2,195 research outputs found
Bathypelagic particle flux signatures from a suboxic eddy in the oligotrophic tropical North Atlantic: production, sedimentation and preservation
Particle fluxes at the Cape Verde Ocean Observatory (CVOO) in the eastern tropical North Atlantic for the period December 2009 until May 2011 are discussed based on bathypelagic sediment trap time-series data collected at 1290 and 3439 m water depth. The typically oligotrophic particle flux pattern with weak seasonality is modified by the appearance of a highly productive and low oxygen (minimum concentration below 2 µmol kg−1 at 40 m depth) anticyclonic modewater eddy (ACME) in winter 2010. The eddy passage was accompanied by unusually high mass fluxes of up to 151 mg m−2 d−1, lasting from December 2009 to May 2010. Distinct biogenic silica (BSi) and organic carbon flux peaks of ∼ 15 and 13.3 mg m−2 d−1, respectively, were observed in February–March 2010 when the eddy approached the CVOO. The flux of the lithogenic component, mostly mineral dust, was well correlated with that of organic carbon, in particular in the deep trap samples, suggesting a tight coupling. The lithogenic ballasting obviously resulted in high particle settling rates and, thus, a fast transfer of epi-/meso-pelagic signatures to the bathypelagic traps. We suspect that the two- to three-fold increase in particle fluxes with depth as well as the tight coupling of mineral dust and organic carbon in the deep trap samples might be explained by particle focusing processes within the deeper part of the eddy. Molar C : N ratios of organic matter during the ACME passage were around 18 and 25 for the upper and lower trap samples, respectively. This suggests that some productivity under nutrient (nitrate) limitation occurred in the euphotic zone of the eddy in the beginning of 2010 or that a local nitrogen recycling took place. The δ15N record showed a decrease from 5.21 to 3.11 ‰ from January to March 2010, while the organic carbon and nitrogen fluxes increased. The causes of enhanced sedimentation from the eddy in February/March 2010 remain elusive, but nutrient depletion and/or an increased availability of dust as a ballast mineral for organic-rich aggregates might have contributed. Rapid remineralisation of sinking organic-rich particles could have contributed to oxygen depletion at shallow depth. Although the eddy formed in the West African coastal area in summer 2009, no indications of coastal flux signatures (e.g. from diatoms) were found in the sediment trap samples, confirming the assumption that the suboxia developed within the eddy en route. However, we could not detect biomarkers indicative of the presence of anammox (anaerobic ammonia oxidation) bacteria or green sulfur bacteria thriving in photic zone suboxia/hypoxia, i.e. ladderane fatty acids and isorenieratene derivatives, respectively. This could indicate that suboxic conditions in the eddy had recently developed and/or the respective bacterial stocks had not yet reached detection thresholds. Another explanation is that the fast-sinking organic-rich particles produced in the surface layer did not interact with bacteria from the suboxic zone below. Carbonate fluxes dropped from ∼ 52 to 21.4 mg m−2 d−1 from January to February 2010, respectively, mainly due to reduced contribution of shallow-dwelling planktonic foraminifera and pteropods. The deep-dwelling foraminifera Globorotalia menardii, however, showed a major flux peak in February 2010, most probably due to the suboxia/hypoxia. The low oxygen conditions forced at least some zooplankton to reduce diel vertical migration. Reduced “flux feeding” by zooplankton in the epipelagic could have contributed to the enhanced fluxes of organic materials to the bathypelagic traps during the eddy passage. Further studies are required on eddy-induced particle production and preservation processes and particle focusin
Interannual variability (2000–2013) of mesopelagic and bathypelagic particle fluxes in relation to variable sea ice cover in the eastern Fram Strait
