Revolving doors and conflicts of interest in health regulatory agencies in Brazil

Regulatory health agencies exist in most public health systems (PHS) and play a crucial role in enacting regulation and overseeing economic activities in order to ensure the quality of health systems, goods and services.1 Multiple practices of corruption such as bribery or fraud have been reported in health policy and systems.2 Public health agencies are particularly susceptible to ‘regulatory capture’,3 4 a process by which an agency advances the special interests of the industries and of other actors it is entrusted with regulating. One of the mechanisms that can potentially lead to an agency capture is the so-called ‘revolving door’,5 the situation where an exchange of roles between public regulators and regulated institutions may result in health policy decisions which are biased in favour of industry interests. Revolving doors have previously been described in the USA and Europe, with an emphasis on legislative, energy, financial and patent agencies. However, there is little empirical evidence on the scale and scope of this problem in PHS. In this commentary, we explore the extent of the revolving doors phenomenon in Brazil by analysing the professional trajectories of public agents who held high positions at the two key health regulatory agencies in the country between 1999 and 2018

An equatorial ultra iron-poor star identified in BOSS

We report the discovery of SDSS J131326.89-001941.4, an ultra iron-poor red giant star ([Fe/H] ~ -4.3) with a very high carbon abundance ([C/Fe]~ +2.5). This object is the fifth star in this rare class, and the combination of a fairly low effective temperature (Teff ~ 5300 K), which enhances line absorption, with its brightness (g=16.9), makes it possible to measure the abundances of calcium, carbon and iron using a low-resolution spectrum from the Sloan Digital Sky Survey. We examine the carbon and iron abundance ratios in this star and other similar objects in the light of predicted yields from metal-free massive stars, and conclude that they are consistent. By way of comparison, stars with similarly low iron abundances but lower carbon-to-iron ratios deviate from the theoretical predictions.Comment: 6 pages, 4 figures, accepted for publication in A&

The Pristine survey II: a sample of bright stars observed with FEROS

Extremely metal-poor (EMP) stars are old objects formed in the first Gyr of the Universe. They are rare and, to select them, the most successful strategy has been to build on large and low-resolution spectroscopic surveys. The combination of narrow- and broad band photometry provides a powerful and cheaper alternative to select metal-poor stars. The on-going Pristine Survey is adopting this strategy, conducting photometry with the CFHT MegaCam wide field imager and a narrow-band filter centred at 395.2 nm on the CaII-H and -K lines. In this paper we present the results of the spectroscopic follow-up conducted on a sample of 26 stars at the bright end of the magnitude range of the Survey (g<=15), using FEROS at the MPG/ESO 2.2 m telescope. From our chemical investigation on the sample, we conclude that this magnitude range is too bright to use the SDSS gri bands, which are typically saturated. Instead the Pristine photometry can be usefully combined with the APASS gri photometry to provide reliable metallicity estimates.Comment: AN accepte

The Pristine survey - XV. A CFHT ESPaDOnS view on the Milky Way halo and disc populations

We present a one-dimensional, local thermodynamic equilibrium homogeneous analysis of 132 stars observed at high resolution with ESPaDOnS. This represents the largest sample observed at high resolution (R ∼40 000) from the Pristine survey. This sample is based on the first version of the Pristine catalogue and covers the full range of metallicities from [Fe/H] ∼-3 to ∼+0.25, with nearly half of our sample (58 stars) composed of very metal-poor (VMP) stars ([Fe/H] ≤ -2). This wide range of metallicities provides the opportunity of a new detailed study of the Milky Way stellar population. Because it includes both dwarf and giant stars, it also enables the analysis of any potential bias induced by the Pristine selection process. Based on Gaia EDR3, the orbital analysis of this Pristine-ESPaDOnS sample shows that it is composed of 65 halo stars and 67 disc stars. After a general assessment of the sample chemical properties with the α-elements Mg and Ca, we focus on the abundance of carbon and the neutron capture elements Ba and Sr. While most of our VMP subsample is carbon normal, we also find that 14 stars out of the 38 stars with [Fe/H] ≤ -2 and measured carbon abundances turn out to be carbon-enhanced metal-poor (CEMP) stars. We show that these CEMP stars are nearly exclusively (i.e. 12 stars out of 14) in the regime of low luminosity, unevolved, dwarf stars, which we interpret as the consequence of bias of the Pristine filter against C-rich giants. Among the VMP stars, we identify two CEMP stars with no enhancement in neutron-capture process elements and another one enriched in s-process element. Finally, one VMP star is found with a very low [Sr/Fe] abundance ratio for its metallicity, as expected if it had been accreted from an ultra-faint dwarf galaxy

