Occurrence of a Likely Tuff Bed between the Middle and Upper Siwaliks, Taunsa area, Dera Ghazi Khan, Eastern Sulaiman Range, Pakistan

A likely tuff bed lies along the gradational contact of the Middle and Upper Siwaliks in eastern Sulaiman Range, Taunsa area of Dera Ghazi Khan district, Pakistan. This tuffaceous unit is 0.5–3 m thick and extends for 10 km along the north-south strike in the eastern limb of the Zindapir anticline. It is greyish white to white on fresh surface, fine-grained to silty at the bottom and clayey at the top and thus shows a fining upward grain-size grading. The lower part of the ash bed shows a prominent lamination defined by megascopically visible abundant biotite, while the central and upper parts are so fine-grained that the individual minerals cannot be seen in hand sample. Unlike the lower well-laminated part, the central and upper parts are crudely laminated to apparently massive. The bulk samples analysed with X-ray diffraction consist of quartz, feldspar (plagioclase), biotite, clays, calcite and some ore mineral likely spinel, while the clay-size fractions contain illite, chlorite, biotite and probably their mixed-layered varieties. The colour, texture, presence of abundant biotite and stratigraphic position of the Taunsa tuff correlate with those reported from Potwar plateau and from Kashmir basin. However, the apparent absence of smectite from the XRD pattern makes the Taunsa ash bed different from both Potwar and Kashmir tuffs. The present stratigraphic position of the tuff bed corresponds to shallow diagenetic zone, while the absence of smectite in the tuff and crystallinity of illite suggest that the tuff is probably derived upon reworking from a deeper diagenetic zone belonging to a lower stratigraphic level. The Eocene or other older pre-Siwalik units in Pakistan may have or had some primary ashfall deposits as reported in the northwestern Himalayas of India. This older volcanic ash may have been reworked to its present site of occurrence along the gradational contact of the Middle and the Upper Siwaliks in Taunsa area of Dera Ghazi Khan. However, the primary source of the Taunsa tuff may belong more likely to Chagai arc in Pakistan than to Dacht-e-Nawar volcanic complex in Afghanistan

Occurrence of a Likely Tuff Bed between the Middle and Upper Siwaliks, Taunsa area, Dera Ghazi Khan, Eastern Sulaiman Range, Pakistan: Occurrence of a Likely Tuff Bed between the Middle and Upper Siwaliks, Taunsa area, Dera Ghazi Khan, Eastern Sulaiman Range, Pakistan

A likely tuff bed lies along the gradational contact of the Middle and Upper Siwaliks in eastern Sulaiman Range, Taunsa area of Dera Ghazi Khan district, Pakistan. This tuffaceous unit is 0.5–3 m thick and extends for 10 km along the north-south strike in the eastern limb of the Zindapir anticline. It is greyish white to white on fresh surface, fine-grained to silty at the bottom and clayey at the top and thus shows a fining upward grain-size grading. The lower part of the ash bed shows a prominent lamination defined by megascopically visible abundant biotite, while the central and upper parts are so fine-grained that the individual minerals cannot be seen in hand sample. Unlike the lower well-laminated part, the central and upper parts are crudely laminated to apparently massive. The bulk samples analysed with X-ray diffraction consist of quartz, feldspar (plagioclase), biotite, clays, calcite and some ore mineral likely spinel, while the clay-size fractions contain illite, chlorite, biotite and probably their mixed-layered varieties. The colour, texture, presence of abundant biotite and stratigraphic position of the Taunsa tuff correlate with those reported from Potwar plateau and from Kashmir basin. However, the apparent absence of smectite from the XRD pattern makes the Taunsa ash bed different from both Potwar and Kashmir tuffs. The present stratigraphic position of the tuff bed corresponds to shallow diagenetic zone, while the absence of smectite in the tuff and crystallinity of illite suggest that the tuff is probably derived upon reworking from a deeper diagenetic zone belonging to a lower stratigraphic level. The Eocene or other older pre-Siwalik units in Pakistan may have or had some primary ashfall deposits as reported in the northwestern Himalayas of India. This older volcanic ash may have been reworked to its present site of occurrence along the gradational contact of the Middle and the Upper Siwaliks in Taunsa area of Dera Ghazi Khan. However, the primary source of the Taunsa tuff may belong more likely to Chagai arc in Pakistan than to Dacht-e-Nawar volcanic complex in Afghanistan

Developing better digital health measures of Parkinson's disease using free living data and a crowdsourced data analysis challenge.

One of the promising opportunities of digital health is its potential to lead to more holistic understandings of diseases by interacting with the daily life of patients and through the collection of large amounts of real-world data. Validating and benchmarking indicators of disease severity in the home setting is difficult, however, given the large number of confounders present in the real world and the challenges in collecting ground truth data in the home. Here we leverage two datasets collected from patients with Parkinson's disease, which couples continuous wrist-worn accelerometer data with frequent symptom reports in the home setting, to develop digital biomarkers of symptom severity. Using these data, we performed a public benchmarking challenge in which participants were asked to build measures of severity across 3 symptoms (on/off medication, dyskinesia, and tremor). 42 teams participated and performance was improved over baseline models for each subchallenge. Additional ensemble modeling across submissions further improved performance, and the top models validated in a subset of patients whose symptoms were observed and rated by trained clinicians