Exact buckling analysis of composite elastic columns including multiple delamination and transverse shear

The exact analytical solution of buckling in beams with multiple delaminations is presented. In order to investigate analytically the influence of axial and shear strains on buckling loads, the geometrically exact beam theory is employed with no simplification of the governing equations. The critical forces are then obtained by the linearized stability theory. The parametric studies are designed so that they give us fundamental understanding of the effects of the delamination number, length and position on the buckling load. The effect of shear is found to be of substantial importance. (c) 2007 Elsevier Ltd. All rights reserved

Analytical solution for buckling of asymmetrically delaminated Reissner's elastic columns including transverse shear

The exact analytical solution of buckling in delaminated columns is presented. In order to investigate analytically the influence of axial and shear strains on buckling loads the geometrically exact beam theory is employed with no simplification of the governing equations. The critical forces are then obtained by the linearized stability theory. In the paper, we limit the studies to linear elastic columns with a single delamination, but with arbitrary longitudinal and vertical asymmetry of delamination and arbitrary boundary conditions. The studies of quantitative and qualitative influence of transverse shear are shown in detail and extensive results for buckling loads with respect to delamination length, thickness and longitudinal position are presented. (c) 2007 Elsevier Ltd. All rights reserved

Assessment of the proportion of neonates and children in low and middle income countries with access to a healthcare facility: A systematic review

<p>Abstract</p> <p>Background</p> <p>Comprehensive antenatal, perinatal and early postnatal care has the potential to significantly reduce the 3.58 million neonatal deaths that occur annually worldwide. This paper systematically reviews data on the proportion of neonates and children < 5 years of age that have access to health facilities in low and middle income countries. Gaps in available data by WHO region are identified, and an agenda for future research and advocacy is proposed.</p> <p>Methods</p> <p>For this paper, "utilization" was used as a proxy for "access" to a healthcare facility, and the term "facility" was used for any clinic or hospital outside of a person's home staffed by a "medical professional". A systematic literature search was conducted for published studies of children up to 5 years of age that included the neonatal age group with an illness or illness symptoms in which health facility utilization was quantified. In addition, information from available Demographic and Health Surveys (DHS) was extracted.</p> <p>Results</p> <p>The initial broad search yielded 2,239 articles, of which 14 presented relevant data. From the community-based neonatal studies conducted in the Southeast Asia region with the goal of enhancing care-seeking for neonates with sepsis, the 10-48% of sick neonates in the studies' control arms utilized a healthcare facility. Data from cross-sectional surveys involving young children indicate that 12 to 86% utilizing healthcare facilities when sick. From the DHS surveys, a global median of 58.1% of infants < 6 months were taken to a facility for symptoms of ARI.</p> <p>Conclusions</p> <p>There is a scarcity of data regarding the access to facility-based care for sick neonates/young children in many areas of the world; it was not possible to generalize an overall number of neonates or young children that utilize a healthcare facility when showing signs and symptoms of illness. The estimate ranges were broad, and there was a paucity of data from some regions. It is imperative that researchers, advocates, and policy makers join together to better understand the factors affecting health care utilization/access for newborns in different settings and what the barriers are that prevent children from being taken to a facility in a timely manner.</p

Cold atoms in space: community workshop summary and proposed road-map

We summarise the discussions at a virtual Community Workshop on Cold Atoms in Space concerning the status of cold atom technologies, the prospective scientific and societal opportunities offered by their deployment in space, and the developments needed before cold atoms could be operated in space. The cold atom technologies discussed include atomic clocks, quantum gravimeters and accelerometers, and atom interferometers. Prospective applications include metrology, geodesy and measurement of terrestrial mass change due to, e.g., climate change, and fundamental science experiments such as tests of the equivalence principle, searches for dark matter, measurements of gravitational waves and tests of quantum mechanics. We review the current status of cold atom technologies and outline the requirements for their space qualification, including the development paths and the corresponding technical milestones, and identifying possible pathfinder missions to pave the way for missions to exploit the full potential of cold atoms in space. Finally, we present a first draft of a possible road-map for achieving these goals, that we propose for discussion by the interested cold atom, Earth Observation, fundamental physics and other prospective scientific user communities, together with the European Space Agency (ESA) and national space and research funding agencies.publishedVersio

