Tomographic Image of the Southern California Mantle

P wave teleseismic travel time delays recorded by the Southern California Array are inverted by the method of backprojection tomography to obtain images of variations in the P wave velocity structure to a depth of 750 km. Two major upper mantle features arc resolved: one beneath the Transverse Ranges region and another beneath the Salton Trough region. The Transverse Ranges feature appears as a curtainlike, east trending, high-velocity anomaly. This feature is ∼60 km thick, extends most deeply on its eastern end (to ∼250 km), and attains a maximum velocity −3% greater than average southern California mantle of the same depth. The Salton Trough feature, which is not as well resolved as the Transverse Ranges feature, is composed of low velocities in the upper 70–100 km. These P wave velocities arc depressed 3–4% compared to average southern California mantle. Tests of the inversion indicate the major aspects of the imaged structure are authentic

Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies

Diabetic kidney disease (DKD) occurs in ∼40% of patients with diabetes and causes kidney failure, cardiovascular disease, and premature death. We analyzed the response of a murine DKD model to five treatment regimens using single-cell RNA sequencing (scRNA-seq). Our atlas of ∼1 million cells revealed a heterogeneous response of all kidney cell types both to DKD and its treatment. Both monotherapy and combination therapies targeted differing cell types and induced distinct and non-overlapping transcriptional changes. The early effects of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on the S1 segment of the proximal tubule suggest that this drug class induces fasting mimicry and hypoxia responses. Diabetes downregulated the spliceosome regulator serine/arginine-rich splicing factor 7 (Srsf7) in proximal tubule that was specifically rescued by SGLT2i. In vitro proximal tubule knockdown of Srsf7 induced a pro-inflammatory phenotype, implicating alternative splicing as a driver of DKD and suggesting SGLT2i regulation of proximal tubule alternative splicing as a potential mechanism of action for this drug class

Radioisotopes and the Age of the Earth

RATE is an acronym applied to a research project investigating radioisotope dating sponsored by the Institute for Creation Research and the Creation Research Society. It stands for Radioisotopes and the Age of The Earth. This article summarizes the purpose, history, and intermediate findings of the RATE project five years into an eight-year effort. It reports on the latest status of the research on helium diffusion through minerals in granitic rock, accelerated nuclear decay theory, radiohalos, isochron discordance studies, case studies in rock dating, and carbon-14 in deep geologic strata. Each of the RATE scientists will present separate technical papers at the Fifth International Conference on Creationism on the details of this research

Precise measurements help gauge Pacific Northwest\u27s Earthquake potential

Except for the recent rumblings of a few moderate earthquakes and the eruption of Mt. St. Helen\u27s, all has been relatively quiet on the Pacific Northwestern front. The Cascades region in the Pacific Northwest, a sporadically active earthquake and volcanic zone, still has great seismic potential [Atwater, 1987], as comparisons with other subduction zones around the world have shown [Heaton and Kanamori, 1984]. Recent tsunami propagation models [Satake, 1996] and tree ring studies suggest that the last great Cascadia earthquake occurred in the winter of 1700 A.D. and had a magnitude of −8.9. The North Cascades or Wenatchee earthquake followed in 1872. With an estimated magnitude greater than 7, it was the largest earthquake in the written history of Washington and Oregon

A multi-decade record of high quality fCO2 data in version 3 of the Surface Ocean CO2 Atlas (SOCAT)

The Surface Ocean CO2 Atlas (SOCAT) is a synthesis of quality-controlled fCO2 (fugacity of carbon dioxide) values for the global surface oceans and coastal seas with regular updates. Version 3 of SOCAT has 14.7 million fCO2 values from 3646 data sets covering the years 1957 to 2014. This latest version has an additional 4.6 million fCO2 values relative to version 2 and extends the record from 2011 to 2014. Version 3 also significantly increases the data availability for 2005 to 2013. SOCAT has an average of approximately 1.2 million surface water fCO2 values per year for the years 2006 to 2012. Quality and documentation of the data has improved. A new feature is the data set quality control (QC) flag of E for data from alternative sensors and platforms. The accuracy of surface water fCO2 has been defined for all data set QC flags. Automated range checking has been carried out for all data sets during their upload into SOCAT. The upgrade of the interactive Data Set Viewer (previously known as the Cruise Data Viewer) allows better interrogation of the SOCAT data collection and rapid creation of high-quality figures for scientific presentations. Automated data upload has been launched for version 4 and will enable more frequent SOCAT releases in the future. High-profile scientific applications of SOCAT include quantification of the ocean sink for atmospheric carbon dioxide and its long-term variation, detection of ocean acidification, as well as evaluation of coupled-climate and ocean-only biogeochemical models. Users of SOCAT data products are urged to acknowledge the contribution of data providers, as stated in the SOCAT Fair Data Use Statement. This ESSD (Earth System Science Data) “living data” publication documents the methods and data sets used for the assembly of this new version of the SOCAT data collection and compares these with those used for earlier versions of the data collection (Pfeil et al., 2013; Sabine et al., 2013; Bakker et al., 2014). Individual data set files, included in the synthesis product, can be downloaded here: doi:10.1594/PANGAEA.849770. The gridded products are available here: doi:10.3334/CDIAC/OTG.SOCAT_V3_GRID

