Firming up the foundations: reflections on verifying the quotations in a historical dictionary, with reference to "A Dictionary of South African English on Historical Principles"

A Dictionary of South African English on Historical Principles (DSAEHist) is rooted in quotation evidence. It contains just over 8 000 South African English entries, with about 45 000 citations to support those words included as headwords in the dictionary. Using the legacy electronic format in which DSAEHist was typeset, the Dictionary Unit for South African English embarked on a digitising process of DSAEHist, during which it became clear that the quotations would benefit from a full review involving the verification of all quotations against their original sources. This article examines the evolution of the quotation verification project from its beginnings as an entirely manual exercise to its current use of software developed for the purpose. Some of the project’s achievements, such as antedatings and primary source identification, are highlighted, and challenges, such as unverifiable quotations and sometimes highly convoluted research paths, are described. In addition to this, the article looks at the necessarily systematic nature of quotation handling and the main types of considerations determining methodology (for example, lexicographic, bibliographic and typographic requirements)

A Pollen Record of the Presence of Hunter-fisher Communities in the Vicinity of Lake Retsamo, Finnish Lapland

A pollen profile from Lake Retsamo, Finnish Lapland, is presented. The entire Holocene vegetation history is illustrated from an open-land phase following the disappearance of the ice, through birch woodland to the pine dominated forest of today. Phases during which the vegetation surrounding the lake has been disturbed in some way are pinpointed. The longest, most destructive of these phases is dated from mid 15th to mid 17th century and is interpreted as being related to a Sámi winter village, remains of which are visible on the lake shore. There is slighter evidence for up to four earlier disturbance phases but the interpretation of these is more controversial: they may be anthropogenic but could be in connection with naturally occurring fires. The slow rate of sediment accumulation (av. 0.034 cm year) means that the temporal resolution of all phases is poor when compared with that of a peat profile adjacent to another winter village, Einehlammet. The interference phases are assessed relative to the overall picture of the advance of hunter-fisher populations into Lapland

Patterns in recent and Holocene pollen accumulation rates across Europe - the Pollen Monitoring Programme Database as a tool for vegetation reconstruction

The collection of modern, spatially extensive pollen data is important for the interpretation of fossil pollen assemblages and the reconstruction of past vegetation communities in space and time. Modern datasets are readily available for percentage data but lacking for pollen accumulation rates (PARs). Filling this gap has been the motivation of the pollen monitoring network, whose contributors monitored pollen deposition in modified Tauber traps for several years or decades across Europe. Here we present this monitoring dataset consisting of 351 trap locations with a total of 2742 annual samples covering the period from 1981 to 2017. This dataset shows that total PAR is influenced by forest cover and climate parameters, which determine pollen productivity and correlate with latitude. Treeless vegetation produced PAR values of at least 140 grains cm−2 yr−1. Tree PAR increased by at least 400 grains cm−2 yr−1 with each 10 % increase in forest cover. Pollen traps situated beyond 200 km of the distribution of a given tree species still collect occasional pollen grains of that species. The threshold of this long-distance transport differs for individual species and is generally below 60 grains cm−2 yr−1. Comparisons between modern and fossil PAR from the same regions show similar values. For temperate taxa, modern analogues for fossil PARs are generally found downslope or southward of the fossil sites. While we do not find modern situations comparable to fossil PAR values of some taxa (e.g. Corylus), CO2 fertilization and land use may cause high modern PARs that are not documented in the fossil record. The modern data are now publicly available in the Neotoma Paleoecology Database and aid interpretations of fossil PAR data.publishedVersio

American Society of Clinical Oncology/College ofAmerican Pathologists guideline recommendations forimmunohistochemical testing of estrogen andprogesterone receptors in breast cancer

Purpose: To develop a guideline to improve theaccuracy of immunohistochemical (IHC) estrogen receptor(ER) and progesterone receptor (PgR) testing in breastcancer and the utility of these receptors as predictivemarkers.Methods: The American Society of Clinical Oncologyand the College of American Pathologists convened aninternational Expert Panel that conducted a systematicreview and evaluation of the literature in partnership withCancer Care Ontario and developed recommendations foroptimal IHC ER/PgR testing performance.Results: Up to 20% of current IHC determinations ofER and PgR testing worldwide may be inaccurate (falsenegative or false positive). Most of the issues with testinghave occurred because of variation in preanalyticvariables, thresholds for positivity, and interpretationcriteria.Recommendations: The Panel recommends that ER andPgR status be determined on all invasive breast cancers andbreast cancer recurrences. A testing algorithm that relieson accurate, reproducible assay performance is proposed.Elements to reliably reduce assay variation are specified. It is recommended that ER and PgR assays be consideredpositive if there are at least 1% positive tumor nuclei in the sample on testing in the presence of expected reactivity of internal (normal epithelial elements) and external controls. The absence of benefit from endocrine therapy for women with ER-negative invasive breast cancers has been confirmed in large overviews of randomized clinical trials.(Arch Pathol Lab Med. 2010;134:907–922

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD