94 research outputs found
âFrom âCompatriotsâ to âAliensâ: The Changing Coverage of Migration on Russian Televisionâ
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2015
- Field of study
An Integrated Approach to Postgraduate Curriculum in Translation Studies
- Publication venue
- Publication date
- 01/01/2016
- Field of study
This article details how a group of instructors at Hamad bin Khalifa University in Qatar instituted an integrated curriculum for all students entering the universityâs Master in Translation Studies and Master in Audiovisual Translation. First, it discusses the unique multicultural context in which these two programs operate. It then describes the details of the implementation, focusing on the role that an oral history project played in the curriculum. It ends with an appraisal of the programâs success and a consideration of future directions, looking at the need for integrated approaches to learning in the context of emerging institutions of higher education
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.
- Author
- Abigail Hynes
- Aditya Mandal
- Adrian Barnardo
- Aftab Ala
- Agostino Colli
- Alan Shepherd
- Alan Watson
- Alastair McNair
- Alberto Mattalia
- Alexandra McKay
- Alice Wright
- Alison Brind
- Alison Loftus
- Alison Paton
- Alistair King
- Allister Grant
- Altaf Palegwala
- Amir Shah
- Amit Singhal
- Ana Lleo
- Andrea Broad
- Andrea Crosignani
- Andrea Galli
- Andrew Austin
- Andrew Bathgate
- Andrew Bell
- Andrew Burroughs
- Andrew Chilton
- Andrew Davis
- Andrew Douds
- Andrew Douglass
- Andrew Fraser
- Andrew Gibbins
- Andrew Higham
- Andrew L Mason
- Andrzej Piotrowicz
- Andy Li
- Angelo Andriulli
- Anna Fouracres
- Annarosa Floreani
- Anne Eastick
- Anton Gunasekera
- Antonio Benedetti
- Antonio Picciotto
- Aruna Dias
- Ashis Mukhopadhya
- Ashley Brown
- Asifabbas Naqvi
- Athar Saeed
- Bal Shinder
- Barbara Coco
- Barbara Foglieni
- Barbara Hoeroldt
- Becky Holbrook
- Beverley Longhurst
- Bob Grover
- Brian D. Juran
- Bridget Bird
- Bridget Gunson
- Bronwen Williams
- Bruce R Bacon
- Caradog Thomas
- Carl A. Anderson
- Carlo Ferrari
- Carly Brown
- Carmela Cursaro
- Carol Thomas
- Carole Collins
- Carole Foale
- Caroline Cowley
- Caroline Hamilton
- Caroline Lawlor
- Caroline Mulvaney-Jones
- Caroline Palmer
- Carolyn MacNicol
- Caron Innes
- Casey S. Greene
- Catherine Gray
- Catherine Vincent
- Charles Grimley
- Charles Millson
- Chin Lye Ch'ng
- Chris Evans
- Chris Ford
- Christine Dickson
- Christopher Healey
- Christopher Hovell
- Christopher I. Amos
- Christopher Macdonald
- Christopher Shallcross
- Christopher Shorrock
- Claire Duggan
- Claudio Tiribelli
- Craig Lammert
- Cristina Barlassina
- Cynthia Levy
- D Williams
- Dakai Zhu
- Daniel Forton
- Daniele Cusi
- Daniele Prati
- Darren Clement
- David C. Qian
- David Elphick
- David Gorard
- David Jones
- David Neal
- David Ramanaden
- David Tyrer
- Dawn Sirdefield
- Deb Ghosh
- Debashis Das
- Delyth Braim
- Denise Gocher
- Denise O'Donnell
- Dermot Gleeson
- Diane Simpson
- Domenico Alvaro
- Donna Cotterill
- Douglas Thorburn
- Earl Williams
- Eileen Marshall
- Eleanor Dungca
- Elizabeth J Atkinson
- Elizabeth Tanqueray
- Elva Wilhelmsen
- Emily Archer
- Emma Durant
- Emma Grieve
- Emma Gunter
- Erik M Schlicht
- Ervin Shpuza
- Estelle Nambela
- Esther Unitt
- Fabio Macaluso
- Fabio Marra
- Faiz Ali
- Federica Malinverno
- Filomena Morisco
- Fiona Gordon
- Fiona Wright
- Floriano Rosina
- Florin Muscariu
- Frances Hines
- Francesca Bernuzzi
- Gang Xie
- Gary Bray
- Gayle Clifford
- Geeta Prasad
- George Abouda
- George Bird
- George F. Mells
- George Lipscomb
- George MacFaul
- Giancarlo Spinzi
- Gianfranco Elia
- Gideon M. Hirschfield
- Gill Watts
- Giovanni Casella
- Glynis Stansfield
- Gordon Wood
- Graeme Alexander
- Graham Butcher
- Graham Foster
- Grazia A Niro
- Gregory Whatley
- Greta Van Duyvenvoorde
- Guan Lim
- Gwen Baxter
- Hannah Dewhurst
- Harriet Gordon
- Harriet Mitchison
- Heather J. Cordell
- Helen Doyle
- Helen Fairlamb
- Helen Sweeting
- Helen Wooldridge
- Hemant Gupta
- Henry C Bodenheimer Jr
- Hilary Pateman
- Howard Curtis
- Howard Klass
- Hyder Hussaini
- Hye-Jeong Lee
- Ian Drake
- Ian Gee
- Ian Gooding
- Ian Rees
- Ilaria Bianchi
- Ilaria Sogno
- Imran Patanwala
- Imroz Salam
- Isobel Amey
- Jaber Gasem
- Jacky Orpe
- Jacqueline Brighton
- James A. B. Floyd
- James Featherstone
- James Gotto
- James Neuberger
- Jane Bowles
- Jane Collier
- Jane Gitahi
- Jane Maiden
- Jane Metcalf
- Janeane Hails
- Janette Curtis
- Janie Keggans
- Janine Musselwhite
- Javaid Subhani
- Jayne Jones
- Jean Kordula
- Jeff Butterworth
- Jennie Kendall
- Jennifer Morrison
- Jeremy Shearman
- Jeremy Tibble
- Jessica Whiteman
- Jia Qu
- Jill Conder
- Jinyi Zhang
- Jo Ridpath
- Joanna Allison
- Joanna Sayer
- Jocelyn Fraser
- John Dillon
- John Mclindon
- John Ramage
- Jonathan Booth
- Jonathan Brown
- Joseph A Odin
- Joy Sadeghian
- Joy Wilkins
- Julia Maltby
- Julie Browning
- Julie Colley
- Julie Tregonning
- Juliette Verheyden
- Kapil Kapur
- Karen Hogben
- Karen Warner
- Karin Young
- Kate Martin
- Kate Ocker
- Katharine Pollock
- Katherine A. Siminovitch
- Katherine I. Morley
- Kathryn Houghton
- Katie Seward
- Katie Spurdle
- Keith Elliott
- Keith George
- Kelly Amor
- Kerenza Boulton
- Kerry Flahive
- Kevin Yoong
- Kimberley Netherton
- Kirsten Walker
- Kirsty Martin
- Konrad Koss
- Konstantinos N. Lazaridis
- LaiTing Tan
- Landon L Chan
- Leonie Grellier
- Linda Jones
- Linda Kent
- Linda March
- Lisa Morgan
- Liz Farrington
- Lizzie Stafford
- Lola Dali-kemmery
- Lorenzo Morini
- Lorraine Hankey
- Lory Saveria CrocĂš
- Louise Winter
- Lourdes Cumlat
- Luca Fabris
- Lucie Hobson
- Luigi Muratori
- Lyn Graves
- Lynn Currie
- Lynn O'Donohoe
- M. Eric Gershwin
- Maggie Hughes
- Mandy Carnahan
- Marco Carbone
- Marco Marzioni
- Marek Czajkowski
- Maria Consiglia Bragazzi
- Maria Francesca Donato
- Maria Hamilton
- Maria Hayes
- Maria Vinci
- Mariam Nasseri
- Marie Green
- Marie Quinn
- Marina Leoni
- Mario Strazzabosco
- Marisa Mills
- Mariza de Andrade
- Mark Ainsworth
- Mark Aldersley
- Mark Cox
- Mark Narain
- Mark Wilkinson
- Mark Wright
- Markus Gess
- Marta Spreafico
- Martin Lombard
