Strategizing niceness in co-opetition: The case of knowledge exchange in supply chain innovation projects

© 2015 Elsevier B.V. All rights reserved. Abstract In this paper, we take a novel approach to address the dilemma of innovation sharing versus protection among supply chain partners. The paper conducts an exploratory study that introduces factors affecting a firm\u27s optimum supply chain innovation strategy. We go beyond the conventional Prisoners\u27 Dilemma, with its limiting assumptions of players\u27 preferences and symmetry, to explore a larger pool of 2 × 2 games that may effectively model the problem. After classifying firm types according to collaboration motive and relative power, we use simulation to explore the effects of firm type, opponent type, and payoff structure on repeated innovation interactions (or, equivalently, long-term relations) and optimality of \u27niceness\u27. Surprisingly, we find that opponent type is essentially irrelevant in long-term innovation interactions, and focal firm type is only conditionally relevant. The paper contributes further by introducing reciprocation of strategy type (nice versus mean), showing that reciprocation is recommended, while identifying and explaining the exceptions to this conclusion

Regional and Seasonal Variation of Polycyclic Aromatic Hydrocarbons in Water and Mollusca at Quarna North of Shatt AL-Arab River

Distribution and seasonal variations and sources of of the sixteen polycyclic aromatic hydrocarbons (PAHs) was studied in surface water and and  fuor species of molluscs (Theodoxus Jordani, Melanoides taberculata Melanopsis nodosa, Bellamya bengalensis ) from three stations at Al-Quarna in Shatt Al Arab river during the low tide period from September, 2018 to March, 2019 . Liquid-liquid extraction was used for water samples, while PAHs in molluscs were extracted using Soxhlet Extraction and finally analyzed by means of gas chromatography.  physical and chemical parameter were measured such as . Water Temperature range from (13°C to 39°C), Dissolved oxygen range from (6.5 mg/l to 3.84 mg/l),PH range from (8.15-7.17) and Electrical conductivity (2.59 ms/cm- 4.75 ms/cm). Results of PAHs in water samples was ranged from (1.4754ng / l) during summer in the first station to (3.4215ng / l) during winter at the third station. While the total PAHs in molluscs range from  0.876 ng/g dry weight in the T.jordani in station 1during summer to 9.093 ng/g dry weight in the B.bengalensis during winter . The Highest concentration of PAHs in  the four species were arranged as fellow :Bellamya bengalensis ˃ Melanopsis nodosa ˃ Melanoides taberculata ˃ Theodoxus Jordani. When we compares the concentration  TPHs in water and molluscs with other study it allies within these concentration. Keywords: PAH, water, Mollusca, Pollution,Qurna,ShattAL-Arab River,Basrah,Iraq DOI: 10.7176/JNSR/9-14-05 Publication date:July 31st 201

Clinical Profile of Non-Motor Symptoms in Patients with Essential Tremor: Impact on Quality of Life and Age-Related Differences

Background: Identifying the clinical phenotypes of non-motor symptoms (NMSs) of essential tremor (ET) among different populations is necessary due to their impact on the quality of life (QoL). This study aimed to investigate the clinical phenotype and impact of NMSs on QoL in Egyptian patients with ET. Methods: Thirty ET patients were compared to 30 matched controls. Subjects were evaluated by the Fahn-Tolosa-Marin Tremor Rating Scale, Non-Motor Symptoms Scale (NMSS), Montreal Cognitive Assessment, Hamilton Anxiety Rating Scale, Beck Depression Inventory, Pittsburgh Sleep quality Index, and the Short Form 36 Health Survey Questionnaire. Both groups were divided into two subgroups of younger (45 years, 16 patients) groups, to investigate age-related differences. Results: ET patients showed significantly worse cognition, depression, anxiety, sleep and NMSS domains (p < 0.001), compared to controls, that negatively affected and predicted QoL. Older patients had more cognitive impairment (p = 0.003) and worse sleep/fatigue (p = 0.032) and sexual functions (p = 0.006), compared to younger group. Discussion: The study supports that NMSs are integral part of ET, negatively affect QoL, and similarly affect younger and older patients. Therefore, NMSs should be explored for proper care of ET patients