On the 12C/13C isotopic ratio at the dawn of chemical evolution

The known Mega and Hyper Metal-Poor (MMP-HMP) stars with [Fe/H]<-6.0 and <-5.0, respectively, likely belong to the CEMP-no class, i.e. carbon-enhanced stars with low or absent second peak neutron capture elements. They are likely second generation stars and the few elements measurable in their atmospheres are used to infer the properties of single or very few progenitors. The high carbon abundance in the CEMP-no stars offers a unique opportunity to measure the carbon isotopic ratio, which directly monitors the presence of mixing between the He and H-burning layers either within the star or in the progenitor(s). By means of high-resolution spectra acquired with the ESPRESSO spectrograph at the VLT we aim to derive values for the 12C/13C ratio at the lowest metallicities. A spectral synthesis technique based on the SYNTHE code and on ATLAS models is used within a Markov-chain Monte Carlo methodology to derive 12C/13C in the stellar atmospheres of five of the most metal poor stars. These are the Mega Metal-Poor giant SMS J0313-6708 ([Fe/H]<-7.1), the Hyper Metal-Poor dwarf HE1327-2326 ([Fe/H]=-5.8),the Hyper Metal-Poor giant SDSS J1313-0019 ([Fe/H] = -5.0) and the Ultra Metal-Poor subgiant HE0233-0343 ([Fe/H]=-4.7). We also revise a previous value for the Mega Metal-Poor giant SMSS J1605-1443 with ([Fe/H] = -6.2). In four stars we derive an isotopic value while for HE1327-2326 we provide a lower limit. All Measurements are in the range 39<12C/13C<100 showing that the He- and H-burning layers underwent partial mixing either in the stars or, more likely, in their progenitors. This provides evidence of a primary production of 13C at the dawn of chemical evolution. [abridged]Comment: 10 pages, 6 figure, accepted A&

Major decline of hepatitis C virus incidence rate over two decades in a cohort of drug users

Injecting drug users (DU) are at high risk for hepatitis C virus (HCV) and HIV infections. To examine the prevalence and incidence of these infections over a 20-year period (1985–005), the authors evaluated 1276 DU from the Amsterdam Cohort Studies who had been tested prospectively for HIV infection and retrospectively for HCV infection. To compare HCV and HIV incidences, a smooth trend was assumed for both curves over calendar time. Risk factors for HCV seroconversion were determined using Poisson regression. Among ever-injecting DU, the prevalence of HCV antibodies was 84.5% at study entry, and 30.9% were co-infected with HIV. Their yearly HCV incidence dropped from 27.5/100 person years (PY) in the 1980s to 2/100 PY in recent years. In multivariate analyses, ever-injecting DU who currently injected and borrowed needles were at increased risk of HCV seroconversion (incidence rate ratio 29.9, 95% CI 12.6, 70.9) compared to ever-injecting DU who did not currently inject. The risk of HCV seroconversion decreased over calendar time. The HCV incidence in ever-injecting DU was on average 4.4 times the HIV incidence, a pattern seen over the entire study period. The simultaneous decline of both HCV and HIV incidence probably results from reduced risk behavior at the population level

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies, and the Distant Universe

We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median $z\sim 0.03$). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between $z\sim 0.6$ and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research