded assessors will conduct a telephone disability assessment with the modified Rankin Scale at 90 days. The primary outcome for analysis is a shift (defined as improvement) in death or disability on this scale. For a cluster size of 60 patients with AIS per intervention and with various assumptions including an intracluster correlation coefficient of 0.03, a sample size of 16,800 patients at 140 centres will provide 90 % power (α 0.05) to detect at least a 16 % relative improvement (shift) in an ordinal logistic regression analysis of the primary outcome. The treatment effect will also be assessed in all patients with ICH who are recruited during each treatment study period.
Discussion
HeadPoST is a large international clinical trial in which we will rigorously evaluate the effects of different head positioning in patients with acute stroke.
Trial registration
ClinicalTrials.gov identifier: NCT02162017 (date of registration: 27 April 2014); ANZCTR identifier: ACTRN12614000483651 (date of registration: 9 May 2014). Protocol version and date: version 2.2, 19 June 2014
Reaching for the stars â JWST/NIRSpec spectroscopy of a lensed star candidate at z = 4.76
We present JWST/NIRSpec observations of a highly magnified star candidate at a photometric redshift of zphot â 4.8, previously detected in JWST/NIRCam imaging of the strong lensing (SL) cluster MACS J0647+7015 (z = 0.591). The spectroscopic observation allows us to precisely measure the redshift of the host arc at zspec = 4.758 ± 0.004, and the starâs spectrum displays clear Lyman- and Balmer-breaks commensurate with this redshift. A fit to the spectrum suggests a B-type super-giant star of surface temperature âK with either a redder F-type companion (â âK) or significant dust attenuation (AV â 0.82) along the line of sight. We also investigate the possibility that this object is a magnified young globular cluster rather than a single star. We show that the spectrum is in principle consistent with a star cluster, which could also accommodate the lack of flux variability between the two epochs. However, the lack of a counter image and the strong upper limit on the size of the object from lensing symmetry, r âČ 0.5âpc, could indicate that this scenario is somewhat less likely â albeit not completely ruled out by the current data. The presented spectrum seen at a time when the Universe was only âŒ1.2âGyr old showcases the ability of JWST to study early stars through extreme lensing
Reaching for the stars -- JWST/NIRSpec spectroscopy of a lensed star candidate at
We present JWST/NIRSpec observations of a highly magnified star candidate at
a photometric redshift of , previously detected in
JWST/NIRCam imaging of the strong lensing (SL) cluster MACS J0647+7015
(). The spectroscopic observation allows us to precisely measure the
redshift of the host arc at , and the star's
spectrum displays clear Lyman- and Balmer-breaks commensurate with this
redshift. A fit to the spectrum suggests a B-type super-giant star of surface
temperature K with either a redder F-type
companion (K) or significant dust attenuation
() along the line of sight. We also investigate the possibility
that this object is a magnified young globular cluster rather than a single
star. We show that the spectrum is in principle consistent with a star cluster,
which could also accommodate the lack of flux variability between the two
epochs. However, the lack of a counter image and the strong upper limit on the
size of the object from lensing symmetry, pc, could indicate
that this scenario is somewhat less likely -- albeit not completely ruled out
by the current data. The presented spectrum seen at a time when the Universe
was only Gyr old showcases the ability of JWST to study early stars
through extreme lensing.Comment: Accepted for publication in MNRAS letters. v2 updated to match the
published versio
Reliability of Therapist Effects in Practice-Based Psychotherapy Research : A Guide for the Planning of Future Studies
This paper aims to provide researchers with practical information on sample sizes for accurate estimations of therapist effects (TEs). The investigations are based on an integrated sample of 48,648 patients treated by 1800 therapists. Multilevel modeling and resampling were used to realize varying sample size conditions to generate empirical estimates of TEs. Sample size tables, including varying sample size conditions, were constructed and study examples given. This study gives an insight into the potential size of the TE and provides researchers with a practical guide to aid the planning of future studies in this field
JWST reveals a possible galaxy merger in triply-lensed MACS0647JD
MACS0647JD is a triply-lensed galaxy originally discovered with
the Hubble Space Telescope. Here we report new JWST imaging, which clearly
resolves MACS0647JD as having two components that are either merging
galaxies or stellar complexes within a single galaxy. Both are very small, with
stellar masses and radii . The brighter
larger component "A" is intrinsically very blue (), likely due
to very recent star formation and no dust, and is spatially extended with an
effective radius . The smaller component "B" appears redder
(), likely because it is older () with mild dust
extinction (), and a smaller radius . We
identify galaxies with similar colors in a high-redshift simulation, finding
their star formation histories to be out of phase. With an estimated stellar
mass ratio of roughly 2:1 and physical projected separation ,
we may be witnessing a galaxy merger 400 million years after the Big Bang. We
also identify a candidate companion galaxy C away, likely
destined to merge with galaxies A and B. The combined light from galaxies A+B
is magnified by factors of 8, 5, and 2 in three lensed images JD1, 2, and
3 with F356W fluxes , , (AB mag 25.1, 25.6, 26.6).
