30 research outputs found
A Preliminary study of the summer feeding habits of juvenile Florida Pompano (Trachinotus carolinus) from open and protected beaches of the northeastern Gulf of Mexico
Pb distribution in bones from the Franklin expedition: synchrotron X-ray fluorescence and laser ablation/mass spectroscopy
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape : A Large-Scale Genome-Wide Interaction Study
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age-and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to similar to 2.8M SNPs with BMI and WHRadjBMI in four strata (men 50y, women 50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR= 50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may providefurther insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.Peer reviewe
The control of leatherjackets, Tipula paludosa Meig., in grassland by early application of insecticide
A new species of Austinixa Heard and Manning 1997 (Decapoda: Pinnotheridae) and new records of A. felipensis (Glassell, 1935) from the Mexican Pacific
Formatting the Public Sector with ICTs: Exploring Institutional Sources and Processes
Part 2: Section 1: National and International PoliciesInternational audienceThis paper discusses the process in which e-government projects are initiated and locally negotiated within the public sector organizations. The issue is explored by employing the theoretical concept of global formats. The concept of formats is employed to explore two interlinked themes: the institutional sources for e-government projects and the processes of locally appropriating these projects within the organizational setting. This paper focuses on an e-government project that was successfully implemented in one of Dubai’s public sector organizations