Mobile Broadband Possibilities considering the Arrival of IEEE 802.16m & LTE with an Emphasis on South Asia

This paper intends to look deeper into finding an ideal mobile broadband solution. Special stress has been put in the South Asian region through some comparative analysis. Proving their competency in numerous aspects, WiMAX and LTE already have already made a strong position in telecommunication industry. Both WiMAX and LTE are 4G technologies designed to move data rather than voice having IP networks based on OFDM technology. So, they aren't like typical technological rivals as of GSM and CDMA. But still a gesture of hostility seems to outburst long before the stable commercial launch of LTE. In this paper various aspects of WiMAX and LTE for deployment have been analyzed. Again, we tried to make every possible consideration with respect to south Asia i.e. how mass people of this region may be benefited. As a result, it might be regarded as a good source in case of making major BWA deployment decisions in this region. Besides these, it also opens the path for further research and in depth thinking in this issue.Comment: IEEE Publication format, ISSN 1947 5500, http://sites.google.com/site/ijcsis

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

Background The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function. Results Here, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. Specifically, we performed experimental whole-genome mutation screening in Candida albicans and Pseudomonas aureginosa genomes, which provided us with genome-wide experimental data for genes associated with biofilm formation and motility. We further performed targeted assays on selected genes in Drosophila melanogaster, which we suspected of being involved in long-term memory. Conclusion We conclude that while predictions of the molecular function and biological process annotations have slightly improved over time, those of the cellular component have not. Term-centric prediction of experimental annotations remains equally challenging; although the performance of the top methods is significantly better than the expectations set by baseline methods in C. albicans and D. melanogaster, it leaves considerable room and need for improvement. Finally, we report that the CAFA community now involves a broad range of participants with expertise in bioinformatics, biological experimentation, biocuration, and bio-ontologies, working together to improve functional annotation, computational function prediction, and our ability to manage big data in the era of large experimental screens.Peer reviewe

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

BackgroundThe Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function.ResultsHere, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. Specifically, we performed experimental whole-genome mutation screening in Candida albicans and Pseudomonas aureginosa genomes, which provided us with genome-wide experimental data for genes associated with biofilm formation and motility. We further performed targeted assays on selected genes in Drosophila melanogaster, which we suspected of being involved in long-term memory.ConclusionWe conclude that while predictions of the molecular function and biological process annotations have slightly improved over time, those of the cellular component have not. Term-centric prediction of experimental annotations remains equally challenging; although the performance of the top methods is significantly better than the expectations set by baseline methods in C. albicans and D. melanogaster, it leaves considerable room and need for improvement. Finally, we report that the CAFA community now involves a broad range of participants with expertise in bioinformatics, biological experimentation, biocuration, and bio-ontologies, working together to improve functional annotation, computational function prediction, and our ability to manage big data in the era of large experimental screens.</p

Transfer learning towards combating antibiotic resistance

Transfer learning with deep neural networks has revolutionized the fields of computer vision and natural language processing in the last decade. This is especially significant for fields such as biology where we usually have small labeled data but an abundance of unlabeled data. Using abundant unlabeled data to enhance performance on a small labeled dataset is the hallmark of transfer learning. In this dissertation, I tap into the potential of transfer learning to solve critical problems in the antibiotic resistance domain. Antibiotic resistance occurs when bacteria gain functionality to thwart mechanisms through which antibiotics work to kill or inhibit bacteria. This resistance is leading to alarming rates of mortality and morbidity among the world population. Two critical aspects in combating antibiotic resistance is searching for novel sources of antibiotics, and identifying genes that confer antibiotic resistance ability to a bacteria. As I show, in both of these cases, we have small labeled datasets but large unlabeled data at our disposal. I have incorporated transfer learning techniques in both cases, significantly improving on current state-of-the-art performance typically achieved by alignment based approaches such as BLAST or HMMER. I also introduce a novel optimization method to train neural networks that offer reliable uncertainty estimates when the model is tested on Out-of-distribution (OoD) data. Finally, I offer future directions on how transfer learning can be further utilized to solve these critical problems.</p

MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are an important class of natural products that contain antibiotics and a variety of other bioactive compounds. The existing methods for discovery of RiPPs by combining genome mining and computational mass spectrometry are limited to discovering specific classes of RiPPs from small datasets, and these methods fail to handle unknown post-translational modifications. Here, we present MetaMiner, a software tool for addressing these challenges that is compatible with large-scale screening platforms for natural product discovery. After searching millions of spectra in the Global Natural Products Social (GNPS) molecular networking infrastructure against just eight genomic and metagenomic datasets, MetaMiner discovered 31 known and seven unknown RiPPs from diverse microbial communities, including human microbiome and lichen microbiome, and microorganisms isolated from the International Space Station

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens.

BackgroundThe Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function.ResultsHere, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. Specifically, we performed experimental whole-genome mutation screening in Candida albicans and Pseudomonas aureginosa genomes, which provided us with genome-wide experimental data for genes associated with biofilm formation and motility. We further performed targeted assays on selected genes in Drosophila melanogaster, which we suspected of being involved in long-term memory.ConclusionWe conclude that while predictions of the molecular function and biological process annotations have slightly improved over time, those of the cellular component have not. Term-centric prediction of experimental annotations remains equally challenging; although the performance of the top methods is significantly better than the expectations set by baseline methods in C. albicans and D. melanogaster, it leaves considerable room and need for improvement. Finally, we report that the CAFA community now involves a broad range of participants with expertise in bioinformatics, biological experimentation, biocuration, and bio-ontologies, working together to improve functional annotation, computational function prediction, and our ability to manage big data in the era of large experimental screens