The Fram Strait connects the Atlantic and Arctic Oceans and is a key conduit for sea ice advected southward by the Transpolar Drift and northward inflow of warm Atlantic Waters. Continued sea ice decline and “Atlantification” are expected to influence pelagic–benthic coupling in the Fram Strait and Arctic as a whole. However, interannual variability and the impact of changing ice conditions on deepwater particle fluxes in the Arctic remain poorly characterized. Here, we present long-term sediment trap records (2000–2013) from mesopelagic (200 m) and bathypelagic (2,300 m) depths at two locations (HGIV and HGN) in the Fram Strait subjected to variable ice conditions. Sediment trap catchment areas were estimated and combined with remote sensing data and a high-resolution model to determine the ice cover, chlorophyll concentration, and prevailing stratification regimes. Surface chlorophyll increased between 2000 and 2013, but there was no corresponding increase in POC flux, suggesting a shift in the efficiency of the biological carbon pump. A decrease in particulate biogenic Si flux, %opal, Si:POC, and Si:PIC at mesopelagic depths indicates a shift away from diatom-dominated export as a feasible explanation. Biogenic components accounted for 72% ± 16% of mass flux at 200 m, but were reduced to 34% ± 11% at 2,300 m, substituted by a residual (lithogenic) material. Total mass fluxes of biogenic components, including POC, were higher in the bathypelagic. Biomarkers and ∂13C values suggest both lateral advection and ice-rafted material contribute to benthic carbon input, although constraining their precise contribution remains challenging. The decadal time series was used to describe two end-members of catchment area conditions representing the maximum temperatures of Atlantic inflow water in 2005 at HGIV and high ice coverage and a meltwater stratification regime at HGN in 2007. Despite similar chlorophyll concentrations, bathypelagic POC flux, Si flux, Si:POC, and Si:PIC were higher and POC:PIC was lower in the high-ice/meltwater regime. Our findings suggest that ice concentration and associated meltwater regimes cause higher diatom flux. It is possible this will increase in the future Arctic as meltwater regimes increase, but it is likely to be a transient feature that will disappear when no ice remains
Возникновение и развитие еврейской прессы Крыма
В статье выделяются основные этапы процесса возникновения и развития еврейской прессы Крыма, вводится в научный оборот ряд еврейских изданий.У статті виділяються основні етапи процесу виникнення і розвитку єврейської преси Криму, вводиться в науковий обіг ряд єврейських видань.The article researches the Jewish Crimean mass-media
Fractional two-branes, toric orbifolds and the quantum McKay correspondence
We systematically study and obtain the large-volume analogues of fractional
two-branes on resolutions of orbifolds C^3/Z_n. We study a generalisation of
the McKay correspondence proposed in hep-th/0504164 called the quantum McKay
correspondence by constructing duals to the fractional two-branes. Details are
explicitly worked out for two examples -- the crepant resolutions of C^3/Z_3
and C^3/Z_5.Comment: 34 pages, 2 figures, LaTeX (JHEP3 style); (v2) typos corrected; (v3)
sec 3 reorganise
Immunologic Profiling of the Atlantic Salmon Gill by Single Nuclei Transcriptomics
ACKNOWLEDGMENTS The authors thank all of the animal staff at Kårvik havbruksstasjonen for their expert care of the research animals, and the University of Manchester Genomics Technology core facility (UK) for performing chromium 10x library preparation for snRNAseq. We also thanks the reviewers for their constructive comments on the original manuscript FUNDING AW is supported by the Tromsø forskningsstiftelse (TFS) grant awarded to DH (TFS2016DH). The Sentinel North Transdisciplinary Research Program Université Laval and UiT awarded to DH supports this work. SW is supported a grant from the Tromsø forskningsstiftelse (TFS) starter grant TFS2016SW. Experimental costs were covered by HFSP grant “Evolution of seasonal timers” RGP0030/2015 awarded to AL and DH. Storage resources were provided by the Norwegian National Infrastructure for Research Data (NIRD, project NS9055K).Peer reviewedPublisher PD
Cytomegalovirus (CMV) Disease Despite Weekly Preemptive CMV Strategy for Recipients of Solid Organ and Hematopoietic Stem Cell Transplantation
BACKGROUND:
Transplant recipients presenting with cytomegalovirus (CMV) disease at the time of diagnosis of CMV DNAemia pose a challenge to a preemptive CMV management strategy. However, the rate and risk factors of such failure remain uncertain.
