2,017 research outputs found
Relationships, health, and well-being:The role of responsiveness
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2019
- Field of study
Perceived responsiveness in suicidal ideation: An experience sampling study in psychiatric patients
- Author
- Publication venue
- Wiley-Blackwell Publishing, Inc.
- Publication date
- 01/06/2024
- Field of study
Introduction: Perceived responsiveness, or the extent to which one feels understood, validated and cared for by close others, plays a crucial role in people's wellâbeing. Can this interpersonal process also protect people at risk? We assessed whether fluctuations in suicidal ideation were associated with fluctuations in the degree of perceived responsiveness that psychiatric patients (admitted in the context of suicide or indicating suicidal ideation) experienced in daily interactions immediately after discharge.
Methods: Fiftyâseven patients reported on suicidal ideation (5 times a day) and perceived responsiveness (daily) for four consecutive weeks. The effects of established risk factorsâthwarted belongingness, perceived burdensomeness, and hopelessnessâwere assessed as well.
Results: The more patients felt that close others had been responsive to them, the less suicidal ideation they reported. At low levels of thwarted belongingness, perceived burdensomeness, or hopelessness, perceived responsiveness seemed to play a protective role, negatively coâoccurring with suicidal ideation. When thwarted belongingness, perceived burdensomeness, and hopelessness were high, perceived responsiveness did not have an effect.
Conclusion: Perceived responsiveness could be a protective factor for suicidal ideation for people at risk only when they are experiencing low levels of negative perceptions. When experiencing highly negative perceptions, however, perceived responsiveness seems to matter less
CD4CD8αα Lymphocytes, A Novel Human Regulatory T Cell Subset Induced by Colonic Bacteria and Deficient in Patients with Inflammatory Bowel Disease
- Author
- A Franke
- AM Bilate
- Anne Jarry
- B Willing
- BS Reis
- C Koenecke
- C Lambert
- C Manichanh
- Chantal Bridonneau
- CL Maynard
- CĂ©line Bossard
- D Mucida
- DJ Campbell
- Elodie Quévrain
- EO Glocker
- Francine Jotereau
- Frédéric Altare
- G Das
- G Sarrabayrouse
- Guillaume Meurette
- Guillaume Sarrabayrouse
- H Sokol
- H Sokol
- Harry Sokol
- J Carton
- J Zhao
- JF Fonteneau
- JH Buckner
- Joe-Marc Chauvin
- K Atarashi
- K Atarashi
- K Fujio
- K Honda
- K Machiels
- Karim Asehnoune
- Laurence Preisser
- M Senju
- MA Koch
- MA Suni
- MG Roncarolo
- N Gagliani
- Nathalie LabarriĂšre
- Philippa Marrack
- S Miquel
- S Sakaguchi
- SK Lathrop
- SZ Josefowicz
- SZ Josefowicz
- T Duhen
- T Tanoue
- T Yamaguchi
- W Chen
- Y Nagano
- Y Parel
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2014
- Field of study
It has become evident that bacteria in our gut affect health and disease, but less is known about how they do this. Recent studies in mice showed that gut Clostridium bacteria and their metabolites can activate regulatory T cells (Treg) that in turn mediate tolerance to signals that would ordinarily cause inflammation. In this study we identify a subset of human T lymphocytes, designated CD4CD8αα T cells that are present in the surface lining of the colon and in the blood. We demonstrate Treg activity and show these cells to be activated by microbiota; we identify F. prausnitzii, a core Clostridium strain of the human gut microbiota, as a major inducer of these Treg cells. Interestingly, there are fewer F. prausnitzii in individuals suffering from inflammatory bowel disease (IBD), and accordingly the CD4CD8αα T cells are decreased in the blood and gut of patients with IBD. We argue that CD4CD8αα colonic Treg probably help control or prevent IBD. These data open the road to new diagnostic and therapeutic strategies for the management of IBD and provide new tools to address the impact of the intestinal microbiota on the human immune system
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.
