A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging

Older adults and particularly those at risk for developing dementia typically show a decline in episodic memory performance, which has been associated with altered memory network activity detectable via functional magnetic resonance imaging (fMRI). To quantify the degree of these alterations, a score has been developed as a putative imaging biomarker for successful aging in memory for older adults (Functional Activity Deviations during Encoding, FADE; Düzel et al., Hippocampus, 2011; 21: 803–814). Here, we introduce and validate a more comprehensive version of the FADE score, termed FADE-SAME (Similarity of Activations during Memory Encoding), which differs from the original FADE score by considering not only activations but also deactivations in fMRI contrasts of stimulus novelty and successful encoding, and by taking into account the variance of young adults' activations. We computed both scores for novelty and subsequent memory contrasts in a cohort of 217 healthy adults, including 106 young and 111 older participants, as well as a replication cohort of 117 young subjects. We further tested the stability and generalizability of both scores by controlling for different MR scanners and gender, as well as by using different data sets of young adults as reference samples. Both scores showed robust agegroup-related differences for the subsequent memory contrast, and the FADE-SAME score additionally exhibited age-group-related differences for the novelty contrast. Furthermore, both scores correlate with behavioral measures of cognitive aging, namely memory performance. Taken together, our results suggest that single-value scores of memory-related fMRI responses may constitute promising biomarkers for quantifying neurocognitive aging

Coulomb dissociation of N 20,21

Neutron-rich light nuclei and their reactions play an important role in the creation of chemical elements. Here, data from a Coulomb dissociation experiment on N20,21 are reported. Relativistic N20,21 ions impinged on a lead target and the Coulomb dissociation cross section was determined in a kinematically complete experiment. Using the detailed balance theorem, the N19(n,γ)N20 and N20(n,γ)N21 excitation functions and thermonuclear reaction rates have been determined. The N19(n,γ)N20 rate is up to a factor of 5 higher at

Die Berliner Wespen im Aquarium

DIE BERLINER WESPEN IM AQUARIUM Die Berliner Wespen im Aquarium / Stettenheim, Julius (Public Domain) ( - ) Cover front ( - ) Title page ( - ) Preface ( - ) Vor einem Wasserbecken (6) Fisch-Menschen und Menschen-Fische. 1. Der Gründling (11) Parlaments-Feuilleton des Berliner Aquariums (12) Die Volière im Aquarium (15) Berliner Aquarellen (16) Fisch-Menschen und Menschen-Fische. 2. Der Backfisch (18) Einige Amphibien (19) Das Lied vom Häring (22) Berliner Aquarellen (24) Fisch-Menschen und Menschen-Fische. 3. Die Sirene (26) Sumpfromantik (27) Fritz Muckenich und sein Sohn Willem im Aqarium (28) Die kokette Auster. Ein romantisches Lied (32) Fisch-Menschen und Menschen-Fische. 4. Der Bückling (35) Infusorien-Lieder (36) Denkzettelchen aus dem Wespennest (38) Der Becher im Aquarium (39) Denkzettelchen aus dem Wespennest (40) Betrachtungen eines alten Dorsches (41) Was einmal ein alter leichtsinniger Corpsbarsch gesungen (44) Kleiner Führer an den interessantesten Geschöpfen des Berliner Aquariums vorbei (45) Das träumende Aquarium (51) Zoophytisches Lied (55) Fisch-Menschen und Menschen-Fische. 5. Der Bierfisch (56) Auszüge aus dem neusten, noch feuchten Journal: Die Kiemen (57) Vom frischen Fass der Erkenntniss (63) Contents (64) Advertising ( - ) Cover back ( - ) ColorChart ( -

Survey-report state buildings, institutions and plants.

Cover title.pt. 1. Wisconsin School for the Blind, Janesville, Wisconsin School for the Deaf, Delavan -- pt. 2. Grand Army Home for Veterans, King, Wisconsin -- pt. 3. Stout Institute, Menomonie, Wisconsin -- pt. 4. Wisconsin Institute of Technology, Platteville, Wisconsin -- pt. 5. State teachers colleges -- pt. 6. Wisconsin State Sanatorium, Lake Tomahawk State Camp -- pt. 7. Central State Hospital, Waupun, Wisconsin -- pt. 8. Wisconsin State Reformatory, Green Bay, Wisconsin -- pt. 9. Wisconsin State Prison, Waupun, Wisconsin -- pt. 10. Wisconsin State Prison for Women, Wisconsin Industrial Home for Women, Taycheedah, Wisconsin -- pt. 11. State Public School, Sparta, Wisconsin -- pt. 12. Industrial School for Boys, Waukesha, Industrial School for Girls, Oregon -- pt. 13. Northern Wisconsin Colony and Training School, Chippewa Falls, Wisconsin, Southern Wisconsin Colony and Training School, Union Grove, Wisconsin -- pt. 14. Mendota State Hospital, Mendota, Wisconsin, Winnebago State Hospital -- pt. 15. Camp Hayward, Hayward, Wisconsin -- pt. 16. Wisconsin Workshop for the Blind, Milwaukee, Wisconsin.Mode of access: Internet

Structure of ¹³Be studied in proton knockout from ¹⁴B

The neutron-unbound isotope 13Be has been studied in several experiments using different reactions, different projectile energies, and different experimental setups. There is, however, no real consensus in the interpretation of the data, in particular concerning the structure of the low-lying excited states. Gathering new experimental information, which may reveal the 13Be structure, is a challenge, particularly in light of its bridging role between 12Be, where the N = 8 neutron shell breaks down, and the Borromean halo nucleus 14Be. The purpose of the present study is to investigate the role of bound excited states in the reaction product 12Be after proton knockout from 14B, by measuring coincidences between 12Be, neutrons, and γ rays originating from de-excitation of states fed by neutron decay of 13Be. The 13Be isotopes were produced in proton knockout from a 400 MeV/nucleon 14B beam impinging on a CH2 target. The 12 Be-n relative-energy spectrum d σ /d Ef n was obtained from coincidences between 12Be(g.s.) and a neutron, and also as threefold coincidences by adding γ rays, from the de-excitation of excited states in 12Be. Neutron decay from the first 5/2+ state in 13Be to the 2+ state in 12Be at 2.11 MeV is confirmed. An energy independence of the proton-knockout mechanism is found from a comparison with data taken with a 35 MeV/nucleon 14B beam. A low-lying p-wave resonance in 13Be(1/2−) is confirmed by comparing proton- and neutron-knockout data from 14B and 14Be