- Martin Prince
- Martyn Carter
- Mary Crossey
- Mary Ninkovic
- Massimo Colombo
- Massimo Zuin
- Matthew Brookes
- Matthew Cowan
- Matthew Cramp
- Matthew Foxton
- Maurizia Brunetto
- Mauro Podda
- Maxton Pitcher
- Mazn Karmo
- Mcdonald Mupudzi
- Melanie Harrison
- Melanie Kent
- Mervyn Davies
- Mesbah Rahman
- Metod Oblak
- Michael F. Seldin
- Michael Heneghan
- Mike Mendall
- Minesh Patel
- Mirko Tarocchi
- Mohamed Dawwas
- Mousa Hani S
- Natalie Taylor
- Natalie Wheatley
- Neil Fisher
- Nicholas Sharer
- Nicola Lancaster
- Nikki White
- Noma Ncube
- null null
- null null
- null null
- Nurani Sivaramakrishnan
- Oza Chirag
- Paolo Muratori
- Parizade Raymode
- Patrick Goggin
- Paul Banim
- Paul Kitchen
- Paul Richardson
- Paul Southern
- Paula Townshend
- Peter Bramley
- Peter K Gregersen
- Peter Mills
- Phillipa Desousa
- Pier Maria Battezzati
- Pierluigi Toniutto
- Piero L Almasio
- Piero Portincasa
- Pietro Andreone
- Pietro Invernizzi
- Piotr Milkiewicz
- Pradeep Sanghi
- Pranab Gyawali
- PuiChing Chan
- Purushothaman Premchand
- Rachel Abrahams
- Raj Srirajaskanthan
- Ray Mathew
- Ray Shidrawi
- Rebecca Bishop
- Rebecca Casey
- Rebecca Cloudsdale
- Rebecca Jones
- Renzo Montanari
- Reuben Ayres
- Richard Aspinall
- Richard Evans
- Richard Marley
- Richard Miller
- Richard N. Sandford
- Richard Sturgess
- Robert P Myers
- Robert Przemioslo
- Roberta Lazzari
- Roger McCorry
- Roland Ede
- Roman Galaska
- Rory Harvey
- Rosanna Fontana
- Rose Damant
- Rupert Ransford
- Ruth Penn
- Saket Singhal
- Sally Batham
- Sally-Ann Rolls
- Sallyanne Pearson
- Samantha Ducker
- Sambit Sen
- Samir Vyas
- Sandra Greer
- Sanjiv Jain
- Sarah Besley
- Sarah Jones
- Sarah Thornthwaite
- Sass Levi
- Savino Bruno
- Senayon Desmennu
- Sharat Misra
- Sherill Tripoli
- Silvia Colombo
- Simon Dyer
- Simon Panter
- Simon Rushbrook
- Simon Taylor-Robinson
- Simon Whalley
- Simon Williams
- Sonia Rossi
- Sonia Tarallo
- Sophie Holder
- Stephen D Ryder
- Steve Pereira
- Steven Mann
- Stewart Campbell
- Subramaniam Ramakrishnan
- Subrata Saha
- Sue Glenn
- Sue Walsh
- Sunil Dolwani
- Susan Congreave
- Susan Gallagher
- Susan Jones
- Susan Lord
- Susan Slininger
- Sushma Saksena
- Suzie Marriott
- Syed Shaukat
- Talal Valliani
- Theodore Ngatchu
- Thiriloganathan Mathialahan
- Tim Harding
- Tobias Balschun
- Toby Delahooke
- Tom Lee
- Tom Yapp
- Tracey Shewan
- Udi Shmueli
- Valentina Liakina
- Valeria Silvestre
- Velimir A Luketic
- Victoria Lambourne
- Vincenzo O Palmieri
- Vincenzo Ronca
- Voi Shim Wong
- William Stableforth
- Yafang Li
- Yeng Ang
- Yolanda Baird
- Younghun Han
- Publication venue
- Nat Commun
- Publication date
- 01/01/2015
- Field of study
Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 Ă 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
- Author
- 94
- Abigail Hynes 159
- Aditya Mandal
- Adrian Barnardo 182
- Aftab Ala 138
- Agostino Colli 45
- Alan Shepherd 213
- Alan Watson 81
- Alastair McNair 175
- Alberto Mattalia 54
- Alexandra McKay 132
- Alice Wright 245
- Alison Brind 294
- Alison Loftus 91
- Alison Paton 119
- Alistair King
- Allister Grant
- Almasio 33 Piero L.
- Altaf Palegwala 98
- Amir Shah 189
- Amit Singhal
- Amos 2 Christopher I.
- Ana Lleo 12
- Anderson 8 Carl A.
- Andrea Broad 139
- Andrea Crosignani 39
- Andrew Austin 119
- Andrew Bell 305
- Andrew Burroughs 249
- Andrew Chilton 166
- Andrew Douds 243
- Andrew Gibbins 122
- Andrew Higham 293
- Andrew Bathgate
- Andrew Davis
- Andrew Douglass
- Andrew Fraser
- Andrzej Piotrowicz
- Andy Li 303
- Angelo Andriulli 37
- Anna Fouracres 247
- Annarosa Floreani 51
- Anne Eastick
- Anton Gunasekera
- Antonio Benedetti 40
- Antonio Picciotto 59
- Aruna Dias 82
- Ashis Mukhopadhya
- Ashley Brown
- Asifabbas Naqvi
- Athar Saeed 139
- Atkinson 19 Elizabeth J.
- Bacon 28 Bruce R.
- Bal Shinder 258
- Barbara Coco 43
- Barbara Foglieni 11
- Barbara Hoeroldt 244
- Becky Holbrook 222
- Beverley Longhurst 240
- Bob Grover 151
- Bodenheimer Jr 29 Henry C.
- Bridget Bird 191
- Bridget Gunson 287
- Bronwen Williams
- Caradog Thomas
- Carlo Ferrari 49
- Carly Brown 270
- Carmela Cursaro 36
- Carol Thomas 156
- Carole Collins 300
- Carole Foale 138
- Caroline Cowley 182
- Caroline Mulvaney Jones
- Caroline Hamilton
- Caroline Lawlor
- Caroline Palmer
- Carolyn MacNicol 163
- Caron Innes
- Catherine Vincent 31
- Catherine Gray
- Chan 19 Landon L.
- Charles Grimley
- Charles Millson
- Chin Lye Ch’
- Chris Evans 190
- Chris Ford
- Christine Dickson 239
- Christopher Healey 71
- Christopher Hovell 122
- Christopher Shorrock 90
- Christopher Shallcross
- Claire Duggan 159
- Claudio Tiribelli 48
- Cordell Heather J.
- Craig Lammert 7
- Cristina Barlassina 38
- Cynthia Levy 32
- Dakai Zhu 2
- Daniel Forton 275
- Daniele Prati 11
- Daniele Cusi
- Darren Clement 294
- David Elphick 106
- David Jones 188
- David Ramanaden 86
- David Tyrer 252
- David Gorard
- David Neal
- Dawn Sirdefield
- Deb Ghosh
- Debasish Das 166
- Delyth Braim
- Denise Gocher 289
- Denise O’
- Dermot Gleeson
- Diane Simpson 239
- Domenico Alvaro 35
- Donna Cotterill 305
- Douglas Thorburn 249
- Earl Williams 246
- Eileen Marshall 249
- Eleanor Dungca 107
- Elizabeth Tanqueray 221
- Elva Wilhelmsen 165
- Emily Archer 271
- Emma Grieve 196
- Emma Gunter 246
- Emma Durant
- Eric Gershwin 15 M.
- Ervin Shpuza
- Estelle Nambela
- Esther Unitt 289
- Fabio Macaluso 34
- Faiz Ali 156
- Federica Malinverno 46
- Filomena Morisco 57
- Fiona Gordon 288
- Fiona Wright 189
- Floriano Rosina 60
- Florin Muscariu
- Floyd James A. B.
- Frances Hines
- Francesca Bernuzzi 41
- Galli Andrea
- Gang Xie
- Gary Bray 272
- Gayle Clifford 270
- Geeta Prasad 285
- George Lipscomb 91
- George MacFaul 187
- George Abouda
- George Bird
- Giancarlo Spinzi 61
- Gianfranco Elia 49
- Gill Watts 285
- Giovanni Casella 44
- Glynis Stansfield 163
- Gordon Wood 140
- Graeme Alexander 101
- Graham Foster 80
- Graham Butcher
- Greene Casey S.
- Gregersen Peter K.
- Gregory Whatley 280
- Greta Van Duyvenvoorde 90
- Guan Lim 135
- Gwen Baxter 191
- Hannah Dewhurst 246
- Harriet Gordon 145
- Harriet Mitchison 107
- Helen Doyle 109
- Helen Wooldridge 117
- Helen Fairlamb
- Helen Sweeting
- Hemant Gupta
- Hilary Pateman
- Hirschfield Gideon M.