- Author
- Adam Resnick
- Alan Mackay
- Alexei N. Kisljakov
- Andrew J. Martin
- Andrew S. Moore
- André O. von Bueren
- Angel Montero Carcaboso
- Angela J. Waanders
- Anna Burford
- Baker
- Barrow
- Bax
- Bender
- Bjerke
- Bouffet
- Buczkowicz
- Cai
- Cai
- Carmen de Torres
- Carvalho
- Castel
- Ceccarelli
- Chan
- Chris Jones
- Christopher Chandler
- Cynthia Hawkins
- Darach Crimmins
- David Castel
- David T.W. Jones
- Davis
- Diana Carvalho
- Dmitry M. Konovalov
- Dorra Hâmida-Ben Brahim
- Elisa Izquierdo
- Fontebasso
- Fontebasso
- Funato
- Grasso
- Hamid Nikbakht
- Harry J. Han
- Hennika
- Henry C. Mandeville
- Ho-Keung Ng
- Jacques Grill
- Janat Fazal-Salom
- Jane Cryan
- Jane Pears
- Jaume Mora
- John Caird
- Jones
- Jones
- Jones
- JoĂŁo N. Stavale
- Kathryn R. Taylor
- Khuong-Quang
- Korshunov
- Korshunov
- Kramm
- Kun Mu
- Leslie R. Bridges
- Louis
- Lucas T. Bidinotto
- Ludmila I. Shats
- Lynley Marshall
- Lynn Bjerke
- Mara Vinci
- Marie-Anne Debily
- Mariona Sunol
- Maryam Fouladi
- Matthew Clarke
- Meera Nandhabalan
- Michael Baudis
- Michael Farrell
- Michelle Monje
- Nada Jabado
- Natacha Entz-Werle
- Nicolaides
- Northcott
- Ofelia Cruz
- Ostrom
- Paugh
- Paugh
- Paugh
- Pichai Raman
- Puget
- Qin
- Richards
- Rui M. Reis
- Safa Al-Sarraj
- Saoussen Trabelsi
- Sara Temelso
- Saumya Gupta
- Schiffman
- Schwartzentruber
- Sergey Popov
- Shlien
- Stefan M. Pfister
- Stergios Zacharoulis
- Sturm
- Sturm
- Sucheta Vaidya
- Suzanne J. Baker
- Taylor
- Taylor
- Temime-Smaali
- Temime-Smaali
- Tiberi
- Valeria Molinari
- Venkatesh
- Welcker
- Wu
- Wu
- Wu
- Xingang Li
- Yada
- Yang
- Zarghooni
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors. Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct. Uncommon pathway dysregulation is seen in small subsets of tumors, further defining the molecular diversity of the disease, opening up avenues for biological study and providing a basis for functionally defined future treatment stratification
Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).
- Author
- A'Court C.
- Aaroe H.
- Abd El-Aziz A.
- Abdalla Saad J.
- Abdel-Qader M.
- Abdelrahman H.
- Abdul A.
- Abe M. (Masahiko)
- Abe M. (Masatake)
- Abe M. (Mitsunori)
- Abe S.
- Abe Y.
- Abhayaratna W.
- Abou Seif S. K.
- Abraham S.
- Abu-Mahfouz M.
- Abushal S.
- Accetta Gabriele
- Accogli M.
- Adachi S.
- Adachi S. (Sen)
- Adachi S. (Susumu)
- Adachi T.
- Adak D.
- Adriaansen H.
- Agakhanyan A.
- Agata J.
- Ageta M.
- Aggarwala A.
- Agliardi P.
- Agnelli G.
- Agnelli Giancarlo
- Agrawal A.
- Aguilar J.
- Ahbeck E.
- Ahlmark H.
- Ahmad K.
- Ahmad N.
- Ahmad S.
- Ahmed F.
- Ahmed W.
- Ahn J. J.
- Ahuad Guerrero R. A.
- Ainsworth P.
- Airaksinen J.
- Akahane K.
- Akiyama M.
- Aktas O.
- Akutsu M.
- Al Mahmeed W.
- Al Mahmeed Wael
- Al Mulla A.
- Al Naeemi A.
- Al Omairi M.
- Al-Khalili F.
- Alaguibe E. D.
- Alban F.
- Alberts M.
- Alborough E.
- Aldegather J.
- Aleksandrova E.
- Alfaro T. A. A.
- Alfieri A.
- Ali A.
- Alkan D. Uzun
- Allasia B.
- Almeida Fernandez C. A.
- Alonso C. (Carmela)
- Alonso C. (Concepcion)
- Alpay D.
