100 research outputs found
Two-mode overconstrained three-DOFs rotational-translational linear-motor-based parallel-kinematics mechanism for machine tool applications
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- 01/07/2007
- Field of study
The paper introduces a family of three-DOFs translational-rotational Parallel-Kinematics Mechanisms (PKMs) as well as the mobility analysis of such family using Lie-group theory. Each member of this family has two-rotational one-translational DOFs. A novel mechanism is presented and analyzed as a representative of that family. The use and the practical value of that modular mechanism are emphasized.<br /
High-precision five-axis machine for high-speed material processing using linear motors and parallel-serial kinematics
- Publication venue
- IEEE Xplore
- Publication date
- 01/01/2006
- Field of study
The paper describes some details of the mechanical and kinematics design of a five-axis mechanism. The design has been utilized to physically realize an industrial-scale five-axis milling machine that can carry a three KW spindle. However, the mechanism could be utilized in other material processing and factory automation applications. The mechanism has five rectilinear joints/axes. Two of these axes are arranged traditionally, i.e. in series, and the other three axes utilize the concept of parallel kinematics. This combination results in a design that allows three translational and two rotational two-mode degrees of freedom (DOFs). The design provides speed, accuracy and cost advantages over traditional five-axis machines. All axes are actuated using linear motors. <br /
Resting Regulatory CD4 T Cells: A Site of HIV Persistence in Patients on Long-Term Effective Antiretroviral Therapy
- Author
- A Brussel
- A Demoustier
- A Kinter
- A O'Garra
- AJ Chase
- AL Kinter
- AL Kinter
- Anne-Marie Balazuc
- B Ramratnam
- B Ramratnam
- Bamory Dembele
- BT Rouse
- C Baecher-Allan
- C Grant
- C Iyasere
- CA Piccirillo
- Coralie Pallier
- Cécile Goujard
- D Finzi
- D Finzi
- DC Douek
- EM Aandahl
- Emilie Le Névot
- FX Wang
- G Lehrman
- H von Boehmer
- Houria Hendel-Chavez
- HW Lim
- J Harnaha
- Jacques Gasnault
- JD Siliciano
- JD Siliciano
- Jean-François Delfraissy
- JK Wong
- K Oswald-Richter
- Karim Abbed
- L Geeraert
- L Li
- L Weiss
- L Ylisastigui
- M Ahmadzadeh
- M Hermankova
- Marie-Ghislaine de Goër de Herve
- N Sagot-Lerolle
- N Seddiki
- NO Camara
- O Lambotte
- O Lambotte
- Peter Sommer
- QE Yang
- R Cabrera
- S Sakaguchi
- SA Younes
- SF Ziegler
- T Pierson
- T Takahashi
- TR Malek
- Tu-Anh Tran
- TW Chun
- TW Chun
- TW Chun
- W Liu
- Y Belkaid
- Yassine Taoufik
- Publication venue
- Public Library of Science
- Publication date
- 01/10/2008
- Field of study
BACKGROUND: In HIV-infected patients on long-term HAART, virus persistence in resting long-lived CD4 T cells is a major barrier to curing the infection. Cell quiescence, by favouring HIV latency, reduces the risk of recognition and cell destruction by cytotoxic lymphocytes. Several cell-activation-based approaches have been proposed to disrupt cell quiescence and then virus latency, but these approaches have not eradicated the virus. CD4+CD25+ regulatory T cells (Tregs) are a CD4+ T-cell subset with particular activation properties. We investigated the role of these cells in virus persistence in patients on long-term HAART. METHODOLOGY/PRINCIPAL FINDINGS: We found evidence of infection of resting Tregs (HLADR(-)CD69(-)CD25(hi)FoxP3+CD4+ T cells) purified from patients on prolonged HAART. HIV DNA harbouring cells appear more abundant in the Treg subset than in non-Tregs. The half-life of the Treg reservoir was estimated at 20 months. Since Tregs from patients on prolonged HAART showed hyporesponsiveness to cell activation and inhibition of HIV-specific cytotoxic T lymphocyte-related functions upon activation, therapeutics targeting cell quiescence to induce virus expression may not be appropriate for purging the Treg reservoir. CONCLUSIONS: Our results identify Tregs as a particular compartment within the latent reservoir that may require a specific approach for its purging
Theia: Faint objects in motion or the new astrometry frontier
- Author
- Albertus Conrado
- Amorim Antonio
- Anglada-Escude Guillem
- Bertone Stefano
- Boehm Celine
- Bouy Herve
- Boylan-Kolchin Michael
- Brandeker Alexis
- Brown Anthony
- Brown Warren
- Cardoso Vitor
- Chemin Laurent
- Claudi Riccardo
- Collaboration The Theia
- Correia Alexandre C. M.