- Howard Curtis
- Howard Klass
- Hyder Hussaini 247
- Hye Jeong Lee 167
- Ian Gooding 108
- Ian Rees 157
- Ian Drake
- Ian Gee
- Ilaria Bianchi 41
- Ilaria Sogno 41
- Imran Patanwala 252
- Imroz Salam 158
- Isobel Amey 304
- Jaber Gasem 87
- Jacky Orpe 256
- Jacqueline Brighton 138
- James Featherstone 147
- James Gotto 314
- James Neuberger 287
- Jane Bowles 318
- Jane Collier 231
- Jane Gitahi 288
- Jane Maiden 98
- Jane Metcalf
- Janeane Hails 101
- Janette Curtis 278
- Janie Keggans 191
- Janine Musselwhite
- Javaid Subhani 83
- Jayne Jones 260
- Jean Kordula
- Jeff Butterworth
- Jennie Kendall
- Jennifer Morrison 222
- Jeremy Shearman 271
- Jeremy Tibble 93
- Jessica Whiteman
- Jia Qu 25
- Jill Conder 293
- Jinyi Zhang 23
- Jo Ridpath 147
- Joanna Allison
- Joanna Sayer
- Jocelyn Fraser 304
- John Dillon 214
- John Ramage 146
- John Mclindon
- Jonathan Booth 245
- Jonathan Brown
- Joy Sadeghian 153
- Joy Wilkins 164
- Julia Maltby 253
- Julie Colley 258
- Julie Browning
- Julie Tregonning
- Juliette Verheyden
- Juran 7 Brian D.
- Kapil Kapur 79
- Karen Hogben 122
- Karen Warner
- Karin Young 196
- Kate Martin 252
- Kate Ocker 199
- Katharine Pollock
- Kathryn Houghton 188
- Katie Seward 92
- Katie Spurdle
- Keith Elliott 79
- Keith George 265
- Kelly Amor 255
- Kerenza Boulton 265
- Kerry Flahive 140
- Kevin Yoong 183
- Kimberley Netherton 283
- Kirsten Walker
- Kirsty Martin
- Konrad Koss 126
- LaiTing Tan 135
- Lazaridis 7 Konstantinos N.
- Leonie Grellier 164
- Linda Jones 245
- Linda March 238
- Linda Kent
- Lisa Morgan 302
- Liz Farrington 247
- Lizzie Stafford 231
- Lola Dali kemmery 253
- Lorenzo Morini 56
- Lorraine Hankey 122
- Lory Saveria Croce ` 48
- Louise Winter 312
- Lourdes Cumlat 306
- Luca Fabris 50
- Lucie Hobson
- Luigi Muratori 36
- Luketic 27 Velimir A.
- Lyn Graves 247
- Lynn Currie
- Lynn O’
- Maggie Hughes
- Mandy Carnahan
- Marco Carbone 101
- Marco Marzioni 40
- Marek Czajkowski
- Maria Consiglia Bragazzi 42
- Maria Francesca Donato 46
- Maria Hayes 240
- Maria Vinci 65
- Maria Hamilton
- Mariam Nasseri 151
- Marie Green 254
- Marie Quinn 303
- Marina Leoni 249
- Mario Strazzabosco
- Marisa Mills 260
- Mariza de Andrade 19
- Mark Ainsworth 231
- Mark Cox 295
- Mark Narain 159
- Mark Wright 286
- Mark Aldersley
- Mark Wilkinson
- Markus Gess 170
- Marra Fabio
- Marta Spreafico 11
- Martin Lombard 252
- Martin Prince 104
- Martyn Carter
- Mary Crossey
- Mary Ninkovic
- Mason 21 Andrew L.
- Massimo Colombo 46
- Massimo Zuin
- Matthew Brookes 254
- Matthew Cowan 279
- Matthew Cramp 238
- Matthew Foxton 105
- Maurizia Brunetto 43
- Mauro Podda 41
- Maxton Pitcher
- Mazn Karmo 109
- Mcdonald Mupudzi 286
- Melanie Harrison 70
- Melanie Kent
- Mells George F.
- Mervyn Davies
- Mesbah Rahman 68
- Metod Oblak 300
- Michael Heneghan 167
- Mike Mendall
- Minesh Patel
- Mohamed Dawwas 101
- Morley Katherine I.
- Mousa Hani S. 41
- Myers 22 Robert P.
- Natalie Taylor 265
- Natalie Wheatley 108
- Neil Fisher 123
- Nicholas Sharer 239
- Nicola Lancaster
- Nikki White
- Niro 37 Grazia A.
- Noma Ncube
- Nurani Sivaramakrishnan 186
- Odin 26 Joseph A.
- Oza Chirag
- Palmieri 58 Vincenzo O.
- Paolo Muratori 36
- Parizade Raymode 166
- Patrick Goggin 240
- Paul Banim 165
- Paul Kitchen 182
- Paul Richardson 252
- Paul Southern 92
- Paula Townshend
- Peter Bramley
- Peter Mills
- Phillipa Desousa
- Pier Maria Battezzati 39
- Pierluigi Toniutto 64
- Piero Portincasa 58
- Pietro Andreone 36
- Pietro Invernizzi
- Piotr Milkiewicz 24
- Pradeep Sanghi
- Pranab Gyawali 77
- PuiChing Chan 296
- Purushothaman Premchand 78
- Qian 2 David C.
- Rachel Abrahams 117
- Raj Srirajaskanthan 176
- Ray Shidrawi 153
- Ray Mathew
- Rebecca Bishop
- Rebecca Casey
- Rebecca Cloudsdale
- Rebecca Jones
- Renzo Montanari 55
- Reuben Ayres 248
- Richard Aspinall 240
- Richard Evans 88
- Richard Marley 80
- Richard Miller 183
- Richard Sturgess 70
- Robert Przemioslo 216 Christopher Macdonald
- Roberta Lazzari 51
- Roger McCorry 85
- Roland Ede
- Roman Galaska 71
- Rory Harvey 84
- Rosanna Fontana 37
- Rose Damant 98
- Rupert Ransford 313
- Ruth Penn
- Ryder Stephen D.
- Saket Singhal 258
- Sally Ann Rolls 156
- Sally Batham
- Sallyanne Pearson 244
- Samantha Ducker 188
- Sambit Sen 179
- Samir Vyas 257
- Sandford Richard N.
- Sandra Greer 312
- Sanjiv Jain 283
- Sarah Jones 159
- Sarah Besley
- Sarah Thornthwaite
- Sass Levi
- Savino Bruno 41
- Schlicht 7 Erik M.
- Seldin 15 Michael F.
- Senayon Desmennu
- Sharat Misra
- Sherill Tripoli
- Silvia Colombo 47
- Siminovitch Katherine A.
- Simon Panter 270
- Simon Rushbrook 215
- Simon Taylor Robinson 162
- Simon Williams 163
- Simon Dyer
- Simon Whalley
- Sonia Rossi 41
- Sonia Tarallo 60
- Sophie Holder
- Steve Pereira 284
- Steven Mann
- Stewart Campbell
- Subramaniam Ramakrishnan 296
- Subrata Saha 191
- Sue Glenn 106
- Sue Walsh 280
- Sunil Dolwani
- Susan Gallagher 294
- Susan Lord 118
- Susan Congreave
- Susan Jones
- Susan Slininger
- Sushma Saksena
- Suzie Marriott 248
- Syed Shaukat 152
- Talal Valliani 216
- Tarocchi Mirko
- Theodore Ngatchu
- Thiriloganathan Mathialahan 89
- Tim Harding
- Tobias Balschun 20
- Toby Delahooke
- Tom Yapp 69
- Tom Lee
- Tracey Shewan 279
- Udi Shmueli 221
- Valentina Liakina 30
- Valeria Silvestre 105
- Victoria Lambourne 253
- Vincenzo Ronca 41
- Voi Shim Wong 306
- William Stableforth 247
- Williams 197 D.
