203 research outputs found
Interruption of the Arterial Inferior Alveolar Flow and its Effects on Mandibular Collateral Circulation and Dental Tissues
The interruption of circulation through the inferior alveolar artery was followed by the establishment of a fast retrograde blood flow through the vessel. The mental artery and the mandibular branch of the sublingual artery were the main vessels to contribute to that flow. No histopathologic changes were found in the experimental hemimandibles; however, temporary regressive changes were found in the dental pulps of molars.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67920/2/10.1177_00220345750540040301.pd
Observation of the spin-charge thermal isolation of ferromagnetic Ga_{0.94}Mn_{0.06}As by time-resolved magneto-optical measurement
The dynamics of magnetization under femtosecond optical excitation is studied
in a ferromagnetic semiconductor Ga_{0.94}Mn_{0.06}As with a time-resolved
magneto-optical Kerr effect measurement with two color probe beams. The
transient reflectivity change indicates the rapid rise of the carrier
temperature and relaxation to a quasi-thermal equilibrium within 1 ps, while a
very slow rise of the spin temperature of the order of 500ps is observed. This
anomalous behavior originates from the thermal isolation between the charge and
spin systems due to the spin polarization of carriers (holes) contributing to
ferromagnetism. This constitutes experimental proof of the half-metallic nature
of ferromagnetic Ga_{0.94}Mn_{0.06}As arising from double exchange type
mechanism originates from the d-band character of holes
Spin-polarized current amplification and spin injection in magnetic bipolar transistors
The magnetic bipolar transistor (MBT) is a bipolar junction transistor with
an equilibrium and nonequilibrium spin (magnetization) in the emitter, base, or
collector. The low-injection theory of spin-polarized transport through MBTs
and of a more general case of an array of magnetic {\it p-n} junctions is
developed and illustrated on several important cases. Two main physical
phenomena are discussed: electrical spin injection and spin control of current
amplification (magnetoamplification). It is shown that a source spin can be
injected from the emitter to the collector. If the base of an MBT has an
equilibrium magnetization, the spin can be injected from the base to the
collector by intrinsic spin injection. The resulting spin accumulation in the
collector is proportional to , where is the proton
charge, is the bias in the emitter-base junction, and is the
thermal energy. To control the electrical current through MBTs both the
equilibrium and the nonequilibrium spin can be employed. The equilibrium spin
controls the magnitude of the equilibrium electron and hole densities, thereby
controlling the currents. Increasing the equilibrium spin polarization of the
base (emitter) increases (decreases) the current amplification. If there is a
nonequilibrium spin in the emitter, and the base or the emitter has an
equilibrium spin, a spin-valve effect can lead to a giant magnetoamplification
effect, where the current amplifications for the parallel and antiparallel
orientations of the the equilibrium and nonequilibrium spins differ
significantly. The theory is elucidated using qualitative analyses and is
illustrated on an MBT example with generic materials parameters.Comment: 14 PRB-style pages, 10 figure
Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing
Background: The presence of histone 3 lysine 9 (H3K9) methylation on the mouse inactive X chromosome has been controversial over the last 15 years, and the functional role of H3K9 methylation in X chromosome inactivation in any species has remained largely unexplored. Results: Here we report the first genomic analysis of H3K9 di- and tri-methylation on the inactive X: we find they are enriched at the intergenic, gene poor regions of the inactive X, interspersed between H3K27 tri-methylation domains found in the gene dense regions. Although H3K9 methylation is predominantly non-genic, we find that depletion of H3K9 methylation via depletion of H3K9 methyltransferase Set domain bifurcated 1 (Setdb1) during the establishment of X inactivation, results in failure of silencing for around 150 genes on the inactive X. By contrast, we find a very minor role for Setdb1-mediated H3K9 methylation once X inactivation is fully established. In addition to failed gene silencing, we observed a specific failure to silence X-linked long-terminal repeat class repetitive elements. Conclusions: Here we have shown that H3K9 methylation clearly marks the murine inactive X chromosome. The role of this mark is most apparent during the establishment phase of gene silencing, with a more muted effect on maintenance of the silent state. Based on our data, we hypothesise that Setdb1-mediated H3K9 methylation plays a role in epigenetic silencing of the inactive X via silencing of the repeats, which itself facilitates gene silencing through alterations to the conformation of the whole inactive X chromosome.Andrew Keniry, Linden J. Gearing, Natasha Jansz, Joy Liu, Aliaksei Z. Holik, Peter F. Hickey, Sarah A. Kinkel, Darcy L. Moore, Kelsey Breslin, Kelan Chen, Ruijie Liu, Catherine Phillips, Miha Pakusch, Christine Biben, Julie M. Sheridan, Benjamin T. Kile, Catherine Carmichael, Matthew E. Ritchie, Douglas J. Hilton and Marnie E. Blewit
The XMM Cluster Survey: Exploring scaling relations and completeness of the Dark Energy Survey Year 3 redMaPPer cluster catalogue
We cross-match and compare characteristics of galaxy clusters identified in
observations from two sky surveys using two completely different techniques.
One sample is optically selected from the analysis of three years of Dark
Energy Survey observations using the redMaPPer cluster detection algorithm. The
second is X-ray selected from XMM observations analysed by the XMM Cluster
Survey. The samples comprise a total area of 57.4 deg, bounded by the area
of 4 contiguous XMM survey regions that overlap the DES footprint. We find that
the X-ray selected sample is fully matched with entries in the redMaPPer
catalogue, above 20 and within 0.10.9. Conversely, only 38\%
of the redMaPPer catalogue is matched to an X-ray extended source. Next, using
120 optically clusters and 184 X-ray selected clusters, we investigate the form
of the X-ray luminosity-temperature (), luminosity-richness
() and temperature-richness () scaling relations.