Cold atoms in space: community workshop summary and proposed road-map

We summarise the discussions at a virtual Community Workshop on Cold Atoms in Space concerning the status of cold atom technologies, the prospective scientific and societal opportunities offered by their deployment in space, and the developments needed before cold atoms could be operated in space. The cold atom technologies discussed include atomic clocks, quantum gravimeters and accelerometers, and atom interferometers. Prospective applications include metrology, geodesy and measurement of terrestrial mass change due to, e.g., climate change, and fundamental science experiments such as tests of the equivalence principle, searches for dark matter, measurements of gravitational waves and tests of quantum mechanics. We review the current status of cold atom technologies and outline the requirements for their space qualification, including the development paths and the corresponding technical milestones, and identifying possible pathfinder missions to pave the way for missions to exploit the full potential of cold atoms in space. Finally, we present a first draft of a possible road-map for achieving these goals, that we propose for discussion by the interested cold atom, Earth Observation, fundamental physics and other prospective scientific user communities, together with the European Space Agency (ESA) and national space and research funding agencies

Terrestrial Very-Long-Baseline Atom Interferometry:Workshop Summary

This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more km-scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions

Cold atoms in space: community workshop summary and proposed road-map

We summarise the discussions at a virtual Community Workshop on Cold Atoms in Space concerning the status of cold atom technologies, the prospective scientific and societal opportunities offered by their deployment in space, and the developments needed before cold atoms could be operated in space. The cold atom technologies discussed include atomic clocks, quantum gravimeters and accelerometers, and atom interferometers. Prospective applications include metrology, geodesy and measurement of terrestrial mass change due to, e.g., climate change, and fundamental science experiments such as tests of the equivalence principle, searches for dark matter, measurements of gravitational waves and tests of quantum mechanics. We review the current status of cold atom technologies and outline the requirements for their space qualification, including the development paths and the corresponding technical milestones, and identifying possible pathfinder missions to pave the way for missions to exploit the full potential of cold atoms in space. Finally, we present a first draft of a possible road-map for achieving these goals, that we propose for discussion by the interested cold atom, Earth Observation, fundamental physics and other prospective scientific user communities, together with the European Space Agency (ESA) and national space and research funding agencies

Inference of the Molecular Mechanism of Action from Genetic Interaction and Gene Expression Data

Inference of new and useful hypotheses from heterogeneous sources of genome-scale experimental data requires new computational methods that can integrate different types of data. Gene expression and genetic interaction data are two most informative data types, each allowing the identification of genes at different levels of cellular regulatory network hierarchy. We present an integrative data analysis approach, which, rather than correlating the findings from the two data sets, uses each type of data independently to identify the components of molecular pathways and combines them into a single directed network. Our computational genomics approach is based on a set of inference rules traditionally used for reasoning on genetic experiments, which we have formalized and implemented in a software tool. The approach uses chemogenetic interaction and expression data to infer the type of relation between the chemical substance (perturber) and a transcription factor by using previous knowledge on the set of genes whose expression the transcription factor in question regulates. We have used the proposed approach to successfully infer the models for the action of the drug rapamycin and of a DNA damaging agent on their molecular targets and pathways in yeast cells. The developed method is available as a web-based tool at http://www.ailab.si/perturbagen

Analytical solution for buckling of asymmetrically delaminated Reissner\u27s elastic columns including transverse shear

The exact analytical solution of buckling in delaminated columns is presented. In order to investigate analytically the influence of axial and shear strains on buckling loads the geometrically exact beam theory is employed with no simplification of the governing equations. The critical forces are then obtained by the linearized stability theory. In the paper, we limit the studies to linear elastic columns with a single delamination, but with arbitrary longitudinal and vertical asymmetry of delamination and arbitrary boundary conditions. The studies of quantitative and qualitative influence of transverse shear are shown in detail and extensive results for buckling loads with respect to delamination length, thickness and longitudinal position are presented. (c) 2007 Elsevier Ltd. All rights reserved

Exact buckling analysis of composite elastic columns including multiple delamination and transverse shear

The exact analytical solution of buckling in beams with multiple delaminations is presented. In order to investigate analytically the influence of axial and shear strains on buckling loads, the geometrically exact beam theory is employed with no simplification of the governing equations. The critical forces are then obtained by the linearized stability theory. The parametric studies are designed so that they give us fundamental understanding of the effects of the delamination number, length and position on the buckling load. The effect of shear is found to be of substantial importance. (c) 2007 Elsevier Ltd. All rights reserved