Extracting W Boson Couplings from the e+e−e^{+}e^{-} Production of Four Leptons

We consider the processes $e^{+}e^{-}\rightarrow \ell^{+} \ell^{\prime -}\nu \bar{\nu}^{\prime}$, including all possible charged lepton combinations, with regard to measuring parameters characterizing the $W$ boson. We calculate at what level these processes can be used to measure anamolous triple-boson vertice coupling parameters for the cases of $e^{+}e^{-}$ colliders at 500 $GeV$ and 1 $TeV$ center of mass energies.Comment: 13 pages,OCIP/C-93-

SUSY Magnetic Moments Sum Rules and Supersymmetry Breaking

It was recently shown that unbroken N=1 Susy relates, in a model independent way, the magnetic transitions between states of different spin within a given charged massive supermultiplet. We verify explicitly these sum rules for a vector multiplet in the case of massless and massive fermions. The purpose of this analysis is to provide the ground for the broken susy case. We study the modifications of these results when an explicit soft Susy breaking realized through a universal mass for all scalars is present. As a by-product we provide a computation of the $g-2$ of the $W$ boson in the standard model which corrects previous evaluations in the literature.Comment: 16+5 pages, Latex,(feynman.tex to print the figures), DFPD 94/TH/2

Using Virtual Reality to Assess the Elderly: The Impact of Human-Computer Interfaces on Cognition

Prospective memory (PM) is defined be the capacity to remember to realize an intended action in the future. This is a very important cognitive function that permit to maximize autonomy in everyday life. Unfortunately, few assessment tool, valid, reliable and ecological is accessible for clinicians. To obtain a verisimilar and ecologically prospective memory assessment tool, virtual reality seems to be a promising way. A specific and sensible tool could help the clinician to detect subtle changes in the cognition of the elderly and, ideally detect pathological aging soon before the beginning of decline. Because older adults are not really at ease with technology, these (dis)abilities could be confounded with cognitive inefficacy and lead to false positives diagnostics. To avoid this, the psychometrician must consider the impact of human-computer interfaces (HMI) on cognition. This paper present three experiments that show the impact of HMI on stress, capacity to achieve a task and on cognitive load. The first pilot study shown that a “heavy to use” HMI generated stress and difficulty to achieve the task with healthy adults. The second pilot study revealed that VMT-2 is judged moderately challenging cognitively and it seems to be more for older participants. The third pilot study shown that a complex virtual environment (in terms of navigation and interaction) is more cognitively challenging than a simple virtual environment for older peoples compared to young participants. These results indicated the importance of considering HMI as a potential variable that could create bias in the cognitive measurement

Dominant Three-Body Decays of a Heavy Higgs and Top Quark

We calculate the dominant three body Higgs decays, $H \to W^+W^-(Z^0, \gamma)$ and $H \to t\overline{t}(Z^0,\gamma ,g)$, in the Standard Model. We find that the branching ratios of these decays are of the order of few percent for large Higgs masses. We comment on the behaviour of the partial decay width $\Gamma (H \to t\overline{b}W^-)$ below the $t\overline{t}$ threshold. Numerical results of the following three body top decays, $t \to W^+b(\gamma ,g,Z^0)$ and $t \to W^+bH$, are also given. We discuss the feasibility of observing these Higgs and top decays at future high energy colliders.Comment: 19 pages (13 Figs can be sent by request), TeX, MZ-TH/92-2

Emergent Electroweak Symmetry Breaking with Composite W, Z Bosons

We present a model of electroweak symmetry breaking in a warped extra dimension where electroweak symmetry is broken at the UV (or Planck) scale. An underlying conformal symmetry is broken at the IR (or TeV) scale generating masses for the electroweak gauge bosons without invoking a Higgs mechanism. By the AdS/CFT correspondence the W,Z bosons are identified as composite states of a strongly-coupled gauge theory, suggesting that electroweak symmetry breaking is an emergent phenomenon at the IR scale. The model satisfies electroweak precision tests with reasonable fits to the S and T parameter. In particular the T parameter is sufficiently suppressed since the model naturally admits a custodial SU(2) symmetry. The composite nature of the W,Z-bosons provide a novel possibility of unitarizing WW scattering via form factor suppression. Constraints from LEP and the Tevatron as well as discovery opportunities at the LHC are discussed for these composite electroweak gauge bosons.Comment: 39 pages, 4 figure

Virtual Effects of Split SUSY in Higgs Productions at Linear Colliders

In split supersymmetry the gauginos and higgsinos are the only supersymmetric particles possibly accessible at foreseeable colliders like the CERN Large Hadron Collider (LHC) and the International Linear Collider (ILC). In order to account for the cosmic dark matter measured by WMAP, these gauginos and higgsinos are stringently constrained and could be explored at the colliders through their direct productions and/or virtual effects in some processes. The clean environment and high luminosity of the ILC render the virtual effects of percent level meaningful in unraveling the new physics effects. In this work we assume split supersymmetry and calculate the virtual effects of the WMAP-allowed gauginos and higgsinos in Higgs productions e+e- -> Z h and e+e- -> \nu_e \bar_\nu_e h through WW fusion at the ILC. We find that the production cross section of e+e- -> Zh can be altered by a few percent in some part of the WMAP-allowed parameter space, while the correction to the WW-fusion process e+e- -> \nu_e \bar_\nu_e h is below 1%. Such virtual effects are correlated with the cross sections of chargino pair productions and can offer complementary information in probing split supersymmetry at the colliders.Comment: more discussions added (7 pages, 10 figs

