Post-global and Post-digital Children’s Literature: Some Users’ Legitimation Strategies on the Net

Our starting point is the hypothesis that we live in a post-digital and post-global era, even a post-data one. In this current time, our objects of study have become transmedial and the different media versions of a product cannot be separated one from the other, but rather should be taken as one single object. These transmedial cultural objects are subject to readings, discussions, and appropriation in social networks, which exist in a “permanent now”, ephemeral by its very nature. In this context, we ask ourselves what the role and the function of the literary is. In a moment when online users claim ownership of the product, what value and position do they give to the literary? We intend to search for testimonies in social networks for three products of children’s literature: "My Little Pony", "Caillou" and "Manolito Gafotas", in order to observe what is being said in social networks about them. Working with "Goodreads", "Babelio", "Reddit" and "Tumblr" that function as platforms for reviews and fan expression, we will carry out an analysis of our corpus by means of some digital tools. Our goal is to show how literature still acts as a legitimizing instance and how networks function as a vector for globalization/localisation in the current post-digital, post-global and transmedial context

Caminando hacia un modelo de ACP

La Atención Centrada en la Persona (ACP) es un enfoque de atención gerontológica alternativo al modelo tradicional que se ha venido desarrollando hasta ahora en el ámbito internacional, con un incipiente interés en nuestro sector sociosanitario, en los diferentes recursos para personas dependientes: servicios comunitarios, centros de día y residencias. La idea de este proyecto de intervención es fomentar un cambio de modelo de atención, de un Modelo de Atención centrado en el Servicio a un Modelo de Atención Gerontológico Centrada en la Persona en un Centro de Estancias Diurnas para Personas Mayores, en este caso, en el Centro de Día de Fraga (Huesca). Este modelo de intervención no es algo que se implanta y se termina, sino que es UN CAMINO a seguir, una MANERA DE TRABAJAR, con creatividad y flexibilidad

The angiotensin-(1-7)/Mas receptor a xis protects from endothelial cell senescence via klotho and Nrf2 activation

Endothelial cell senescence is a hallmark of va scular aging that pre disposes to vascular disease. We aimed to explore the capacity of the renin-angiotensin system (RAS) heptapeptide angiotensin (Ang)-(1-7) to counteract human endothelial cell senescence and to identify intracellular pathways mediati ng its potential protective action. In human umbilical vein endothelial cell (HUVEC) cult ures, Ang II promoted cell senescence, as revealed by the enhancement in se nescence-associated galactosidase (SA- -gal+) positive staining, total and telomeric DNA damage, adhesion molecules expression and human mononuclear adhesion to HUVEC monolaye rs. By activating the G-coupled receptor Mas, Ang-(1-7) inhibit ed the pro-senescence action of Ang II, but also of a non- RAS stressor such as the cytokine IL-1 . Moreover, Ang-(1-7) enhanced endothelial klotho levels, while klotho silencing resulted in th e loss of the anti-senescence action of the heptapeptide. Indeed, both Ang-(1-7) and recombinant klotho activated the cytoprotective Nrf2/heme-oxygenase-1 (HO)-1 pathway. The HO-1 inhibitor tin protoporphyrin IX prevented the anti-senescence action evoked by Ang-(1-7) or recombinant klotho. Overall, the present study ide ntifies Ang-(1-7) as an anti-senescence peptide displaying its protectiv e action beyond the RAS by consecutively activating klotho and Nrf2/HO-1. Ang-(1-7) mimetic dru gs may thus prove useful to prevent endothelial cell senescence and its re lated vascular complications

Reconfiguration Algorithm to Reduce Power Losses in Offshore HVDC Transmission Lines

The race to increase the efficiency and reduce the power losses in transmission systems has resulted in the substantial growth of high-voltage direct current (HVDC) transmission systems. Moreover, the interconnection of these transmission systems significantly increases their reliability. However, the control of these meshed grids is a key problem that usually is managed through the control of the VSCs in those grids, but the control of the VSC can be complemented with a reconfiguration algorithm. This paper proposes the use of the particle swarm optimization algorithm, in order to reconfigure meshed HVDC transmission systems and reduce losses. The proposed algorithm has been tested in the CIGRE benchmark grid, which comprises of several offshore wind farms that generate energy sent to the grid through several HVDC transmission lines. The results show that as the energy generation changes due to wind changes, the grid topology must be reconfigured in order to achieve the maximum efficiency. Doing this reconfiguration, power savings around 18–19% could be achieve