Best practice data standards for discrete chemical oceanographic observations

© The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Jiang, L.-Q., Pierrot, D., Wanninkhof, R., Feely, R. A., Tilbrook, B., Alin, S., Barbero, L., Byrne, R. H., Carter, B. R., Dickson, A. G., Gattuso, J.-P., Greeley, D., Hoppema, M., Humphreys, M. P., Karstensen, J., Lange, N., Lauvset, S. K., Lewis, E. R., Olsen, A., Pérez, F. F., Sabine, C., Sharp, J. D., Tanhua, T., Trull, T. W., Velo, A., Allegra, A. J., Barker, P., Burger, E., Cai, W-J., Chen, C-T. A., Cross, J., Garcia, H., Hernandez-Ayon J. M., Hu, X., Kozyr, A., Langdon, C., Lee., K, Salisbury, J., Wang, Z. A., & Xue, L. Best practice data standards for discrete chemical oceanographic observations. Frontiers in Marine Science, 8, (2022): 705638, https://doi.org/10.3389/fmars.2021.705638.Effective data management plays a key role in oceanographic research as cruise-based data, collected from different laboratories and expeditions, are commonly compiled to investigate regional to global oceanographic processes. Here we describe new and updated best practice data standards for discrete chemical oceanographic observations, specifically those dealing with column header abbreviations, quality control flags, missing value indicators, and standardized calculation of certain properties. These data standards have been developed with the goals of improving the current practices of the scientific community and promoting their international usage. These guidelines are intended to standardize data files for data sharing and submission into permanent archives. They will facilitate future quality control and synthesis efforts and lead to better data interpretation. In turn, this will promote research in ocean biogeochemistry, such as studies of carbon cycling and ocean acidification, on regional to global scales. These best practice standards are not mandatory. Agencies, institutes, universities, or research vessels can continue using different data standards if it is important for them to maintain historical consistency. However, it is hoped that they will be adopted as widely as possible to facilitate consistency and to achieve the goals stated above.Funding for L-QJ and AK was from NOAA Ocean Acidification Program (OAP, Project ID: 21047) and NOAA National Centers for Environmental Information (NCEI) through NOAA grant NA19NES4320002 [Cooperative Institute for Satellite Earth System Studies (CISESS)] at the University of Maryland/ESSIC. BT was in part supported by the Australia’s Integrated Marine Observing System (IMOS), enabled through the National Collaborative Research Infrastructure Strategy (NCRIS). AD was supported in part by the United States National Science Foundation. AV and FP were supported by BOCATS2 Project (PID2019-104279GB-C21/AEI/10.13039/501100011033) funded by the Spanish Research Agency and contributing to WATER:iOS CSIC interdisciplinary thematic platform. MH was partly funded by the European Union’s Horizon 2020 Research and Innovation Program under grant agreement N°821001 (SO-CHIC)

The contribution of X-linked coding variation to severe developmental disorders

Abstract: Over 130 X-linked genes have been robustly associated with developmental disorders, and X-linked causes have been hypothesised to underlie the higher developmental disorder rates in males. Here, we evaluate the burden of X-linked coding variation in 11,044 developmental disorder patients, and find a similar rate of X-linked causes in males and females (6.0% and 6.9%, respectively), indicating that such variants do not account for the 1.4-fold male bias. We develop an improved strategy to detect X-linked developmental disorders and identify 23 significant genes, all of which were previously known, consistent with our inference that the vast majority of the X-linked burden is in known developmental disorder-associated genes. Importantly, we estimate that, in male probands, only 13% of inherited rare missense variants in known developmental disorder-associated genes are likely to be pathogenic. Our results demonstrate that statistical analysis of large datasets can refine our understanding of modes of inheritance for individual X-linked disorders

Flat-slab subduction, topography, and mantle dynamics in southwestern Mexico

Topography above subduction zones arises from the isostatic contribution of crustal and lithospheric buoyancy, as well as the dynamic contribution from slab-driven mantle flow. We evaluate those effects in southwestern Mexico, where a segment of the Cocos slab subducts horizontally. The eastern part of the volcanic arc - the Trans-Mexican Volcanic Belt - stands at an average elevation of 2.3 km, nearly 1.3 km above the fore-arc. Lateral changes in bulk crustal density are relatively small, and seismic imaging shows that there is little variation in crustal thickness between these two regions. Thus, the elevation difference between the arc and the fore-arc should arise from differences in mantle properties. We present finite element models of flat-slab subduction that provide a simultaneous match to topography, plate velocities, and stress state in the overriding plate. We find that the dynamic effects are primarily controlled by the amount of coupling at the subduction interface and in the mantle wedge, the lack of slab anchoring into the lower mantle, and the absence of continental mantle lithosphere. With a mantle wedge and a subduction interface that are, respectively, 2 and 4 orders of magnitude weaker than the asthenosphere, the flat slab exerts a downward pull that can explain most of the elevation difference between the fore-arc and the arc. We infer that lateral viscosity variations play a significant role in shaping dynamic topography in complex tectonic settings and that sublithospheric dynamics can influence the topography at wavelengths that are significantly shorter than previously recognize