Current Status of Baricitinib as a Repurposed Therapy for COVID-19

The emergence of the COVID-19 pandemic has mandated the instant (re)search for potential drug candidates. In response to the unprecedented situation, it was recognized early that repurposing of available drugs in the market could timely save lives, by skipping the lengthy phases of preclinical and initial safety studies. BenevolentAI’s large knowledge graph repository of structured medical information suggested baricitinib, a Janus-associated kinase inhibitor, as a potential repurposed medicine with a dual mechanism; hindering SARS-CoV2 entry and combatting the cytokine storm; the leading cause of mortality in COVID-19. However, the recently-published Adaptive COVID-19 Treatment Trial-2 (ACTT-2) positioned baricitinib only in combination with remdesivir for treatment of a specific category of COVID-19 patients, whereas the drug is not recommended to be used alone except in clinical trials. The increased pace of data output in all life sciences fields has changed our understanding of data processing and manipulation. For the purpose of drug design, development, or repurposing, the integration of different disciplines of life sciences is highly recommended to achieve the ultimate benefit of using new technologies to mine BIG data, however, the final say remains to be concluded after the drug is used in clinical practice. This review demonstrates different bioinformatics, chemical, pharmacological, and clinical aspects of baricitinib to highlight the repurposing journey of the drug and evaluates its placement in the current guidelines for COVID-19 treatment

Effect of Low Level Laser Therapy on Gingival Inflammation in Patients undergoing Fixed Orthodontic Treatment: A Randomized Clinical Trial

AIM: The aim of this study was to compare the effect of low level laser therapy (LLLT) with non-LLLT as an adjunct to mechanical debridement in patients who develop gingival inflammation during fixed orthodontic treatment. MATERIALS AND METHODS: Thirty subjects undergoing comprehensive fixed orthodontic treatment were randomly allocated. Split mouth design was applied for each patient, where the four quadrants were randomly allocated to receive full mouth debridement. The test group (quadrant) received three laser sessions (days 1, 3, and 5) besides debridement while the control group (quadrant) received debridement only. Both bleeding index (BI) and plaque index (PI) were measured after 1 and 3 months, while the total colony forming units (CFU) were measured after 2 and 6 weeks. RESULTS: Clinical assessments (BI and PI) showed a statistically significant decrease at the first follow-up (after 1 month) and a slight increase in the second (after 3 months) that did not reach the base line. While, the total CFU showed a significant decrease in both follow-ups. CONCLUSION: Laser showed superior results in the treatment of gingival inflammation induced by fixed orthodontic appliances other than debridement only

Effect of different slow release potassium fertilizer rates on growth and productivity of banana cv.Williams plants

This study was carried out during the two successive seasons (2017 and 2018) on the first and second ratoon of healthy uniform banana cv. Williams (Musa spp.) Plants grown in sandy soil under drip irrigation system in a private orchard located at El-Tahadi region, Cairo Alexandria desert road, Behaira governorate, Egypt. The investigation aimed to study the effect of different slow release potassium fertilizer (SRKF) (50% K2O) rates (100%, 75% and 50%) were added as soil drench during mid March, mid June and mid September while, potassium sulphate dose used in control treatment was added at monthly intervals as soil application from mid March until mid October on vegetative growth, productivity, total yield income and net return/feddan of banana plants. The obtained results showed that, all treatments had a significant effect on enhancing the vegetative growth parameters, i.e. number of green leaves /plant, plant total assimilation area (m2/plant), leaf total chlorophyll content (CCI) and leaf macro element content (N, P and K) as (%) as well as leaf micro element content (Fe, Zn and Mn) as (ppm). Also, improving yield (ton/feddan), bunch weight (kg), number of hands/bunch, hand weight (kg), number of fingers/hand, finger weight (g), finger length (cm), finger circumference (cm), finger pulp weight (g), finger pulp/peel (ratio), TSS (%), TSS/TA (ratio), total sugars (%). In addition, the total yield income (1000 LE) and net return/feddan (1000 LE) in both seasons. Moreover, all treatments had no significant effect on plant pseudostem height (cm), pseudostem circumferences (cm) and leaf area (m2) of plant in both seasons and bunch length (cm) in the first season only. Treatment of: slow release potassium at 100% gave the highest values of physical and chemical properties of banana plants cv. Williams in both seasons compared to, control treatment (100% potassium sulphate) and slow release potassium at 50% gave the lowest values