- Courbin Frederic
- Crosta Mariateresa
- Crouzier Antoine
- Cyr-Racine Francis-Yan
- da Silva Antonio
- Damasso Mario
- Das Payel
- Davies Melvyn
- Dayal Pratika
- de Mora Jordi Portell i
- de Val-Borro Miguel
- Diaferio Antonaldo
- Ensslin Torsten
- Erickcek Adrienne
- Evans Dafydd Wyn
- Fairbairn Malcolm
- Falcao Antonio
- Fortin Morgane
- Freese Katherine
- Fridlund Malcolm
- Garcia Paulo
- Gnedin Oleg
- Goobar Ariel
- Gordo Paulo
- Goullioud Renaud
- Hambly Nigel
- Hara Nathan
- Hobbs David
- Hog Erik
- Holl Berry
- Holland Andrew
- Ibata Rodrigo
- Jordi Carme
- Klioner Sergei
- Kopeikin Sergei
- Krone-Martins Alberto
- Labadie Lucas
- Lacroix Thomas
- Laskar Jacques
- Le Poncin-Lafitte Christophe
- Leger Alain
- Luri Xavier
- Majumdar Subhabrata
- Makarov Valeri
- Malbet Fabien
- Mamon Gary
- Massey Richard
- McArthur Barbara
- Mennesson Bertrand
- Michalik Daniel
- Moitinho de Almeida Andre
- Mora Alcione
- Mourao Ana
- Moustakas Leonidas
- Murray Neil
- Muterspaugh Matthew
- Oertel Micaela
- Ostorero Luisa
- Perez-Garcia Angeles
- Platais Imants
- Quirrenbach Andreas
- Randall Lisa
- Read Justin
- Regos Eniko
- Rory Barnes
- Rybicki Krzysztof
- Schneider Jean
- Scholtz Jakub
- Scott Pat
- Shao Michael
- Siebert Arnaud
- Sozzetti Alessandro
- Spolyar Douglas
- Tereno Ismael
- Tomsick John
- Traub Wesley
- Valluri Monica
- Villaver Eva
- Walker Matt
- Walton Nicholas
- Watkins Laura
- White Glenn
- Wyrzykowski Lukasz
- Wyse Rosemary
- Publication venue
- 'Center for Open Science'
- Publication date
- 01/07/2017
- Field of study
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- di Tomasso Nora N.
- di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- Do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
- Dowling Anna T.
- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari Mina
- Ellis Helen E.
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin E.
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M.
- Estrella Claudia R.
- Ezzouine Hanane
- Fan Eddy
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- França Ana G.
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan N.
- Garcia Patricio H.
- Gattinoni Luciano
- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa Dina
- Gomes Rui M.
- Gomez Pablo E.
- Gomez-Flores Saira S.
- Gonz Á Lez Raquel Montiel
- Gonzalez Daniel R.
- Gonzalez Marcos
- González Rojas Manuel A.
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer C.
- Gordo Federico
- Gosselin Ryan J.
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth O.
- Grigoriev Evgeny
- Grijalba Carolina Quintana
- Grissom Colin K.
- Gritsan Alexey I.
- Grubissich Nicolas
- Gueret Renaud M.
- Gurjar Mohan
- Guttormsen Anne B.
- Guérin Claude
- Gómez Pilar Ricart Aroa
- Hacking Danielle J.
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha J.
- Han Hui
- Han Yi
- Hang Ai Y.
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M.
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge J.
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert J.
- Heunks Leo M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter C.
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X.
- Huang Qing Q.
- Huang Xiao B.
- Huerta Francisco P.
- Huff Nidhi G.
- Humphreys Sally K.
- Hunt Anna
- Hurtado Javier
- Hutchison Robyn A.