FCNC Top Quark Decays in Extra Dimensions

The flavor changing neutral top quark decay t -> c X is computed, where X is a neutral standard model particle, in a extended model with a single extra dimension. The cases for the photon, X= \gamma$, and a Standard Model Higgs boson, X = H, are analyzed in detail in a non-linear$R_\xi gauge. We find that the branching ratios can be enhanced by the dynamics originated in the extra dimension. In the limit where 1/R >> ->, we have found Br(t -> c \gamma) \simeq 10^{-10} for 1/R = 0.5 TeV. For the decay t -> c H, we have found Br(t -> cH) \simeq 10^{-10} for a low Higgs mass value. The branching ratios go to zero when 1/R -> \infty.Comment: Accepted to be published in the Europ. Phys. Jour. C; 16 pages, 2 figure

Physics of leptoquarks in precision experiments and at particle colliders

We present a comprehensive review of physics effects generated by leptoquarks (LQs), i.e., hypothetical particles that can turn quarks into leptons and vice versa, of either scalar or vector nature. These considerations include discussion of possible completions of the Standard Model that contain LQ fields. The main focus of the review is on those LQ scenarios that are not problematic with regard to proton stability. We accordingly concentrate on the phenomenology of light leptoquarks that is relevant for precision experiments and particle colliders. Important constraints on LQ interactions with matter are derived from precision low-energy observables such as electric dipole moments, (g-2) of charged leptons, atomic parity violation, neutral meson mixing, Kaon, B, and D meson decays, etc. We provide a general analysis of indirect constraints on the strength of LQ interactions with the quarks and leptons to make statements that are as model independent as possible. We address complementary constraints that originate from electroweak precision measurements, top, and Higgs physics. The Higgs physics analysis we present covers not only the most recent but also expected results from the Large Hadron Collider (LHC). We finally discuss direct LQ searches. Current experimental situation is summarized and self-consistency of assumptions that go into existing accelerator-based searches is discussed. A progress in making next-to-leading order predictions for both pair and single LQ productions at colliders is also outlined.Comment: 136 pages, 22 figures, typographical errors fixed, the Physics Reports versio

Dynamic protein methylation in chromatin biology

Post-translational modification of chromatin is emerging as an increasingly important regulator of chromosomal processes. In particular, histone lysine and arginine methylation play important roles in regulating transcription, maintaining genomic integrity, and contributing to epigenetic memory. Recently, the use of new approaches to analyse histone methylation, the generation of genetic model systems, and the ability to interrogate genome wide histone modification profiles has aided in defining how histone methylation contributes to these processes. Here we focus on the recent advances in our understanding of the histone methylation system and examine how dynamic histone methylation contributes to normal cellular function in mammals

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Funding Information: GMP, PN, and CW are supported by NHLBI R01HL127564. GMP and PN are supported by R01HL142711. AG acknowledge support from the Wellcome Trust (201543/B/16/Z), European Union Seventh Framework Programme FP7/2007–2013 under grant agreement no. HEALTH-F2-2013–601456 (CVGenes@Target) & the TriPartite Immunometabolism Consortium [TrIC]-Novo Nordisk Foundation’s Grant number NNF15CC0018486. JMM is supported by American Diabetes Association Innovative and Clinical Translational Award 1–19-ICTS-068. SR was supported by the Academy of Finland Center of Excellence in Complex Disease Genetics (Grant No 312062), the Finnish Foundation for Cardiovascular Research, the Sigrid Juselius Foundation, and University of Helsinki HiLIFE Fellow and Grand Challenge grants. EW was supported by the Finnish innovation fund Sitra (EW) and Finska Läkaresällskapet. CNS was supported by American Heart Association Postdoctoral Fellowships 15POST24470131 and 17POST33650016. Charles N Rotimi is supported by Z01HG200362. Zhe Wang, Michael H Preuss, and Ruth JF Loos are supported by R01HL142302. NJT is a Wellcome Trust Investigator (202802/Z/16/Z), is the PI of the Avon Longitudinal Study of Parents and Children (MRC & WT 217065/Z/19/Z), is supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215–2001) and the MRC Integrative Epidemiology Unit (MC_UU_00011), and works within the CRUK Integrative Cancer Epidemiology Programme (C18281/A19169). Ruth E Mitchell is a member of the MRC Integrative Epidemiology Unit at the University of Bristol funded by the MRC (MC_UU_00011/1). Simon Haworth is supported by the UK National Institute for Health Research Academic Clinical Fellowship. Paul S. de Vries was supported by American Heart Association grant number 18CDA34110116. Julia Ramierz acknowledges support by the People Programme of the European Union’s Seventh Framework Programme grant n° 608765 and Marie Sklodowska-Curie grant n° 786833. Maria Sabater-Lleal is supported by a Miguel Servet contract from the ISCIII Spanish Health Institute (CP17/00142) and co-financed by the European Social Fund. Jian Yang is funded by the Westlake Education Foundation. Olga Giannakopoulou has received funding from the British Heart Foundation (BHF) (FS/14/66/3129). CHARGE Consortium cohorts were supported by R01HL105756. Study-specific acknowledgements are available in the Additional file : Supplementary Note. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services. Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe