Final characterisation and design of the Gamma-ray Cherenkov Telescope (GCT) for the Cherenkov Telescope Array

The Gamma-ray Cherenkov Telescope (GCT) is one of the telescopes proposed for the Small Sized Telescope (SST) section of CTA. Based on a dual-mirror Schwarzschild-Couder design, which allows for more compact telescopes and cameras than the usual single-mirror designs, it will be equipped with a Compact High-Energy Camera (CHEC) based on silicon photomultipliers (SiPM). In 2015, the GCT prototype was the first dual-mirror telescope constructed in the prospect of CTA to record Cherenkov light on the night sky. Further tests and observations have been performed since then. This report describes the current status of the GCT, the results of tests performed to demonstrate its compliance with CTA requirements, and the optimisation of the design for mass production. The GCT collaboration, including teams from Australia, France, Germany, Japan, the Netherlands and the United Kingdom, plans to install the first telescopes on site in Chile for 2019-2020 as part of the CTA pre-production phase

The gamma-ray Cherenkov telescope for the Cherenkov telescope array

The Cherenkov Telescope Array (CTA) is a forthcoming ground-based observatory for very-high-energy gamma rays. CTA will consist of two arrays of imaging atmospheric Cherenkov telescopes in the Northern and Southern hemispheres, and will combine telescopes of different types to achieve unprecedented performance and energy coverage. The Gamma-ray Cherenkov Telescope (GCT) is one of the small-sized telescopes proposed for CTA to explore the energy range from a few TeV to hundreds of TeV with a field of view ≳ 8° and angular resolution of a few arcminutes. The GCT design features dual-mirror Schwarzschild-Couder optics and a compact camera based on densely-pixelated photodetectors as well as custom electronics. In this contribution we provide an overview of the GCT project with focus on prototype development and testing that is currently ongoing. We present results obtained during the first on-telescope campaign in late 2015 at the Observatoire de Paris-Meudon, during which we recorded the first Cherenkov images from atmospheric showers with the GCT multi-anode photomultiplier camera prototype. We also discuss the development of a second GCT camera prototype with silicon photomultipliers as photosensors, and plans toward a contribution to the realisation of CTA

The gamma-ray Cherenkov telescope for the Cherenkov telescope array

The Cherenkov Telescope Array (CTA) is a forthcoming ground-based observatory for very-high-energy gamma rays. CTA will consist of two arrays of imaging atmospheric Cherenkov telescopes in the Northern and Southern hemispheres, and will combine telescopes of different types to achieve unprecedented performance and energy coverage. The Gamma-ray Cherenkov Telescope (GCT) is one of the small-sized telescopes proposed for CTA to explore the energy range from a few TeV to hundreds of TeV with a field of view ≳ 8° and angular resolution of a few arcminutes. The GCT design features dual-mirror Schwarzschild-Couder optics and a compact camera based on densely-pixelated photodetectors as well as custom electronics. In this contribution we provide an overview of the GCT project with focus on prototype development and testing that is currently ongoing. We present results obtained during the first on-telescope campaign in late 2015 at the Observatoire de Paris-Meudon, during which we recorded the first Cherenkov images from atmospheric showers with the GCT multi-anode photomultiplier camera prototype. We also discuss the development of a second GCT camera prototype with silicon photomultipliers as photosensors, and plans toward a contribution to the realisation of CTA

The GCT camera for the Cherenkov Telescope Array

The Gamma Cherenkov Telescope (GCT) is one of the designs proposed for the Small Sized Telescope (SST) section of the Cherenkov Telescope Array (CTA). The GCT uses dual-mirror optics, resulting in a compact telescope with good image quality and a large field of view with a smaller, more economical, camera than is achievable with conventional single mirror solutions. The photon counting GCT camera is designed to record the flashes of atmospheric Cherenkov light from gamma and cosmic ray initiated cascades, which last only a few tens of nanoseconds. The GCT optics require that the camera detectors follow a convex surface with a radius of curvature of 1 m and a diameter of ~35 cm, which is approximated by tiling the focal plane with 32 modules. The first camera prototype is equipped with multi-anode photomultipliers, each comprising an 8×8 array of 6×6 mm 2 pixels to provide the required angular scale, adding up to 2048 pixels in total. Detector signals are shaped, amplified and digitised by electronics based on custom ASICs that provide digitisation at 1 GSample/s. The camera is self-triggering, retaining images where the focal plane light distribution matches predefined spatial and temporal criteria. The electronics are housed in the liquid-cooled, sealed camera enclosure. LED flashers at the corners of the focal plane provide a calibration source via reflection from the secondary mirror. The first GCT camera prototype underwent preliminary laboratory tests last year. In November 2015, the camera was installed on a prototype GCT telescope (SST-GATE) in Paris and was used to successfully record the first Cherenkov light of any CTA prototype, and the first Cherenkov light seen with such a dual-mirror optical system. A second full-camera prototype based on Silicon Photomultipliers is under construction. Up to 35 GCTs are envisaged for CTA

The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1--a meta-analysis of 15 prospective cohort studies. The International Perinatal HIV Group.

To evaluate the relation between elective cesarean section and vertical transmission of human immunodeficiency virus type 1 (HIV-1), we performed a meta-analysis using data on individual patients from 15 prospective cohort studies. North American and European studies of at least 100 mother-child pairs were included in the meta-analysis. Uniform definitions of modes of delivery were used. Elective cesarean sections were defined as those performed before onset of labor and rupture of membranes. Multivariate logistic-regression analysis was used to adjust for other factors known to be associated with vertical transmission. The primary analysis included data on 8533 mother-child pairs. After adjustment for receipt of antiretroviral therapy, maternal stage of disease, and infant birth weight, the likelihood of vertical transmission of HIV-1 was decreased by approximately 50 percent with elective cesarean section, as compared with other modes of delivery (adjusted odds ratio, 0.43; 95 percent confidence interval, 0.33 to 0.56). The results were similar when the study population was limited to those with rupture of membranes shortly before delivery. The likelihood of transmission was reduced by approximately 87 percent with both elective cesarean section and receipt of antiretroviral therapy during the prenatal, intrapartum, and neonatal periods, as compared with other modes of delivery and the absence of therapy (adjusted odds ratio, 0.13; 95 percent confidence interval, 0.09 to 0.19). Among mother-child pairs receiving antiretroviral therapy during the prenatal, intrapartum, and neonatal periods, rates of vertical transmission were 2.0 percent among the 196 mothers who underwent elective cesarean section and 7.3 percent among the 1255 mothers with other modes of delivery. The results of this meta-analysis suggest that elective cesarean section reduces the risk of transmission of HIV-1 from mother to child independently of the effects of treatment with zidovudine

Genetic studies of body mass index yield new insights for obesity biology

Note: A full list of authors and affiliations appears at the end of the article. Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p