- Altamirano Bellorin S.
- Altun A.
- Alunni M.
- Alvarez D'Amelio A.
- Alvarez Garcia P.
- Alvarez Lopez H.
- Alvarez D.
- Alvarez M.
- Alves da Costa F. A.
- Alves de Oliveira Gomes J.
- Alzand B.
- Amano T.
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- Andersson A.
- Andersson L. (Lars)
- Andersson L. (Lisbeth)
- Ando H.
- Ando S.
- Andrzejewski D.
- Angaran P.
- Angchaisuksiri P.
- Angchaisuksiri Pantep
- Angel G.
- Ann W.
- Antonova P.
- Antonsen H.
- Aoki K.
- Aoyama T.
- Arabetti C.
- Aracil Villar J.
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- Yoshida T. (Tomoki)
- Yoshimura A.
- Yoshizawa N.
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- Zhao R. P.
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- Zhirov I
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- Zhuravleva E.
- Zhurba S.
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- Zubeeva G.
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- Zurbrigk F. J.
- Zutz S.
- Zyczynska-Szmon M.
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2018
- Field of study
Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and â„1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (nâ=â5069) or prospectively (nâ=â5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (â€6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; pâ=â0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)
Machine learning uncovers the most robust self-report predictors of relationship quality across 43 longitudinal couples studies
- Author
- Alan Reifman
- Allison A. Vaughn
- Amanda M. Vicary
- Amie M. Gordon
- Amy Muise
- Andrea B. Horn
- Anik Debrot
- Bahns
- Brett J. Peters
- Brian G. Ogolsky
- C. Rebecca Oldham
- Carter
- Cathy Surra
- Cheryl Harasymchuk
- Cheryl L. Carmichael
- Claudia C. Brumbaugh
- Colleen J. Allison
- Courtney L. Gosnell
- Dacher Keltner
- Darby Saxbe
- David C. de Jong
- Eli J. Finkel
- Emily A. Impett
- Eran Bar-Kalifa
- Erica B. Slotter
- Erin L. Ramsdell
- Eshkol Rafaeli
- Esther S. Kluwer
- Eva C. DeHaas
- Finkel
- Francesca Righetti
- Gal Lazarus
- Galena K. Rhoades
- Genuer
- Geoff MacDonald
- Grace Larson
- Gurit E. Birnbaum
- Hagar Ter Kuile
- Haran Sened
- Harry T. Reis
- James J. Kim
- Jami Eller
- Jaye L. Derrick
- Jeffrey L. Kirchner
- Jeffry A. Simpson
- Jennifer Clarke
- Jeremy P. Jamieson
- Jessica A. Maxwell
- Jill M. Logan
- Jody Davis
- Joel
- Joel
- Laura B. Luchies
- Laura V. Machia
- Lavner
- Lindsey M. Rodriguez
- Madoka Kumashiro
- Maija Reblin
- Marie-Joelle Estrada
- Mariko L. Visserman
- Matthew D. Hammond
- Meinrad Perrez
- Michael K. Coolsen
- Michael R. Maniaci
- Michael Reicherts
- Miller
- Moran Mizrahi
- Natalie O. Rosen
- Nickola C. Overall
- Niehuis
- Paul W. Eastwick
- Paula R. Pietromonaco
- Peggy A. Hannon
- Pietromonaco
- R. Chris Fraley
- Rebecca J. Cobb
- Rebecca L. Brock
- Reuma Gadassi-Polack
- Ron Rogge
- Rony Pshedetzky-Shochat
- Ruddy Faure
- Rusbult
- Sally I. Powers
- Samantha Joel
- Scott M. Stanley
- Scott Wolf
- Serena Chen
- Shelly L. Gable
- Shevaun Stocker
- Sophie Bergeron
- Sylvia Niehuis
- Thery Prok
- Wang
- Wilhelm Hofmann
- William S. Rholes
- Ximena B. Arriaga
- Yuthika U. Girme
- Zachary G. Baker
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 01/01/2020
- Field of study
Given the powerful implications of relationship quality for health and well-being, a central mission of relationship science is explaining why some romantic relationships thrive more than others. This large-scale project used machine learning (i.e., Random Forests) to 1) quantify the extent to which relationship quality is predictable and 2) identify which constructs reliably predict relationship quality. Across 43 dyadic longitudinal datasets from 29 laboratories, the top relationship-specific predictors of relationship quality were perceived-partner commitment, appreciation, sexual satisfaction, perceived-partner satisfaction, and conflict. The top individual-difference predictors were life satisfaction, negative affect, depression, attachment avoidance, and attachment anxiety. Overall, relationship-specific variables predicted up to 45% of variance at baseline, and up to 18% of variance at the end of each