Effect of sedimentary heterogeneities in the sealing formation on predictive analysis of geological CO₂ storage

Numerical models of geologic carbon sequestration (GCS) in saline aquifers use multiphase fluid flow-characteristic curves (relative permeability and capillary pressure) to represent the interactions of the non-wetting CO2 and the wetting brine. Relative permeability data for many sedimentary formations is very scarce, resulting in the utilisation of mathematical correlations to generate the fluid flow characteristics in these formations. The flow models are essential for the prediction of CO2 storage capacity and trapping mechanisms in the geological media. The observation of pressure dissipation across the storage and sealing formations is relevant for storage capacity and geomechanical analysis during CO2 injection. This paper evaluates the relevance of representing relative permeability variations in the sealing formation when modelling geological CO2 sequestration processes. Here we concentrate on gradational changes in the lower part of the caprock, particularly how they affect pressure evolution within the entire sealing formation when duly represented by relative permeability functions. The results demonstrate the importance of accounting for pore size variations in the mathematical model adopted to generate the characteristic curves for GCS analysis. Gradational changes at the base of the caprock influence the magnitude of pressure that propagates vertically into the caprock from the aquifer, especially at the critical zone (i.e. the region overlying the CO2 plume accumulating at the reservoir-seal interface). A higher degree of overpressure and CO2 storage capacity was observed at the base of caprocks that showed gradation. These results illustrate the need to obtain reliable relative permeability functions for GCS, beyond just permeability and porosity data. The study provides a formative principle for geomechanical simulations that study the possibility of pressure-induced caprock failure during CO2 sequestration

PENGARUH MODEL PEMBELAJARAN SCRAMBLE TERHADAP HASIL BELAJAR TEMATIK MUATAN PENDIDIKAN PANCASILA DAN KEWARGANEGARAAN SISWA KELAS III SE-GUGUS 3 SANDEN BANTUL

This study aims to determine the differences in learning outcomes of PPKn subjects between scramble learning model classes and direct instruction model classes. This type of research is quasi-experiment. The results showed that the learning outcomes of PPKn subjects were taught using a higher scramble learning model while those taught using the direct instruction model were lower. The Z test results obtained Zhitung = 4,2790 and Ztable = 1,645. From the results of the Z test, it can be concluded that Zhitung> Ztable, means that there are differences in learning outcomes of PPKn Subjects between scramble learning model classes and direct instruction model classes. Based on the results of the Z test, it can be concluded that the scramble learning model is more influential than the direct instruction model on the learning outcomes of PPKn Subjects.Â

Peran Humas Dalam Meningkatkan Citra Positif Pada Badan Pengembangan Sumber Daya Manusia (BPSDM) Provinsi Jawa Timur

Every agency or organization definitely needs a positive image or good among the public. A good image is a need of an agency or organization, so this is one of the tasks carried out by public relations through the programs carried out. Because the success gained by an agency is inseparable from public relations who are able to run its role well. For the sake of creating a positive image, public relations must be able to carry out its role properly, because BPSDM is an agency tasked with educating the state civil apparatus before carrying out duties according to his position. So here public relations must be able to create, build, improve and maintain the image of the organization among the public. Public relations has the obligation to develop a harmonious relationship with the public because this is a public relations activity to build a good relationship to create a good image. The purpose of this study was to analyze the role of public relations in enhancing a positive image in the government agency BPSDM East Java Province. This type of research is qualitative descriptive. The subjects of this study were 3 public relations staff. Data analysis here uses the Miles and Huberman models using source triangulation. The results of this study indicate that the role of BPSDM public relations in East Java Province namely as a communication facilitator, expert advisor, problem solving facilitator and communication technician has been going well.Keywords: positive image; public relations

Optimización del gasto presupuestal y la gestión de unidad ejecutora en el frente policial Cajamarca, 2021

La investigación se desarrolló para conseguir el objetivo de determinar la relación que existe entre la optimización del gasto presupuestal y la gestión de unidad ejecutora en el Frente Policial Cajamarca, 2021, se busca un mecanismo para una mejor atención a los requerimientos de las áreas usuarias a la entidad. Es un estudio de enfoque cuantitativo, de tipo básico de alcance correlacional, diseño no experimental/corte transversal, con una población finita, el método de análisis de datos que se aplicó fue el Rho de Spearman, aplicando dos instrumentos que presentan validez y confiabilidad por parte de expertos, con dimensiones como planificación, control, organización y evaluación, teniendo como resultado principal que el coeficiente de correlación entre las variables optimización del gasto presupuestal y gestión de unidad ejecutora es 0.018, lo cual muestra que no existe una correlación lineal. El valor de significancia (bilateral) 0.912 que es mayor al valor de Sig I= 0,05 (Sig E < Sig I) y se tiene como conclusión que existe relación positiva entre la optimización del gasto presupuestal y la gestión de unidad ejecutora en el Frente Policial Cajamarca

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs

Comment in Lowering the High Cost of Cancer Drugs--III. [Mayo Clin Proc. 2016] Lowering the High Cost of Cancer Drugs--I. [Mayo Clin Proc. 2016] Lowering the High Cost of Cancer Drugs--IV. [Mayo Clin Proc. 2016] In Reply--Lowering the High Cost of Cancer Drugs. [Mayo Clin Proc. 2016] US oncologists call for government regulation to curb drug price rises. [BMJ. 2015

Development and characterisation of a large diameter decellularised vascular allograft