- Yafang Li
- Yeng Ang 312
- Yolanda Baird 304
- Younghun Han
- Publication venue
- Publication date
- 01/01/2015
- Field of study
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study
- Author
- Abdullah Nassreen
- Accurso Antonello
- Accurso Antonello
- Achuthan Raj
- Adam Rahma
- Adelekan Matthew
- Adwani Asha
- Aertssen Anna
- Agrawal Amit
- Agrawal Avi
- Ain Quratul
- Ainsworth Rachel
- Akerlund Malin
- Akolekar Deepika
- Alder Louise
- Alexander Susanna
- Ali Deedar
- Ali Rozina
- Allan Anna
- Allum William
- Aloraifi Fatima
- Amin Khalid
- Amorosi Vittoria
- Arif Tahera
- Armstrong Alexander
- Asaad Oubida
- Asgeirsson Kristjan
- Athanasiou Irene
- Audisio Riccardo
- Azmy Iman
- Bache Sarah
- Bains Salena
- Bajrusevic Sladana
- Balasubramanian Balapathiran
- Balata Safa Ahmed
- Bali Radhika
- Barnes Nicola
- Barnes Nicola LP
- Barrows Sara
- Barry Peter
- Barua Ellora
- Basu Naren
- Bathla Sonia
- Benyon Sarah L
- Bernaudo Lorenzo
- Bhaskar Pud
- Bibi Saira
- Biddle M
- Bignell Kym
- Biswas Bashishta
- Blazeby Jane
- Bourne Roger
- Brock Lisa
- Brown Victoria
- Bucata Claudiu
- Bucknor Alexandra
- Byrne Miriam
- Cain Henry
- Callaghan Maria
- Canny Rebecca
- Catanuto Giuseppe
- Cawthorn Simon
- Ceccarino Raffaele
- Chagla Leena
- Challoner Tom
- Chana Jagdeep
- Chand Natalie
- Chandrashekar Mysore
- Charalambous Michalis
- Charalampou-Dis Petros
- Chew Ben
- Chicken Dennis Wayne
- Chin Kian
- Chong Kelvin
- Choy Christina
- Christopoulos Petros
- Chrysafi Ada
- Clark Sarah
- Clarke Natalie
- Coco Guido
- Colizzi Livio
- Collab Breast Reconstruction Res
- Collis Nick
- Conroy Elizabeth
- Constantinou Chloe
- Critchley Adam
- Cullinane Carolyn
- Curnier Alain
- Curran Terry-Ann
- Dauria Marta
- Dave Rajiv
- Dave Rajiv V
- Dave Rajiv V
- Davey Simon
- de Sousa Emma
- Debanth Debasish
- Depasquale Ivan
- Devane Liam
- Dhooma Naseem
- Di Micco Rosa
- Dixon JM
- Dordea Matei
- Douek Michael
- Down Sue
- Downey Sarah
- Dragoumis Dimitris
- Dumitru Dorin
- Dunn Julie
- Durbar Michael
- El-Sharief Deena
- Elahi Bilal
- Elfadl Dalia
- Epurescu Daniel
- Evoy Denis
- Exarchos Georgios
- Fabio Santanelli di Pompeo
- Fafemi Oladapo
- Fage Elena
- Farrell Eric
- Ferguson Douglas
- Fiddes Roanne
- Figus Andrea
- Fopp Laura
- Foster Rachel
- Fuller Mairi
- Fustaino Loredana
- Gahir Jasdeep
- Gandamihardja Tasha
- Gandhi Ashu
- Gardiner Matthew
- Gardiner Matthew
- Garg Neeraj
- Garnsey Clare
- Geraghty James
- Geropantas Konstantinos
- Ghali Shadi
- Ghilli Matteo
- Gill Emma
- Goh Steven
- Govindarajulu Sasirekha
- Graja Tomasz
- Granger Emily
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- Tomlins Abigail
- Trapszo Pawel
- Trickey Adam
- Turton Philip
- Udayasankar S
- Valassiadou Kalliope
- Verjee Liaquat S
- Vidya Raghavan
- Vigneswaran Natali
- Vinayagam Raman
- Vollermere Angela J
- Walker Philip
- Weiler-Mithoff Eva
- Weston-Petrides Gina
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- Wilson Sherif
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- Woollard Alex
- Woollard Alexander
- Yoshimura Ryo
- Young Oliver
- Younis Ibby
- Youssef Mina
- Zechmeister Katalin
- Zeidan Bashar
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Background:
Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy.
Methods:
Consecutive women undergoing mastectomyâ±âIBR for breast cancer JulyâDecember, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomyâ±âIBR were compared and risk factors associated with delays explored.
Results:
A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [nâ=â675, 26.6%]; pedicled flaps [nâ=â105,4.1%] and free-flaps [nâ=â228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays.
Conclusions:
IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients
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- Grady Michelle L.
- Grafham Darren
- Graham Joe
- Grandbois Edward
- Grant Jennifer
- Grant Michael
- Grant Susan
- Graves Tina A.
- Gray Bruce
- Gray Emma
- Gray Lain
- Green Lisa
- Greenhalgh James
- Greenhill Joe
- Gregg Philippa
- Gregory Simon
- Grewal Nennu
- Gribble Susan
- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
- Griffiths Mark
- Griffiths-Jones Sam
- Grigoriev Igor
- Grimwood Jane
- Grocock Russell
- Groza Matthew
- Gu Jingli
- Gu Jun
- Gu Jun
- Gu Wenyi
- Gu Wenyi
- Gu Xiaochang
- Guan Qiaoning
- Guarin Hannibal
- Guel Metzalli
- Guerra William
- Guevara Whitney V.
- Gui Qi
- Gunaratne Preethi
- Gunning Kate
- Guo Daorong
- Guo Jane
- Guo Lili
- Gustafson Erik
- Guthrie Ian
- Guyer Mark
- Gwilliam Rhian
- Gyaltsen Kunsang
- Gyapay GĂĄbor
- Görlich Yvonne
- Ha Chi
- Hafez Nabil
- Haglund Krista
- Hagopian Daniel
- Hagos Birhane
- Haim Allen
- Hajek Patrick
- Hall Brett Lynn
- Hall Brittany
- Hall Jennifer
- Hall Rebekah
- Hall-Tamly Gretta
- Halls Karen
- Hallsworth-Pepin Kym
- Hamada Junko
- Hamilton Cerissa
- Hamilton Keelan A.
- Hamilton Matt
- Hamlett John
- Hamlett John
- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
- Han Shunsheng
- Han Xurong
- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
- Harley Joanne
- Harper David
- Harper Georgina
- Harper Patrik
- Harradence Grant
- Harris Anthony
- Harrison Charlene-Lou
- Harrison Elliot
- Harrison Ruth
- Hart Elizabeth
- Hasegawa Tomoko
- Hashimoto Etsuko
- Hashimoto Wakako
- Hassan Daniel
- Hatcher Beath
- Hattori Masahira
- Haugen Eric
- Haussler David
- Havlak Paul
- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
- Hawkins Trevor
- Hawley Kellie
- Haydu Lauren
- Hayes Kerry
- He Fengying
- He Jiaying
- He Lin
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- Heath Paul
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- Heilig Roland
- Heiner Cheryl
- Heinze Ivonne
- Heitmann Katja
- Helfenbein Keven
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- Hellsten Uffe
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- Henderson Carl
- Henderson Nicholas
- Henderson Nina
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- Henning Karla
- Hepa Victor
- Herd Tim
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- Hernandez Judith
- Hernandez Omar
- Herseim Allyson
- Hewitt Stephen
- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
- Holden Jane
- Holdgate Janet
- Hollaway Mara
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- Holloway Ele
- Holmes Andrea
- Holmes Ian
- Holmes Sarah
- Holroyd Simon
- Holtz Ann
- Holtzer Caleb
- Homsi Deana K.
- Homsi Farah J.
- Honan Tracy
- Hood Leroy
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- Hornischer Klaus
- Hornsby Amber
- Hornsby Geoff
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- Howard Philip
- Howard Stephanie R.
- Howden Philip
- Howe Kevin
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- Howell Latoya Lynette
- Howells Sally Lucinda
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- Hu George
- Hu Jie
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- Huang Fang
- Huang Guyang
- Huang Katherine
- Huang Mei
- Huang Wayne
- Huang Wei
- Huang Wei
- Huang Wei
- Huang Zhengping
- Hubbard Timothy
- Huber James W.
- Huckle Elizabeth
- Hue Heather
- Hughes Jaime
- Hughes Jennifer
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- Hulme Bill
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- Hume Jennifer
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- Hunt Paul
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- Hunter Giselle
- Hunter Rov, II
- Hupman Matt
- Huynh Sandy
- Hyde David
- Hynds Christopher
- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
- Inagaki Naomi
- Ince Michael
- Ingram Drew
- Inoue Shuuji
- Isak Amber
- Isherwood Judith
- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
- Isozaki Emi
- Israni Sanjay
- Ito Fumiaki
- Ito Noriko
- Itoh Takehiko
- Iwakawa Shinobu
- Iwatate Mariko
- Iwatsu Mikiko
- Iyer Vivek
- Izatt Janet
- Izmajlowicz Monica
- Izumiyama Tomohiro
- Jacintho Mark
- Jackson Laronda R.