MACS0647JD is significantly brighter than other galaxies recently discovered
at similar redshifts with JWST. Without magnification, it would have AB mag
27.3 (). With a high confidence level, we obtain a photometric
redshift of based on photometry measured in 6 NIRCam filters
spanning , out to rest-frame. JWST NIRSpec
observations planned for January 2023 will deliver a spectroscopic redshift and
a more detailed study of the physical properties of MACS0647JD.Comment: 27 pages, 14 figures, submitted to Natur
Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.
Esophageal adenocarcinoma (EAC) has a poor outcome, and targeted therapy trials have thus far been disappointing owing to a lack of robust stratification methods. Whole-genome sequencing (WGS) analysis of 129 cases demonstrated that this is a heterogeneous cancer dominated by copy number alterations with frequent large-scale rearrangements. Co-amplification of receptor tyrosine kinases (RTKs) and/or downstream mitogenic activation is almost ubiquitous; thus tailored combination RTK inhibitor (RTKi) therapy might be required, as we demonstrate in vitro. However, mutational signatures showed three distinct molecular subtypes with potential therapeutic relevance, which we verified in an independent cohort (n = 87): (i) enrichment for BRCA signature with prevalent defects in the homologous recombination pathway; (ii) dominant T>G mutational pattern associated with a high mutational load and neoantigen burden; and (iii) C>A/T mutational pattern with evidence of an aging imprint. These subtypes could be ascertained using a clinically applicable sequencing strategy (low coverage) as a basis for therapy selection.Whole-genome sequencing of esophageal adenocarcinoma samples was performed as part of the International Cancer Genome Consortium (ICGC) through the oEsophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium and was funded by Cancer Research UK. We thank the ICGC members for their input on verification standards as part of the benchmarking exercise. We thank the Human Research Tissue Bank, which is supported by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, from Addenbrookeâs Hospital and UCL. Also the University Hospital of Southampton Trust and the Southampton, Birmingham, Edinburgh and UCL Experimental Cancer Medicine Centres and the QEHB charities. This study was partly funded by a project grant from Cancer Research UK. R.C.F. is funded by an NIHR Professorship and receives core funding from the Medical Research Council and infrastructure support from the Biomedical Research Centre and the Experimental Cancer Medicine Centre. We acknowledge the support of The University of Cambridge, Cancer Research UK (C14303/A17197) and Hutchison Whampoa Limited. We would like to thank Dr. Peter Van Loo for providing the NGS version of ASCAT for copy number calling. We are grateful to all the patients who provided written consent for participation in this study and the staff at all participating centres.
Some of the work was undertaken at UCLH/UCL who received a proportion of funding from the Department of Healthâs NIHR Biomedical Research Centres funding scheme. The work at UCLH/UCL was also supported by the CRUK UCL Early Cancer Medicine Centre.This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/ng.365
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Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma
Abstract: The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning algorithm to identify cancer genes in individual patients considering all types of damaging alterations simultaneously. Analysing 261 EACs from the OCCAMS Consortium, we discover helper genes that, alongside well-known drivers, promote cancer. We confirm the robustness of our approach in 107 additional EACs. Unlike recurrent alterations of known drivers, these cancer helper genes are rare or patient-specific. However, they converge towards perturbations of well-known cancer processes. Recurrence of the same process perturbations, rather than individual genes, divides EACs into six clusters differing in their molecular and clinical features. Experimentally mimicking the alterations of predicted helper genes in cancer and pre-cancer cells validates their contribution to disease progression, while reverting their alterations reveals EAC acquired dependencies that can be exploited in therapy
Expert range maps of global mammal distributions harmonised to three taxonomic authorities
AimComprehensive, global information on species' occurrences is an essential biodiversity variable and central to a range of applications in ecology, evolution, biogeography and conservation. Expert range maps often represent a species' only available distributional information and play an increasing role in conservation assessments and macroecology. We provide global range maps for the native ranges of all extant mammal species harmonised to the taxonomy of the Mammal Diversity Database (MDD) mobilised from two sources, the Handbook of the Mammals of the World (HMW) and the Illustrated Checklist of the Mammals of the World (CMW).LocationGlobal.TaxonAll extant mammal species.MethodsRange maps were digitally interpreted, georeferenced, error-checked and subsequently taxonomically aligned between the HMW (6253 species), the CMW (6431 species) and the MDD taxonomies (6362 species).ResultsRange maps can be evaluated and visualised in an online map browser at Map of Life (mol.org) and accessed for individual or batch download for non-commercial use.Main conclusionExpert maps of species' global distributions are limited in their spatial detail and temporal specificity, but form a useful basis for broad-scale characterizations and model-based integration with other data. We provide georeferenced range maps for the native ranges of all extant mammal species as shapefiles, with species-level metadata and source information packaged together in geodatabase format. Across the three taxonomic sources our maps entail, there are 1784 taxonomic name differences compared to the maps currently available on the IUCN Red List website. The expert maps provided here are harmonised to the MDD taxonomic authority and linked to a community of online tools that will enable transparent future updates and version control
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