Kyste Dermoïde Du Plancher Buccal

Le kyste dermoïde du plancher buccal est une entité rare. Il touche essentiellement le sujet jeune. Nous rapportons l\'observation d\'un nourrisson âgé de 9 mois qui a été amené par ses parents pour fistule sous mentale sans aucune gêne fonctionnelle associée. L\'examen clinique a révélé une voussure du plancher buccal antérieur. L\'IRM a montré une lésion kystique du plancher buccal en hyposignal T1 et hypersignal T2. L\'enfant a été opéré par voie endobuccale. Les suites opératoires étaient simples. L\'examen anatomopathologique a conclu à un kyste dermoïde. Nous discutons, dans ce travail, les caractéristiques cliniques, radiologiques et les volets thérapeutiques de cette entité. Keywords: kyste dermoïde, plancher buccal. Journal Tunisien d\'ORL et de chirurgie cervico-faciale Vol. 18 2007: pp. 58-6

Hypoglycemic and antihyperglycemic effects of Anabasis articulata (Forssk) Moq (Chenopodiaceae), an Algerian medicinal plant

Anabasis articulata leaves decoction is widely used by Algerian traditional medicine practitioners as a remedy for the treatment of diabetes. The aqueous extract was found to be non-toxic at 1000 mg/kg, asno deaths or hazardous signs were recorded during treatment or the observation period (24 and 72 h) in either control or treated groups of mice. Experiments were performed in non-diabetic mice, and inhyperglycemic mice (glucose treated and alloxan treated mice) to confirm the antidiabetic potential of A. articulata. Our results showed that the orally administration at a dose of 400 mg/kg decreased the glycaemia by 29.89% after 6 h (p < 0.05), corresponding to the greatest decrease of blood glucose in normoglycaemic mice. This dose also lowered blood glucose concentrations in diabetic mice revealing antihyperglycemic effect of A. articulata leaves. The class of phytochemical responsible for antidiabetic effects in aqueous leaf extract was also investigated. Phytochemical screening showed that the aqueous extract contains alkaloids (1.25%) and saponin (1.30%). Our findings showed that saponin (5 mg/Kg) was the active fraction, since it restores the normal blood glucose levels after 21 days of treatment. The alkaloid fraction did not significantly reduce the blood glucose level. The present studyconfirms the antidiabetic proprieties of A. articulata leaves previously reported by Algerian healers

Formes histologiques particulieres du cancer du nasopharynx

Le carcinome épidermoïde du nasopharynx est la forme histopathologique la plus fréquente. Cependant, d'autres formeshistologiques, bien qu’exceptionnelles peuvent se voir. Le but de notre travail est d'étudier le profil thérapeutique et évolutif de ces entités. Nous rapportons trois observations particulières de cancer du cavum. Il s'agissait de 3 patientes âgées respectivement de 15, 36 et 33 ans. La première patiente, atteinte d'un mélanome malin du cavum (T2aN2Mo) (UICCC 97), a bénéficié d'un évidement ganglionnaire cervical radical droit suivi d'une chimiothérapie. La patiente est décédée un mois et demi plus tard. La deuxième patiente, atteinte d'un carcinome mucoépidermoïde du cavum (T4NoMo) (UICCC 97) a bénéficié d'uneradio-chimiothérapie concomitante avec rémission complète à 17 mois de recul. La troisième patiente, présente un carcinome adénoïde kystique du cavum (T2bNoMo) (UICCC 97), a bénéficié d'une exérèse tumorale large avec évidement ganglionnaire cervical homolatéral suivie d'une radiothérapie post opératoire. Elle a présenté des métastases pulmonaires 12 mois après, traitées par chimiothérapie avec une réponse partielle. Actuellement, elle est à 18 mois de recul après la chimiothérapie. Ces formes histopathologiques du cancer du cavum sont exceptionnelles (< 1 % des tumeurs malignes du cavum). Il n'existe aucune particularité clinique ou radiologique et le diagnostic reste histopathologique. Ces tumeurs posent un problème de prise en charge puisqu’il n’existe pas de traitement codifié pour ces formes rares. Le pronostic dépend du stade de la maladie et du type histologique.Mots clés : nasopharynx, cancer, mélanome, carcinome mucoépidermoïde, carcinome adénoïde kystique, chirurgie, radiothérapie, chimiothérapie