- Jackson Terri
- Jacob Leni Susan
- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
- James Kent W.
- Jareborg Niclas
- Jarek Michael
- Jassal Bijay
- Jeffery Grant
- Jeffery Kim
- Jeffrey Colin
- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
- Jia Xingchang
- Jiang Lu
- Jiang Yanrui
- Jiang Ziyou
- Jimenez Alberto
- Jin Jian
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- Jin Yongsan
- Johansen Tina
- Johnson Bennie
- Johnson Cheryl
- Johnson Christopher
- Johnson David
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- Johnson Rudy
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- Jolivet Angela
- Jolley Keith
- Jones Abigail
- Jones Charlien
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- Jones Matthew
- Jones Michael
- Jones Micheil
- Jones Myrna D.
- Jones Steven
- Jong Pieter De
- Jordan Yun
- Joseph Shirin
- Joy Ann
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- Joy Victoria
- Joyce Gillian
- Jubb Mark
- Jung Eugine
- JĂ€rke Doris
- Kadner Kristen
- Kagan Ryan
- Kahsai Orsalem
- Kaida Kaoru
- Kale Pat
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- Kamal Michael
- Kamat Asha
- Kamholz Sandra
- Kana Arnold
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- Kang Kelie
- Kang Ning
- Kapur Hitesh
- Karolchik Donna
- Karunaratne Kanchi
- Kasprzyk Arek
- Katayama Takujiro
- Kato Takako
- Kauer Gerhard
- Kaul Rajinder
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- Kawagoe Chiharu
- Kawasaki Kazuhiko
- Kay Michael
- Kaye Danielle
- Kearney Lyndal
- Keefe Damian
- Keen Gifford
- Keenan Stephen
- Kegelmeyer Laura
- Kegg Lisa
- Kelley Simon
- Kells Cristyn
- Kelly Shayna P.
- Kelly Susan H.
- Kershaw Joanna
- Kettleborough Ross
- Keys David
- Khan Arsi
- Khan Umer F.
- Khan Ziad Mohid
- Khine Susu
- Khurama Divya
- Kidd Cathy
- Kierstan Peter
- Kieu Alix
- Kim Jennifer
- Kim Joomyeong
- Kim Kyung
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- Kimberley Andrew
- Kimura Moe
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- Kingswood Colin
- Kisamo Haika
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- Klages Sven
- Klingle Gillian
- Knights Andrew
- Kobayashi Mai
- Kodira Chinnappa
- Kohlberg Sara
- Kojima Kazuyasu
- Kolbe William
- Kong Yi
- Korf Ian
- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
- Kudoh Jun
- Kuehl Jennifer
- Kuharic Patrick
- Kuhn Carol
- Kulish Larissa
- Kuroki Yoko
- Kwan Chinnie
- Kyle Amy
- LaButti Kurt
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- Lad Heena
- Lafrades Melanie
- Lagemann Dorothee
- Lai Jianghua
- Lai Teresa
- Laidlaw Philip
- Laing Michael
- Laird Gavin
- Lam Edward
- Lam Marissa
- Lama Dawa
- Lamar Betty
- Lambart Christine
- Lamble Ralph
- Lamerdin Jane E.
- Lander Eric S.
- Landers Tom
- Langford Cordelia
- Lansang Christine
- Lao Victoria
- Lapidus Alla
- Larke Ben
- Lato Bernadette
- Latreille Phil
- Lau Timun
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- Layman Dan
- Leal Belita
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- Lee Byung-in
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- Lee Kenneth
- Lee Lisa
- Lee Peter
- Legall Fitzherbert Henderson, III
- Leger Jean Pierre
- Lehman Karl
- Lehmann RĂŒdiger
- Lehoczky Jessica
- Lehrach Hans
- Lehvaslaiho Minna
- Lei Meng
- Lemke Johannes
- Lennon Gregory
- Leonard Shawn
- Leonard Steven
- Leongamornlert Daniel
- Lesar Kendra
- Levan Jaclyn M.
- Leversha Margaret
- Levine Rosie
- Levy Andrew
- Levy Michaël
- Lewis Doreen
- Lewis Ernest K.
- Lewis Keith
- Lewis Lakeshia C.
- Lewis Lora R.
- Lewis Tammy
- Leyba Tina
- Li Changfeng
- Li Chenji
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- Li Zhangwan
- Lieuallen Kim
- Lightning Julia
- Lim Meng K.
- Lindblad-Toh Kerstin
- Lindo Ken
- Lindquist K.
- Lindsay Sarah
- Lindstrom Kirsten
- LIne Matthew
- Ling Wei
- Linkowski Albert
- Linsdell Sally
- Little Peter
- Liu Boyong
- Liu Boyong
- Liu Cong
- Liu Dianwu
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- Liu Jing
- Liu Jing
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- Liu Siqi
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- Liu Wei
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- Liu Ying
- Liu Yu
- Liu Yu
- Liu Zhanwei
- Liyanage Dhammika
- Llewellyn-Silva Crystal
- Lloyd Christine
- Lloyd David
- Lobb Rebecca
- Lock Victoria
- Lock William
- Lodziak Anne
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- London Darin
- London Pamela
- Longden Ian
- Longmire Johnathan L.
- Lopez Frederick
- Lopez John
- Lopez Jose
- Lopez Lora
- Loraine Howard
- Lord Rachel
- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
- Loveland Jane
- Lovell Jamie
- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
- Lu Tao
- Lu Xiuhua
- Lu Yongxiang
- Lu Yontao T.
- Lu Yue
- Lucas Robert
- Lucas Susan
- Lucier Alice
- Lucier Raymond L.
- Ludeman Thom
- Lui Annie
- Lundgren Lyndsey
- Luo Chunqing
- Luo Chunqing
- Lv Gang
- Lv Gang
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- Lynch Daniel
- Löhnert Tschong-Hun
- Ma Cheng
- Ma Gary
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- Ma Qingmei
- Ma Xiaohui
- Maas Jason
- Mabbitt Richard
- Macdonald Pendexter
- Machrus Migdad
- Macht Madison
- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
- Maglott Donna
- Maheshwari Manjula
- Mahindartne Mathew
- Mahmoodi Venus
- Mahnke Ryan
- Mailey Brian
- Major John
- Malfatti Stephanie
- Malloy Kevin
- Maltbie Mary I.
- Mangum Brian
- Manning Jonathan
- Manohar Chitra
- Mapua Patricia
- Marabella Dick
- Mardis Elaine R.
- Mareth David
- Mariano Marisa
- Marinelli Lisa
- Mark Graham A.
- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
- Marriott Neil
- Marrone Anne
- Marroquin Christian
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- Marsh Victoria
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- Martin Joel
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- Martin Sancha
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- Martinez Diego
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- Maslen Gareth
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- Masood Hadi
- Massey Elizabeth
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- Matsushita Yoshitaka
- Matthews Charles D.
- Matthews Lucy
- Matthews Nick
- Matthews Paul
- Matthews Sterling D.
- Mauceli Evan
- Maunes Cynthia
- Maupin Rachel
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- Maynard Madalynne
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- McGhee Tina
- McGuire Sarah
- McGurn Phil
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- McLaren Stuart
- McLay Kirsten
- McLean James
- McLellan Michael D.
- McLeod Michael P.
- McMurdo John
- McMurray Amanda
- McMurray Des
- McMurray Kimberly
- McMurray Kimberly L.
- McNinch Jenny
- McPherson John
- McPherson John D.
- McVicker Graham
- McWilliams Natalie
- Mead Kelly
- Meador Michael G.
- Medina Catherine
- Mehta Nalini
- Meidi Patrick
- Meier Elke
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- Mejima Mio
- Meldrim James
- Melsopp Craig
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- Meneus Louis
- Meng Shanshan
- Menuge Noel
- Mercado Christian
- Mercado George
- Mercado Iracema C.
- Mercer Simon
- Merritt Christina E.
- Mesirov Jill P.
- Metzker Michael Lee
- Meyer Rekha
- Meyer Rick
- Miah Asab
- Michaelis Evelyn
- Micklem Gos
- Mieczkowski Carl
- Mier Maggie
- Miguel Trini
- Mihalev Atanas
- Mihalkanin Danielle
- Mihova Tanya
- Miles Simon
- Mileur Mason W.
- Miller Christie
- Miller Donald
- Miller Nancy
- Milne Sarah
- Miner George R.