- Hutton Paula J.
- Ibañez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu P.
- Imperio María C.
- Insaurralde Carolina S.
- Inskip Deborah M.
- Ioannou Nicholas
- Iotti Giorgio A.
- Irvine Donald A.
- Ismail Dina
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F.
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola Yves D.
- Jassal Mandeep
- Javeed Areej
- Javier-Blanco
- Jhamatthew Thomas Rajeev R.
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio G.
- Jochmans S. bastien
- Jog Sameer A.
- Jovanovic Bojan
- Judy Claine
- Jurado M. . Teresa
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana G.
- Kansuke-Koyama
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
- Kheir Fayez M.
- Kimura Hiroyasu
- Kiourtzieva Ellada V.
- Kitch Barrett T.
- Knapman Karl M.
- Knoll Jenny
- Knowles Serena
- Kol Mark R.
- Kong Jing
- Kraßler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- Laake Jon H.
- Laake Jon Henrik
- Labarca Eduardo F.
- Laffey John
- Laffey John G.
- Laffey John G.
- Lamb Keith D.
- Lanspa Michael J.
- Larsson Anders
- Larsson Niklas
- le Moal Charlene
- Lebbinck Herve
- Lee Jarone
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus Jordana S.
- Leon Yoshido Hector H.
- Li Bin
- Li Qingdong
- Li Qiong J.
- Li Wenwen
- Li Xiao L.
- Li Xinyu
- Li Yimin
- Li Yuan Y.
- Li-Xin Zhou
- Liew Kong Y.
- Ling Long L.
- Liu Haitao
- Liu Jian
- Liu Jing L.
- Liu Ling
- Llano Miguel
- Llinares Moya David D.
- Lohner Ralph
- Loiacono Flavia A.
- Lombardo Andrea
- Lopez Esther Bermejo
- Lopez-Delgado Juan C.
- Lora Fredy S.
- Lora Pilar
- Lorente Jose A.
- Losada Elena Perez
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon Sanchez Eugenio
- Luo Xiaoming
- Lynch Joan M.
- López-Messa Juan B.
- Maazouzi Wajdi
- MacFadyen Rosaleen
- MacFie Caroline C.
- Madotto Fabiana
- Maeyama Hiroki N.
- Maghrabi Khalid A.
- Magret Monica
- Mahto Heera L.
- Mancebo Jordi
- Manoharan Venika
- Marcos Diego Pastor
- Marcu Alexandra
- Maria Villa
- Marin Julien
- Marin Maria C.
- Martinez Felipe T.
- Martinho Aurelia M.
- Marum Susan M.
- Massa Eleni V.
- Mataloun Sergio
- Matamis Dimitrios
- Matsumoto Shuhei
- Mattei Alessia
- May Martin M.
- McArthur Colin
- McAuley Daniel F.
- McAuley Daniel F.
- McAuley Danny
- McCalman Katie H.
- McKechnie Stuart
- McKee Raymond
- McKenna Toni E.
- McLeod Alex
- McNamee Lia
- McNicholas Bairbre
- Meaney Edel A.
- Meco Basak Ceyda
- Meersseman Philippe
- Mehta Sangeeta
- Mejia Francisco Javier Flores
- Mellis Clare
- Memon Mohammedfaruk
- Mercat Alain
- Mesar Tomaz
- Messias António M.
- Messika Jonathan
- Meybohm Patrick
- Michel Philippe
- Millar Rebecca T.
- Miller Jennene J.
- Miller Russel R.
- Mirabella Lucia
- Miryam-Prieto-González
- Mizuguchi Ichiko
- Mochizuki Katsunori
- Mohr Nicholas M.
- Mojoli Francesco
- Moles Silvia Iglesias
- Molin Alexandre
- Montanha Gustavo M.
- Monteiro Jorge M.
- Montero Laura Alvarez
- Montes Oscanoa Fredy A.
- Monti Giacomo
- Montini Luca M.
- Moock Marcelo
- Morin Anna-Karin
- Mortaza Satar
- Morton Alex
- Mouloudi Eleni K.
- Mukkera Satyanarayana Reddy
- Mustafa Ghanem M.
- Muthuchellappan Radhakrishnan
- Myra-Rinia
- Máca Jan
- Nagy Eva O.
