7 research outputs found
Historical Ontology
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2002
- Field of study
Potential Pitfalls in Diagnostic Digital Image Analysis: Experience with Ki-67 and PHH3 in Gastrointestinal Neuroendocrine Tumors
- Author
- Publication venue
- Donald and Barbara Zucker School of Medicine Academic Works
- Publication date
- 01/01/2020
- Field of study
© 2019 Elsevier GmbH Gastrointestinal neuroendocrine tumors, or GI-NETs are a highly diverse group of tumors derived from neuroendocrine cells of the GI tract. In GI-NET, a spectrum of histological and molecular parameters exists to predict prognosis and survival. Immunohistochemistry for Ki67, a nuclear antigen that is present in all but the G0 phase of the cell cycle with specificity for proliferating cells, can be used to determine a tumors proliferation index. With this in mind, grading of gastrointestinal neuroendocrine tumors is critical for prognosis and can impact clinical decision making. Recently, digital image analysis (DIA) has been shown in studies to be a superior and less time-consuming alternative to the manual scoring of Ki-67 in breast cancer, secondary to its theoretical diagnostic reproducibility. In DIA, the correct identification of tumor cells and non-tumor is paramount to avoid over or under calculation of biomarker expression. Additionally, DIA requires a pathologist to manually outline a tumor in large tissue areas of hematoxylin and eosin (H&E) sections, which is impractical. The findings in our study showed that ventana virtuoso software computer analyzed Ki-67 only correlated well with Neuroendocrine carcinomas while manual analysis of mitotic index and Ki67 were found to be gold standard. The performance of DIA in our study was plagued by software issues. In future, the advent of new digital imaging technologies such as virtual dual staining will hopefully improve diagnostic accuracy and reproducibility across different DIA platforms. Ultimately, determination of therapeutic strategies should be guided by an amalgamation of clinicopathologic characteristics not limited to mitotic index and Ki-67. As well, A visual check of the results should always be performed and correlated with other findings
Addiction Markets
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- Moukheiber
- Moynihan
- Moynihan
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- Murray
- National Bioethics Advisory Commission
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- O sexo inseguro
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- Oliveira
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- Schering-Plough
- Schuklenk
- Scott
- Sell
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- Serra
- Setbon
- Shapin
- Sheahan
- Shorter
- Sikkink
- Silva
- Smith
- Someya
- Spears
- Spiegel
- Starr
- Stiglitz
- Strathern
- Strathern
- Teen depression: 3 million kids suffer from it
- Teixeira
- Temple
- Thase
- Toulmin
- Tribalat
- Trostle
- Trouillot
- Tsutani
- Turkle
- Turner
- U.S. Food and Drug Administration
- Ueda
- Un généraliste sur cinq deux pharmaciens sur trois
- unaids
- unicef/who
- United Nations
- Van der Geest
- Van der Geest
- Varmus
- Vastag
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- Vuckovic
- Vuckovic
- Waisman
- Whyte
- Whyte
- Whyte
- Whyte
- Whyte
- Wilken
- Williamson
- World Health Organization
- World Health Organization
- World Medical Association
- Young
- Yunes
- Yvorel
- Publication venue
- 'Duke University Press'
- Publication date
- 01/01/2006
- Field of study
Treating AIDS
- Author
- Abbott
- Abrams
- Abramson
- Acordo trips ou acordo adpic
- Acurcio
- Agamben
- Agar
- Agar
- Alden
- Alderman
- Alvarez
- Anderson
- Angell
- Angell
- Angell
- Angell
- Appadurai
- Appadurai
- Applbaum
- Applbaum
- Applbaum
- Applbaum
- Applbaum
- Applbaum
- Arendt
- Arendt
- Arie
- Arnold
- Arrais
- Avorn
- Bachmann
- Bank World
- Bank World
- Bank World
- Barbosa
- Barfod
- Bastos
- Bastos
- Bastos
- Baszanger
- Bayer
- bbc Online
- Becker
- Bellow
- Benatar
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- Bergeron
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- Bermudez
- Bermudez
- Bermudez
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- Biehl
- Biehl
- Biehl
- Biehl
- Biehl
- Biehl
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- Bloch
- Bluebond-Langner
- Boltanski
- Boltanski
- Bosk
- Bosk
- Bosk
- Bosk
- Bosk
- Botbol-Baum
- Bourdieu
- Bourgois
- Bowker
- Boyer
- Braithwaite
- Brandt
- Brass
- Breslau
- Briggs
- Brodwin
- Bury
- Bury
- Cadet-Taïrou
- Cadet-Taïrou
- Cadet-Taïrou
- Cahuzac
- Caldeira
- Callaway
- Cardoso
- Carpenter
- Carpentier
- Carpentier
- Cassier
- Cecchi
- Center for Drug Evaluation and Research
- Chabal
- Chambliss
- Charpak
- Chen
- Chernobyl’s legacy to science
- Cholley
- Christakis
- Clary
- Cohen
- Cohen
- Comaroff
- Comaroff
- Conrad
- Coombe
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids [cn]
- Coppel
- Coppel
- Cosendey
- Costes
- Courtwright
- Crouch
- Crozier
- Dagognet
- Dagognet
- Daniel
- Das
- Das
- Das
- Das
- Das
- Das
- Davis
- de Castilho
- De Grazia
- de Vries
- de Zulueta
- Deleuze
- Desjarlais
- Desjarlais
- Deux médecins dénoncent les dérives liées au Subutex
- Dickersin
- DiMasi
- Dixon
- Doimo
- Dourado
- Dourado
- Dumit
- Edwards
- Ehrenberg
- Eisenberg
- El consumo de tranquilizantes crecio entre un 8 y un 9 por ciento
- Elkin
- Elliott
- Elliott
- Encyclopedia of Global Industries
- Epstein
- Escorel
- Estroff
- Etkin
- European Monitoring Center for Drugs and Drug Addiction
- Farmer
- Farmer
- Farmer
- Farmer
- Farmer
- Farmer
- Fassin
- Ferguson
- Feroni
- Fischer
- Fischer
- Fleising
- Fonseca
- Foucault
- Foucault
- Foucault
- Foucault
- Franklin
- Fraser
- Gabe
- Galbraith
- Galvão
- Galvão
- Gasquet
- Gattari
- Geertz
- Geertz
- Gibier
- Giddens
- Giddens
- Glenmullen
- Gomart
- Good
- Good
- Good
- Good
- Goozner
- Gorman
- Government of India
- Groupe de Travail de 1’inserm
- Guess
- Guillemin
- Hacking
- Hacking
- Hacking
- Hacking
- Hahn
- Hahn
- Harries
- Harrington
- Harvard aids Institute
- Hassenteufel
- Hayden
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Hilts
- Hirschman
- Homedes
- Hopenhayn
- Ignatieff
- Inhorn
- James
- Jeffery
- Jeffrey
- Johansson
- Jonas
- Juma
- Just how tainted has medicine become?
- Kamat
- Kapp
- Karim
- Kassirer
- Kaufman
- Kawabuchi
- Keller
- Kervasdoué
- Khan
- Kim
- Kim
- King
- Kisuule
- Klein
- Kleinman
- Kleinman
- Kleinman
- Kleinman
- Kleinman
- Kleinman
- Klerman
- Klerman
- Klerman
- Klerman
- Knorr Cetina
- Kopp
- Kopytoff
- Kotler
- Kramer
- Kremer
- Kumar
- Lagnado
- Lakoff
- Lakoff
- LaPiazza
- Larvie
- Latour
- Leclerc
- Lemmens
- Lemoine
- Lert
- Leshner
- Leslie
- Leslie
- Lewin
- Lexchin
- Lexchin
- Lindenbaum
- Lock
- Lock
- Lock
- Lovell
- Lovell
- Lovell
- Lovell
- Lovell
- Lowy
- Luhrmann
- Luiza
- Lurie
- Lurie
- Lévi-Strauss
- Macklin
- Macro
- Maestracci
- Malt
- Marks
- Marks
- Marks
- Marks
- Marks
- Marks
- Marks
- Marks
- Marshall
- Maurin
- Medawar
- Medawar
- Ministério da Saúde [ms]
- Ministério da Saúde [ms]
- Ministério da Saúde [ms]
- Misra
- Moatti
- Mogensen
- Moore
- Moreno
- Morris
- Moukheiber
- Moynihan
- Moynihan
- Mundy
- Murray
- National Bioethics Advisory Commission
- National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research
- Nguyen
- Nichter
- O sexo inseguro
- Office of the Inspector General Department of Health and Human Services