- Miner Sheri
- Miner Tracie
- Minja Emmanuel
- Minoshima Shinsei
- Minx Patrick J.
- Misra Monica
- Mistry Dippica
- Mistry Shailesh
- Mitchell Jake
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- Montgomery Mishelle
- Mooney Paul
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- Moore Niki
- Moreland Andrea
- Morgan Jenna
- Morgan Margaret B.
- Morita Hiroko
- Morris Sidney
- Mortimore Beverly
- Morton Jerry
- Motoyama Ayuko
- Mott Richard
- Moyzis Robert K.
- Mu Feng
- Mukherjee Shibani
- Mullenger Ian
- Mullikin Jim
- Mulrain Leon
- Munday Brian
- Munday Elaine
- Mundt Mark O.
- Mungall Andy
- Munidasa Mala
- Munk A. Christine
- Munk Christie A.
- Munson Glen
- Murakami Katsuhiko
- Murayama Yuji
- Murnane Clare
- Murphy Matthew B.
- Murphy Michael
- Murray Christine
- Murray Debra Dianne
- Murray Jennifer
- Murrell Kerry
- Muzny Donna Marie
- Myers Alison
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- Nagamine Kentaro
- Nagao Syunsuke
- Nagaraja R.
- Nair Latha
- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
- Nakamura Etsuko
- Nakato Eriko
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- Nandkeshwar Richard
- Nankervis Colin E.
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- Naylor Jerome
- Nazareth Lynne V.
- Neal Dearl D.
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- Nelson Catherine
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- Nelson Deborah A.
- Nelson Joanne
- Nelson Kathryn
- Nelson Ward
- Nesbitt Ryan
- Neunkirch Jennifer
- Newes Christian
- Newman April
- Ng Bee
- Ng Terrance
- Ngo Robin Ngoc
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- Nguyen Minh
- Nguyen Na
- Nguyen Natalie M.
- Nguyen Ngoc Bich
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- Ni Lin
- Niblett David
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- Nickerson Tim
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- Ning Zemin
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- Niu Yuxin
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- Nivens Amber
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- Nolan Matt
- Norbu Chou Dolma
- Norbu Nyima
- Nordsiek Gabriele
- Norris Sarah Louise
- Novik Karen
- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
- Obregon Melissa
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- Ohno Saho
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- Ohtsubo Masafumi
- Oinn Tom
- Okoawo Ose
- Okui Michiyo
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- Okwuonu Geoffrey O.
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- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
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- Olson Maynard V.
- Omotosho Bamidele
- Onoda Junko
- Oomori Nobuhiro
- Ooshima Kenshiro
- Oragunye Njideka
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- Osborn Anthony
- Osborne Joan
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- Ovcharenko Ivan
- Overton-Larty Emma
- Oviedo Rodolfo J.
- Ow David
- Ozawa Ritsuko
- Ozersky Philip
- Pace Araceli C.
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- Pahlavan Shane
- Palaniappan Krishnaveni
- Palazzolo Michael
- Palmeiri Anthony
- Palmer Sophie
- Pan Jiaofeng
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- Panasenko Vladimir
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- Parker David Neil
- Parker Stephen
- Parkin Christopher
- Parkin Kim
- Parks Kenya L.
- Parry-Brown Ginny
- Parson-Quintana Beverly
- Pasternak Shiran
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- Patel Vishal V.
- Patrick James
- Paul Heidie A.
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- Payton Brett A.
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- Peng Yi
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- Pennacchio Len A.
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- Percy Chantel
- Perez Agapito
- Perez Lesette M.
- Perito Andrew
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- Perrier Rene
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- Pesavento Brad
- Peters Anna
- Peters Leonard G.
- Peterson Jane
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- Pettett Roger
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- Phan Hoan
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- Piscia C.
- Pitesky Maurice
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- Poliakov Alex
- Pollard Martin
- Polman Jos
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- Porter Keith
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- Poundstone Pat
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- Prado Daisy
- Prange Christa
- Prathalingham Radhika
- Predki Paul
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- Putnam Nicholas
- Qasem Osama
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- Qi Xiaohua
- Qian Xufang
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- Qiang Boqin
- Qiang Boqin
- Qiao Zhenyong
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- Quail Michael
- Quan Glenda
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- Quince Chris
- Quiroz Juana B.
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- Radionenko Maxim
- Rajagopal Mohan
- Ramasami Umadevi
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- Ramirez Lucia
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- Ray Aditya
- Ray Vernada
- Raymond Chris
- Raymond Christina
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- Reid Mary
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- Reily Amy D.
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- Reinhardt Richard
- Reiter Charlie
- Ren Shuangxi
- Ren Shuangxi
- Ren Yanru
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- Richardson Paul
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- Richardson Susan
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- Riethman Harold
- Riethoven Lyn
- Rigby Rachel
- Riley B.E
- Rise Cecil
- Rivera Angel
- Rives Catharine M.
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- Robinson Donna L.
- Robinson Melanie
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- Rodriguez Alex
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- Rokhsar Daniel
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- Rosenbloom Kate R.
- Roskin Krishna M.
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- Rowen Lee
- Rubenfield Marc
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- Ruiz San Juana
- Rule Angela
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- Santibanez Jireh
- Santoyo-Lopez Javier
- Sanuki Naoko
- Sarmiento R.
- Sasaki Takashi
- Satpathy Suraj
- Saunders David
- Saunders Elizabeth H.
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- Sawhill William W.
- Saxman Eric
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- Worley Kim Carlyle
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- Wray Paul
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- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
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- Wu Jung-Rung
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- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
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- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
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- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
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- Younger Ruth
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- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
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- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study
- Author
- 't Hart Ellen P.
- ?a?inkovĂĄ Pavla
- Aaserud Olaf
- Abbruzzese Giovanni
- Acharya T.
- Akhtar Shahbana
- Albanese Alberto
- Alegre Javier
- Alegre Javier
- Allain Philippe
- Alusi Sundus
- Amico Enrico
- Andrade Carlos
- Andrews S. C.
- Andrews Thomasin
- Andrews Thomasin
- Anheim Mathieu
- Antczak Jakub
- Armstrong Matthew
- Armstrong Richard
- Arques Penelope Navas
- Arran N.
- Arran Natalie
- Artiga MarĂa JosĂ© Saiz
- Axelson E.
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachoud-LĂ©vi Anne-Catherine
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Bardinet E.
- Barker Roger A.
- Barrero Francisco
- Barth Katrin
- Barth Katrin
- Barthélémy Rekha
- Bas Jordi
- Bascuñana Mónica
- Bechtel N.
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Bentivoglio Anna Rita
- Bentivoglio Rita
- Berglund Peter
- Berna C.
- Berrissoul Hassan
- Bertini Elisabetta
- Betz Sabrina
- Biunno Ida
- BjĂžrgo Kathrine
- BjĂžrnevoll Inga
- Blaszcyk Magdalena
- Blin Stéphanie
- Bocwinska Dorota
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen S.
- Bohlen Stefan
- Bojakowska-Jaremek Kamila
- Bolwijn J. J. W.
- Bonelli Raphael
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Boogaerts Andrea
- Borowsky B.
- Bos Reineke
- Bos Reineke
- Bosca Maria E.
- Bosredon Cecile
- Bost Marie
- Boukbiza Ouhaid Lagha
- Bourne Colin
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brockie Peter
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buck Andrea
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burrows Liz
- Busquets NĂșria
- Busse Monica
- Butcher Cynthia
- BĂŒrk Katrin
- C Jan Frich
- Caldentey Juan Garcia
- Callaghan J.
- Callaghan Jenny
- Callaghan Jenny
- Callaghan Jenny
- Calmeyn Godelinde
- Calopa Matilde
- Campbell C.
- Campbell C.
- Campbell M.
- Campos Anabel
- Capellari Sabina
- Capetian Philipp
- Carette Maryline Cabaret Anne-Sophie
- Carrillo FĂĄtima
- Carruesco Gemma Tome
- Cash D. M.
- Castaldo Anna
- Catena Judit LĂłpez
- Chu Carol
- Chu Carol
- Chu Carol
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Clapton Jackie
- Clayton Carole
- Clenaghan Catherine
- Coelho Miguel
- Coleman A.
- Come Adrien
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Cortegana Hermoso Eva Pacheco
- Cortelli Pietro
- Coulthard Elizabeth
- Courtin Françoise
- Craufurd D.
- Craufurd David
- Crawford H.