- Nakamura Tomoyuki
- Namih Miriam
- Nassar Antonio P.
- Nasu Michitaka
- Navalpotro Miguel Angel Blasco
- Navarra Leanlove
- Navarro Gonzalo
- Neal John
- Negoita Silvius Ioan
- Newby Lynette
- Nichol Alistair
- Nielsen Jonas
- Niimi Daisuke
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- Nitta Kenichi
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- Ortiz Claudia A.
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- Ouanes Islem
- Ourailogloy Vasilis
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- Ozcelik Menekse
- Palaniswamy Vijayanand
- Palma Daniela M.
- Palmese Salvatore
- Palo Jose Emmanuel
- Panarello Giovanna
- Panwar Rakshit
- Papanikolaou Metaxia N.
- Papavasilopoulou Theonymfi G.
- Papazian Laurent
- Papurica Marius
- Para Luis Herrera
- Parhar Ken
- Parotto Matteo
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- Patroniti Nicolò
- Pattarino Pierpaolo Terragni Ilaria
- Pecci Elisabetta
- Pellegrini Carlos A.
- Pelletier Nicolas
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- Pereira Carlos S.
- Perez Cesar P.
- Perez Manuel P.
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- Pillai Suresh
- Pintado Maria C.
- Piquilloud Lise
- Piras Claudio
- Pittini Gustavo
- Plotnikow Gustavo A.
- Poblano Manuel
- Poli Michela M.
- Pota Vincenzo
- Pozo Norberto C.
- Pozzi Matteo
- Preez Pieter D.
- Pronovost Antoine
- Protti Alessandro
- Protti Alessandro
- Qin Bingyu
- Qin Junping
- Qin Shu H.
- Qin Tie H.
- Qiu Haibo
- Raaijmakers Monique
- Rafael S. nchez I.
- Raimondi Ferdinando
- Raj Ashok S.
- Ramakrishnan Nagarajan
- Ramesh Venkatapura J.
- Ramirez-Alfaro Christian M.
- Ramirez-Gutierrez Alvaro
- Rampinelli Adenilton M.
- Ranero Jorge Luis
- Ranieri Marco
- Raponi Francesco
- Recio Noelia N.
- Reschreiter Henrik
- Reske Andreas W.
- Reuter Danielle
- Reynolds Claire
- Rezoagli Emanuele
- Rhayakar Rachana V.
- Rialp Gemma
- Richecoeur Jack R.
- Ricome Sylvie
- Rigaud Jean-Philippe
- Rios Fernando
- Riss Katharina C.
- Rittayamai Nuttapol
- Roberts Brigit L.
- Robine Adrien
- Robles Joanne B.
- Roche-Campo Ferran
- Rodgers Helen J.
- Rodriguez Lucia L.
- Rodriguez Ruben
- Rosa Jonas I.
- Roser Tomas P.
- Rossi Anna
- Roux Damien
- Rubenfeld Gordon
- Rugonfalvi Szabolcs
- Ruiz Silvia Rodriguez
- Ruiz-Aguilar Antonio L.
- Rylander Christian C.
- Ryosuke Sekine
- Sabelnikovs Olegs
- Sable Safal D.
- Saenz María G.
- Saez Alejandro A.
- Sagar Sudha V.
- Saito Koji
- Saito Shigeki
- Salahuddin Nawal
- Salas Javier E.
- Sales Vanessa M.
- Samkaoui Nacer
- Sanchez Roberto Jimenez
- Sanchez-Hurtado Luis A.
- Sanchez-Medina Jorge R.
- Sandesc Dorel
- Santoli Francesco L.
- Santos Cristina
- Sauvadet Elise P.
- Savioli Monica
- Scafetti Sergio
- Schiavone Vincenzo
- Schiavoni Lorenzo
- Schiöler Fredrik
- Schlichting Adam B.
- Schmidt Marcello
- Schneider Francis
- Schomer Ashley
- Schouten Jeroen A.
- Schuetz Michael
- Schultz Marcus J.
- Schäfer Susanne
- Scott Christopher J.
- Seasman Colette
- Seethala Raghu
- Sellors Gareth P.