- Okie
- Oliveira
- O’Nell
- Paley
- Palier
- Pan American Health Organization
- Paraguassú
- Parker
- Parker
- Parker
- Parker
- Parker
- Parker
- Parker
- Parkhurst
- Peabody
- Petersen
- Petryna
- Petryna
- Pincus
- Pocock
- Pool
- Power
- Prakash
- Rabinow
- Rabinow
- Rabinow
- Rabinow
- Rabinow
- Rabinow
- Ramesh
- Rampton
- Ramsey
- Rapp
- Relman
- Rettig
- Rhodes
- Rieff
- Rodwin
- Rose
- Rose
- Rose
- Rose
- Rosenberg
- Rosário Costa
- Rothman
- Rothman
- Rothman
- Sabel
- Sachs
- Saradamma
- Sassen
- Sassen
- Sassen
- Scheper-Hughes
- Scheper-Hughes
- Scheper-Hughes
- Scheper-Hughes
- Scheper-Hughes
- Scheper-Hughes
- Schering-Plough
- Schuklenk
- Scott
- Sell
- Serra
- Serra
- Setbon
- Shapin
- Sheahan
- Shorter
- Sikkink
- Silva
- Smith
- Someya
- Spears
- Spiegel
- Starr
- Stiglitz
- Strathern
- Strathern
- Teen depression: 3 million kids suffer from it
- Teixeira
- Temple
- Thase
- Toulmin
- Tribalat
- Trostle
- Trouillot
- Tsutani
- Turkle
- Turner
- U.S. Food and Drug Administration
- Ueda
- Un généraliste sur cinq deux pharmaciens sur trois
- unaids
- unicef/who
- United Nations
- Van der Geest
- Van der Geest
- Varmus
- Vastag
- Vaughan
- Vuckovic
- Vuckovic
- Waisman
- Whyte
- Whyte
- Whyte
- Whyte
- Whyte
- Wilken
- Williamson
- World Health Organization
- World Health Organization
- World Medical Association
- Young
- Yunes
- Yvorel
- Publication venue
- 'Duke University Press'
- Publication date
- 01/01/2006
- Field of study
Pharmaceuticals in Urban Ecologies
- Author
- Abbott
- Abrams
- Abramson
- Acordo trips ou acordo adpic
- Acurcio
- Agamben
- Agar
- Agar
- Alden
- Alderman
- Alvarez
- Anderson
- Angell
- Angell
- Angell
- Angell
- Appadurai
- Appadurai
- Applbaum
- Applbaum
- Applbaum
- Applbaum
- Applbaum
- Applbaum
- Arendt
- Arendt
- Arie
- Arnold
- Arrais
- Avorn
- Bachmann
- Bank World
- Bank World
- Bank World
- Barbosa
- Barfod
- Bastos
- Bastos
- Bastos
- Baszanger
- Bayer
- bbc Online
- Becker
- Bellow
- Benatar
- Benatar
- Bergeron
- Bergeron
- Berman
- Bermudez
- Bermudez
- Bermudez
- Biehl
- Biehl
- Biehl
- Biehl
- Biehl
- Biehl
- Biehl
- Biehl
- Biehl
- Binder
- Bloch
- Bluebond-Langner
- Boltanski
- Boltanski
- Bosk
- Bosk
- Bosk
- Bosk
- Bosk
- Botbol-Baum
- Bourdieu
- Bourgois
- Bowker
- Boyer
- Braithwaite
- Brandt
- Brass
- Breslau
- Briggs
- Brodwin
- Bury
- Bury
- Cadet-Taïrou
- Cadet-Taïrou
- Cadet-Taïrou
- Cahuzac
- Caldeira
- Callaway
- Cardoso
- Carpenter
- Carpentier
- Carpentier
- Cassier
- Cecchi
- Center for Drug Evaluation and Research
- Chabal
- Chambliss
- Charpak
- Chen
- Chernobyl’s legacy to science
- Cholley
- Christakis
- Clary
- Cohen
- Cohen
- Comaroff
- Comaroff
- Conrad
- Coombe
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids [cn]
- Coppel
- Coppel
- Cosendey
- Costes
- Courtwright
- Crouch
- Crozier
- Dagognet
- Dagognet
- Daniel
- Das
- Das
- Das
- Das
- Das
- Das
- Davis
- de Castilho
- De Grazia
- de Vries
- de Zulueta
- Deleuze
- Desjarlais
- Desjarlais
- Deux médecins dénoncent les dérives liées au Subutex
- Dickersin
- DiMasi
- Dixon
- Doimo
- Dourado
- Dourado
- Dumit
- Edwards
- Ehrenberg
- Eisenberg
- El consumo de tranquilizantes crecio entre un 8 y un 9 por ciento
- Elkin
- Elliott
- Elliott
- Encyclopedia of Global Industries
- Epstein
- Escorel
- Estroff
- Etkin
- European Monitoring Center for Drugs and Drug Addiction
- Farmer
- Farmer
- Farmer
- Farmer
- Farmer
- Farmer
- Fassin
- Ferguson
- Feroni
- Fischer
- Fischer
- Fleising
- Fonseca
- Foucault
- Foucault
- Foucault
- Foucault
- Franklin
- Fraser
- Gabe
- Galbraith
- Galvão
- Galvão
- Gasquet
- Gattari
- Geertz
- Geertz
- Gibier
- Giddens
- Giddens
- Glenmullen
- Gomart
- Good
- Good
- Good
- Good
