Lessons Learned from Creating a Mobile Version of an Educational Board Game to Increase Situational Awareness

This paper reports on an iterative design process for a serious game, which aims to raise situational awareness among different stakeholders in a logistics value chain by introducing multi-user role-playing games. It does so in several phases: After introducing the field of logistics as a problem domain for an educational challenge, it firstly describes the design of an educational board game for the field of disruption handling in logistics processes. Secondly, it de-scribes how the board game can be realized in an open-source mobile serious games platform and identifies lessons learned based on advantages and issues found. Thirdly, it derives requirements for a re-design of the mobile game and finally draws conclusions.SALOM

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.Peer reviewe

Priority control of berth allocation problem in container terminals

This paper presents a decision support system for the core problem of berth allocation decision in a container terminal. The allocation of berths to the calling vessels is complex with the fact that different service level requirements are required for different vessels. Terminal managers demand for effective decision support systems that would aid them with the allocation problem considering service priorities. Consequently, this study provides a DSS, built by a dynamic discrete-event simulation model embedded with an optimization tool that determines the priority controls for the berth allocation to the calling vessels. To show the practical application of the DSS, a comprehensive case study from a Turkish container terminal considering the current state and future expansion plans that also provides an indication of the usability aspect of the program on other ports around the world has been conducted. Further experiments are conducted based on data from the Port of Rotterdam. The DSS presented in this study may help port authorities in determining more efficient allocation decisions within a container terminal

A novel approach to yard planning under vessel arrival uncertainty

10.1007/s10696-011-9124-1Flexible Services and Manufacturing Journal243274-29

Automated guided vehicle mission reliability modelling using a combined fault tree and Petri net approach

This is an open access article published by Springer and distributed under the terms of the Creative Commons Attribution Licence, https://creativecommons.org/licenses/by/4.0/Automated guided vehicles (AGVs) are be- ing extensively used for intelligent transportation and distribution of materials in warehouses and autoproduction lines due to their attributes of high efficiency and low costs. Such vehicles travel along a predefined route to deliver desired tasks without the supervision of an operator. Much effort in this area has focused primarily on route optimisation and traffic management of these AGVs. However, the health management of these vehicles and their optimal mission configuration have received little attention. To assure their added value, taking a typical AGV transport system as an example, the capability to evaluate reliability issues in AGVs are investigated in this paper. Following a Failure Modes Effects and Criticality Analysis (FMECA), the reliability of the AGV system is analysed via Fault Tree Analysis (FTA) and the vehicles mission reliability is evaluated using the Petri net (PN) method. By performing the analysis the acceptability of failure of the mission can be analysed, and hence the service capability and potential profit of the AGV system can be reviewed and the mission altered where performance is unacceptable. The PN method could easily be extended to have the capability to deal with eet AGV mission reliability assessment