- Seoane-Quiroga Leticia
- Serra Carolina
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- Sivashanmugavel Mageswaran
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- Tibblin Anna Oscarsson
- Tinnirello Andrea
- Tiribelli Norberto
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- Veljovic Milic
- Venti Aaron
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- Villagomez Asisclo J.
- Villamagua Boris G.
- Villar Veronica
- Vinzio Mauricio
- Virgilio Corcoles G.
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- Volta Carlo A.
- Wang Chunting
- Wang Hua X.
- Wang Shou H.
- Wang Wei
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- Watanabe Eizo
- Watt Philip
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- Williams Alexandra J.
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- Woods Paul W.
- Wrathall David W.
- Wrigge Hermann
- Wu Ya Q.
- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale J.
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
Theia: Faint objects in motion or the new astrometry frontier
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- Albertus Conrado
- Amorim Antonio
- Anglada-Escude Guillem
- Bertone Stefano
- Boehm Celine
- Bouy Herve
- Boylan-Kolchin Michael
- Brandeker Alexis
- Brown Anthony
- Brown Warren
- Cardoso Vitor
- Chemin Laurent
- Claudi Riccardo
- Collaboration The Theia
- Correia Alexandre C. M.
- Courbin Frederic
- Crosta Mariateresa
- Crouzier Antoine
- Cyr-Racine Francis-Yan
- da Silva Antonio
- Damasso Mario
- Das Payel
- Davies Melvyn
- Dayal Pratika
- de Mora Jordi Portell i
- de Val-Borro Miguel
- Diaferio Antonaldo
- Ensslin Torsten
- Erickcek Adrienne
- Evans Dafydd Wyn
- Fairbairn Malcolm
- Falcao Antonio
- Fortin Morgane
- Freese Katherine
- Fridlund Malcolm
- Garcia Paulo
- Gnedin Oleg
- Goobar Ariel
- Gordo Paulo
- Goullioud Renaud
- Hambly Nigel
- Hara Nathan
- Hobbs David
- Hog Erik
- Holl Berry
- Holland Andrew
- Ibata Rodrigo
- Jordi Carme
- Klioner Sergei
- Kopeikin Sergei
- Krone-Martins Alberto
- Labadie Lucas
- Lacroix Thomas
- Laskar Jacques
- Le Poncin-Lafitte Christophe
- Leger Alain
- Luri Xavier
- Majumdar Subhabrata
- Makarov Valeri
- Malbet Fabien
- Mamon Gary
- Massey Richard
- McArthur Barbara
- Mennesson Bertrand
- Michalik Daniel
- Moitinho de Almeida Andre
- Mora Alcione
- Mourao Ana
- Moustakas Leonidas
- Murray Neil
- Muterspaugh Matthew
- Oertel Micaela
- Ostorero Luisa
- Perez-Garcia Angeles
- Platais Imants
- Quirrenbach Andreas
- Randall Lisa
- Read Justin
- Regos Eniko
- Rory Barnes
- Rybicki Krzysztof
- Schneider Jean
- Scholtz Jakub
- Scott Pat
- Shao Michael
- Siebert Arnaud
- Sozzetti Alessandro
- Spolyar Douglas
- Tereno Ismael
- Tomsick John
- Traub Wesley
- Valluri Monica
- Villaver Eva
- Walker Matt
- Walton Nicholas
- Watkins Laura
- White Glenn
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- Wyse Rosemary
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- 'Center for Open Science'
- Publication date
- 01/07/2017
- Field of study
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at √s=0.9 and 2.36 TeV
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- Publication venue
- Publication date
- 01/01/2010
- Field of study
Measurements of inclusive charged-hadron transverse-momentum and pseudorapidity distributions are presented for proton-proton collisions at root s = 0.9 and 2.36 TeV. The data were collected with the CMS detector during the LHC commissioning in December 2009. For non-single-diffractive interactions, the average charged-hadron transverse momentum is measured to be 0.46 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 0.9 TeV and 0.50 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 2.36 TeV, for pseudorapidities between -2.4 and +2.4. At these energies, the measured pseudorapidity densities in the central region, dN(ch)/d eta vertical bar(vertical bar eta vertical bar and pp collisions. The results at 2.36 TeV represent the highest-energy measurements at a particle collider to date
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.
