Range extensions of the seaweeds Codium taylorii and Caulerpa prolifera into the lower Laguna Madre, Texas

Between January 1999 and April 2000 two chlorophyte algae, Codium taylorii Silva and Caulerpa prolifera F. obovata (Forsskal) Lamouroux were found in the lower Laguna Madre (LLM). Both are coenocytic algae and are members of the chlorophyte class Bryopsidophyceae ( van den Hoek et al. 1995). The species descriptions in Taylor (1960) were used in the identification of the specimens. Her barium specimens have been deposited at the University of Texas- Pan American Coastal Studies Laboratory (accession numbers COlO - C. prolifera, COl 1 - C. taylorii) , University of California at Berkeley (UC 1753606 - C. taylorii) , University of Michigan and the University of Texas Marine Science Institute

Re-occurrence of the tropical green macroalga, Penicillus capitatus (Chlorophyta: Bryopsidales), in Lower Laguna Madre of South Texas.

The siphonaceous green alga Penicillus capitatus Lamarck is a common macroalga of the Carribean and Gulf of Mexico (Littler & Littler 2000). This shaving brush-shaped macroalga was a common inhabitant of the Lower Laguna Madre Texas (LLM) until about 40 years ago when the population was decimated following a salinity decline in the fall of 1959, another salinity reduction due to Hurricane Carla in 1961, and finally a severe freeze in 1962 (Sorensen 1963). Since that time, there have been no reports of P. capitatus in the LLM. During a reconnaissance trip in July 2006, a small population was found in the southern portion of the LLM. The species descriptions by Taylor (1960) and Sorensen (1979) were used in the identification of specimens. Herbarium specimens have been deposited in the herbaria of The University of Texas-Pan American Coastal Studies Laboratory (accession number C012), and the University of Texas at Austin Marine Science Institute

A Comparison of Salinity Effects from Hurricanes Dolly (2008) and Alex (2010) in a Texas Lagoon System

A comparison of salinity effects from hurricanes Dolly (2008) and Alex (2010) in a Texas lagoon system.Hurricanes are not uncommon along the Gulf of Mexico coast, but there are few studies of the effects they have on coastal embayments. Hurricanes Dolly (2008) and Alex (2010) were both Category 2 storms affecting the Lower Laguna Madre (LLM) of Texas. Surveys were performed to assess poststorm water quality after landfall of both storms at up to 18 sample stations. The main difference between storm effects was salinity reduction because of stormwater input from the watershed. Effects from Hurricane Dolly were of short duration and small magnitude, whereas the effects from Hurricane Alex were extensive and lasted more than a month. Differences in spatial patterns in salinity were significantly more pronounced across the LLM than were temporal differences. Precipitation of 50–100 cm caused stormwater discharge to exceed 1000 m s−1 to the LLM during the Alex event and depressed salinity over more than three-fourths (ca. 500 km2) of the estuary for 2 months. Storm-related effects on water-column physiochemistry were persistently lowest near freshwater drains (Arroyo Colorado). Salinity remained less than 5 for more than 2 months during the Alex freshet. Freshwater input from Hurricane Dolly was relatively minor because the storm precipitation was largely restricted to the small Arroyo Colorado watershed. Effects from Alex were delayed but were greater because of the bulk of the precipitation falling in the Rio Grande/Rio Bravo drainage basin in México. The greatest impact from that freshwater disturbance was the loss of seagrasses after prolonged exposure to hyposalinity. Hurricanes Dolly and Alex both affected the LLM but with contrasting impacts that reflected spatial and meteorological differences between the two storms

Dependence of solar reflector soiling on location relative to a ferromanganese smelter

A solar reflector soiling study was carried out at a ferromanganese smelter in South Africa to assess the soiling rates at different locations around the plant. Several meteorological parameters were monitored to give insight into the conditions that lead to increased soiling. Mineralogical characterization of dust samples collected from the reflectors and the atmosphere revealed that only a certain size fraction is of importance with regard to soiling, and that the dust can be attributed to both raw materials and smelter products. Proximity to the dust source was the primary driver for increased soiling. The site that experienced the most soiling was very close to raw material heaps; this was deemed an outlier and was excluded from the summary statistics. The secondary driver for increased soiling was location relative to the smelter dust sources and the wind’s direction and speed. The reflector set at the best location experienced 13.1% less soiling than the set at the ‘worst’ (but still feasible) location, represented by an averaged mean daily reflectance loss of 0.0186. The study revealed that while there are periods of intense soiling at this particular site, proper planning of reflector location in relation to the smelter dust sources can significantly mitigate the soiling rate.The European Union’s Horizon 2020 research and innovation programme.http://www.saimm.co.za/journal-papersam2024Mechanical and Aeronautical EngineeringSDG-09: Industry, innovation and infrastructur

Results of the randomized phase IIB ADMIRE trial of FCR with or without mitoxantrone in previously untreated CLL

