Trends and multi-annual variability of water temperatures in the river Danube, Serbia

This is the peer reviewed version of the following article: BASARIN, B. ... et al, 2016. Trends and multi-annual variability of water temperatures in the river Danube, Serbia. Hydrological Processes, 30 (18), pp. 3315-3329, which has been published in final form at http://dx.doi.org/10.1002/hyp.10863. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.The relationship between air (Ta) and water temperature (Tw) is very important because it shows how the temperature of a water body might respond to future changes in surface Ta. Mean monthly Tw records of three gauging stations (Bezdan, Bogojevo i Veliko Gradište) were analysed alongside mean monthly discharge (Q) for the same stations. Additionally, Ta series from two meteorological stations (Sombor and Veliko Gradište) were correlated with Tw variations over the period 1950–2012. Locally weighted scatter point smoothing (LOWESS) was used to investigate long-term trends in the raw data, alongside the Mann–Kendall (MK) trend test. Trend significance was established using Yue–Pilon's pre-whitening approaches to determine trends in climate data. Also, the rescaled adjusted partial sums (RAPS) method was used to detect dates of possible changes in the time series. Statistically significant warming trends were observed for annual and seasonal minimum and maximum Tw at all investigated sites. The strongest warming was observed at Bogojevo gauging station for seasonal maximum Tw, with +0.05 °C per year on average. RAPS established that the trend began in the 1980s. This behaviour is linked to climate patterns in the North and East Atlantic which determine the amount of heat advected onto mainland Europe. Statistically significant correlations were found for all Tw on an annual basis. Overall, the strongest correlations (p < 0.01) between Tw residuals and the North Atlantic Oscillation (NAO) were recorded for the winter period. These findings suggest possible predictability of Tw over seasonal time-scales

Risk factors associated with short-term complications in mandibular fractures: the MANTRA study—a Maxillofacial Trainee Research Collaborative (MTReC)

Abstract Introduction Complications following mandibular fractures occur in 9–23% of patients. Identifying those at risk is key to prevention. Previous studies highlighted smoking, age and time from injury to presentation as risk factors but rarely recorded other possible confounders. In this paper, we use a collaborative snapshot audit to document novel risk factors and confirm established risks for complications following the treatment of mandibular fractures. Methods The audit was carried out by 122 OMFS trainees across the UK and Ireland (49 centres) over 6 months, coordinated by the Maxillofacial Surgery Trainees Research Collaborative. Variables recorded included basic demography, medical and social history, injury mechanism and type, management and 30-day outcome. Results Nine hundred and forty-seven (947) patients with fractured mandibles were recorded. Surgical management was carried out in 76.3%. Complications at 30 days occurred 65 (9%) of those who were managed surgically. Risk factors for complications included male sex, increasing age, any medical history, increasing number of cigarettes smoked per week, increasing alcohol use per week, worse oral hygiene and increased time from injury to presentation. Discussion We have used a large prospective snapshot audit to confirm established risk factors and identify novel risk factors. We demonstrate that time from injury to presentation is confounded by other indicators of poor health behaviour. These results are important in designing trial protocols for management of mandibular fractures and in targeting health interventions to patients at highest risk of complications. </jats:sec

PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair

Replicative repair of interstrand crosslinks (ICL) generated by platinum chemotherapeutics is orchestrated by the Fanconi anemia (FA) repair pathway to ensure resolution of stalled replication forks and the maintenance of genomic integrity. Here, we identify novel regulation of FA repair by the cancer-associated glycolytic enzyme PFKFB3 that has functional consequences for replication-associated ICL repair and cancer cell survival. Inhibition of PFKFB3 displays a cancer-specific synergy with platinum compounds in blocking cell viability and restores sensitivity in treatment-resistant models. Notably, the synergies are associated with DNA-damage-induced chromatin association of PFKFB3 upon cancer transformation, which further increases upon platinum resistance. FA pathway activation triggers the PFKFB3 assembly into nuclear foci in an ATR- and FANCM-dependent manner. Blocking PFKFB3 activity disrupts the assembly of key FA repair factors and consequently prevents fork restart. This results in an incapacity to replicate cells to progress through S-phase, an accumulation of DNA damage in replicating cells, and fork collapse. We further validate PFKFB3-dependent regulation of FA repair in ex vivo cultures from cancer patients. Collectively, targeting PFKFB3 opens up therapeutic possibilities to improve the efficacy of ICL-inducing cancer treatments

Résistances — À l'horizon — Représenter la diversité dans la cité — Oser

Ce numéro 75 des Cahiers victoriens et édouardiens rassemble sept communications effectuées lors du colloque annuel de la Sfeve qui s’est tenu à l’université de Dijon en janvier 2010 et qui s’intitulait « Résistances », six communications données lors du 50e congrès de la SAES qui s’est tenu à Lille en mai 2010 et qui s’intitulait « À l’horizon », une communication du colloque de la Sfeve de Cergy en janvier 2011 sur le thème « Représenter la diversité dans la cité » et enfin deux communications effectuées lors du 51e congrès de la SAES de mai 2011 intitulé « Oser » accueilli par Paris III . L’ensemble des articles a été recueilli par le professeur Laurent Bury, président de la Sfeve. This issue of Cahiers victoriens et édouardiens is a collection of articles based upon papers given on four occasions: seven papers from the annual Sfeve conference which was held in Dijon in January 2010 and was entitled ‘Resistance’, six papers from the 50th SAES conference which was held in Lille in May 2010 named ‘On the horizon’, one paper from the Sfeve conference which was held in Cergy in January 2010 and was entitled ‘Representing diversity in the city’ as well as two papers from the 51st SAES conference which was held in Paris III in May 2011 named ‘Daring’. The volume is edited by Professor Laurent Bury, President of the Société française des études victoriennes et édouardiennes (Sfeve)

Management of oral and maxillofacial trauma during the first wave of the COVID-19 pandemic in the United Kingdom

We assess the effect of coronavirus disease 2019 (COVID-19) on UK oral and maxillofacial (OMF) trauma services and patient treatment during the first wave of the pandemic. From 1 April 2020 until 31 July 2020, OMF surgery units in the UK were invited to prospectively record all patients presenting with OMF trauma. Information included clinical presentation, mechanism of injury, how it was managed, and whether or not treatment included surgery. Participants were also asked to compare the patient’s care with the treatment that would normally have been given before the crisis. Twenty-nine units across the UK contributed with 2,229 entries. The most common aetiology was mechanical fall (39%). The most common injuries were soft tissue wounds (52%) and, for hard tissues, mandibular fractures (13%). Of 876 facial fractures, 79 patients’ treatment differed from what would have been normal pre-COVID, and 33 had their treatment deferred. Therefore the care of 112 (14%) patients was at variance with normal practice because of COVID restrictions. The pattern of OMFS injuries changed during the first COVID-19 lockdown. For the majority, best practice and delivery of quality trauma care continued despite the on-going operational challenges, and only a small proportion of patients had changes to their treatment. The lessons learnt from the first wave, combined with adequate resources and preoperative testing of patients, should allow those facial injuries in the second wave to receive best-practice care