METHODS:
Solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT) recipients with a first episode of CMV polymerase chain reaction (PCR) DNAemia within the first year posttransplantation were evaluated (n = 335). Patient records were reviewed for presence of CMV disease at the time of CMV DNAemia diagnosis. The distribution and prevalence of CMV disease were estimated, and the odds ratio (OR) of CMV disease was modeled using logistic regression.
RESULTS:
The prevalence of CMV disease increased for both SOT and HSCT with increasing diagnostic CMV PCR load and with screening intervals >14 days. The only independent risk factor in multivariate analysis was increasing CMV DNAemia load of the diagnostic CMV PCR (OR = 6.16; 95% confidence interval, 2.09–18.11). Among recipients receiving weekly screening (n = 147), 16 (10.8%) had CMV disease at the time of diagnosis of CMV DNAemia (median DNAemia load 628 IU/mL; interquartile range, 432–1274); 93.8% of these cases were HSCT and lung transplant recipients.
CONCLUSIONS:
Despite application of weekly screening intervals, HSCT and lung transplant recipients in particular presented with CMV disease at the time of diagnosis of CMV DNAemia. Additional research to improve the management of patients at risk of presenting with CMV disease at low levels of CMV DNAemia and despite weekly screening is warranted
The impact of coarse-grain protrusion on near-bed hydrodynamics
In steep rivers, sediment is often transported over immobile cobbles and boulders. Previous studies of such conditions have observed that the entrainment rate of the mobile sediment strongly depends on the level of protrusion of the immobile grains. Here experiments are conducted in a laboratory flume in order to quantify how different levels of protrusion of large aggregates above a fixed fine-sediment bed, modeled as a patch of hemispheres, modify the local hydrodynamics near the fine-sediment bed. Five protrusion levels defined by P = k∕R = {0%, 20%, 40%, 60%, 80%} were investigated, where k is the protrusion height and R the radius. For small protrusion (P = 20%), enhanced shear stress and turbulence intensity on the fine-sediment bed is observed as the mixing layer generated at the hemisphere top impacts the fine-sediment bed. Moreover, sweep events generated near the top of the hemispheres reach the fine-sediment bed. For large protrusions (P ≥ 60%), the mixing layer generated near the top of the hemispheres does not reach the fine grains with the consequence that the shear stress drops. The remaining turbulence near the fine-sediment bed, although enhanced by the wakes generated by the hemispherical caps, is quasi-isotropic. The transition between these two distinct near-bed flow regimes is found to be around P = 40%, corresponding to the protrusion levels observed by Grams and Wilcock (2014, https://doi.org/10.1002/2013JF002925) above which the erosion of fine sediment ceases
Analysis and quantification of the diversities of aerosol life cycles within AeroCom
Simulation results of global aerosol models have been assembled in the framework of the AeroCom intercomparison exercise. In this paper, we analyze the life cycles of dust, sea salt, sulfate, black carbon and particulate organic matter as simulated by sixteen global aerosol models. The diversities among the models for the sources and sinks, burdens, particle sizes, water uptakes, and spatial dispersals have been established. These diversities have large consequences for the calculated radiative forcing and the aerosol concentrations at the surface.
The AeroCom all-models-average emissions are dominated by the mass of sea salt (SS), followed by dust (DU), sulfate (SO_4), particulate organic matter (POM), and finally black carbon (BC). Interactive parameterizations of the emissions and contrasting particles sizes of SS and DU lead generally to higher diversities of these species, and for total aerosol. The lower diversity of the emissions of the fine aerosols, BC, POM, and SO_4, is due to the use of similar emission inventories, and does therefore not necessarily indicate a better understanding of their sources. The diversity of SO_4-sources is mainly caused by the disagreement on depositional loss of precursor gases and on chemical production. The diversities of the emissions are passed on to the burdens, but the latter are also strongly affected by the model-specific treatments of transport and aerosol processes. The burdens of dry masses decrease from largest to smallest: DU, SS, SO_4, POM, and BC.