- Author
- Abar Aden Elmi
- Abdelmoula Fatma
- Abe Haruka
- Abechi Priscilla
- Abias Abe G
- Abid Nabil
- Abouelhoda Mohamed
- Abuzaid Nadir
- Abworo Edward O
- Adetifa Ifedayo MO
- Adewumi Olubusuyi M
- Adeyemi Kayode T
- Adu Bright
- Africa Pathogen Genomics Initiative (Africa PGI)‡
- Agoti Charles N
- Agwa Sara Hassan
- Agweyu Ambrose
- Ahmed El Bara
- Ahmed Elhadi A
- Ahmed Shymaa S
- Ahmed Side Mohamed
- Ahmed Yahaya Ali
- Ahuka-Mundeke Steve
- Ajayi Nnennaya A
- Ajogbasile Fehintola V
- Akoua-Koffi Chantal G
- Akpede George O
- Allam Mushal
- Amoako Daniel G
- Ampofo William K
- Amuri Adrienne A
- Amuzu Dominic SY
- Andeko Julia C
- Andriamandimby Soa Fy
- Anoh Etilé A
- Anscombe Catherine
- Anyaneji Ugochukwu J
- Arnaldo Paulo
- Aryeetey Sherihane
- Audu Rosemary A
- Awandare Gordon A
- Ayei James
- Ayekaba Mitoha Ondo'o
- Ayivor-Djanie Reuben
- Aziz Ramy Karam
- Baker David
- Balde Aladje
- Barasa Edwine
- Batchi-Bouyou Armel L
- Baxter Cheryl
- Bbosa Nicholas
- Bedford Trevor
- Bediako Yaw
- Behillil Sylvie
- Bejon Philip
- Belarbi Essia
- Beloufa Mohamed Amine
- Ben Boubaker Ilhem Boutiba
- Bester Phillip A
- Bhiman Jinal N
- Biscornet Leon
- Bolajoko Bankole
- Bonney Joseph HK
- Bootsma Sacha
- Bouzid Amal
- Bridges Daniel J
- Brook Cara
- Budiaki Sylvie L
- Butera Yvan
- Campbell Allan
- Carr Rosina AA
- Carvalho Kevin S
- Chabuka Lucious
- Chinedu Ugwu
- Choga Wonderful T
- Chouikha Anissa
- Christoffels Alan
- Combe Patrice
- Cotten Matthew
- Damaris Matoke-Muhia
- de Laurent Zaydah R
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- Dellagi Koussay
- Deng Lul Lojok
- Derrar Fawzi
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- Diarra Bassirou
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- Enouf Vincent
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- Francisco Ngiambudulu M
- Gargouri Saba
- Gaseitsiwe Simani
- George Uwem E
- Giandhari Jennifer
- Githinji George
- Goba Augustine
- Goedhals Dominique
- Gorman Richmond
- Gorova Vivianne
- Grace Chukwa
- Grant Donald S
- Grayo Solène
- Gueye Abdou Salam
- Gumbo Hlanai
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- Ismail Arshad
- Iyanu Fred-Akintunwa
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- Johnson Adeniji A
- Joseph Rageema
- Juru Agnes
- Kadjo Herve Albéric Adje
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- Karim Wasim Abdul
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- Sylvanus Okogbenin
- Sylverken Augustina A
- Takawira Faustinos T
- Tamfum Jean-Jacques M
- Tatfeng Mirabeau Y
- Taweh Fahn M
- Tebeje Yenew K
- Tegally Houriiyah
- Tegomoh Bryan
- Tessema Sofonias K
- Testimony Olumade
- Thilliez Gaetan
- Tomori Oyewale
- Top Ndeye Marieme
- Tordo Noël
- Trabelsi Sameh
- Treurnicht Florette
- Triki Henda
- Trotter Alexander J
- Tshiabuila Derek
- Tsofa Benjamin
- Tumedi Kefentse A
- Tyers Lynn
- Uwanibe Jessica N
- van der Werf Sylvie
- van Wyk Stephanie
- van Zyl Gert U
- Velavan Thirumalaisamy P
- Venter Marietjie
- Victoir Kathleen
- Vinze Anika
- von Gottberg Anne
- Wamala Joseph F
- Wanjohi Dorcas W
- Wasfi Fares
- Wiley Michael R
- Wilkinson Eduan
- Williamson Carolyn
- Wolter Nicole
- Wurie Isatta
- Xavier Joicymara S
- Yadouleton Anges
- Yasuda Jiro
- Zekri Abdel-Rahman N
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 15/09/2022
- Field of study
Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the pandemic on the continent, a number that now exceeds 100,000 genomes. Our results show an increase in the number of African countries that are able to sequence domestically and highlight that local sequencing enables faster turnaround times and more-regular routine surveillance. Despite limitations of low testing proportions, findings from this genomic surveillance study underscore the heterogeneous nature of the pandemic and illuminate the distinct dispersal dynamics of variants of concern-particularly Alpha, Beta, Delta, and Omicron-on the continent. Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve while the continent faces many emerging and reemerging infectious disease threats. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
- Author
- Aanniz Tarek
- Abar Aden Elmi
- Abbad Anass
- Abdelfattah May
- Abdelhamid W.
