Osteochondral defects : present situation and tissue engineering approaches

Articular cartilage is often damaged due to trauma or degenerative diseases, resulting in severe pain and disability. Most clinical approaches have been shown to have limited capacity to treat cartilage lesions. Tissue engineering (TE) has been proposed as an alternative strategy to repair cartilage. Cartilage defects often penetrate to the subchondral bone, or full-thickness defects are also produced in some therapeutic procedures. Therefore, in TE strategies one should also consider the need for a simultaneous regeneration of both cartilage and subchondral bone in situations where osteochondral defects are present, or to provide an enhanced support for the cartilage hybrid construct. In this review, different concepts related to TE in osteochondral regeneration will be discussed. The focus is on the need to produce new biphasic scaffolds that will provide differentiated and adequate conditions for guiding the growth of the two tissues, satisfying their different biological and functional requirements

Electron and Photon Scattering on Three-Nucleon Bound States

A big spectrum of processes induced by real and virtual photons on the 3He and 3H nuclei is theoretically investigated through many examples based on nonrelativistic Faddeev calculations for bound and continuum states. The modern nucleon-nucleon potential AV18 together with the three-nucleon force UrbanaIX is used. The single nucleon current is augmented by explicit pi- and rho-like two-body currents which fulfill the current continuity equation together with the corresponding parts of the AV18 potential. We also employ the Siegert theorem, which induces many-body contributions to the current operator. The interplay of these different dynamical ingredients in the various electromagnetic processes is studied and the theory is compared to the experimental data. Overall we find fair to good agreement but also cases of strong disagreement between theory and experiment, which calls for improved dynamics. In several cases we refer the reader to the work of other groups and compare their results with ours. In addition we list a number of predictions for observables in different processes which would challenge this dynamical scenario even more stringently and systematically.Comment: 154 pages, 80 figures includes as ps files, 21 additional figures as jpeg file

Variabilidade comportamental em humanos: efeitos de regras e contingências

Dois experimentos investigaram, com estudantes universitários, a variabilidade aprendida. No Experimento 1, quatro grupos (n = 5) foram submetidos a dois esquemas de reforçamento para seqüências de respostas de pressão às teclas P e Q do computador. Para o grupo Variabilidade (VAR) o reforçamento era dependente do alto grau de variação entre as seqüências, e para o grupo Acoplado (ACO) o reforçamento independia dessa variabilidade. Foram manipuladas a ordem de apresentação dessas contingências e o intervalo entre elas (0 e 3 meses). No Experimento 2, essas contingências foram combinadas a instruções verbais (regras) que as descreviam correta ou incorretamente (quatro grupos, n = 5). Os resultados mostraram: 1) maior variabilidade em VAR, independente das demais variáveis manipuladas, 2) desempenho em ACO afetado parcialmente pela ordem das contingências, pelo intervalo e pelas regras. Em ambos os estudos, os sujeitos não foram capazes de descrever as contingências em vigor. Esses resultados indicam o controle operante da variabilidade observada