The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population: The MCC-Spain Study

INTRODUCTION: The evidence on the relationship between breast cancer and different types of antihypertensive drugs taken for at least 5 years is limited and inconsistent. Furthermore, the debate has recently been fueled again with new data reporting an increased risk of breast cancer among women with a long history of use of antihypertensive drugs compared with nonusers. METHODS: In this case-control study, we report the antihypertensive drugs-breast cancer relationship in 1,736 breast cancer cases and 1,895 healthy controls; results are reported stratifying by the women's characteristics (i.e., menopausal status or body mass index category) tumor characteristics and length of use of antihypertensive drugs. RESULTS: The relationship among breast cancer and use of calcium channel blockers (CCB) for 5 or more years had odds ratio (OR) = 1.77 (95% CI, 0.99 to 3.17). Stratifying by BMI, the OR increased significantly in the group with BMI ≥ 25 (OR 2.54, 95% CI, 1.24 to 5.22). CCBs were even more strongly associated with more aggressive tumors, (OR for invasive tumors = 1.96, 95% CI = 1.09 to 3.53; OR for non ductal cancers = 3.97, 95% CI = 1.73 to 9.05; OR for Erbb2+ cancer = 2.97, 95% CI: 1.20 to 7.32). On the other hand, premenopausal women were the only group in which angiotensin II receptor blockers may be associated with breast cancer (OR = 4.27, 95% CI = 1.32 to 13.84) but this could not be identified with any type or stage. Use of angiotensin-converting-enzyme inhibitors, beta blockers and diuretics were not associated with risk. CONCLUSIONS: In this large population-based study we found that long term use of calcium channel blockers is associated with some subtypes of breast cancer (and with breast cancer in overweight women)

Radon (222Rn) outgassing in San Juan volcanic tubes during the Cumbre Vieja eruption 2021, and preliminary values in the newly volcanic tubes.

During the eruption at Cumbre Vieja ridge (La Palma, Canary Islands, 2021) a radon (222Rn) detector (CORENTIUM Pro alpha particles counter) was emplaced inside the Las Palomas lava tube (San Juan eruption, 1949). In addition, a CO2 meter logger was emplaced to determine relationships between the 2021 eruption and radon plus CO2 inner fluxes. There is a geostructural relationship between the 1949 and 2021 eruptions, probably connected by a previous fault, shown the volcanic vents¿ alignment trending NW-SE. In October 2021, the radon and CO2 loggers were moved to the upper part of the lava tube, in the San Juan volcanic vent (Llano del Banco hollow dyke). Once the eruption ended (in early 2022) both loggers were placed in one newly formed lava tube, and data will be collected in February 2023. Preliminary results show daily average radon values ranging between 2 - 9 Bq/m3, although sporadic peaks of about 270 and 650 Bq/m3 were recorded related to volcano-tectonic earthquakes and volcanic intensity. In general, basaltic eruptions of alkaline affinity show low radon values due to the low concentration in the magma body of uranium and related chemical elements (Th, Ra, etc.). Geochemical analysis of emitted lavas shows a U concentration of about 1 to 5 ppm (g/g) and Th 9.5 ppm. Summer values of Rn increased up to 3 KBq/m3, related to the climate conditions instead of volcanic activity

The NLRP3 inhibitor Dapansutrile improves the therapeutic action of lonafarnib on progeroid mice