- Abdella Saro
- Abdellah Faouzi
- Abdelmjid El Oualid
- Abdelmoula Fatma
- Abdelmoulah F.
- Abderrahmane Maaroufi
- Abderrazak Rfaki
- Abdillahi Idil Salah
- Abdissa Alemseged
- Abdo I.
- Abdoelraheem Mohamed Hassan
- Abe Haruka
- Abebe Markos
- Abechi Priscilla
- Abera Adugna
- Abi Rachid
- Abias Abe G.
- Abichu Getachew
- Abid N.
- Abid Nabil
- Abid Salma
- Abilio Nuro
- Abimbola Sharon
- Abo Shama Noura M
- Abosede O.
- Aboubaker Mohamed Houmed
- Abouelhoda Mohamed
- Abouelnaga S.
- Abualas Elamin
- Abubeker Ramalia Chabi
- Abuelenein Ehab Abdelkader
- Abuzaid Nadir
- Abworo Edward O.
- Ada Diosdado Odjama Nseng
- Addidle Michael
- Adegbola Richard
- Adegnika Akim A.
- Adegnika Ayola Akim
- Adel Abd Monaem
- Adeniji Johnson A.
- Adepetun Tomiwa
- Adesegun A.
- Adesuyi Omoare
- Adetifa Ifedayo M. O.
- Adewumi Olubusuyi M.
- Adewumi Oluwatimilehin
- Adewumi Praise
- Adeyemi Kayode T.
- Adhikari Bishwo N.
- Adil El Hamouchi
- Adjiratou Aissatou B. A.
- Adnew Bethlehem
- Adu Bright
- Adu Eric
- Adusei-Poku Mildred
- Agbenyo Seyram Bless
- Agbodzi B.
- Ageez A.M.
- Agoti Charles N.
- Aguenaou Hassan
- Agwa Sara Hassan
- Agweyu Ambrose
- Ahmed El Bara
- Ahmed Elhadi A.
- Ahmed Hatem
- Ahmed M.
- Ahmed O. S.
- Ahmed Rahma
- Ahmed Shymaa S.
- Ahmed Side Mohamed
- Ahmed Yahaya Ali
- Ahouidi Ambroise
- Ahuka-Mundeke Steve
- Ahumibe Anthony
- Ahyong Vida
- Aissam El Aliani
- Ajayi Nnennaya A.
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- Ajili F.
- Ajogbasile F.V.
- Ajogbasile Fehintola V.
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- Akenji Blaise MBoringong
- Akhoud Youssef
- Akinola Monilade
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- AlEmam Adba Alfatih
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- Algheriani Raiva
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- Ali Mohamed Ahmed
- Ali Mushal
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- Allam Loubna
- Allam Mushal
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- Lalemi Mary
- Lambisia Arnold W.
- Lamboni Lallepak
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- Langat Sombo
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- Layibo Yasser
- Le Viet Thanh
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- Maritz Jean
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- Massinga Arsenia
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- Zahran Manal Hamdy
- Zekri Abdel-Rahman N.
- Zhang J.
- Zhou Pei
- Zinyowera Sekesai
- Zong Minko O.
- Zongo Arsène
- Zorgani A.
- Zouaki Amal
- Zulu P.
- Zumla Ali
- Zumla Alimuddin
- Zuze Boitumelo
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 07/10/2022
- Field of study
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century
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