The aims of this study were to develop a biological large diameter vascular graft by decellularisation of native human aorta to remove the immunogenic cells whilst retaining the essential biomechanical, and biochemical properties for the ultimate benefit of patients with infected synthetic grafts. Donor aortas (n = 6) were subjected to an adaptation of a propriety decellularisation process to remove the cells and acellularity assessed by histological analysis and extraction and quantification of total DNA. The biocompatibility of the acellular aortas was determined using standard contact cytotoxicity tests. Collagen and denatured collagen content of aortas was determined and immunohistochemistry was used to determine the presence of specific extracellular matrix proteins. Donor aortas (n = 6) were divided into two, with one half subject to decellularisation and the other half retained as native tissue. The native and decellularised aorta sections were then subject to uniaxial tensile testing to failure [axial and circumferential directions] and suture retention testing. The data was compared using a paired t-test. Histological evaluation showed an absence of cells in the treated aortas and retention of histoarchitecture including elastin content. The decellularised aortas had less than 15 ng mg¯¹ total DNA per dry weight (mean 94% reduction) and were biocompatible as determined by in vitro contact cytotoxicity tests. There were no gross changes in the histoarchitecture [elastin and collagen matrix] of the acellular aortas compared to native controls. The decellularisation process also reduced calcium deposits within the tissue. The uniaxial tensile and suture retention testing revealed no significant differences in the material properties (p > 0.05) of decellularised aorta. The decellularisation procedure resulted in minimal changes to the biological and biomechanical properties of the donor aortas. Acellular donor aorta has excellent potential for use as a large diameter vascular graft

Relación de las condiciones crediticias con el nivel de endeudamiento de los clientes de electrodomésticos de Elektra y Efe en la ciudad de Cajamarca 2017

RESUMEN El presente trabajo se sustenta en larealidad actual de falta de conocimiento que tienen las personas acerca de las condiciones del crédito de consumo destinado a la compra de electrodomésticos, lo que ha generado gran un problema debido a la falta de información. El objetivo principal fue determinar el nivel de conocimiento de las condiciones de crédito que tienen los clientes que adquieren electrodomésticos en la ciudad de Cajamarca. En este sentido la investigación se enfocó en el sector comercial, pues es ahí donde se expenden mayormente los electrodomésticos. Se determinó que hay falta de información acerca de la composición de las cuotas, tasas, plazos, comisiones, seguros y otros conllevandolos en algunos casos a incumplir sus pagos y convertírse en morosos o incapaces de pagar. En la investigacion se aplicó como técnica de investigación la encuesta que permitío indagar la opinión y actitudes que tuvo la población en estudio, fue de carácter impersonal por que no es indispensable la presencia del investigador. En el estudio se aplicó encuesta con preguntas cerradas, cada pregunta tiene una escala de medición. Se tomó en cuenta la escala de Lickert, por ser el instrumento que brindo mayor apoyo. Como resultado de la investigacion se ha determinado que existe alto índice de desinformacion del cliente que toma un credito y por tanto la existencia en relación directa con el indice de endeudamiento de los clientes. Palabras clave: Condiciones de crédito, Cliente, Tasa de interés, plazo, endeudamiento.ABSTRACT This work is based on current reality of lack of knowledge that people have about the conditions of consumer credit for the purchase of appliances, which has generated great problems due to the lack of information. The main objective was to determine the level of knowledge of the credit conditions of customers who purchase appliances in the city of Cajamarca. In this sense, the research focused on the commercial sector, since that is where most appliances are expended. It was determined that there is a lack of information about the composition of fees, fees, terms, commissions, insurance and others leading them in some cases to default on their payments and become delinquent or unable to pay. In research, the survey that allowed us to investigate the opinion and attitudes of the population under study was applied as a research technique. It was impersonal because the presence of the researcher is not indispensable. In the study, a questionnaire with closed questions was applied, each question has a measurement scale. The scale of Lickert was taken into account, as it was the instrument that offered the greatest support. As a result of the investigation it has been determined that there is a high index of disinformation of the client that takes a credit and therefore the existence in direct relation with the index of indebtedness of the clients. Keywords: Credit conditions, Customer, Interest rate, term, knowledge

Inhibition of prolyl oligopeptidase : A promising pathway to prevent the progression of age-related macular degeneration

Dry age-related macular degeneration (AMD) is a currently untreatable vision threatening disease. Impaired proteasomal clearance and autophagy in the retinal pigment epithelium (RPE) and subsequent photoreceptor damage are connected with dry AMD, but detailed pathophysiology is still unclear. In this paper, we discover inhibition of cytosolic protease, prolyl oligopeptidase (PREP), as a potential pathway to treat dry AMD. We showed that PREP inhibitor exposure induced autophagy in the RPE cells, shown by increased LC3-II levels and decreased p62 levels. PREP inhibitor treatment increased total levels of autophagic vacuoles in the RPE cells. Global proteomics was used to examine the phenotype of a commonly used cell model displaying AMD characteristics, oxidative stress and altered protein metabolism, in vitro. These RPE cells displayed induced protein aggregation and clear alterations in macromolecule metabolism, confirming the relevance of the cell model. Differences in intracellular target engagement of PREP inhibitors were observed with cellular thermal shift assay (CETSA). These differences were explained by intracellular drug exposure (the unbound cellular partition coefficient, Kpuu). Importantly, our data is in line with previous observations regarding the discrepancy between PREP's cleaving activity and outcomes in autophagy. This highlights the need to further explore PREP's role in autophagy so that more effective compounds can be designed to battle diseases in which autophagy induction is needed. The present work is the first report investigating the PREP pathway in the RPE and we predict that the PREP inhibitors can be further optimized for treatment of dry AMD.Peer reviewe