International cohort study for pediatric Behçet’s Disease: update 2011

PubMe

Position Paper on Young Vascular Surgeons Training of the Mediterranean Federation for the Advancing of Vascular Surgery (MeFAVS):State of the Art and Perspectives

The Mediterranean Federation for the Advancing of Vascular Surgery (MeFAVS) was founded in 2018, with the aim to promote cooperation among vascular professionals within Mediterranean countries. Due to its prominent social and economic impact on national health systems, diabetic peripheral artery was selected as the very first topic to be investigated by the federation. In this second paper, different experiences from delegates of participating countries were shared to define common strategies to harmonize, standardize, and optimize education and training in the Vascular Surgery specialty

Zn treatment effects on biological potential of fennel bulbs as affected by in vitro digestion process

Zn treatment effects on the stability of polyphenols, MDA (malondialdehyde) content, antioxidant and lipoxygenase inhibition activities of two varieties of fennel bulbs were studied by using an in vitro gastrointestinal digestion model. Likewise, the effect of Zn on viability cells of E. coli was also performed. The results revealed that high amounts of total phenolic and flavonoid compounds were released during the digestion process, especially after the intestinal phase. Additionally, the antioxidant and lipoxygenase inhibitory activity were affected by the gastrointestinal digestion process and seems to be correlated with total phenol contents. On the other hand, the viability of E. coli was not affected by the activity of our tested bulbs during passage through the artificial digestion model, but the treated bulbs activity contribute relatively to the inhibition growth of bacteria. The survival of E. coli in fennel bulbs was challenged with simulated gastrointestinal fluids and the results showed that the E. coli strains, despite having experienced a viability reduction at the intestinal phase, were able to overcome the exposure to the gastrointestinal synthetic fluids. This E. coli ability reinforces the need for good hygienic measures to assure safe fresh produce, even for those that are rich in antibacterial compounds.info:eu-repo/semantics/publishedVersio

A Common and Unstable Copy Number Variant Is Associated with Differences in Glo1 Expression and Anxiety-Like Behavior

Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby identified a ∼475 kb tandem duplication on chromosome 17 that includes Glo1 (30,174,390–30,651,226 Mb; mouse genome build 36). We developed a PCR-based strategy and used it to detect this duplication in 23 of 71 inbred strains tested, and in various outbred and wild-caught mice. Presence of the duplication is associated with a cis-acting expression QTL for Glo1 (LOD>30) in BXD recombinant inbred strains. However, evidence for an eQTL for Glo1 was not obtained when we analyzed single SNPs or 3-SNP haplotypes in a panel of 27 inbred strains. We conclude that association analysis in the inbred strain panel failed to detect an eQTL because the duplication was present on multiple highly divergent haplotypes. Furthermore, we suggest that non-allelic homologous recombination has led to multiple reversions to the non-duplicated state among inbred strains. We show associations between multiple duplication-containing haplotypes, Glo1 expression and anxiety-like behavior in both inbred strain panels and outbred CD-1 mice. Our findings provide a molecular basis for differential expression of Glo1 and further implicate Glo1 in anxiety-like behavior. More broadly, these results identify problems with commonly employed tests for association in inbred strains when CNVs are present. Finally, these data provide an example of biologically significant phenotypic variability in model organisms that can be attributed to CNVs

Effect of in vitro gastrointestinal digestion on the total phenolic contents and antioxidant activity of wild Mediterranean edible plant extracts