The role of the inflammasomes in aging and progeroid syndromes remain understud-ied. Recently, MCC950, a NLRP3 inhibitor, was used in Zmpste24−/− mice to amelio-rate the phenotypes. However, the safety of MCC950 was questioned due to livertoxicity observed in humans. Nevertheless, inhibition of the inflammasomes wouldbe a beneficial therapy for progeria. Here, we show that OLT1177 (dapansutrile),other NLRP3 inhibitor, improved cellular and animal phenotypes using progeroid fi-broblasts and a Lmna G609G/G609G mouse model. In both cases dapansutrile reducedprogerin accumulation, NLRP3-inflammasome activation and secretory phenotype ofsenescence, extended the lifespan of progeroid animals, preserved bodyweight, andreduced kyphosis, inflammation, and senescence. Interestingly, dapansutrile furtherimproved the effect of lonafarnib, the only FDA-approved drug for the progeria. Thecombination of both drugs reduced the inflammation and senescence, extended sur-vival and ameliorated various progeroid defects both in vitro and in vivo, comparedwith treatment using lonafarnib alone. These findings and the safety of dapansutriledemonstrated in several clinical trials proposes it as a possible co-adjuvant treatmentwith lonafarnid in HGP

Risk model for prostate cancer using environmental and genetic factors in the spanish multi-case-control (MCC) study

Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. 818 PCa cases and 1,006 healthy controls were compared. Subjects were interviewed on major lifestyle factors and family history. Fifty-six PCa susceptibility SNPs were genotyped. Risk models based on logistic regression were developed to combine environmental factors, family history and a genetic risk score. In the whole model, compared with subjects with low risk (reference category, decile 1), those carrying an intermediate risk (decile 5) had a 265% increase in PCa risk (OR = 3.65, 95% CI 2.26 to 5.91). The genetic risk score had an area under the ROC curve (AUROC) of 0.66 (95% CI 0.63 to 0.68). When adding the environmental score and family history to the genetic risk score, the AUROC increased by 0.05, reaching 0.71 (95% CI 0.69 to 0.74). Genetic susceptibility has a stronger risk value of the prediction that modifiable risk factors. While the added value of each SNP is small, the combination of 56 SNPs adds to the predictive ability of the risk model

Business and professional ethics as a transversal capacity in undergraduate studies: multidisciplinary application through e-learning resources for the gamification of teaching and learning based on serious games

[EN] The current economic and social scenarios and the appearance of various institutional initiatives such as the Sustainable Development Goals, make it necessary to adapt the current curricula by incorporating the analysis and study of aspects related to business and professional ethics. This project aims to reinforce the current efforts of the University of Zaragoza, providing a comprehensive and multidisciplinary approach to the teaching of this subject as a new transversal capacity. To this end, a set of activities related to business ethics throughout different curricula has been planned, thus complementing the isolated and optional vision that is currently being offered. In total, it is expected to reach more than 995 students from 6 degrees and 4 centers, taking advantage of e-learning methodologies and tools for the gamification of the learning process. The newly created project aims to be a starting point and aspires to make more and more teachers aware of the importance of analyzing the ethical perspective in their areas of knowledge, as a valuable transversal capacity with which to skill students.[ES] Los actuales escenarios económicos y sociales y la aparición de diversas iniciativas institucionales como los Objetivos de Desarrollo Sostenible, hacen necesario adaptar los actuales planes de estudio incorporando el análisis y el estudio de aspectos relacionados con la ética empresarial y profesional. Este proyecto pretende reforzar los esfuerzos actuales de la Universidad de Zaragoza, dotando de un enfoque integral y multidisciplinar a la enseñanza de este asunto como una nueva capacidad transversal. Para ello, se han diseñado un conjunto de actividades relacionadas con la ética empresarial a lo largo de diferentes planes de estudios, complementando así la visión aislada y optativa que se está ofreciendo en este momento. En total se prevé llegar a más de 995 alumnos de 6 titulaciones y 4 centros, aprovechando a su vez metodologías y herramientas de e-learning para la gamificación del proceso de aprendizaje. El proyecto, de nueva creación, pretende ser un punto de partida y aspira a conseguir que cada vez más profesores sean conscientes de la importancia de analizar la perspectiva ética en sus áreas de conocimiento, como capacidad transversal valiosa con la que dotar al estudiantado.Llera, E.; Valero, J.; Aranda-Usón, A.; Garrido, A.; Gutiérrez, J.; Llena Macarulla, F.; Marco-Fondevila, M.... (2022). La ética empresarial y profesional como capacidad transversal en los estudios de Grado: aplicación multidisciplinar a través de recursos e-learning para la gamificación de la enseñanza y el aprendizaje basado en serious games. Editorial Universitat Politècnica de València. 547-556. https://doi.org/10.4995/INRED2022.2022.1584254755