- Goozner
- Gorman
- Government of India
- Groupe de Travail de 1’inserm
- Guess
- Guillemin
- Hacking
- Hacking
- Hacking
- Hacking
- Hahn
- Hahn
- Harries
- Harrington
- Harvard aids Institute
- Hassenteufel
- Hayden
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Healy
- Hilts
- Hirschman
- Homedes
- Hopenhayn
- Ignatieff
- Inhorn
- James
- Jeffery
- Jeffrey
- Johansson
- Jonas
- Juma
- Just how tainted has medicine become?
- Kamat
- Kapp
- Karim
- Kassirer
- Kaufman
- Kawabuchi
- Keller
- Kervasdoué
- Khan
- Kim
- Kim
- King
- Kisuule
- Klein
- Kleinman
- Kleinman
- Kleinman
- Kleinman
- Kleinman
- Kleinman
- Klerman
- Klerman
- Klerman
- Klerman
- Knorr Cetina
- Kopp
- Kopytoff
- Kotler
- Kramer
- Kremer
- Kumar
- Lagnado
- Lakoff
- Lakoff
- LaPiazza
- Larvie
- Latour
- Leclerc
- Lemmens
- Lemoine
- Lert
- Leshner
- Leslie
- Leslie
- Lewin
- Lexchin
- Lexchin
- Lindenbaum
- Lock
- Lock
- Lock
- Lovell
- Lovell
- Lovell
- Lovell
- Lovell
- Lowy
- Luhrmann
- Luiza
- Lurie
- Lurie
- Lévi-Strauss
- Macklin
- Macro
- Maestracci
- Malt
- Marks
- Marks
- Marks
- Marks
- Marks
- Marks
- Marks
- Marks
- Marshall
- Maurin
- Medawar
- Medawar
- Ministério da Saúde [ms]
- Ministério da Saúde [ms]
- Ministério da Saúde [ms]
- Misra
- Moatti
- Mogensen
- Moore
- Moreno
- Morris
- Moukheiber
- Moynihan
- Moynihan
- Mundy
- Murray
- National Bioethics Advisory Commission
- National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research
- Nguyen
- Nichter
- O sexo inseguro
- Office of the Inspector General Department of Health and Human Services
- Okie
- Oliveira
- O’Nell
- Paley
- Palier
- Pan American Health Organization
- Paraguassú
- Parker
- Parker
- Parker
- Parker
- Parker
- Parker
- Parker
- Parkhurst
- Peabody
- Petersen
- Petryna
- Petryna
- Pincus
- Pocock
- Pool
- Power
- Prakash
- Rabinow
- Rabinow
- Rabinow
- Rabinow
- Rabinow
- Rabinow
- Ramesh
- Rampton
- Ramsey
- Rapp
- Relman
- Rettig
- Rhodes
- Rieff
- Rodwin
- Rose
- Rose
- Rose
- Rose
- Rosenberg
- Rosário Costa
- Rothman
- Rothman
- Rothman
- Sabel
- Sachs
- Saradamma
- Sassen
- Sassen
- Sassen
- Scheper-Hughes
- Scheper-Hughes
- Scheper-Hughes
- Scheper-Hughes
- Scheper-Hughes
- Scheper-Hughes
- Schering-Plough
- Schuklenk
- Scott
- Sell
- Serra
- Serra
- Setbon
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- Sikkink
- Silva
- Smith
- Someya
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- Teen depression: 3 million kids suffer from it
- Teixeira
- Temple
- Thase
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- Tribalat
- Trostle
- Trouillot
- Tsutani
- Turkle
- Turner
- U.S. Food and Drug Administration
- Ueda
- Un généraliste sur cinq deux pharmaciens sur trois
- unaids
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- Van der Geest
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- Waisman
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- Whyte
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- Young
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- Publication venue
- 'Duke University Press'
- Publication date
- 01/01/2006
- Field of study
Pharmaceutical Governance
- Author
- Abbott
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- Abramson
- Acordo trips ou acordo adpic
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- Chernobyl’s legacy to science
- Cholley
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- Cohen
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- Comaroff
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- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids
- Coordenação Nacional de dst e aids [cn]
- Coppel
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- Elkin
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- Just how tainted has medicine become?