The recent interest in wild edible plants is associated with their health benefits, which are mainly due to their richness in antioxidant compounds, particularly phenolics. Nevertheless, some of these compounds are metabolized after ingestion, being transformed into metabolites frequently with lower antioxidant activity. The aim of the present study was to evaluate the influence of the digestive process on the total phenolic contents and antioxidant activity of extracts from four wild edible plants used in the Mediterranean diet (Beta maritima L., Plantago major L., Oxalis pes-caprae L. and Scolymus hispanicus L.). HPLC-DAD analysis revealed that S. hispanicus is characterized by the presence of caffeoylquinic acids, dicaffeoylquinic acids and flavonol derivatives, P. major by high amounts of verbascoside, B. maritima possesses 2,4-dihydroxybenzoic acid, 5-O-caffeoylquinic acid, quercetin derivatives and kaempferol-3-O-rutinoside, and O. pes-caprae extract contains hydroxycinnamic acids and flavone derivatives. Total phenolic contents were determined by Folin-Ciocalteu assay, and antioxidant activity by the ABTS, DPPH, ORAC and FRAP assays. Phenolic contents of P. major and S. hispanicus extracts were not affected by digestion, but they significantly decreased in B. maritima after both phases of digestion process and in O. pes-caprae after the gastric phase. The antioxidant activity results varied with the extract and the method used to evaluate the activity. Results showed that P. major extract has the highest total phenolic contents and antioxidant activity, with considerable values even after digestion, reinforcing the health benefits of this species.European Union (FEDER funds through COMPETE)European Union (EU)European Union (FEDER)European Union (EU)Programa de Cooperacion Interreg V-A Espana - Portugal (POCTEP) 2014-2020 [0377_IBERPHENOL_6_E]project INTERREG - MD. Net: When Brand Meets PeopleFCT Portuguese Foundation for Science and Technolog

INFOGEST static in vitro simulation of gastrointestinal food digestion

peer-reviewedSupplementary information is available at http://dx.doi.org/10.1038/s41596-018-0119-1 or https://www.nature.com/articles/s41596-018-0119-1#Sec45.Developing a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on an international consensus developed by the COST INFOGEST network. The method is designed to be used with standard laboratory equipment and requires limited experience to encourage a wide range of researchers to adopt it. It is a static digestion method that uses constant ratios of meal to digestive fluids and a constant pH for each step of digestion. This makes the method simple to use but not suitable for simulating digestion kinetics. Using this method, food samples are subjected to sequential oral, gastric and intestinal digestion while parameters such as electrolytes, enzymes, bile, dilution, pH and time of digestion are based on available physiological data. This amended and improved digestion method (INFOGEST 2.0) avoids challenges associated with the original method, such as the inclusion of the oral phase and the use of gastric lipase. The method can be used to assess the endpoints resulting from digestion of foods by analyzing the digestion products (e.g., peptides/amino acids, fatty acids, simple sugars) and evaluating the release of micronutrients from the food matrix. The whole protocol can be completed in ~7 d, including ~5 d required for the determination of enzyme activities.COST action FA1005 INFOGEST (http://www.cost-infogest.eu/ ) is acknowledged for providing funding for travel, meetings and conferences (2011-2015). The French National Institute for Agricultural Research (INRA, www.inra.fr) is acknowledged for their continuous support of the INFOGEST network by organising and co-funding the International Conference on Food Digestion and workgroup meeting

Neural protection by naturopathic compounds—an example of tetramethylpyrazine from retina to brain

Given the advantages of being stable in the ambient environment, being permeable to the blood–brain and/or blood–eye barriers and being convenient for administration, naturopathic compounds have growingly become promising therapeutic candidates for neural protection. Extracted from one of the most common Chinese herbal medicines, tetramethylpyrazine (TMP), also designated as ligustrazine, has been suggested to be neuroprotective in the central nervous system as well as the peripheral nerve network. Although the detailed molecular mechanisms of its efficacy for neural protection are understood limitedly, accumulating evidence suggests that antioxidative stress, antagonism for calcium, and suppression of pro-inflammatory factors contribute significantly to its neuroprotection. In animal studies, systemic administration of TMP (subcutaneous injection, 50 mg/kg) significantly blocked neuronal degeneration in hippocampus as well as the other vulnerable regions in brains of Sprague–Dawley rats following kainate-induced prolonged seizures. Results from us and others also demonstrated potent neuroprotective efficacy of TMP for retinal cells and robust benefits for brain in Alzheimer’s disease or other brain injury. These results suggest a promising prospect for TMP to be used as a treatment of specific neurodegenerative diseases. Given the assessment of the distribution, metabolism, excretion, and toxicity information that is already available on most neuroprotective naturopathic compounds such as TMP, it would not take much preclinical data to justify bringing such therapeutic compounds to clinical trials in humans