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- CĂĄceres MarĂa Teresa
- D'Alessio Barbara
- da Silva Wildson Vieira
- Damas Fatima
- Davies Rhys
- De Bruycker Christelle
- De Michele Giuseppe
- de Souza Jenny
- de Tommaso Marina
- de Weert A. Marit
- de YĂ©benes Justo GarcĂa
- de YĂ©benes Justo GarcĂa
- Debruxelles Sabrina
- Dec Malgorzata
- Decolongon J.
- Defebvre Eric Decorte Luc
- Dekker M.
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Delvaux Isabelle
- Descals AsunciĂłn MartĂnez
- Destee Alain
- Di Bella Daniela
- Di Donato Stefano
- Di Maio Luigi
- Di Pietro Anna
- di Poggio Monica Bandettini
- Di Renzo Martina
- Diercks Gabriele
- Dipple Heather
- Dixon Kathryn
- Doherty Karen
- Dose Matthias
- Dougherty Andrew
- Dressler Dirk
- Duché Charlotte
- Dujardin Kathy
- Dumas E. M.
- Dumas Eve M.
- Dunnett Stephen
- Dunnett Stephen
- Dupuit Michel
- Durr Alexandra
- Duru CĂ©cile
- Dziadkiewicz Artur
- Ecker Daniel
- Ecker Daniel
- Edwards Maureen
- Ellrichmann Gisa
- Esposito Chiara
- Eusebio Alexandre
- Evans Carole
- Fairtlough Helen
- Fannemel Madeleine
- Fasquel VĂ©ronique
- Favellato Mariagrazia
- Fenollar MarĂa
- Ferrandes Giovanna
- Ferreira Joaquim
- Ferreira Joaquim J.
- Ferrer Pilar Quiléz
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Fletcher Amy
- Fluchere Frédérique
- Fortuna Lorenza
- Foster Jillian
- Foustanos Isabella
- Fox N. C.
- Foy Kevin
- Frajman E.
- Frech Fernando Alonso
- Fredlund Gunnel
- Freire-Patino Dawn
- Frontali Marina
- Frost C.
- Fullam Ruth
- Fullam Ruth
- Fullam Ruth
- Gago Miguel
- Galassi Roberto
- Gallantrae Deena
- Gallentrae Deena
- Ganos Christos
- Garcia Patrocinio Moreno
- GarcĂa RocĂo GarcĂa-Ramos
- Garde Monica Bascuñana
- Garrett Carolina
- Gaston Itziar
- Geitner Carolin
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Gerrans Emily
- Gethin Louise
- Ghelli Elena
- Gibbard C.
- Gill Paul
- Gilling Mette
- Ginestroni Andrea
- Godefroy Olivier
- Gogol Anna
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- Golding Charlotte
- Gonzenbach Roman
- GonzĂĄlez GonzĂĄlez Sonia
- Goodman Anna
- Gorospe AranzazĂș
- Gorzkowska Agnieszka
- Gorzolla Heike
- Grant Janet
- Griguoli Annamaria
- Gross Diana
- Guedes Leonor Correia
- Guedes Leonor Correia
- Guerra Maria RosĂĄlia
- Guerrero Rosa
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guisasola Luis Menéndez
- Gustafsson Lena
- Guzman Natalie Valle
- Guérid Marie-Anne
- GĂžrvell Per F.
- Haider Salman
- Hallam Caroline
- Hamer Stephanie
- Hamer Stephanie
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia
- Handley Olivia
- Handley Olivia J.
- Harding Alison
- Hare Marianne
- Harrison David
- Hauer Maria
- Hayward Beverley
- Hecht Karen
- Heiberg Arvid
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Held Christine
- Hensman Moss Davina J.
- Hensman Davina
- Hepperger Caroline
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen DurĂĄn
- Herrmann Lennard
- Hicks S.
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Hjermind Lena E.
- Ho Carrie
- Hobbs N.
- Hobson Emma
- Hoffmann Rainer
- Holas Christiane
- Holl Anna
- Holmans Peter
- Hotter Anna
- Howard Liz
- Hughes Max
- Hughes Teresa
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Hyppönen Hannele
- Hölzner Eva
- HĂžsterey-Ugander Ulrika
- Ialongo Tamara
- Idiago JesĂșs Miguel Ruiz
- Illmann Torsten
- Jachinska Katarzyna
- Jack Roisin
- Jacobsen Oda
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Jasinska-Myga Barbara
- Johns Nicola
- Johnson H.
- Johnson Liz
- Jones Lesley
- Jones Lesley
- Jones Mary
- Jones R.
- Jones Una
- Julié Celine
- Jung Hans H.
- Jurgens C.
- Justo D.
- Kaelin Alain
- Kaminski Barbara
- Kapfhammer Hans-Peter
- Kavalier Fred
- Kazoka Mbombe
- Keenan S.
- Kennard C.
- Kershaw Ann
- Kesse Andrea
- Khalil Hanan
- KlempĂr JirĂ
- Klimberg Aneta
- Klodowska-Duda Gabriela
- Klöppel Stefan
- Koivisto Susana Pro
- Koivisto Susana Pro
- Koivisto Susana Pro
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kotz Peter
- Kraus Alison
- Kraus Alison
- Kraus Alison
- Kraus P.
- Krawczyk Malgorzata
- Kremer B.
- Kremer Berry
- Krysa Wioletta
- Krystkowiak Pierre
- Kwiecinski Hubert
- Labuschagne I.
- LafoucriĂšre Danielle
- Lahiri N.
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer B.
- Landwehrmeyer Bernhard
- Landwehrmeyer G. Bernhard
- Lang Christina
- Langbehn Douglas
- Lange Herwig
- Lange Herwig
- Larsen Ida Unmack
- Lashwood Alison
- Lau Puay Ngoh
- LaurĂ Matilde
- Laver Fiona
- Leavitt Blair R.
- Lee S.
- Leenders K. L.
- Lehericy S.
- Lemaire Marie-HĂ©lĂšne
- Levey Jamie
- Lewerenz Jan
- Lewerenz Jan
- Lewis Monica
- Lewis Monica
- LeythÀuser Gabriele
- Lezius Franziska
- Liessens Dirk
- Lilek Sabine
- Linnsand Petra
- Lo Kitty
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lopera MĂłnica Rodriguez
- Lorentzen Eirin
- Loutfi Ghada
- Lucena Carolina Mendez
- Löhle Matthias
- Maass Antonia
- Magnet Markus
- Maiwald Robert
- MajerovĂĄ Veronika
- Malone I.
- Man A. Hoff
- Mandich Paola
- Manouvrier Sylvie
- Mantaux BĂ©atrice
- Manzanares Salvadora
- Marchese Roberta
- Marcinkowski Jerzy
- Marelli C.
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Markova Ivana
- Markova Ivana
- Marquard Ralf
- Martikainen Kirsti
- Martinez-Horta SaĂŒl
- Martinez-Jaurrieta Maria Dolores
- MartĂn Esther SuarĂ©z San
- MartĂnez-Descals AsunciĂłn
- Mason Sarah
- Massarelli Marco
- Massaro Francesca
- Matheson Kirsty
- Mazzante Irene
- McGill Marie
- McKenzie Sue
- Mead Simon
- Mechi Claudia
- Mendes Tiago
- Mestre Tiago
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Mihaylova Violeta
- Milchman C.
- Milkereit Eva
- Minet CĂ©cile
- Minster Sara
- Minster Sara
- Mir Pablo
- Monaco W.
- Monza Daniela
- Monza Daniela
- Morales Blas
- Moreau Laura Vivancos
- Moreno Jose Manuel Garcia
- Moreno José Luis López-Sendón
- Mundler Laura
- Murch Ann
- Murphy Helen
- Musgrave Hannah
- Möller Jens Carsten
- MĂŒhlau Mark
- MĂŒller Christoph
- MĂŒller Nicole
- MĂŒnchau Alexander
- MĂŒtze Lisanne
- Nanetti Lorenzo
- Neleborn-LingefjÀrd Liselotte
- Nemeth Andrea H.
- Nepper Solveig
- Nielsen JĂžrgen
- Nielsen JĂžrgen E.
- Niess Anke
- Nigaud K.
- Novak Marianne
- Nowak Malgorzata
- O'Donovan Kirsty
- O'Keefe Deidre
- O'Regan A.
- Oehmen Martin
- Olivier Audrey
- Olofsson Carina
- Opala Gregorz
- Ordidge R.
- Ortega Paloma
- Orth Michael
- Orth Michael
- Orth Michael
- Otti Daniela
- Oughton Emma
- Owen G.
- Owen Michael
- Padieu HĂ©lĂšne
- Paganini Marco
- Painold Annamaria
- Pardiñas Antonio F.