MicroRNAs as Potential Biomarkers for Childhood Epilepsy

BACKGROUND: Epilepsy is the most frequent chronic neurologic condition in childhood. Its clinical diagnosis is based on electroencephalograms (EEG) and neuroimaging techniques. MicroRNAs (miRNAs) modulate gene expression of several genes and are aberrantly expressed in several diseases. AIM: Evaluation of using circulating miR-106b and miR-146a as diagnostic and prognostic biomarkers in children patients with epilepsy. METHODS: Thirty epileptic children and twenty controls were enrolled in our study. They were assessed for the expression pattern of miR-106b and miR-146a in plasma using quantitative real-time PCR and determination of plasma Immunoglobulin levels. RESULTS: MiR-146a and miR-106b expression patterns were significantly up-regulated in children patients than that in normal controls. Plasma Immunoglobulins were differentially expressed in epileptic patients in comparison with healthy controls. No correlations were found between expression levels of miRNAs (miR-146a and miR-106b) and clinical data or immunoglobulin levels in children patients with epilepsy. CONCLUSION: Our findings suggest that up-regulated plasma miR-106b and miR-146a could be used as biomarkers for epilepsy evaluation

Trans-species transmission of Brucellae among ruminants hampering brucellosis control efforts in Egypt

Aims: This study aimed to identify the genotypic fingerprinting of Brucella melitensis biovar 3 isolates from ruminants in Kafr El-Sheikh, Egypt, to compare with other peers globally and to highlight the epidemiology and potential causes of brucellosis control failure.Kafr El-Sheikh University, Grant/Award Number: KFSU-3-13-04Depto. de Sanidad AnimalCentro de Vigilancia Sanitaria Veterinaria (VISAVET)TRUEpu

Exploring factors influencing nurses’ attitudes towards their role in dental care

Background The burden of oral disease requires collaboration between health care professionals. Nurses are frequently exposed to patients and can play a vital role in prevention of oral diseases. This study aimed to investigate nurses’ attitudes towards their role in dental care and its associated factors. Methods This cross-sectional, survey-based study recruited a total of 525 nurses in Eastern Saudi Arabia, using a snow-ball sampling technique. Data was collected using an online, pre-validated 40-item questionnaire with four domains (attitudes, knowledge, practices, and demographic data). Results Nurses showed satisfactory attitudes (52.8 ± 8.2) and average knowledge (13.4 ±3.9). More than two thirds (70.3%) reported responding to patients’ questions about oral health conditions, 47.1% and 19.7% conducted oral health screening and education respectively. Referral practices were reported by 266 (50.7%) of the participants with pain being the main reason for referrals. Attending lectures/ trainings on oral health and having a formal education about oral health were significantly associated with nurses’ positive attitudes towards their role in dental care (P<0.001). Conducting oral health screening or education were also significantly associated with positive attitudes (P = 0.001). Conclusion Positive attitudes were observed among those with undergraduate oral health backgrounds, in continuous education, and those who were involved in oral health screenings. There is a need for under and postgraduate inclusion of oral health training in nurses’ education.publishedVersio

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London