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- Moynihan
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- Nguyen
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- Sheahan
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- Sikkink
- Silva
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- Someya
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- Strathern
- Strathern
- Teen depression: 3 million kids suffer from it
- Teixeira
- Temple
- Thase
- Toulmin
- Tribalat
- Trostle
- Trouillot
- Tsutani
- Turkle
- Turner
- U.S. Food and Drug Administration
- Ueda
- Un généraliste sur cinq deux pharmaciens sur trois
- unaids
- unicef/who
- United Nations
- Van der Geest
- Van der Geest
- Varmus
- Vastag
- Vaughan
- Vuckovic
- Vuckovic
- Waisman
- Whyte
- Whyte
- Whyte
- Whyte
- Whyte
- Wilken
- Williamson
- World Health Organization
- World Health Organization
- World Medical Association
- Young
- Yunes
- Yvorel
- Publication venue
- 'Duke University Press'
- Publication date
- 01/01/2006
- Field of study
C
- Author
- A Barnett
- A Barnett
- A Barnett
- A Barnett
- A Barnett
- A Barnett
- A Barnett
- A Blumstein
- A Blumstein
- A Blumstein
- A Charnes
- A Kershenbaum
- A Mayer
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- A Schrijver
- A Stoorvogel
- A Touran
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- B Everitt
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- BDO Anderson
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- Center for Naval Analyses
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- CL Lawson
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- ES Quade
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- GP Hodgkinson
- H Edelsbrunner
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- Hacking 1
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- K Astrom
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- KG Murty
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- KL Clarkson
- KL Hoffman
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- KL Hoffman
- KM Sage
- KP Heiss
- KR Harrigan
- L Adler
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- L Green
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- LR Beach
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- M Barahona
- M Green
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- M Grotschel
- M Grotschel
- M Guignard
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- M Kojima
- M Lorr
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- M Schwartz
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- ME Porter
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- MW Cooper
- N Christofides
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- N Wiener
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- NL Biggs
- OL Mangasarian
- P Alfeld
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- PE Sweeney
- PHA Sneath
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- R Fourer
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- RW Cottle
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- S Beer
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- S Martello
- S Stollmack
- S Zenios
- SF Richard
- SIAM
- SM Robinson
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- ST Allison
- T Asano
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- T Sueyoshi
- T Sueyoshi
- TB Sheridan
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- TH Davenport
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- W Fleming
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- Y Pochet
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1996
- Field of study