9 research outputs found
One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel–Crafts Alkylation of γ-Hydroxybutyrolactams
The Friedel–Crafts reaction of novel 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones was used for low cost, one-pot preparation of polycyclic indole derivatives structurally similar to Ergot alkaloids
A Simple Route to Polysubstituted Indoles Exploiting Azide Induced Furan Ring Opening
A straightforward, efficient indole
synthesis based on thermolysis of 2-(2-azidobenzyl)furans
with attack of the formed nitrene moiety onto the <i>ipso</i> position of furan ring has been developed. The cyclization is accompanied
by furan ring opening and affords indoles with a 2-acylvinyl substituent
suitable for further modifications