study. Individual differences also performed well (21% and 12%, respectively). Actor-reported variables (i.e., own relationship-specific and individual-difference variables) predicted two to four times more variance than partner-reported variables (i.e., the partnerâs ratings on those variables). Importantly, individual differences and partner reports had no predictive effects beyond actor-reported relationship-specific variables alone. These findings imply that the sum of all individual differences and partner experiences exert their influence on relationship quality via a personâs own relationship-specific experiences, and effects due to moderation by individual differences and moderation by partner-reports may be quite small. Finally, relationship-quality change (i.e., increases or decreases in relationship quality over the course of a study) was largely unpredictable from any combination of self-report variables. This collective effort should guide future models of relationships
Search for continuous gravitational waves from 20 accreting millisecond x-ray pulsars in O3 LIGO data
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Search for gravitational waves from Scorpius X-1 with a hidden Markov model in O3 LIGO data
- Author
- Abbott R
- Abe H
- Acernese F
- Ackley K
- Adhikari N
- Adhikari R
- Adkins V
- Adya V
- Affeldt C
- Agarwal D
- Agathos M
- Agatsuma K
- Aggarwal N
- Aguiar O
- Aiello L
- Ain A
- Ajith P
- Akutsu T
- Albanesi S
- Alfaidi R
- Allocca A
- Altin P
- Amato A
- Anand C
- Anand S
- Ananyeva A
- Anderson S
- Anderson W
- Ando M
- Andrade T
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- Andrés-Carcasona M
- Angelova S
- Ansoldi S
- Antelis J
- Antier S
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- Appavuravther E
- Appert S
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- Arellano F
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
All-sky search for short gravitational-wave bursts in the third Advanced LIGO and Advanced Virgo run
- Author
- Abbott R
- Abbott T
- Acernese F
- Ackley K
- Adams C
- Adhikari N
- Adhikari R
- Adya V
- Affeldt C
- Agarwal D
- Agathos M
- Agatsuma K
- Aggarwal N
- Aguiar O
- Aiello L
- Ain A
- Ajith P
- Akutsu T
- Albanesi S
- Allocca A
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Constraints on the cosmic expansion history from GWTC-3
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley K.
- Adhikari N.
- Adhikari R.
- Adkins V.
- Adya V.
- Affeldt C.
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- Publication venue
- Publication date
- 19/11/2021
- Field of study
We use 47 gravitational-wave sources from the Third LIGO-Virgo-KAGRA Gravitational-Wave Transient Catalog (GWTC-3) to estimate the Hubble parameter H(z), including its current value, the Hubble constant H0â. Each gravitational-wave (GW) signal provides the luminosity distance to the source and we estimate the corresponding redshift using two methods: the redshifted masses and a galaxy catalog. Using the binary black hole (BBH) redshifted masses, we simultaneously infer the source mass distribution and H(z). The source mass distribution displays a peak around 34Mââ, followed by a drop-off. Assuming this mass scale does not evolve with redshift results in a H(z) measurement, yielding H0â=68â7+12âkmsâ1Mpcâ1 (68% credible interval) when combined with the H0â measurement from GW170817 and its electromagnetic counterpart. This represents an improvement of 17% with respect to the H0â estimate from GWTC-1. The second method associates each GW event with its probable host galaxy in the catalog GLADE+, statistically marginalizing over the redshifts of each event's potential hosts. Assuming a fixed BBH population, we estimate a value of H0â=68â6+8âkmsâ1Mpcâ1 with the galaxy catalog method, an improvement of 42% with respect to our GWTC-1 result and 20% with respect to recent H0â studies using GWTC-2 events. However, we show that this result is strongly impacted by assumptions about the BBH source mass distribution; the only event which is not strongly impacted by such assumptions (and is thus informative about H0â) is the well-localized event GW190814
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