Experimental Investigation of Heat Exchange between Thermal Mass and Room Environments

The different technologies of passive cooling concepts have to rely on a good thermal coupling between a building’s thermal mass and indoor air. In many cases, the ceiling is the only surface remaining for a good coupling. Further research is necessary to investigate discrepancies between existing correlations. Therefore, the overall aim of the work described in this thesis is the investigation of heat transfer at a heated ceiling in an experimental chamber. Acoustic baffles obstruct the surface of the ceiling and impede heat transfer. However, there is nearly no published data about the effect of such baffles on heat transfer. Available results from simulations should be verified with an experimental investigation. Consequently, one of the primary aims of this work was to experimentally determine the influence of such acoustic baffles. A suitable experimental chamber has been built at Biberach University of Applied Sciences. The thesis describes the experimental chamber, the experimental programme as well as results from five different test series. With a value of ±0.1W/(m² K) for larger temperature differences, uncertainty in resulting convective heat transfer coefficients for natural convection is comparable to that of results from an existing recent experimental work often recommended for use. Additionally, total heat transfer (by convection and radiation) results are presented. Results are given for natural, forced and mixed convection conditions at an unobstructed heated ceiling. Furthermore, results for acoustic baffles in both an unventilated and a ventilated chamber are shown. Natural convection results show a very good agreement with existing correlations. Under mixed convection conditions, convective heat transfer at an unobstructed ceiling decreases to the limiting case described by natural convection. Installation of acoustic baffles leads to a reduction in total heat transfer (convection and radiation) between 20% and 30% when compared to the case of an unobstructed ceiling

Third order nonlinear susceptibility of InN at near band-gap wavelengths

The authors report room-temperature measurements of the third order nonlinear susceptibility modulus ∫ (3) ∫ of thick (∼600 nm) InN layers. Transmission measurements provide a room-temperature value for the optical band gap of the samples slightly above 1500 nm. Third order nonlinear optical susceptibility has been measured using degenerate four wave mixing experiments at wavelengths near and above band gap. ∫ (3) ∫ values of (4.2-10) × 10-10 esu were measured at this wavelength range. The associated relaxation time of the generated population grating at 1500 nm was measured. The obtained value of 4.8 ps is consistent with a nonradiative recombination mechanism. © 2007 American Institute of Physics.Peer Reviewe

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

Influenza A viruses are a threat to humans due to their ability to cross species barriers, as illustrated by the 2009 H1N1v pandemic and sporadic H5N1 transmissions. Interspecies transmission requires adaptation of the viral polymerase to importin-α, a cellular protein that mediates transport into the nucleus where transcription and replication of the viral genome takes place. In this study, we analysed replication, host specificity and pathogenicity of avian and mammalian influenza viruses, in importin-α-silenced cells and importin-α-knockout mice, to understand the role of individual importin-α isoforms in adaptation. For efficient virus replication, the polymerase subunit PB2 and the nucleoprotein (NP) of avian viruses required importin-α3, whereas PB2 and NP of mammalian viruses showed importin-α7 specificity. H1N1v replication depended on both, importin-α3 and -α7, suggesting ongoing adaptation of this virus. Thus, differences in importin-α specificity are determinants of host range underlining the importance of the nuclear envelope in interspecies transmission

Diversification of importin-α isoforms in cellular trafficking and disease states.

The human genome encodes seven isoforms of importin α which are grouped into three subfamilies known as α1, α2 and α3. All isoforms share a fundamentally conserved architecture that consists of an N-terminal, autoinhibitory, importin-β-binding (IBB) domain and a C-terminal Arm (Armadillo)-core that associates with nuclear localization signal (NLS) cargoes. Despite striking similarity in amino acid sequence and 3D structure, importin-α isoforms display remarkable substrate specificity in vivo. In the present review, we look at key differences among importin-α isoforms and provide a comprehensive inventory of known viral and cellular cargoes that have been shown to associate preferentially with specific isoforms. We illustrate how the diversification of the adaptor importin α into seven isoforms expands the dynamic range and regulatory control of nucleocytoplasmic transport, offering unexpected opportunities for pharmacological intervention. The emerging view of importin α is that of a key signalling molecule, with isoforms that confer preferential nuclear entry and spatiotemporal specificity on viral and cellular cargoes directly linked to human diseases

The development of memory maintenance strategies:Training cumulative rehearsal and interactive imagery in children aged between 5 and 9

The current study explored the extent to which children above and below the age of 7 years are able to benefit from either training in cumulative rehearsal or in the use of interactive imagery when carrying out working memory tasks. Twenty-four 5- to 6-year-olds and 24 8- to 9-year olds were each assigned to one of three training groups who either received cumulative rehearsal, interactive imagery, or passive labelling training. Participants’ ability to maintain material during a filled delay was then assessed, and the nature of the distraction that was imposed during this delay was varied to shed further light on the mechanisms that individuals used to maintain the memoranda in working memory in the face of this distraction. The results suggest that the rehearsal training employed here did improve recall by virtue of encouraging rehearsal strategies, in a way that was not observed among participants receiving interactive imagery training. The fact that these effects were not mediated by age group counts against the view that younger individuals are either unable to rehearse, or show impoverished verbal serial recall because they do not spontaneously engage in rehearsal