9 research outputs found

    One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel–Crafts Alkylation of γ-Hydroxybutyrolactams

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    The Friedel–Crafts reaction of novel 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones was used for low cost, one-pot preparation of polycyclic indole derivatives structurally similar to Ergot alkaloids

    A Simple Route to Polysubstituted Indoles Exploiting Azide Induced Furan Ring Opening

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    A straightforward, efficient indole synthesis based on thermolysis of 2-(2-azido­benzyl)­furans with attack of the formed nitrene moiety onto the <i>ipso</i> position of furan ring has been developed. The cyclization is accompanied by furan ring opening and affords indoles with a 2-acylvinyl substituent suitable for further modifications

    WITH(OUT): On the markedness relation between comitatives/instrumentals and abessives

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