ADMIRE was a multi-center, randomized-controlled, open, phase IIB superiority trial in previously untreated Chronic Lymphocytic Leukemia (CLL). Conventional frontline therapy in fit patients is fludarabine, cyclophosphamide and rituximab (FCR). Initial evidence from non-randomized Phase II trials suggested that the addition of mitoxantrone to FCR (FCM-R) improved remission rates. 215 patients were recruited to assess the primary endpoint of complete remission (CR) rates according to IWCLL criteria. Secondary endpoints were progression-free survival (PFS), overall survival (OS), overall response rate, minimal residual disease (MRD) negativity and safety. At final analysis, CR rates were 69.8% FCR vs 69.3% FCM-R [adjusted odds ratio (OR): 0.97; 95%CI: (0.53-1.79), P=0.932]. MRD-negativity rates were 59.3% FCR vs 50.5% FCM-R [adjusted OR: 0.70; 95% CI: (0.39-1.26), P=0.231]. During treatment, 60.0% (n=129) of participants received G-CSF as secondary prophylaxis for neutropenia, a lower proportion on FCR compared with FCM-R (56.1 vs 63.9%). The toxicity of both regimens was acceptable. There are no significant differences between the treatment groups for PFS and OS. The trial demonstrated that the addition of mitoxantrone to FCR did not increase the depth of response. Oral FCR was well tolerated and resulted in impressive responses in terms of CR rates and MRD negativity compared to historical series with intravenous chemotherapy

1937: Abilene Christian College Bible Lectures - Full Text

Delivered in the auditorium of Abilene Christian College, Abilene, Texas, February 193

Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project

Background Adaptive designs offer great promise in improving the efficiency and patient-benefit of clinical trials. An important barrier to further increased use is a lack of understanding about which additional resources are required to conduct a high-quality adaptive clinical trial, compared to a traditional fixed design. The Costing Adaptive Trials (CAT) project investigated which additional resources may be required to support adaptive trials. Methods We conducted a mock costing exercise amongst seven Clinical Trials Units (CTUs) in the UK. Five scenarios were developed, derived from funded clinical trials, where a non-adaptive version and an adaptive version were described. Each scenario represented a different type of adaptive design. CTU staff were asked to provide the costs and staff time they estimated would be needed to support the trial, categorised into specified areas (e.g. statistics, data management, trial management). This was calculated separately for the non-adaptive and adaptive version of the trial, allowing paired comparisons. Interviews with 10 CTU staff who had completed the costing exercise were conducted by qualitative researchers to explore reasons for similarities and differences. Results Estimated resources associated with conducting an adaptive trial were always (moderately) higher than for the non-adaptive equivalent. The median increase was between 2 and 4% for all scenarios, except for sample size re-estimation which was 26.5% (as the adaptive design could lead to a lengthened study period). The highest increase was for statistical staff, with lower increases for data management and trial management staff. The percentage increase in resources varied across different CTUs. The interviews identified possible explanations for differences, including (1) experience in adaptive trials, (2) the complexity of the non-adaptive and adaptive design, and (3) the extent of non-trial specific core infrastructure funding the CTU had. Conclusions This work sheds light on additional resources required to adequately support a high-quality adaptive trial. The percentage increase in costs for supporting an adaptive trial was generally modest and should not be a barrier to adaptive designs being cost-effective to use in practice. Informed by the results of this research, guidance for investigators and funders will be developed on appropriately resourcing adaptive trials

Isotopes in pyrogenic carbon: a review

Pyrogenic carbon (PC; also known as biochar, charcoal, black carbon and soot) derived from natural and anthropogenic burning plays a major, but poorly quantified, role in the global carbon cycle. Isotopes provide a fundamental fingerprint of the source of PC and a powerful tracer of interactions between PC and the environment. Radiocarbon and stable carbon isotope techniques have been widely applied to studies of PC in aerosols, soils, sediments and archaeological sequences, with the use of other isotopes currently less developed. This paper reviews the current state of knowledge regarding (i) techniques for isolating PC for isotope analysis and (ii) processes controlling the carbon (<sup>13</sup>C and <sup>14</sup>C), nitrogen, oxygen, hydrogen and sulfur isotope composition of PC during formation and after deposition. It also reviews the current and potential future applications of isotope based studies to better understand the role of PC in the modern environment and to the development of records of past environmental change

Decadal-scale litter manipulation alters the biochemical and physical character of tropical forest soil carbon

© 2018 Elsevier Ltd Climate change and rising atmospheric carbon dioxide (CO2) concentrations are likely to alter tropical forest net primary productivity (NPP), potentially affecting soil C storage. We examined biochemical and physical changes in soil C fractions in a humid tropical forest where experimental litter manipulation changed total soil C stocks. We hypothesized that: (1.) low-density soil organic C (SOC) fractions are more responsive to altered litter inputs than mineral-associated SOC, because they cycle relatively rapidly. (2.) Any accumulation of mineral-associated SOC with litter addition is relatively stable (i.e. low leaching potential). (3.) Certain biomolecules, such as waxes (alkyl) and proteins (N-alkyl), form more stable mineral-associations than other biomolecules in strongly weathered soils. A decade of litter addition and removal affected bulk soil C content in the upper 5 cm by +32% and −31%, respectively. Most notably, C concentration in the mineral-associated SOC fraction was greater in litter addition plots relative to controls by 18% and 28% in the dry and wet seasons, respectively, accounting for the majority of greater bulk soil C stock. Radiocarbon and leaching analyses demonstrated that the greater mineral-associated SOC in litter addition plots consisted of new and relatively stable C, with only 3% of mineral-associated SOC leachable in salt solution. Solid-state13C NMR spectroscopy indicated that waxes (alkyl C) and microbial biomass compounds (O-alkyl and N-alkyl C) in mineral-associated SOC are relatively stable, whereas plant-derived compounds (aromatic and phenolic C) are lost from mineral associations on decadal timescales. We conclude that changes in tropical forest NPP will alter the quantity, biochemistry, and stability of C stored in strongly weathered tropical soils