The all-models-average residence time is shortest for SS with about half a day, followed by S_O4 and DU with four days, and POM and BC with six and seven days, respectively. The wet deposition rate is controlled by the solubility and increases from DU, BC, POM to SO_4 and SS. It is the dominant sink for SO_4, BC, and POM, and contributes about one third to the total removal rate coefficients of SS and DU species. For SS and DU we find high diversities for the removal rate coefficients and deposition pathways. Models do neither agree on the split between wet and dry deposition, nor on that between sedimentation and turbulent dry Deposition. We diagnose an extremely high diversity for the uptake of ambient water vapor that influences the particle size and thus the sink rate coefficients. Furthermore, we find little agreement among the model results for the partitioning of wet removal into scavenging by convective and stratiform rain.
Large differences exist for aerosol dispersal both in the vertical and in the horizontal direction. In some models, a minimum of total aerosol concentration is simulated at the surface. Aerosol dispersal is most pronounced for SO4 and BC and lowest for SS. Diversities are higher for meridional than for vertical dispersal, they are similar for a given species and highest for SS and DU. For these two components we do not find a correlation between vertical and meridional aerosol dispersal. In addition the degree of dispersals of SS and DU is not related to their residence times. SO_4, BC, and POM, however, show increased meridional dispersal in models with larger vertical dispersal, and dispersal is larger for longer simulated residence times
Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis
Background: Streptococcus suis is a zoonotic pathogen that infects pigs and can occasionally cause serious infections in
humans. S. suis infections occur sporadically in human Europe and North America, but a recent major outbreak has been
described in China with high levels of mortality. The mechanisms of S. suis pathogenesis in humans and pigs are poorly
understood.
Methodology/Principal Findings: The sequencing of whole genomes of S. suis isolates provides opportunities to
investigate the genetic basis of infection. Here we describe whole genome sequences of three S. suis strains from the same
lineage: one from European pigs, and two from human cases from China and Vietnam. Comparative genomic analysis was
used to investigate the variability of these strains. S. suis is phylogenetically distinct from other Streptococcus species for
which genome sequences are currently available. Accordingly, ,40% of the ,2 Mb genome is unique in comparison to
other Streptococcus species. Finer genomic comparisons within the species showed a high level of sequence conservation;
virtually all of the genome is common to the S. suis strains. The only exceptions are three ,90 kb regions, present in the two
isolates from humans, composed of integrative conjugative elements and transposons. Carried in these regions are coding
sequences associated with drug resistance. In addition, small-scale sequence variation has generated pseudogenes in
putative virulence and colonization factors.
Conclusions/Significance: The genomic inventories of genetically related S. suis strains, isolated from distinct hosts and
diseases, exhibit high levels of conservation. However, the genomes provide evidence that horizontal gene transfer has
contributed to the evolution of drug resistance
Evaluering av utprøving av digital hjemmeoppfølging: Delrapport II
Med støtte fra Helsedirektoratet prøver seks lokale prosjekter i kommunal regi ut digital hjemmeoppfølging av personer med kronisk sykdom. Utprøvingen gjennomføres i perioden 2018-2021 som en del av Nasjonalt velferdsteknologiprogram. Formålet med utprøvingen er å få tilstrekkelig kunnskap om digital hjemmeoppfølging til å gi nasjonale anbefalinger om implementering av tiltaket. Utprøvingen evalueres av forskere fra Universitetet i Oslo, Oslo Economics og Nasjonal senter for distriksmedisin. I denne delrapporten beskriver vi erfaringer med og effekter av digital hjemmeoppfølging til og med høsten 2020
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