- Paridi Dominga
- Parkinson Andrew
- Partington-Jones Lucy
- Pastor Barbara Vives
- Pate Louise
- Patel A.
- Patel Aakta
- Paterski Laurent
- Paterson Nicole
- Pearson Pauline
- Peinemann Alexander
- Peluso Silvio
- Peppa Nadia
- Peppa Nadia
- Pepple T.
- Perea MarĂa Fuensanta Noguera
- Peter Mireille
- Petersen Jens
- Petrollini Martina
- Peña José Chacón
- Piacentini Silvia
- Piano Carla
- Pica Emmanul
- Piedad John
- Plomhouse Lucie
- Poda Roberto
- Poewe Werner
- Polo Cecilia Gil
- Porteous Mary
- Pourchot C.
- Pradella Silvia
- Prehn Christian
- Price Kathleen
- Priller Josef
- Probst Daniela
- Prundean Adriana
- PrĂŒĂ Harald
- PÀivÀrinta Markku
- Quarrell Oliver
- Queller S.
- Raab Tina
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Raman Ashok
- Raman Ashok
- Ramirez Inés Legarda
- Ramos-Arroyo Maria A.
- Ramos-Arroyo Maria A.
- Raymond Lucy
- Read J.
- Redondo Luis
- Reetz Kathrin
- REGISTRY investigators
- Reilmann R.
- Reilmann Ralf
- Reinante Gema
- Reisinger Karin
- Ret C. Jauff
- RetterstĂžl Lars
- Rialland Amandine
- Riballo Antonio Villa
- Ribas Guillermo GarcĂa
- RibaĂŻ Pascale
- Ribbat Michael
- Richter Przemyslaw
- Rickards Hugh
- Rissling Ida
- Rivadeneyra Perez Jessica
- Rizzo Giovanni
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- RodrĂguez MarĂa JosĂ© Torres
- Rogers Dawn
- Rohm Stefanie
- Rola Rafal
- Romano Silvia
- Romero Irene
- Romoli Anna Maria
- Roos Raymund
- Roos Raymund A. C.
- Roos Raymund A. C.
- Rosas H. D.
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzinska Monika
- Rumpf Silke
- Russo Cinzia Valeria
- RuĂz Pedro J. GarcĂa
- Ryglewicz Danuta
- RĂžren Niini
- SablonniĂšre Bernard
- Saft Carsten
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sando Sigrid Botne
- Santhouse Alastair
- Santos R. Dar
- Sass Christian
- Say M.
- Scaglione Cesa
- Scahill R.
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schneider Ariane
- Schrader Christoph
- Schwenk Daniela
- Schöggl Helmut
- SchĂŒpbach Michael
- Sciruicchio Vittorio
- SebastiĂĄn A. Rojo
- SebastiĂĄn Ana Rojo
- Sempolowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Silva Mark
- Simonin Clémence
- Simpson Sheila A.
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Smith Paul
- Snowden Julie
- Soleti Francesco
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Somers Nele
- Sorbi Sandro
- Sorrentino Pierpaolo
- Spadaro Maria
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike Jakob
- Squitieri Ferdinando
- Stattin Eva-Lena
- Stebler Yanik
- Stepniak Iwona
- Stokke Bodil
- Stompel Daniel
- Stopford C.
- Stopford Cheryl
- Storch Alexander
- Stout J.
- Stubbe Lars
- Sturrock A.
- StĂĄrkovĂĄ Irena
- StÀdtler Michael
- Suarez MarĂa JosĂ© Lama
- Sulek Anna
- Summers Fiona
- Swain Rachel
- Szczudlik Andrzej
- Szczygiel Elzbieta
- Szinwelski Michal
- SĂĄnchez Vicenta
- SĂŒĂmuth Sigurd
- t'Hart E. P.
- Tabrizi Sarah
- Tabrizi Sarah
- Tabrizi Sarah J.
- Tacik Pawel
- Tan Louis
- Taylor Cat
- Taylor Rachel
- Thibault-Tanchou Stéphanie
- Thomas Gareth
- Thompson Catherine
- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Tobin A.
- Tomasello Chiara
- Torres MarĂa Martirio Antequera
- Toscano Jean
- Townhill Jenny
- Townhill Jenny
- TRACK-HD investigators
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tuuha Katri
- Uhrova Tereza
- Ullah Jasmin
- Ure Alexandra
- ValabrĂšgue R.
- Valadas Anabela
- Valentine Ruth
- van den Bogaard S. J. A.
- van den Bogaard Simon J. A.
- van der Grond J.
- van Hout Monique S. E.
- van Oostrom J. C. H.
- van Paemel Dominique
- van Reijen Dimphna
- van Vugt Jeroen P. P.
- van Walsem Marleen R.
- van Walsem Marleen R.
- Vandenberghe Wim
- Vandenberghe Wim
- Vargas-GonzĂĄlez Laura
- Vaughan Vivien
- Ventura Marta FatĂĄs
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verhoeven Marloes E.
- Verny Christophe
- Verstappen C. C. P.
- Verstraelen Nichola
- Viladrich Celia Mareca
- Vilaplana Garcia Carmen PeirĂł
- Villanueva Clara
- Vinther-Jensen Tua
- Vuillaume Isabelle
- Wahlström Jan
- Wahlström Jan
- Wang C.
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Zaugg Sabine
- Weber Natalia
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wentzel Magnus
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Whalstedt Carina
- Whitehead D.
- Whitlock K.
- Wiedemann Alexandra
- Wikström Birgitta
- Wild E.
- Wild Edward
- Wild Sue
- Wild Sue
- Winkelmann Juliane
- Witjes-Ane M.-N.
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- Witkowski Grzegorz
- Wolz Annett
- Wolz Martin
- Wright Abigail
- Wright Abigail
- Wright Jan
- WĂłjcik Magdalena
- Yardumian Pam
- Yardumian Pam
- Yates Shona
- Zaremba Jacek
- Zaremba Jacek
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zieora-Jakutowicz Karolina
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zittel Simone
- Zucker Birgit
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008â11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003â13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 Ă 10â10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 Ă 10â8 DHFR p=8·37 Ă 10â7 MTRNR2L2 p=2·15 Ă 10â9) and to a lesser extent in REGISTRY (MSH3 p=9·36 Ă 10â4 DHFR p=8·45 Ă 10â4 MTRNR2L2 p=1·20 Ă 10â3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 Ă 10â8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16â0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06â0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-HĂ©lĂšne
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
- Brend Morwenna
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Julia
- Brown Louise
- Brown Nerissa
- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
- Bryden Emma
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burgess Richard
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Butler Susan
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Byrne Rahim
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Debbie
- Campbell Hilary
- Campbell Lewis
- Campbell Marion
- Campbell Ryan
- Campion Alexandra
- Campisi Josie
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmichael Samantha
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr Zoe
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Angus
- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Rachel
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ăve
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Joanne
- Collins Ărin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Concha Pablo
- Connolly Karen
- Constantini Elena
- Constantino-Occhipinti Claudia
- Contou Damien
- Convery Karen
- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-ChĂ©nard Ămilie
- Courtin Laura
- Coutts Amanda
- Couture Lourie
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craddock Richard
- Craner Michelle
- Craven Thomas
- Crawshaw Sarah
- Creagh-Brown Ben
- Creange Vanessa
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Csabi Peter
- Cudlipp Joanna
- Cuesta Jeronimo
- Cuffaro Raffaele
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- CĂĄrcel Sheila
- CĂŽtĂ© Ămilie
- D?Amato Fabiola
- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
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- Rohde Gernot
- Rojo Roceld
- Romagnuolo Tina
- Roman Jaime
- Romberg Birgit
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- Seymour Christopher W.
- Shah Faraaz
- Shahid Tasnin
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- Shakya Roshni
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- Shaw David
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- Siddiqui Atif
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- Siika Wangari
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- Silversides Jon
- Sim Malcolm
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- Simons Koen
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- Singleton Jo
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- Vamplew Luke
- van Amerongen Roosmarijn
- van Bentum-Puijk Wilma
- van Bree Sjoerd
- van de Veerdonk Frank L.
- van den Berg Lettie
- van den Oever Huub
- van der Eng Hetty
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- Wilcox Louise
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- Wilkinson Dean
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- Williamson James D
- Willis Joanna
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- Winters Lauren
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- Wittenberg Wendy
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- Woelke Amy
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- Wong Onyee
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- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
The Jews of Chernivtsi:Destruction and revival in the Ukraine
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2000
- Field of study
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