We find that the fitted forms of the relations are consistent
between the two selection methods and also with other studies in the
literature. However, we find tentative evidence for a steepening of the slope
of the relation for low richness systems in the X-ray selected sample. When
considering the scaling of richness with X-ray properties, we again find
consistency in the relations (i.e., and )
between the optical and X-ray selected samples. This is contrary to previous
similar works that find a significant increase in the scatter of the luminosity
scaling relation for X-ray selected samples compared to optically selected
samples.Comment: Accepted for publication to MNRA
Research priorities for the management of major trauma: an international priority setting partnership with the James Lind Alliance
Objective
The objective of this study is to determine research priorities for the management of major trauma, representing the shared priorities of patients, their families, carers and healthcare professionals.
Design/setting
An international research priority-setting partnership.
Participants
People who have experienced major trauma, their carers and relatives, and healthcare professionals involved in treating patients after major trauma. The scope included chest, abdominal and pelvic injuries as well as major bleeding, multiple injuries and those that threaten life or limb.
Methods
A multiphase priority-setting exercise was conducted in partnership with the James Lind Alliance over 24 months (November 2021–October 2023). An international survey asked respondents to submit their research uncertainties which were then combined into several indicative questions. The existing evidence was searched to ensure that the questions had not already been sufficiently answered. A second international survey asked respondents to prioritise the research questions. A final shortlist of 19 questions was taken to a stakeholder workshop, where consensus was reached on the top 10 priorities.
Results
A total of 1572 uncertainties, submitted by 417 respondents (including 132 patients and carers), were received during the initial survey. These were refined into 53 unique indicative questions, of which all 53 were judged to be true uncertainties after reviewing the existing evidence. 373 people (including 115 patients and carers) responded to the interim prioritisation survey and 19 questions were taken to a final consensus workshop between patients, carers and healthcare professionals. At the final workshop, a consensus was reached for the ranking of the top 10 questions.
Conclusions
The top 10 research priorities for major trauma include patient-centred questions regarding pain relief and prehospital management, multidisciplinary working, novel technologies, rehabilitation and holistic support. These shared priorities will now be used to guide funders and teams wishing to research major trauma around the globe
The Atacama Cosmology Telescope: A Catalog of >4000 Sunyaev–Zel’dovich Galaxy Clusters
We present a catalog of 4195 optically confirmed Sunyaev–Zel'dovich (SZ) selected galaxy clusters detected with signal-to-noise ratio >4 in 13,211 deg2 of sky surveyed by the Atacama Cosmology Telescope (ACT). Cluster candidates were selected by applying a multifrequency matched filter to 98 and 150 GHz maps constructed from ACT observations obtained from 2008 to 2018 and confirmed using deep, wide-area optical surveys. The clusters span the redshift range 0.04 1 clusters, and a total of 868 systems are new discoveries. Assuming an SZ signal versus mass-scaling relation calibrated from X-ray observations, the sample has a 90% completeness mass limit of M500c > 3.8 × 1014 M⊙, evaluated at z = 0.5, for clusters detected at signal-to-noise ratio >5 in maps filtered at an angular scale of 2farcm4. The survey has a large overlap with deep optical weak-lensing surveys that are being used to calibrate the SZ signal mass-scaling relation, such as the Dark Energy Survey (4566 deg2), the Hyper Suprime-Cam Subaru Strategic Program (469 deg2), and the Kilo Degree Survey (825 deg2). We highlight some noteworthy objects in the sample, including potentially projected systems, clusters with strong lensing features, clusters with active central galaxies or star formation, and systems of multiple clusters that may be physically associated. The cluster catalog will be a useful resource for future cosmological analyses and studying the evolution of the intracluster medium and galaxies in massive clusters over the past 10 Gyr
Measurement of the splashback feature around SZ-selected Galaxy clusters with DES, SPT, and ACT
We present a detection of the splashback feature around galaxy clusters selected using the Sunyaev–Zel’dovich (SZ) signal. Recent measurements of the splashback feature around optically selected galaxy clusters have found that the splashback radius, rsp, is smaller than predicted by N-body simulations. A possible explanation for this discrepancy is that rsp inferred from the observed radial distribution of galaxies is affected by selection effects related to the optical cluster-finding algorithms. We test this possibility by measuring the splashback feature in clusters selected via the SZ effect in data from the South Pole Telescope SZ survey and the Atacama Cosmology Telescope Polarimeter survey. The measurement is accomplished by correlating these cluster samples with galaxies detected in the Dark Energy Survey Year 3 data. The SZ observable used to select clusters in this analysis is expected to have a tighter correlation with halo mass and to be more immune to projection effects and aperture-induced biases, potentially ameliorating causes of systematic error for optically selected clusters. We find that the measured rsp for SZ-selected clusters is consistent with the expectations from simulations, although the small number of SZ-selected clusters makes a precise comparison difficult. In agreement with previous work, when using optically selected redMaPPer clusters with similar mass and redshift distributions, rsp is ∼2σ smaller than in the simulations. These results motivate detailed investigations of selection biases in optically selected cluster catalogues and exploration of the splashback feature around larger samples of SZ-selected clusters. Additionally, we investigate trends in the galaxy profile and splashback feature as a function of galaxy colour, finding that blue galaxies have profiles close to a power law with no discernible splashback feature, which is consistent with them being on their first infall into the cluster
- …